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Multimodality Treatment Including Curative Resection of Advanced NSCLC

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ClinicalTrials.gov Identifier: NCT04455984
Recruitment Status : Recruiting
First Posted : July 2, 2020
Last Update Posted : July 7, 2020
Sponsor:
Information provided by (Responsible Party):
Katharina Sinn, Medical University of Vienna

Brief Summary:
This study retrospectively evaluates clinical parameters and outcome of patients with advanced stage non-small cell lung cancer treated with neoadjuvant therapy followed by curative-intent surgery at the Divison of Thoracic Surgery at the Medical University of Vienna

Condition or disease Intervention/treatment
Advanced Non-small-cell Lung Cancer Other: Date collection

Detailed Description:
This study will be undertaken as a retrospective cohort study at Devision of Thoracic Surgery, Medical University of Vienna. All patients with non-small-cell lung cancer, who received an induction chemo- or chemoradiotherapy followed by surgery in a curative intention at the Devision of Thoracic Surgery, Medical University, will be included. The aim of this study is to evaluate peri- and postoperative clinical parameters and short- and long-term outcomes in patients.

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Study Type : Observational
Estimated Enrollment : 190 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Multimodality Treatment Including Curative Resection of Advanced Stage Non-small Cell Lung Cancer - an Explorative, Retrospective Pilot Study
Actual Study Start Date : May 1, 2017
Estimated Primary Completion Date : August 1, 2020
Estimated Study Completion Date : August 1, 2020

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
Neoadjuvant chemoradiotherapy
Patients with advanced NSCLC treated with neoadjuvant platinum-based chemoradiotherapy followed by curative-intent surgery
Other: Date collection
Retrospective data analysis

Neoadjuvant chemotherapy
Patients with advanced NSCLC treated with neoadjuvant platinum-based chemotherapy followed by curative-intent surgery
Other: Date collection
Retrospective data analysis




Primary Outcome Measures :
  1. Overall survival [ Time Frame: 18 years ]
    • Overall survival of stage III NSCLC in resectable patients undergoing induction treatment and curative intent surgery
    • Overall survival of stage III NSCLC in resectable patients undergoing induction treatment and curative intent surgery
    • Overall survival of stage III NSCLC in resectable patients undergoing induction treatment and curative intent surgery Overall survival of stage III NSCLC in resectable patients undergoing induction treatment and curative intent surgery



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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
All patients with non-small-cell lung cancer, who received an induction chemo- or chemoradiotherapy followed by surgery in a curative intention at the Devision of Thoracic Surgery, Medical University.
Criteria

Inclusion Criteria:

  • Patients with advanced NSCLC and multimodality treatment including curative-intent resection

Exclusion Criteria:

  • Patients with early stage NSCLC
  • Patients with advanced NSCLC without multimodality treatment
  • Patients without curative resection

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04455984


Contacts
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Contact: Katharina Sinn, MD 004314040056440 katharina.sinn@meduniwien.ac.at

Locations
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Austria
Medical University of Vienna Recruiting
Vienna, Austria
Contact: Katharina Sinn, MD         
Sponsors and Collaborators
Medical University of Vienna
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Responsible Party: Katharina Sinn, MD, Medical University of Vienna
ClinicalTrials.gov Identifier: NCT04455984    
Other Study ID Numbers: 193132122
First Posted: July 2, 2020    Key Record Dates
Last Update Posted: July 7, 2020
Last Verified: July 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Neoplasms
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms