Evaluation of the Quality of Cardio-Pulmonary Resuscitation (CPR) in Cardiac Arrest Patients

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ClinicalTrials.gov Identifier: NCT00951704

Recruitment Status : Completed

First Posted : August 4, 2009

Last Update Posted : December 13, 2018

Sponsor:

Collaborators:

Turku University Hospital

Uppsala University

Information provided by (Responsible Party):

Tampere University Hospital

Study Description

Brief Summary:

The prognosis of cardiac arrest patients is generally poor. Recent studies have showed that the high quality of CPR increases the survival after cardiac arrest. Therefore the investigators planned this prospective observational study to determine the epidemiology of sudden cardiac arrest in the prehospital setting of Tampere area, the quality of the CPR, and also the associations between depth and frequency of chest compressions and invasive arterial pressure, EtCO2,cerebral oxygenation and iatrogenic injuries associated to chest compressions 1) in patients resuscitated out of hospital by emergency medical service's (EMS's) personals and 2) in-hospital by hospital resuscitation team members. In addition, the investigators will analyze the effects of the chosen method of resuscitation on critical vital signs (Etco2 and invasive pressures): closed-chest CPR is compared to open-chest CPR, or mechanical CPR with a device (AutoPulse-CPR, Cardio Pump) compared to manual CPR guided with quality CPR device. The results will give the investigators important insights into the haemodynamics of CPR which may guide future strategies for the management of cardiac arrest. The research group is also interested in CPR related injuries and mattress effect. Quality of life after CA is evaluated among survivals and the cause of death among non-survivors.

Condition or disease
Cardiac Arrest

Study Design

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Study Type :	Observational
Estimated Enrollment :	1000 participants
Observational Model:	Cohort
Time Perspective:	Prospective
Official Title:	Evaluating the Quality of Prehospital and In-hospital Cardio-pulmonary Resuscitation - Comparing the Compressions to Concurrent Vital Signs (Invasive Blood Pressure, Cerebral Oxygen Saturation, EtCO2) and Iatrogenic Injuries Associated to Chest Compressions.
Study Start Date :	November 2008
Actual Primary Completion Date :	December 2015
Actual Study Completion Date :	December 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: CPR Sudden Cardiac Arrest

U.S. FDA Resources

Groups and Cohorts

Group/Cohort
Cardiac arrest

Outcome Measures

Primary Outcome Measures :

The success rate of current guidelines (depth and frequency of chest compression, epidemiology) [ Time Frame: During the resuscitation ]
Quality of life after CA [ Time Frame: 6 months ]
Quality of life after CA is usually fairly good measurement of quality of resuscitation attempt

Secondary Outcome Measures :

Invasive arterial pressures, cerebral oxygenation (NIRS), EtCO2 [ Time Frame: During the resuscitation ]
survival of cardiac arrest [ Time Frame: hospital discharge ]

Other Outcome Measures:

Change in hemodynamics, Change in cerebral saturation, Change in quality of CPR [ Time Frame: During resuscitation ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:	18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

Adult population >18 years of age with cardiac arrest

Criteria

Inclusion Criteria:

cardiac arrest
> 18 years of age

Exclusion Criteria:

< 18 years of age

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00951704

Locations

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Finland
Tampere University Hospital
Tampere, Pirkanmaa, Finland, 33521
Department of Anesthesiology and Intensive Care, Turku University Hospital
Turku, Finland, 20100

Sponsors and Collaborators

Tampere University Hospital

Turku University Hospital

Uppsala University

Investigators

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Study Director:	Jyrki Tenhunen, MD, PhD	Critical Care Medicine Research Group
Principal Investigator:	Sanna Hoppu, MD, PhD	Tampere University Hospital
Principal Investigator:	Marko Sainio, MD	Turku University Hospital
Study Director:	Klaus Olkkola, MD, PhD	Department of Anesthesiology and Intensive Care, Helsinki University Hospital
Principal Investigator:	Heidi Hellevuo, MD	Tampere University Hospital
Principal Investigator:	Piritta Setälä, MD	Tampere University Hospital
Study Director:	Ilkka Virkkunen, MD, PhD	Tampere University Hospital
Principal Investigator:	Heidi Kangasniemi, MD	Tampere University Hospital
Principal Investigator:	Joonas Tamminen	Tampere University Hospital

More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Kangasniemi H, Setälä P, Huhtala H, Kämäräinen A, Virkkunen I, Jämsen E, Yli-Hankala A, Hoppu S. Out-of-hospital cardiac arrests in nursing homes and primary care facilities in Pirkanmaa, Finland. Acta Anaesthesiol Scand. 2018 Oct;62(9):1297-1303. doi: 10.1111/aas.13152. Epub 2018 May 29.

Setälä P, Hellevuo H, Huhtala H, Kämäräinen A, Tirkkonen J, Hoppu S. Risk factors for cardiopulmonary resuscitation-related injuries sustained during out-of-hospital cardiac arrests. Acta Anaesthesiol Scand. 2018 Oct;62(9):1290-1296. doi: 10.1111/aas.13155. Epub 2018 May 24.

Setälä PA, Virkkunen IT, Kämäräinen AJ, Huhtala HSA, Virta JS, Yli-Hankala AM, Hoppu SE. End-tidal carbon dioxide output in manual cardiopulmonary resuscitation versus active compression-decompression device during prehospital quality controlled resuscitation: a case series study. Emerg Med J. 2018 Jul;35(7):428-432. doi: 10.1136/emermed-2017-207103. Epub 2018 May 16.

Sainio M, Hoppu S, Huhtala H, Eilevstjønn J, Olkkola KT, Tenhunen J. Simultaneous beat-to-beat assessment of arterial blood pressure and quality of cardiopulmonary resuscitation in out-of-hospital and in-hospital settings. Resuscitation. 2015 Nov;96:163-9. doi: 10.1016/j.resuscitation.2015.08.004. Epub 2015 Aug 24.

Sainio M, Sutton RM, Huhtala H, Eilevstjønn J, Tenhunen J, Olkkola KT, Nadkarni VM, Hoppu S. Association of arterial blood pressure and CPR quality in a child using three different compression techniques, a case report. Scand J Trauma Resusc Emerg Med. 2013 Jul 2;21:51. doi: 10.1186/1757-7241-21-51.

Sainio M, Kämäräinen A, Huhtala H, Aaltonen P, Tenhunen J, Olkkola KT, Hoppu S. Real-time audiovisual feedback system in a physician-staffed helicopter emergency medical service in Finland: the quality results and barriers to implementation. Scand J Trauma Resusc Emerg Med. 2013 Jul 1;21:50. doi: 10.1186/1757-7241-21-50.

Hoppu S, Sainio M, Huhtala H, Eilevstjønn J, Tenhunen J, Olkkola KT. Blood pressure during resuscitation in man--the effect of pause during rhythm analysis revisited. Resuscitation. 2011 Nov;82(11):1460-3. doi: 10.1016/j.resuscitation.2011.06.005. Epub 2011 Jun 17.

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Responsible Party:	Tampere University Hospital
ClinicalTrials.gov Identifier:	NCT00951704
Other Study ID Numbers:	R08116
First Posted:	August 4, 2009 Key Record Dates
Last Update Posted:	December 13, 2018
Last Verified:	December 2018

Keywords provided by Tampere University Hospital:


CPR Tissue Perfusion invasive arterial pressure exhaled carbon dioxide	Quality of life Quality of chest compressions Epidemiology of sudden cardiac arrest(OHCA)

Additional relevant MeSH terms:

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Heart Arrest Heart Diseases Cardiovascular Diseases

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