Safety and Effectiveness of Remote Ischemic Conditioning Combined With Intravenous Thrombolysis in Treating Acute Ischemic Stroke (SERICT-AIS)

Inclusion Criteria:

• 1) Age≥18 years, < 80 years, regardless of sex;
• 2) Patients with clinically definite diagnosis of acute ischemic stroke and undergo intravenous thrombolysis;
• 3) Baseline NIHSS >= 5, and <= 25;
• 4) Baseline GCS ≥8;
• 5) Signed and dated informed consent is obtained

Exclusion Criteria:

• 1) Patients who undergo endovascular treatment;
• 2) mRS ≥ 2 before the onset of the disease;
• 3) Double upper limbs or lower limbs paralysis was found in this case;
• 4) Active bleeding of organs within 6 months of admission or current, including cerebral hemorrhage, subarachnoid hemorrhage, gastrointestinal hemorrhage, fundus hemorrhage and so on;
• 5) Other intracranial lesions, such as cerebrovascular malformation cerebral venous diseases, tumor and other diseases involving the brain;
• 6) Concurrent use of anticoagulation drugs including Warfarin, dabigatran, rivaroxaban;
• 7) Severe organ dysfunction or failure;
• 8) Patients suffering from severe hematological diseases or severe coagulation disorder dysfunction
• 9) Those who have a history of severe trauma or had major surgery within 6 months prior to admission;
• 10) Those who have a history of atrial fibrillation;
• 11) The patients who have the contraindication of remote ischemic conditioning treatment, such as severe soft tissue injury, fracture or vascular injury in the upper limb#Acute or subacute venous thrombosis, arterial occlusive disease, subclavian steal syndrome, etc;
• 12) Pregnant or lactating women;
• 13) Previous remote ischemic conditioning therapy or similar treatment;
• 14) Patients with a life expectancy of less than 3 months or patients unable to complete the study for other reasons;
• 15) Severe hepatic and renal dysfunction;
• 16) Unwilling to be followed up or treated for poor compliance;
• 17) He/She is participating in other clinical research or has participated in other clinical research or has participated in this study within 3 months prior to admission;
• 18) Other conditions that the researchers think are not suitable for the group.