Probiotic Use in Chronic Periodontitis Patients
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|ClinicalTrials.gov Identifier: NCT02403960|
Recruitment Status : Completed
First Posted : March 31, 2015
Last Update Posted : November 1, 2015
Aim: to evaluate the additional effects of the 12 weeks usage of a Streptococcus containing probiotic tablet after scaling and rootplaning compared to a placebo tablet.
Materials and methods: 48 periodontitis patients were included in this double-blind, placebo-controlled trial. After scaling and rootplaning, they were given patients used either a placebo (SRP) or probiotic tablet (SRP + P), 2 times a day for 12 weeks. Clinical and microbiological parameters were studied recorded up to 24 weeks after scaling and rootplaning.
|Condition or disease||Intervention/treatment||Phase|
|Periodontitis||Dietary Supplement: probiotic Dietary Supplement: placebo||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||48 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||The Effect of a Streptococcus Probiotic in Periodontal Therapy: a Randomized Controlled Trial|
|Study Start Date :||June 2010|
|Actual Primary Completion Date :||November 2010|
|Actual Study Completion Date :||May 2011|
Active Comparator: probiotic
The participants of the probiotic group were asked to let a probiotic tablet dissolve on their tongue 2 times a day for 3 months.
Dietary Supplement: probiotic
the patients used probiotic tablets in addition to scaling and root planning
Placebo Comparator: placebo
The participants of the control group were asked to let a placebo tablet dissolve on their tongue 2 times a day for 3 months.
Dietary Supplement: placebo
the patients used placebo tablets in addition to scaling and root planning
- probing pocket depth [ Time Frame: 24 weeks ]
- Recession [ Time Frame: 24 weeks ]Recession as measured in millimeters.
- clinical attachment level [ Time Frame: 24 weeks ]clinical attachment level as measured in millimeters
- Bleeding on probing [ Time Frame: 24 weeks ]Bleeding as measured in presence or absence of bleeding on probing the sulcus
- Gingival Index [ Time Frame: 24 weeks ]
- Plaque Index [ Time Frame: 24 weeks ]
- microbial counts of bacteria [ Time Frame: 24 weeks ]microbial counts as measured in colony forming units
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02403960
|Adana, Turkey, 01330|
|Study Chair:||Onur Ozcelik||CU|