Working… Menu

Evaluation of the Lung Recruitment and End-expiratory Lung Collapse in Acute Respiratory Distress Syndrome (ARDS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01670747
Recruitment Status : Completed
First Posted : August 22, 2012
Last Update Posted : March 19, 2015
Information provided by (Responsible Party):
Davide Chiumello, Policlinico Hospital

Brief Summary:
In this study gas-exchange and respiratory mechanics variations to PEEP change will be correlated to CT lung morphological modifications assessed at different airway pressures (5, 15, 30 and 45 cmH2O).

Condition or disease Intervention/treatment
ARDS: Acute Respiratory Distress Syndrome Radiation: Chest computed tomography

Layout table for study information
Study Type : Observational
Estimated Enrollment : 30 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Evaluation of the Lung Recruitment and End-expiratory Lung Collapse in Patients With Acute Respiratory Distress Syndrome
Study Start Date : September 2012
Actual Primary Completion Date : March 2015
Actual Study Completion Date : March 2015

Group/Cohort Intervention/treatment
Sedated and mechanically ventilated patients admitted to ICU
Radiation: Chest computed tomography

Primary Outcome Measures :
  1. Computer Tomography (CT) scan lung recruitment and CT lung weight [ Time Frame: Study day (day 1) ]
    Aim of the study is to determine the relationship between the opening pressures (recruitment) and closing pressures (PEEP) in order to prevent the opening and closing of the lung parenchyma

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients admitted to ICU with diagnosis of ARDS who required mechanical ventilation

Inclusion Criteria:

  • Clinical diagnosis of acute lung injury/ acute respiratory distress syndrome
  • Mechanical ventilation

Exclusion Criteria:

  • Clinical diagnosis of chronic obstructive pulmonary disease
  • Clinical diagnosis of pneumothorax
  • Haemodynamic instability

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01670747

Layout table for location information
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milano, Italy, 20122
Sponsors and Collaborators
Policlinico Hospital
Layout table for investigator information
Principal Investigator: Chiumello Davide, MD Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Publications automatically indexed to this study by Identifier (NCT Number):
Layout table for additonal information
Responsible Party: Davide Chiumello, MD, Policlinico Hospital Identifier: NCT01670747    
Other Study ID Numbers: 201208
First Posted: August 22, 2012    Key Record Dates
Last Update Posted: March 19, 2015
Last Verified: March 2015
Additional relevant MeSH terms:
Layout table for MeSH terms
Respiratory Distress Syndrome, Newborn
Respiratory Distress Syndrome, Adult
Acute Lung Injury
Pulmonary Atelectasis
Pathologic Processes
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Infant, Premature, Diseases
Infant, Newborn, Diseases
Lung Injury