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Magnesium and Metabolic Syndrome: A Dose-response Meta-analysis

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ClinicalTrials.gov Identifier: NCT02151227
Recruitment Status : Completed
First Posted : May 30, 2014
Last Update Posted : December 30, 2014
Sponsor:
Information provided by (Responsible Party):
Ju Sang-yhun, The Catholic University of Korea

Brief Summary:

Magnesium is an essential mineral found in many foods; rich sources include whole grains, green leafy vegetables, coffee, and legumes. Magnesium is a critical cofactor in >300 enzymatic reactions, including those related to energy metabolism. Reduced magnesium intake and serum concentrations have been detected, both cross-sectionally and prospectively,in type 2 diabetes and insulin resistance, hypertension, dyslipidemia, and cardiovascular diseases.

Different studies have reported inadequate magnesium intake and low serum magnesium concentrations may correlated also with metabolic syndrome, defined as a cluster of metabolic disorders including obesity, hypertension, dyslipidemia and impaired glucose tolerance or diabetes mellitus. Previous studies on this subject, however, reported contradicting results. Some investigations reported inadequate magnesium intake and low serum magnesium concentrations while others did not.

To our knowledge, the epidemiological evidence on the relation between dietary magnesium intake and risk of metabolic syndrome has not yet been summarized.Therefore, the investigators will perform a systematic review and dose-response meta-analysis to assess the association between dietary and circulating magnesium level and risk of metabolic syndrome.


Condition or disease
Metabolic Syndrome X Insulin Resistance Syndrome X Metabolic Cardiovascular Syndrome Dysmetabolic Syndrome X

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Study Type : Observational
Actual Enrollment : 12 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Association of Dietary Magnesium Intake and Circulating Magnesium Concentration With Metabolic Syndrome: A Dose-response Meta-analysis
Study Start Date : June 2014
Actual Primary Completion Date : September 2014
Actual Study Completion Date : December 2014

Resource links provided by the National Library of Medicine

Drug Information available for: Magnesium

Group/Cohort
magnesium intake categories
comparators: categories of magnesium intake except lowest category of magnesium intake , controls: lowest category of magnesium intake



Primary Outcome Measures :
  1. Metabolic syndrome risk ratios (Odds ratio, Relative risk, Hazard ratio) [ Time Frame: Baseline ]

Secondary Outcome Measures :
  1. Serum magnesium concentration (mg/dL, mmol/L) [ Time Frame: Baseline ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Adult population: 18 years old and older
Criteria

Inclusion Criteria:

  • Dietary studies in humans 18 years old and older
  • Randomized controlled study, Cohort study, Nested case-control study, Case-control study, Cross-sectional study
  • The exposure of interest is magnesium intake (mg/day) or serum magnesium concentration(mmol/L, mg/dL)

Exclusion Criteria:

  • Non-human studies
  • Authors did not make serum magnesium concentration measurement;
  • The outcome values can not be used for meta-analysis
  • Duplicated articles.
  • Studies are not published as full reports, such as conference abstracts and letters to editors

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02151227


Locations
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Korea, Republic of
Sang-Yhun Ju
Seoul, Korea, Republic of, 150-713
Sponsors and Collaborators
The Catholic University of Korea
Investigators
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Principal Investigator: Sang-yhun Ju, Ph.D. Department of Family Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea
Additional Information:
Publications of Results:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Ju Sang-yhun, M.D., Ph.D., Clinical Associate Professor, The Catholic University of Korea
ClinicalTrials.gov Identifier: NCT02151227    
Other Study ID Numbers: SC14EISI0086
First Posted: May 30, 2014    Key Record Dates
Last Update Posted: December 30, 2014
Last Verified: December 2014
Keywords provided by Ju Sang-yhun, The Catholic University of Korea:
Meta-Analysis
Metabolic Syndrome
Magnesium
Dose Response Effect
Systematic Review
Additional relevant MeSH terms:
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Microvascular Angina
Metabolic Syndrome
Insulin Resistance
Syndrome
Disease
Pathologic Processes
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases
Angina Pectoris
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases