Applicability of Techniques of Lung Expansion
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|ClinicalTrials.gov Identifier: NCT02613832|
Recruitment Status : Completed
First Posted : November 25, 2015
Last Update Posted : November 25, 2015
|Condition or disease||Intervention/treatment||Phase|
|Stroke||Other: EPAP Other: Breath Stacking||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||10 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||Immediate Effect of Expiratory Positive Airway Pressure and Breath Stacking in Non-cooperative Patients Detected by Electrical Impedance Tomography|
|Study Start Date :||August 2014|
|Actual Primary Completion Date :||November 2014|
|Actual Study Completion Date :||January 2015|
Experimental: EPAP Group
The EPAP devices increase the alveolar pressure. This effect is obtained through valves that generate a resistance to airflow during expiration.
The EPAP will be applied with a Spring Load Valve Resistor (Vital Signs, Totowa, NJ, USA), adjusted with a pressure of 10 cmH2O. The Spring Load Valve Resistor will be connected to the expiratory branch of the T-tube. Duration of intervention: 5 minutes.
Other Name: Expiratory Positive Airway Pressure
Experimental: Breath Stacking Group
The Breath Stacking consists on the implementation of subsequent inspiratory efforts through a one way valve, which allows stacked volume of gas during each inspiration, until it reaches a maximum lung volume.
Other: Breath Stacking
The BS will be performed by a T-tube with a one-way inspiratory valve and the expiratory branch occluded. The expiratory occlusion is maintain until observed the presence of a plateau in the impedance plethysmogram by EIT, which corresponds to the absence of inspired air displacement or when a maximum time of 40 seconds was attained. Durantion of intervention:Three BS interventions will be performed at one minute intervals between them.
Other Name: Air Stacking
- Regional Lung Aeration [ Time Frame: Before and 1, 5, 10, 15, 30, 60, 90, 120 minutes post-intervention. ]Change in Regional Lung Aeration (difference between the End-Expiratory Lung Impedance before and post-intervention). Each image along the time represent the relative change in impedance distribution within the transverse section of the chest, from the first scan (before intervention) to current scan. The pixel values are express as percentage changes of local impedance.
- Regional Lung Ventilation [ Time Frame: Before and 1, 5, 10, 15, 30, 60, 90, 120 minutes post-intervention. ]Change in Regional Lung Ventilation (difference between end-inspiratory and end-expiratory lung impedance before and post-intervention).
- Heart Rate [ Time Frame: Before and 1, 5, 10, 15, 30, 60, 90, 120 minutes post-intervention. ]Change in Heart Rate (beats per minute).
- Mean Arterial Pressure [ Time Frame: Before and 1, 5, 10, 15, 30, 60, 90, 120 minutes post-intervention. ]Change in Mean Arterial Pressure (mmHg)
- Respiratory Rate [ Time Frame: Before and 1, 5, 10, 15, 30, 60, 90, 120 minutes post-intervention. ]Change in Respiratory Rate (breath per minute)
- Periferic Saturation of Oxygen [ Time Frame: Before and 1, 5, 10, 15, 30, 60, 90, 120 minutes post-intervention. ]Change in Periferic Saturation of Oxygen (fraction of oxygen-saturated hemoglobin relative to total hemoglobin).
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02613832
|Hospital of Clinics of the Federal University of Pernambuco|
|Recife, PE - Pernambuco, Brazil, 50670330|
|Study Chair:||Caio César A Morais, Master||Universidade Federal de Pernambuco|
|Study Chair:||Shirley L Campos, PHD||Universidade Federal de Pernambuco|