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Effects of Chest Physiotherapy (CPT) on Lung Clearance Index (LCI) in Non Cystic Fibrosis (CF) Bronchiectasis

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ClinicalTrials.gov Identifier: NCT02411981
Recruitment Status : Completed
First Posted : April 8, 2015
Last Update Posted : March 22, 2016
Sponsor:
Information provided by (Responsible Party):
Poncin, Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Study Description
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Brief Summary:
This study will investigate the effects of on technique of chest physiotherapy on pulmonary function. Effects of pulmonary function will be measured by the spirometry, body plethysmography and by the multiple breath nitrogen washout technique.

Condition or disease Intervention/treatment Phase
Bronchiectasis Other: Autogenic drainage Not Applicable

Detailed Description:

This is a before-after intervention study.

Spirometry, body plethysmography and then multiple breath nitrogen washout will be measured before the application of chest physiotherapy.

The chest physiotherapy technique used will be autogenic drainage during 30 minutes. A resting period of 5 minutes will be given to the participant before the following tests.

Spirometry, body plethysmography and then multiple breath nitrogen washout will be measured again, in the same order, after the application of chest physiotherapy.

Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 24 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Short-term Effects of Chest Physiotherapy on Ventilation Inhomogeneity in Non-CF Bronchiectasis
Study Start Date : April 2015
Actual Primary Completion Date : October 2015
Actual Study Completion Date : February 2016
Arms and Interventions
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Arm Intervention/treatment
Autogenic drainage

The autogenic drainage will be the chest physiotherapy technique used for this study.

Autogenic drainage is an airway clearance technique that attempts to obtain the optimal airflow to evacuate the secretions. This technique uses modulation of inspiratory and expiratory airflow at different breathing level within the vital capacity.

 Other: Autogenic drainage


Outcome Measures
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Primary Outcome Measures :
  1. Change of Lung Clearance Index (LCI) [ Time Frame: up to 80 minutes ]
    LCI will me measured before and after the chest physiotherapy session


Secondary Outcome Measures :
  1. Change of Spirometry [ Time Frame: up to 40 minutes ]
    Forced expired volume in one second (FEV1) and Forced expired flow at 25-75% of the forced vital capacity (FEF25-75) will be measured before and after the chest physiotherapy session

  2. Sputum weight [ Time Frame: 35 minutes ]
    Sputum will be collected during the 30 minutes of chest physiotherapy session and 5 minutes immediately after. Sputum weight will be measured and correlated with change of LCI and spirometry values


Eligibility Criteria
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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Non cystic fibrosis bronchiectasis in stable state

Exclusion Criteria:

  • Not in stable state
  • Bronchiectasis with severe respiratory morbidities likely to reduce the chest physiotherapy session efficacy (e.g. : severe chronic obstructive pulmonary disease)
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02411981


Locations
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Belgium
Cliniques universitaires Saint-Luc
Brussels, Belgium, 1200
Sponsors and Collaborators
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Investigators
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Study Director: Sophie Gohy, MD, PhD Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Principal Investigator: William Poncin, PhD student Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study Chair: Grégory Reychler, PhD Cliniques universitaires Saint-Luc- Université Catholique de Louvain
More Information
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Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

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Responsible Party: Poncin, Physiotherapist, Cliniques universitaires Saint-Luc- Université Catholique de Louvain
ClinicalTrials.gov Identifier: NCT02411981    
Other Study ID Numbers: StLuc MBWN2 03
First Posted: April 8, 2015    Key Record Dates
Last Update Posted: March 22, 2016
Last Verified: March 2016
Keywords provided by Poncin, Cliniques universitaires Saint-Luc- Université Catholique de Louvain:
Lung Clearance Index
Non cystic fibrosis Bronchiectasis
Multiple Breath Nitrogen Washout
Additional relevant MeSH terms:
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Bronchiectasis
Bronchial Diseases
Respiratory Tract Diseases