Multiple Breath Washout (MBW) Using Sulfur Hexafluoride Reference Values and Influence of Anthropometric Parameters
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ClinicalTrials.gov Identifier: NCT04099225
Recruitment Status :
First Posted : September 23, 2019
Last Update Posted : September 23, 2019
Information provided by (Responsible Party):
Dr. Frederik Trinkmann, Universitätsmedizin Mannheim
Multiple breath washout (MBW) using Sulphur hexafluoride (SF6) has the potential to reveal ventilation heterogeneity in obstructive lung disease which is frequent in patients with small airway disease. However, it is missed by commonly used tests with reference data being scarce and mostly restricted to younger collectives. We aimed to evaluate the influence of anthropometric parameters on SF6-MBW reference values in pulmonary healthy adults.
Lung clearance index (LCI), acinar (Sacin) and conductive (Scond) ventilation heterogeneity were derived from triplicate SF6-MBW measurements. Global ventilation heterogeneity was calculated for the 2.5% (LCI2.5) and 5% (LCI5) stopping points.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
healthy volunteers including never, active and former smokers
no history of pulmonary disease
absence of dyspnoea, cough, thoracic pain
no self-reported smoking history
normal lung function testing
normal shape of flow-volume curve
normal shape of flow-pressure curve
FEV1/FVC >70% (forced expiratory volume in 1 second / forced vital capacity)
TLC > 80% of predicted (total lung capacity)
TLCO/VA > 80% of predicted (transfer factor corrected for ventilated alveolar volume)
R5 < 150% of predicted (resistance at 5Hz, impulse oscillometry)
- as above, but with self-reported smoking history >10 pack years