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Myocardial Salvage Assessed by Cardiovascular Magnetic Resonance - Impact on Outcome

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ClinicalTrials.gov Identifier: NCT00952224
Recruitment Status : Completed
First Posted : August 6, 2009
Last Update Posted : August 6, 2009
Information provided by:
University of Leipzig

Brief Summary:
In acute myocardial infarction cardiovascular magnetic resonance imaging can retrospectively detect the myocardium at risk and the irreversible injury. This allows for quantifying the extent of salvaged myocardium after reperfusion as a potential strong end point for clinical trials and outcome. The aim of the present study is to determine the prognostic significance and determinants of myocardial salvage assessed by CMR in reperfused ST-elevation myocardial infarction (STEMI).

Condition or disease Intervention/treatment
ST-Elevation Myocardial Infarction Other: magnetic resonance imaging

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Study Type : Observational
Actual Enrollment : 267 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Prognostic Significance and Determinants of Myocardial Salvage Assessed by Cardiovascular Magnetic Resonance in Acute Reperfused Myocardial Infarction
Study Start Date : November 2006
Actual Primary Completion Date : May 2008
Actual Study Completion Date : March 2009

Group/Cohort Intervention/treatment
Acute myocardial infarction patients
Patients undergoing primary percutaneous coronary intervention in ST-elevation myocardial infarction plus magnetic resonance imaging
Other: magnetic resonance imaging
magnetic resonance imaging is used for prognosis assessment

Primary Outcome Measures :
  1. Major adverse cardiac events [ Time Frame: 6 months ]

Secondary Outcome Measures :
  1. Mortality [ Time Frame: 6 months ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Cohort of patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

Inclusion Criteria:

  • ST-elevation myocardial infarction < 12 hours
  • primary percutaneous coronary intervention

Exclusion Criteria:

  • previous myocardial infarction
  • prior fibrinolysis
  • contraindications to CMR at study entry (such as implanted pacemakers, defibrillators, claustrophobia or metallic intracranial implants)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00952224

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University of Leipzig - Heart Center
Leipzig, Germany, 04289
Sponsors and Collaborators
University of Leipzig
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Principal Investigator: Ingo Eitel, MD Heart Center Leipzig - University Hospital
Study Director: Holger Thiele, MD Heart Center Leipzig - University Hospital
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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ClinicalTrials.gov Identifier: NCT00952224    
Other Study ID Numbers: Leipzig MR 1
First Posted: August 6, 2009    Key Record Dates
Last Update Posted: August 6, 2009
Last Verified: August 2009
Keywords provided by University of Leipzig:
myocardial salvage
cardiovascular magnetic resonance
magnetic resonance imaging
myocardial infarction
Additional relevant MeSH terms:
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Myocardial Infarction
ST Elevation Myocardial Infarction
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases