Detection Of β-thalassemia Carriers In Assiut
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|ClinicalTrials.gov Identifier: NCT03822585|
Recruitment Status : Unknown
Verified January 2019 by Shimaa Mohammed Radi Abdelhakeem, Assiut University.
Recruitment status was: Not yet recruiting
First Posted : January 30, 2019
Last Update Posted : January 30, 2019
Thalassemia is different in kids with microcytic hypochromic anemia than general population because there is a confusion between symptoms of thalassemia and iron deficiency anemia in kids and both of them differ in management and prognosis. otherwise the most commonest causes of microcytic hypochromic anemia in kids are iron deficiency anemia and thalassemia and both of them are more common in kids than in general population.
Thalassemia is different in Egypt than anywhere in the world because there is no accurate estimation of incidence and prevalence of such dangerous disease in Egypt inspite of many cases attending thalassemia center (hundreds) and this disease is autosomal recessive and its incidence can be minimized by detection of carrier cases by gene study hopping that to be done as a routine premarital investigation.
|Condition or disease||Intervention/treatment||Phase|
|Beta-Thalassemia||Diagnostic Test: CBC, Iron Study, Serum Ferrittin, HPLC,Genitic Study||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||100 participants|
|Intervention Model:||Single Group Assignment|
|Intervention Model Description:||Close Relatives Of β-Thalassemia Will Do Laboratory Tests|
|Masking:||None (Open Label)|
|Official Title:||Detection of β-thalassemia Carriers Among Close Relatives of β-thalassemia Children Attending Assiut University Children Hospital|
|Estimated Study Start Date :||March 2019|
|Estimated Primary Completion Date :||December 2019|
|Estimated Study Completion Date :||June 2021|
Close Relatives Of β-thalassemia
Laboratory diagnostic tests as (CBC, Iron Study, Serum Ferritin, HPLC, Genetic study) will be done to Brothers, Sisters & Cousins of β-thalassemia Children With Microcytic Hypochromic Anemia Attending Assiut University Child Hospital
Diagnostic Test: CBC, Iron Study, Serum Ferrittin, HPLC,Genitic Study
high performance liquid chromatography (HPLC) has become the preferred technique, as it can detect most of the clinically significant variants. polymerase chain reaction (PCR)-based procedures detect Commonly occurring mutations of the HBB gene .
If targeted mutation analysis fails to detect the mutation, scanning or sequence analysis can be used. Sensitivity of both mutation scanning and sequence analysis is 99%.
- detection of thalassemia carriers in children with microcytic hypochromic anemia [ Time Frame: 2 years ]accurate detection of prevalence rate of thalassemia carriers among relatives of β-thalassemia
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03822585
|Contact: Shimaa MR Abdelhakeem, MDfirstname.lastname@example.org|
|Contact: Ahmed MR Abdelhakeememail@example.com|
|Study Director:||Mohammed HM Ghazally, PROF||Assiut University Child Hospital|