Diets With a Spectrum of Fat Intake for Preventing Obesity: A Randomized Controlled-feeding Trial

Inclusion criteria:

• Students in Zhejiang University or working stuff in the Chinese PLA General Hospital
• 18 ≤ age ≤ 35
• Body Mass Index < 28*
• Are willing to eat all of the study foods even when full
• Are willing to eat only foods provided
• Are willing to avoid strenuous activity during the 6-mo intervention Exclusion criteria：
• Systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg
• Total cholesterol ≥ 239 mg/dL
• Low-density lipoprotein cholesterol ≥ 159 mg/dL
• Triglycerides ≥ 199 mg/dL
• Blood glucose ≥ 110 mg/dL
• Change in body weight exceeding ± 10% during the prior year
• Energy intake is too low or too high
• Unwillingness or special requirement for diet that could not be modified
• Poor adherence during the recruiting meeting or unsatisfactory completion of keeping food diary or filling questionnaire at any time before randomization
• Eating disorder or any psychosocial or scheduling factors that could impede study outcomes
• Have a history of diagnosed CVD, diabetes, cancer or inflammatory diseases
• Have a history of a mental illness
• Have diagnosed endocrine, pulmonary or hematological disease
• Have diagnosed bowel disease or malabsorption that would prevent the participants from complying with the dietary restrictions of the feeding trial
• Renal or liver insufficiency
• Other chronic disease thought to interfere with the effect of the diet or with participation or adherence
• Current use of supplements or anti-inflammation medications or medications affecting glucose, lipid metabolism and blood pressure
• Smoking or alcoholic beverage intake >1 times per week
• Current or planned pregnancy prior to end of study, or breast-feeding
• Irregular menstrual cycles
• Have birth control medication