SCREEN-HFL (SCReening Evaluation of the Evolution of New Heart Failure) - a Longitudinal Study (SHF-L)
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ClinicalTrials.gov Identifier: NCT01581827 |
Recruitment Status :
Completed
First Posted : April 20, 2012
Last Update Posted : April 9, 2018
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Heart failure (when the heart does not pump as well as it used to) is a medical condition which reduces the quality of life for the sufferers. Approximately 10% of people in western societies aged over 75 develop heart failure. There has been a shift towards prevention of this disease and it is hoped that BNP (brain natriuretic peptides) and NT-proBNP (N-terminal proBNP) will prove to be useful indicators of those at greatest risk. The current study therefore plans to follow up the 3500 participants at risk of heart failure from the original SCREEN-HF study.
Participants who are willing to participate will be contacted annually. They will undergo a short physical exam, will be asked to complete a Quality of Life questionnaire and will have a blood sample taken. At the end of the study participants will also have an ECG and an echocardiogram.
Condition or disease |
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Heart Failure |
Study Type : | Observational |
Actual Enrollment : | 3000 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | SCREEN-HFL (SCReening Evaluation of the Evolution of New Heart Failure) - a Longitudinal Study |
Study Start Date : | January 2009 |
Actual Primary Completion Date : | December 2015 |
Actual Study Completion Date : | December 2017 |

Group/Cohort |
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Study population
People at high risk of heart failure (from SCREEN-HF study)
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- Change in NT-proBNP [ Time Frame: baseline and 5 years ]
- Change in echocardiogram [ Time Frame: baseline and 5 years ]
- incidence of new heart failure [ Time Frame: baseline and 5 years ]
Biospecimen Retention: Samples Without DNA

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 60 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Consented and enrolled in the SCREEN-HF study and who agreed to further contact
- Age ≥ 60 years
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Subjects at high-risk of subsequent development of heart failure; comprising at least one of:
- Prior myocardial infarction (MI) without known left ventricular (LV) dysfunction
- Current active ischaemic heart disease
- Prior Cerebrovascular Accident (CVA)
- Known valvular heart disease without known LV dysfunction
- Atrial fibrillation
- Treated hypertension, of at least 2 years duration
- Treated Diabetes mellitus, of at least 2 years duration
- Chronic renal impairment (eGFR < 60 ml/min)
Exclusion Criteria:
- Known systolic or diastolic heart failure
- LV systolic or diastolic dysfunction on echocardiography or other objective imaging modality (if known).

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01581827
Australia, Victoria | |
Monash University | |
Caulfield, Victoria, Australia, 3162 |
Principal Investigator: | Henry Krum, MBBS FRACP PhD | Monash University/Alfred Hospital |
Responsible Party: | Ingrid Hopper, Senior Lecturer, Monash University |
ClinicalTrials.gov Identifier: | NCT01581827 |
Other Study ID Numbers: |
52/09 |
First Posted: | April 20, 2012 Key Record Dates |
Last Update Posted: | April 9, 2018 |
Last Verified: | April 2018 |
Heart Failure BNP NT-proBNP |
Heart Failure Heart Diseases Cardiovascular Diseases |