Working… Menu

Cognitive Dysfunction After Aneurysmal Subarachnoid Haemorrhage

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT01038193
Recruitment Status : Recruiting
First Posted : December 23, 2009
Last Update Posted : January 27, 2021
Information provided by (Responsible Party):
George KC Wong, Chinese University of Hong Kong

Brief Summary:
This is a longitudinal, multi-center, prospective study of aneurysmal subarachnoid haemorrhage patients in neurosurgical units in Hong Kong.

Condition or disease Intervention/treatment
Cognitive Dysfunction Other: Cognitive assessment

Detailed Description:
The investigators aim to recruit a total of 240 aneurysmal subarachnoid haemorrhage patients. The schedule for neuropsychological and functional assessments will be phased in at the second to third week, the third month, and the twelve months after the initial haemorrhage.

Layout table for study information
Study Type : Observational
Estimated Enrollment : 600 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Cognitive Dysfunction After Aneurysmal Subarachnoid Haemorrhage
Study Start Date : March 1, 2009
Estimated Primary Completion Date : March 31, 2024
Estimated Study Completion Date : December 31, 2024

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Bleeding

Group/Cohort Intervention/treatment
aSAH patients
Cognitive assessment
Other: Cognitive assessment
Cognitive and functional assessments at 2-4 weeks, 3 months and 12 months.
Other Name: Cognition

Primary Outcome Measures :
  1. Cognitive dysfunction [ Time Frame: 3 and 12 months ]
    Montreal Cognitive Assessment

Secondary Outcome Measures :
  1. Neurological Outcome [ Time Frame: 3 and 12 months ]
    Modified Rankin Scale

  2. Generic Quality of Life [ Time Frame: 3 and 12 months ]

  3. Activity of Daily Living [ Time Frame: 3 and 12 months ]
    Barthel Index

  4. Disease-specific Quality of Life [ Time Frame: 3 and 12 months ]

  5. Functional Outcome [ Time Frame: 3 and 12 months ]
    Functional Independent Measure (FIM)

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   21 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Aneurysmal subarachnoid hemorrhage patients

Inclusion criteria

  1. Spontaneous subarachnoid haemorrhage with intracranial aneurysms as aetiology
  2. Admission within 96 hours of ictus
  3. Aged between 21 and 75 years
  4. A speaker of Chinese (Mandarin or Cantonese)
  5. Informed consent from patients or their legally acceptable representatives

Exclusion criteria

  1. History of previous cerebrovascular disease or neurological disease other than intracranial aneurysm
  2. History of neurosurgical operation prior to ictus

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01038193

Layout table for location contacts
Contact: George KC Wong (852) 26321316
Contact: Shirley Chiu (852) 26322624

Layout table for location information
China, Hong Kong
Prince of Wales Hospital Recruiting
Hong Kong, Hong Kong, China, 852
Contact: George KC Wong    (852)35052624      
Contact: Carol Chan    (852)35051316      
Principal Investigator: George KC Wong         
Sponsors and Collaborators
Chinese University of Hong Kong
Layout table for investigator information
Principal Investigator: George KC Wong Division of Neurosurgery, CUHK
Publications automatically indexed to this study by Identifier (NCT Number):

Layout table for additonal information
Responsible Party: George KC Wong, Professor (Clinical), Chinese University of Hong Kong Identifier: NCT01038193    
Other Study ID Numbers: GW004
First Posted: December 23, 2009    Key Record Dates
Last Update Posted: January 27, 2021
Last Verified: January 2021
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Keywords provided by George KC Wong, Chinese University of Hong Kong:
Cognition, subarachnoid hemorrhage.
Additional relevant MeSH terms:
Layout table for MeSH terms
Subarachnoid Hemorrhage
Cognitive Dysfunction
Pathologic Processes
Intracranial Hemorrhages
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Cognition Disorders
Neurocognitive Disorders
Mental Disorders