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Subclassification of the Syndrome of Inappropriate ADH Secretion

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01341665
Recruitment Status : Completed
First Posted : April 26, 2011
Last Update Posted : April 26, 2011
Information provided by:
University of Wuerzburg

Brief Summary:

The aim of this study is to evaluate the different types of osmotic dysregulation in patients with Syndrome of Inappropriate ADH (SIADH) and, hence, to analyze the pathophysiology of SIADH.

These types will be characterized by measurement of AVP and copeptin while performing an osmotic stimulation with infusion of hypertonic saline.

Condition or disease

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Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Subclassification of the Syndrome of Inappropriate Antidiuresis Via Copeptin - What is the Genesis of ADH-independent SIADH?
Study Start Date : March 2008
Actual Primary Completion Date : April 2011
Actual Study Completion Date : April 2011

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

patients with chronic hyponatremia (> 3 days) due to SIADH in university hospital in wuerzburg

healthy control subjects with normonatremia


Inclusion Criteria:

  • age > 18 years,
  • hyponatremia < 132 mmol/L

Exclusion Criteria:

  • age < 18 years
  • cerebral metastases
  • serum sodium > 132mmol/L

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01341665

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University of Wuerzburg
Wuerzburg, Bavaria, Germany, 97080
Sponsors and Collaborators
University of Wuerzburg
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Study Chair: Bruno Allolio, MD Ethical commitee
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Responsible Party: Prof. Dr. Bruno Allolio, Department of Endocrinology and Diabetes, University of Wuerzburg Identifier: NCT01341665    
Other Study ID Numbers: 5/08
First Posted: April 26, 2011    Key Record Dates
Last Update Posted: April 26, 2011
Last Verified: April 2011
Keywords provided by University of Wuerzburg:
Additional relevant MeSH terms:
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Water-Electrolyte Imbalance
Metabolic Diseases