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Relation of Consummatory & Anticipatory Food Reward to Obesity

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02084836
Recruitment Status : Completed
First Posted : March 12, 2014
Last Update Posted : December 2, 2017
Sponsor:
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by (Responsible Party):
Oregon Research Institute

Brief Summary:

Obesity is associated with increased risk for mortality, atherosclerotic cerebrovascular disease, coronary heart disease, colorectal cancer, hyperlipidemia, hypertension, gallbladder disease, and diabetes mellitus, resulting in over 111,000 deaths annually in the United States (Calle et al., 1999; Flegal et al., 2005). In the US, 65% of adults are overweight or obese (Hedley et al., 2004). Unfortunately, the treatment of choice for obesity (behavioral weight loss treatment) only results in a 10% reduction in body weight on average and most patients regain this weight within a few years (Jeffery et al., 2000). Further, most obesity prevention programs do not reduce risk for future weight gain (Stice, Shaw, & Marti, 2006). The limited success of treatment and prevention interventions may be due to an incomplete understanding of the processes that increase risk for obesity. Recent data suggest that obese adults show abnormalities in reward from food intake and anticipated food intake relative to lean adults, but the precise nature of these abnormalities is unclear and it has not been established whether these abnormalities predate obesity onset or are a consequence. It is vital to elucidate risk factors for obesity onset to advance understanding of etiological processes and determine the content of prevention and treatment programs.

The goals of this study are to (1) determine whether adolescents at high-risk for obesity, by virtue of having two obese parents, show abnormalities in reward from food intake (consummatory food reward) and anticipated reward from food intake (anticipatory food reward) compared to adolescents who are at low-risk for obesity, (2) determine whether abnormalities in consummatory and anticipatory food reward increase risk for weight gain and obesity onset, (3) examine moderators that may amplify the relations of consummatory and anticipatory food reward to unhealthy weight gain, and (4) examine changes in consummatory and anticipatory food reward in those participants who show obesity onset relative to those not showing obesity onset.


Condition or disease Intervention/treatment
Obesity Other: Functional Magnetic Resonance Imaging

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Study Type : Observational
Actual Enrollment : 162 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Relation of Consummatory & Anticipatory Food Reward to Obesity
Study Start Date : June 2009
Actual Primary Completion Date : July 2014
Actual Study Completion Date : July 2014

Group/Cohort Intervention/treatment
Lean adolescents Other: Functional Magnetic Resonance Imaging



Primary Outcome Measures :
  1. increases in BMI [ Time Frame: 1, 2, and 3 years ]
    To determine whether abnormalities in consummatory and anticipatory food reward increase risk for weight gain and obesity onset.


Secondary Outcome Measures :
  1. (anticipated) reward from food intake [ Time Frame: baseline ]
    To determine whether adolescents at high-risk for obesity, by virtue of having two obese parents, show abnormalities in reward from food intake (consummatory food reward) and anticipated reward from food intake (anticipatory food reward) compared to adolescents who are at low-risk for obesity.


Other Outcome Measures:
  1. Changes in neural response to (anticipated) reward from food intake [ Time Frame: baseline, 2, and 3 year ]
    Examine changes in consummatory and anticipatory food reward in those participants who show obesity onset relative to those not showing obesity onset


Biospecimen Retention:   Samples With DNA
Saliva


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Ages Eligible for Study:   14 Years to 17 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
162 lean adolescents between 14-17 years old with BMIs between the 25th and 75th percentile at baseline
Criteria

Inclusion Criteria:

  • Between 14-17 years old
  • BMI between 25th and 75th percentile

Exclusion Criteria:

  • Contraindicators of functional magnetic resonance imaging (fMRI): metal implants, braces, pregnancy
  • Symptoms of major psychiatric disorders (substance use disorders, conduct disorder, attention deficit hyperactive disorder, major depression, bipolar disorder, panic disorder, agoraphobia, generalized anxiety disorder) binge eating
  • Current use of pyschoactive drugs
  • Serious medical conditions (diabetes, brain injury)
  • Current smoking
  • Relevant food allergies
  • Current weight loss dieting

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02084836


Locations
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United States, Oregon
Oregon Research Institute
Eugene, Oregon, United States, 97403
Sponsors and Collaborators
Oregon Research Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Investigators
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Principal Investigator: Eric Stice, Ph.D. Oregon Research Institute
Publications of Results:

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Oregon Research Institute
ClinicalTrials.gov Identifier: NCT02084836    
Other Study ID Numbers: DK080760
R01DK080760 ( U.S. NIH Grant/Contract )
First Posted: March 12, 2014    Key Record Dates
Last Update Posted: December 2, 2017
Last Verified: November 2017
Keywords provided by Oregon Research Institute:
fMRI obesity adolescents
Additional relevant MeSH terms:
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Obesity
Overnutrition
Nutrition Disorders
Overweight
Body Weight