Idiopathic Pulmonary Fibrosis Job Exposures Study (IPFJES)
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ClinicalTrials.gov Identifier: NCT03211507 |
Recruitment Status :
Completed
First Posted : July 7, 2017
Last Update Posted : December 12, 2019
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Condition or disease | Intervention/treatment |
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IPF Idiopathic Pulmonary Fibrosis | Other: Computer-assisted telephone interview Genetic: Genetic analysis |
Study Type : | Observational |
Actual Enrollment : | 960 participants |
Observational Model: | Case-Control |
Time Perspective: | Prospective |
Official Title: | Idiopathic Pulmonary Fibrosis Job Exposures Study |
Actual Study Start Date : | May 1, 2017 |
Actual Primary Completion Date : | October 5, 2019 |
Actual Study Completion Date : | October 5, 2019 |

Group/Cohort | Intervention/treatment |
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Case
Males with an incident diagnosis of IPF made between the 1st of February 2017 and the 5th of October 2019.
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Other: Computer-assisted telephone interview
Occupational history Genetic: Genetic analysis To include analysis of known susceptibility markers |
Controls
Males with an incident hospital outpatient attendance between the 1st of February 2017 and the 5th of October 2019 who do not have a diagnosis of IPF. At each participating centre a control clinic is randomly selected from all control clinics that the research team is able to recruit from; this clinic is the source clinic for controls for the duration of the study.
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Other: Computer-assisted telephone interview
Occupational history Genetic: Genetic analysis To include analysis of known susceptibility markers |
- Association between asbestos exposure and IPF [ Time Frame: 2 years ]estimated using logistic regression for any vs no asbestos exposure and adjusting for age and smoking status
- Dose-response relationship between asbestos exposure and IPF [ Time Frame: 2 years ]estimated using logistic regression for categories of cumulative exposure and adjusting for age and smoking status
- Gene-environment interaction (for MUC5B rs35705950 and asbestos exposure) odds ratio. [ Time Frame: 2 years ]MUC5B rs35705950 and asbestos exposure odds ratio.
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | Child, Adult, Older Adult |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
For cases
Inclusion Criteria:
- New diagnosis of IPF between February 2017 and October 2019
Exclusion Criteria:
- Unable to give informed consent
- Ever worked outside of the UK
For controls
Inclusion Criteria:
- New outpatient department attendee between February 2017 and October 2019
Exclusion Criteria:
- Unable to give informed consent
- Ever worked outside of the UK (does not include work outside the UK by members of the armed forces or merchant navy)
- Diagnosis of IPF

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03211507
United Kingdom | |
Imperial Healthcare NHS Trust | |
London, United Kingdom |
Study Director: | Carl Reynolds | Imperial College London |
Responsible Party: | Imperial College London |
ClinicalTrials.gov Identifier: | NCT03211507 |
Other Study ID Numbers: |
16SM3627 |
First Posted: | July 7, 2017 Key Record Dates |
Last Update Posted: | December 12, 2019 |
Last Verified: | December 2019 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Studies a U.S. FDA-regulated Drug Product: | No |
Studies a U.S. FDA-regulated Device Product: | No |
Idiopathic Pulmonary Fibrosis |
Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis Fibrosis Pathologic Processes |
Lung Diseases, Interstitial Lung Diseases Respiratory Tract Diseases |