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Impact of Anesthesia Type on Outcome in Patients With Acute Ischemic Stroke (AIS) Undergoing Endovascular Treatment (CANVAS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT02677415
Recruitment Status : Recruiting
First Posted : February 9, 2016
Last Update Posted : September 14, 2021
Information provided by (Responsible Party):
Yuming Peng, Beijing Tiantan Hospital

Brief Summary:
Recent observational studies have found an association between general anaesthesia and increased post-operative mortality in acute ischemic stroke patients undergoing endovascular treatment. It is unknown whether there is a causal relationship in this observation. The investigators are performing a large randomised trial of general versus local anaesthesia to definitively answer the question of whether anaesthetic type alters perioperative outcome.

Condition or disease Intervention/treatment Phase
Acute Stroke Other: Intravenous anesthetics Other: local anesthesia Other: Controlled ventilation Other: Spontaneous breathing Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 640 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Supportive Care
Official Title: Impact of General vs Local Anesthesia on Neurological Function in Patients With Acute Ischemic Stroke Undergoing Endovascular Treatment
Actual Study Start Date : September 2016
Estimated Primary Completion Date : December 2022
Estimated Study Completion Date : December 2022

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Ischemic Stroke

Arm Intervention/treatment
Local anesthesia
local anesthesia and spontaneous breathing will be maintained.
Other: local anesthesia
Other: Spontaneous breathing
General anesthesia
Intravenous anesthetics and controlled ventilation will be used .
Other: Intravenous anesthetics
Other: Controlled ventilation

Primary Outcome Measures :
  1. modified Rankin score [ Time Frame: post-procedural 30 days ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with AIS scheduled to receive emergency endovascular treatment, older than 18; the onset time is within 12 hours.

Exclusion Criteria:

  • Radiological ambiguity concerning infarction and vessel occlusion.
  • Additional intracerebral hemorrhage.
  • Posterior circulation infraction.
  • Coma on admission (Glasgow coma score less than 8).
  • NIHSS less than 10 or more than 35.
  • Severe agitation or seizures on admission.
  • Obvious loss of airway protective reflexes and/or vomiting on admission.
  • Being intubated before treatment on admission.
  • Known allergy to anesthetic or analgesic.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02677415

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Contact: Ruquan Han, M.D., Ph.D. 8610-67096660

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Beijing TianTan Hospital Recruiting
Beijing, China, 100050
Contact: Ruquan Han, M.D., Ph.D    8610-67096660   
Sponsors and Collaborators
Beijing Tiantan Hospital
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Principal Investigator: Ruquan Han, M.D., Ph.D. Department of Anesthesiology, Beijing Tiantan Hospital
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Yuming Peng, M.D., Ph.D., Beijing Tiantan Hospital Identifier: NCT02677415    
Other Study ID Numbers: QML20150508
First Posted: February 9, 2016    Key Record Dates
Last Update Posted: September 14, 2021
Last Verified: September 2021
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided
Keywords provided by Yuming Peng, Beijing Tiantan Hospital:
Ischemic Stroke
Endovascular Procedures
Additional relevant MeSH terms:
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Ischemic Stroke
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Anesthetics, Intravenous
Central Nervous System Depressants
Physiological Effects of Drugs
Anesthetics, General