Assessing Dementia Risk in the Community: The Dementia Population Risk Tool (DemPoRT)
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|ClinicalTrials.gov Identifier: NCT03155815|
Recruitment Status : Completed
First Posted : May 16, 2017
Last Update Posted : February 17, 2020
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|Condition or disease|
The burden of disease from dementia is a growing global concern as incidence increases exponentially with age and average life expectancy has been increasing around the world. Planning for an aging population requires reliable projections of future dementia prevalence and resource requirements, however, existing population projections are simple and have poor predictive accuracy. The Dementia Population Risk Tool (DemPoRT) will predict incidence of dementia in the population setting using multivariable modeling techniques.
The derivation cohort will consist of elderly Ontario respondents of Canadian Community Health Survey (CCHS) (2001, 2003, 2005, 2007; approximately 19 000 males and 25 000 females). Pre-specified predictors include sociodemographic, general health, behavioral, functional and health condition variables. Incident dementia will be identified through individual linkage of survey respondents to population-level administrative health care databases. Using time of first dementia capture as the primary outcome and death as a competing risk, sex-specific proportional hazards regression models will be estimated. The 2008/2009 CCHS survey be used for validation (approximately 4 600 males and 6 300 females). Overall calibration and discrimination will be assessed as well as calibration within predefined subgroups of importance to clinicians and policy makers.
|Study Type :||Observational|
|Actual Enrollment :||75460 participants|
|Official Title:||Dementia Population Risk Tool (DemPoRT): A Predictive Algorithm for Assessing Dementia Risk in the Community Setting|
|Actual Study Start Date :||September 2000|
|Actual Primary Completion Date :||March 2014|
|Actual Study Completion Date :||December 2019|
Eligible respondents to the combined 2001, 2003, 2005 and 2007 Canadian Community Health Surveys, conducted by Statistics Canada.
Eligible respondents to the 2008/2009 Canadian Community Health Survey.
- Dementia capture in administrative data [ Time Frame: Up to 13 years ]Identification of incident dementia in administrative data using a validated case ascertainment definition, supplemented by dementia codes captured on home care and long-term care assessments
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|Ages Eligible for Study:||55 Years and older (Adult, Older Adult)|
|Sexes Eligible for Study:||All|
|Accepts Healthy Volunteers:||Yes|
|Sampling Method:||Probability Sample|
- Respondents to the Canadian Community Health Surveys
- Less than 55 years of age at survey administration
- Prior history of dementia
- Not eligible for Ontario's universal health insurance program
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03155815
|Principal Investigator:||Peter Tanuseputro||Ottawa Hospital Research Institute|
|Responsible Party:||Ottawa Hospital Research Institute|
|Other Study ID Numbers:||
CIHR FRN 142237
|First Posted:||May 16, 2017 Key Record Dates|
|Last Update Posted:||February 17, 2020|
|Last Verified:||February 2020|
|Individual Participant Data (IPD) Sharing Statement:|
|Plan to Share IPD:||No|
|Studies a U.S. FDA-regulated Drug Product:||No|
|Studies a U.S. FDA-regulated Device Product:||No|
Central Nervous System Diseases
Nervous System Diseases