A PET Imaging Agent to Assess the Level of Tumor Tissue-infiltrating CD8 + T Cells in Patients With Solid Tumors

Inclusion Criteria:

1. Age 18-70 years (including boundary values);
2. Have behavioral ability, and voluntarily participate in this clinical study, and sign the informed consent form (ICF);
3. Performance status (ECOG) score 0-1 points (see Appendix 1 for details);
4. Basal heart rate 60-100 beats/min (including boundary values);
5. Blood pressure measurement < hypertension grade 1 level (including a history of hypertension, systolic blood pressure < 140 and diastolic blood pressure < 90 mmHg by exercise or drug treatment);
6. Patients with confirmed solid tumors;
7. Patients who must have at least one image-measurable lesion according to the evaluation criteria for solid tumors (RECISTv1.1);
8. Imaging results show that at least one tumor lesion can be needle biopsy or surgical treatment to obtain specimens (enhanced CT, enhanced MRI or 18F-FDG PET/CT results are acceptable);
9. Patients with immunohistochemical CD8 results within the past month;

Exclusion Criteria:

1. Those who are unable to follow this clinical trial protocol well enough to make visits, or undergo relevant examinations, or treatment.
2. Those who have extremely poor nutritional status and cannot tolerate the trial
3. Those with comorbid major diseases or other malignancies (except those that have healed by one year or do not require additional treatment)
4. Those with known severe allergy to SNA006, similar drugs or excipients. Specialized conditions
5. Patients who have undergone previous splenectomy or splenic disease such as hypersplenism or splenomegaly
6. Patients with brain metastases.
7. Serum virology tests: positive results for any of hepatitis B virus surface antigen, hepatitis C virus antibodies, syphilis-specific antibodies or those who cannot be determined to be negative for human immunodeficiency virus antibodies
8. Patients who have not recovered from a serious infection
9. Patients with drug/alcohol abuse, severe mental disorders
10. Those with claustrophobia, emotional instability, acute persistent spasticity or inability to keep both arms up and lying flat for 15-30 minutes
11. Those who have participated in any other clinical trial within 3 months prior to screening
12. Women who are pregnant or breastfeeding.
13. Those who, in the opinion of the investigator, are not suitable to participate in this clinical study.