National Cerebral and Cardiovascular Center (NCVC) Stroke Registry
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ClinicalTrials.gov Identifier: NCT02251665 |
Recruitment Status :
Active, not recruiting
First Posted : September 29, 2014
Last Update Posted : April 22, 2020
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Condition or disease | Intervention/treatment |
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Stroke, Acute | Other: No intervention |
This is a single-center registry of consecutive patients with acute ischemic stroke, intracerebral hemorrhage, and transient ischemic attack (TIA) who are emergently managed in the stroke care unit in the National Cerebral and Cardiovascular Center, a flagship stroke center in Japan.
Neurological emergencies other than stroke/TIA and subclinical cerebrobvascular inpatients are also enrolled.
Data are collected and analyzed to determine change in underlying characteristics, stroke features and severity, process for diagnosis and acute treatment, and long-term outcomes of stroke/TIA patients over the years.
The National Cerebral and Cardiovascular Center was founded in 1977 in Suita, Osaka, in order to provide the public with the most advanced treatment for cardiovascular and cerebrovascular diseases and to conduct the highest level of basic as well as applied research on the cardiovascular and cerebrovascular systems.
Study Type : | Observational |
Actual Enrollment : | 5374 participants |
Observational Model: | Case-Only |
Time Perspective: | Prospective |
Official Title: | National Cerebral and Cardiovascular Center (NCVC) Stroke Registry |
Actual Study Start Date : | October 2016 |
Estimated Primary Completion Date : | June 2021 |
Estimated Study Completion Date : | March 2025 |

Group/Cohort | Intervention/treatment |
---|---|
Acute ischemic stroke, acute ICH, TIA
Consecutive patients with acute ischemic stroke, intracerebral hemorrhage, and transient ischemic attack who are emergently managed in the stroke care unit or stroke units in the National Cerebral and Cardiovascular Center
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Other: No intervention
a single-center prospective observational study |
- The modified Rankin Scale (mRS), a measure of disability [ Time Frame: 3 monhts ]mRS scores range from 0 (no symptoms at all) to 6 (death)
- Number of participants [ Time Frame: at entry ]Also assessing underlying patients' characteristics prior to index stroke/TIA
- National Institutes of Health Stroke Scale score [ Time Frame: at entry ]Also assessing neurological and cognitive states
- Volume of culprit infarcts/hematoma [ Time Frame: at entry ]ASPECTS on DWI for ischemia or hematoma volume using the ABC/2 method
- The modified Rankin Scale (mRS), a measure of disability [ Time Frame: around 3 weeks ]mRS scores range from 0 (no symptoms at all) to 6 (death). Participants will be followed at hospital discharge, an expected average of 3 weeks.
- The modified Rankin Scale (mRS), a measure of disability [ Time Frame: 1 year ]mRS scores range from 0 (no symptoms at all) to 6 (death)
- Events of cardiovascular diseases including stroke/TIA [ Time Frame: around 3 weeks ]Participants will be followed at hospital discharge, an expected average of 3 weeks.
- Events of cardiovascular diseases including stroke/TIA [ Time Frame: 3 months ]
- Events of cardiovascular diseases including stroke/TIA [ Time Frame: 1 year ]

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Ages Eligible for Study: | Child, Adult, Older Adult |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- A patient with acute ischemic stroke, intracerebral hemorrhage, and transient ischemic attack who are emergently managed in the stroke care unit or stroke units in the National Cerebral and Cardiovascular Center (NCVC)
- Consent to participate in the registration by a patient or relatives obtained using an opt-out approach by the demonstrating contents of the registration on the hospital bulletin board
Exclusion Criteria:
1) Patients considered by the investigator to be unsuitable for participating in this registry

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02251665
Japan | |
National Cerebral and Cardiovascular Center | |
Suita, Osaka, Japan, 564-8565 |
Principal Investigator: | Kazunori Toyoda, MD, PhD | Vice Director of the Hospital, National Cerebral and Cardiovascular Center |
Publications of Results:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Kazunori Toyoda, Director and Chair, Dept. of Stroke and Cerebrovascular Diseases, National Cerebral and Cardiovascular Center |
ClinicalTrials.gov Identifier: | NCT02251665 |
Other Study ID Numbers: |
NationalCardioCenter |
First Posted: | September 29, 2014 Key Record Dates |
Last Update Posted: | April 22, 2020 |
Last Verified: | April 2020 |
Acute ischemic stroke Acute intracerebral hemorrhage Transient ischemic attack |
Stroke Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases |
Nervous System Diseases Vascular Diseases Cardiovascular Diseases |