Factors Associated With Chronic Respiratory Failure in Obesity
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|ClinicalTrials.gov Identifier: NCT01380418|
Recruitment Status : Completed
First Posted : June 27, 2011
Last Update Posted : September 12, 2017
Some overweight individuals develop problems with their breathing such that they gradually breathe less and less. This leads to a lack of oxygen and a buildup of carbon dioxide in the blood, called ventilatory failure. As a consequence, if such a person develops a chest infection, they are more likely to become seriously ill and need intensive care. In addition they are much more likely to develop severe complications during and following operations. This problem can be treated with a machine at home used overnight to help breathing. It is interesting that ventilatory failure only happens in some overweight individuals, and the investigators do not understand what factors make this complication develop. There are a number of theories: for example the distribution of the fat, additional lung disease (such as asthma), the addition of obstructive sleep apnoea, a condition when there are periods of cessation of breathing overnight (which is more common in obese individuals), weak muscles of breathing (perhaps due to fatty infiltration of muscles or vitamin D deficiency), and other hormonal changes.
The investigators intend to measure many potential factors in a range of overweight individuals, some who have ventilatory failure, and some who do not, to try and work out which are the important factors that cause this problem. If the investigators can identify such factors, then this will help predict in advance who is at risk from chest infections and during operations; thus allowing for earlier provision of an overnight breathing machine. This should reduce complications and potentially deaths in such individuals.
|Condition or disease|
|Obesity Obesity Hypoventilation Syndrome|
|Study Type :||Observational|
|Actual Enrollment :||78 participants|
|Official Title:||Factors Associated With Chronic Respiratory Failure in Obesity: A Cross-sectional Study|
|Study Start Date :||June 2011|
|Actual Primary Completion Date :||October 2015|
|Actual Study Completion Date :||October 2015|
Obese BMI>30 18-85 years old
- To determine the physiological between obese patients with OHS and obese patients without OHS [ Time Frame: 1 year ]This will be a detailed ventilatory drive measurements and muscle strength testing. The comparison will be made within the group amongst the range of ventilatory failure
Biospecimen Retention: Samples With DNA
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01380418
|Oxford Radcliffe NHS Trust Hospitals|
|Oxford, United Kingdom, OX3 7LJ|
|Study Director:||John Stradling, FRCP MBBS PHD||University of Oxford|