Magnesium and Metabolic Syndrome: A Dose-response Meta-analysis
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|ClinicalTrials.gov Identifier: NCT02151227|
Recruitment Status : Completed
First Posted : May 30, 2014
Last Update Posted : December 30, 2014
Magnesium is an essential mineral found in many foods; rich sources include whole grains, green leafy vegetables, coffee, and legumes. Magnesium is a critical cofactor in >300 enzymatic reactions, including those related to energy metabolism. Reduced magnesium intake and serum concentrations have been detected, both cross-sectionally and prospectively,in type 2 diabetes and insulin resistance, hypertension, dyslipidemia, and cardiovascular diseases.
Different studies have reported inadequate magnesium intake and low serum magnesium concentrations may correlated also with metabolic syndrome, defined as a cluster of metabolic disorders including obesity, hypertension, dyslipidemia and impaired glucose tolerance or diabetes mellitus. Previous studies on this subject, however, reported contradicting results. Some investigations reported inadequate magnesium intake and low serum magnesium concentrations while others did not.
To our knowledge, the epidemiological evidence on the relation between dietary magnesium intake and risk of metabolic syndrome has not yet been summarized.Therefore, the investigators will perform a systematic review and dose-response meta-analysis to assess the association between dietary and circulating magnesium level and risk of metabolic syndrome.
|Condition or disease|
|Metabolic Syndrome X Insulin Resistance Syndrome X Metabolic Cardiovascular Syndrome Dysmetabolic Syndrome X|
|Study Type :||Observational|
|Actual Enrollment :||12 participants|
|Official Title:||Association of Dietary Magnesium Intake and Circulating Magnesium Concentration With Metabolic Syndrome: A Dose-response Meta-analysis|
|Study Start Date :||June 2014|
|Actual Primary Completion Date :||September 2014|
|Actual Study Completion Date :||December 2014|
magnesium intake categories
comparators: categories of magnesium intake except lowest category of magnesium intake , controls: lowest category of magnesium intake
- Metabolic syndrome risk ratios (Odds ratio, Relative risk, Hazard ratio) [ Time Frame: Baseline ]
- Serum magnesium concentration (mg/dL, mmol/L) [ Time Frame: Baseline ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02151227
|Korea, Republic of|
|Seoul, Korea, Republic of, 150-713|
|Principal Investigator:||Sang-yhun Ju, Ph.D.||Department of Family Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea|