Providing Antibiotic Prescribing Feedback to Primary Care Physicians: The Ontario Program To Improve AntiMicrobial USE (OPTIMISE)
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ClinicalTrials.gov Identifier: NCT03776383 |
Recruitment Status :
Completed
First Posted : December 14, 2018
Last Update Posted : March 3, 2021
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Condition or disease | Intervention/treatment | Phase |
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Antibiotic Prescribing Audit and Feedback | Other: Antibiotic use feedback letter | Not Applicable |

Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 3500 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Intervention Model Description: | 3:3:1 for intervention 1: intervention 2: control |
Masking: | Single (Outcomes Assessor) |
Masking Description: | The data for the outcome are being provided from a third party with no involvement in the study |
Primary Purpose: | Health Services Research |
Official Title: | Ontario Healthcare Implementation Laboratory: A Learning Health System Approach That Leverages Data to Improve Quality in Primary Care: Stage 1 |
Actual Study Start Date : | December 14, 2018 |
Actual Primary Completion Date : | November 30, 2019 |
Actual Study Completion Date : | November 30, 2020 |
Arm | Intervention/treatment |
---|---|
Active Comparator: Antibiotic use feedback letter 1
Antibiotic use feedback letter 1 provides physicians with information on their antibiotic use plus change ideas on appropriate antibiotic prescribing for acute respiratory conditions
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Other: Antibiotic use feedback letter
Mailed letters indicating that the physician prescribes more antibiotics than 75% of their peers |
Active Comparator: Antibiotic use feedback letter 2
Antibiotic use feedback letter 2 provides physicians with information on their antibiotic use plus change ideas on appropriate antibiotic durations for common infections
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Other: Antibiotic use feedback letter
Mailed letters indicating that the physician prescribes more antibiotics than 75% of their peers |
No Intervention: Control
Controls will not receive a letter
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- Antibiotic prescribing rate [ Time Frame: 12 months ]Number of antibiotics prescribed per 100 total prescriptions
- Prolonged duration prescribing rate [ Time Frame: 12 months ]Proportion of antibiotic prescriptions that are >7 days per 100 total prescriptions
- New enrollment for Health Quality Ontario primary care practice reports [ Time Frame: 24 months ]Proportion of new sign ups for Health Quality Ontario primary care practice reports
- New enrollment for Health Quality Ontario primary care practice reports [ Time Frame: 6 months ]Proportion of new sign ups for Health Quality Ontario primary care practice reports
- New enrollment for Health Quality Ontario primary care practice reports [ Time Frame: 12 months ]Proportion of new sign ups for Health Quality Ontario primary care practice reports
- Antibiotic prescribing rate [ Time Frame: 3 months ]Number of antibiotics prescribed per 100 total prescriptions
- Antibiotic prescribing rate [ Time Frame: 6 months ]Number of antibiotics prescribed per 100 total prescriptions
- Antibiotic prescribing rate [ Time Frame: 9 months ]Number of antibiotics prescribed per 100 total prescriptions
- Antibiotic prescribing rate [ Time Frame: 24 months ]Number of antibiotics prescribed per 100 total prescriptions
- Prolonged duration prescribing [ Time Frame: 3 months ]Proportion of antibiotic prescriptions that are >7 days per 100 total prescriptions
- Prolonged duration prescribing [ Time Frame: 6 months ]Proportion of antibiotic prescriptions that are >7 days per 100 total prescriptions
- Prolonged duration prescribing [ Time Frame: 9 months ]Proportion of antibiotic prescriptions that are >7 days per 100 total prescriptions
- Prolonged duration prescribing [ Time Frame: 24 months ]Proportion of antibiotic prescriptions that are >7 days per 100 total prescriptions

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Ages Eligible for Study: | Child, Adult, Older Adult |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Ontario primary care physicians
- Prescribe more antibiotics by volume than 75% of Ontario primary care physicians
- A College of Physicians and Surgeons of Ontario number in 2017-2018
Exclusion Criteria:
- None

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03776383
Canada, Ontario | |
Public Health Ontario | |
Toronto, Ontario, Canada, M5G 1V2 |
Principal Investigator: | Kevin Schwartz, MD MSc | Ontario Agency for Health Protection and Promotion |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Kevin Schwartz, PI, Ontario Agency for Health Protection and Promotion |
ClinicalTrials.gov Identifier: | NCT03776383 |
Other Study ID Numbers: |
2018-046.01 |
First Posted: | December 14, 2018 Key Record Dates |
Last Update Posted: | March 3, 2021 |
Last Verified: | March 2021 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Plan Description: | The data are proprietary and private and cannot be shared with external parties. Study results will be aggregated for publication |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Antibiotic use Audit and feedback implementation science Antimicrobial stewardship |
Anti-Bacterial Agents Anti-Infective Agents |