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Referral Patterns for Hospital Acquired Acute Kidney Injury and Relevance to Renal Outcomes (HA-AKI)

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ClinicalTrials.gov Identifier: NCT01151514
Recruitment Status : Completed
First Posted : June 28, 2010
Last Update Posted : June 28, 2010
Sponsor:
Information provided by:
Centre Hospitalier Universitaire Vaudois

Brief Summary:
Few studies analyzed the referral time to nephrologists and its impact on the patient outcome in a large cohort. The investigators described the incidence and determined the outcome with respect to renal function recovery, renal replacement therapy (RRT) requirement and in-hospital mortality of Hospital Acquired Acute Kidney Injury (HA-AKI) without nephrology referral (nrHA-AKI) and late referred HA-AKI patients to nephrologists (lrHA-AKI) compared with early referral patients (erHA-AKI). The patients included were admitted to the tertiary care academic center of Lausanne (Switzerland) between 2004 and 2008, in the medical and surgical services and in the intensive care unit (ICU).

Condition or disease Intervention/treatment
Renal Replacement Therapy Mortality Other: Nephrologist referral

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Study Type : Observational
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Referral Patterns for Hospital Acquired Acute Kidney Injury and Relevance to Renal Outcomes

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
nrHA-AKI patients
Patients with hospital-acquired acute kidney injury not referred to the nephrologists
Other: Nephrologist referral
Nephrologist specialty, renal replacement therapy
Other Name: Control group: early-referred patients with HA-AKI.

lrHA-AKI patients
Patients with hospital-acquired acute kidney injury whao are late referred to the nephrologists
Other: Nephrologist referral
Nephrologist specialty, renal replacement therapy
Other Name: Control group: early-referred patients with HA-AKI.




Primary Outcome Measures :
  1. Referral patterns for hospital acquired acute kidney injury and relevance to renal outcomes
    Recovery of renal function during hospital stay. Requirement for renal replacement therapy.


Secondary Outcome Measures :
  1. Referral patterns for hospital acquired acute kidney injury and relevance to renal outcomes
    Length of hospital stay. In-hospital mortality.



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
This study population consisted of patients who were hospitalized in the medical and surgical departments as well as in the intensive care untis (ICU) of the University Hospital of Lausanne (Centre Hospitalier Universitaire Vaudois [CHUV]) that is a tertiary care academic medical center. Patients with AKI coming from ICU in the medicine or surgery wards, and patients from medicine or surgery wards, who required a transfer to ICU during the hospital stay, were also included whatever the cause of the transfer.
Criteria

Inclusion Criteria:

  • Adult patients.
  • Hospitalization in the medicine and surgery wards and in the intensive care unit.
  • Hospitalized patients with acquired acute kidney injury according to the
  • Acute Kidney Injury Network (AKIN)criteria.
  • HA-AKI patients with no referral to the nephrologist (nrHA-AKI).
  • HA-AKI patients referred late (more than five days [> 5 days]) to the nephrologist (lrHA-AKI).
  • HA-AKI patients early referred (within five days after sCr increase) to the nephrologist (erHA-AKI).

Exclusion Criteria:

  • Patients with AKI at the time of the hospital admission and during the first
  • 48 hours after admission.
  • Patients hospitalized in other wards.
  • Children under 18.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01151514


Locations
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Switzerland
Nephrology - CHCVs
Sion, Switzerland, 1951
Sponsors and Collaborators
Centre Hospitalier Universitaire Vaudois
Additional Information:
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ClinicalTrials.gov Identifier: NCT01151514    
Other Study ID Numbers: HA-AKI referral
First Posted: June 28, 2010    Key Record Dates
Last Update Posted: June 28, 2010
Last Verified: August 2010
Keywords provided by Centre Hospitalier Universitaire Vaudois:
No referral
Late referral
Acute kidney injury
Intensive care unit
In-hospital mortality
Renal outcome
Requirement for renal replacement therapy
Length of hospital stay
Impact
Incidence
Additional relevant MeSH terms:
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Acute Kidney Injury
Renal Insufficiency
Kidney Diseases
Urologic Diseases