We're building a better ClinicalTrials.gov. Check it out and tell us what you think!
ClinicalTrials.gov Menu

Evaluation of the Quality of Cardio-Pulmonary Resuscitation (CPR) in Cardiac Arrest Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00951704
Recruitment Status : Completed
First Posted : August 4, 2009
Last Update Posted : December 13, 2018
Turku University Hospital
Uppsala University
Information provided by (Responsible Party):
Tampere University Hospital

Brief Summary:
The prognosis of cardiac arrest patients is generally poor. Recent studies have showed that the high quality of CPR increases the survival after cardiac arrest. Therefore the investigators planned this prospective observational study to determine the epidemiology of sudden cardiac arrest in the prehospital setting of Tampere area, the quality of the CPR, and also the associations between depth and frequency of chest compressions and invasive arterial pressure, EtCO2,cerebral oxygenation and iatrogenic injuries associated to chest compressions 1) in patients resuscitated out of hospital by emergency medical service's (EMS's) personals and 2) in-hospital by hospital resuscitation team members. In addition, the investigators will analyze the effects of the chosen method of resuscitation on critical vital signs (Etco2 and invasive pressures): closed-chest CPR is compared to open-chest CPR, or mechanical CPR with a device (AutoPulse-CPR, Cardio Pump) compared to manual CPR guided with quality CPR device. The results will give the investigators important insights into the haemodynamics of CPR which may guide future strategies for the management of cardiac arrest. The research group is also interested in CPR related injuries and mattress effect. Quality of life after CA is evaluated among survivals and the cause of death among non-survivors.

Condition or disease
Cardiac Arrest

Layout table for study information
Study Type : Observational
Estimated Enrollment : 1000 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Evaluating the Quality of Prehospital and In-hospital Cardio-pulmonary Resuscitation - Comparing the Compressions to Concurrent Vital Signs (Invasive Blood Pressure, Cerebral Oxygen Saturation, EtCO2) and Iatrogenic Injuries Associated to Chest Compressions.
Study Start Date : November 2008
Actual Primary Completion Date : December 2015
Actual Study Completion Date : December 2018

Resource links provided by the National Library of Medicine

Cardiac arrest

Primary Outcome Measures :
  1. The success rate of current guidelines (depth and frequency of chest compression, epidemiology) [ Time Frame: During the resuscitation ]
  2. Quality of life after CA [ Time Frame: 6 months ]
    Quality of life after CA is usually fairly good measurement of quality of resuscitation attempt

Secondary Outcome Measures :
  1. Invasive arterial pressures, cerebral oxygenation (NIRS), EtCO2 [ Time Frame: During the resuscitation ]
  2. survival of cardiac arrest [ Time Frame: hospital discharge ]

Other Outcome Measures:
  1. Change in hemodynamics, Change in cerebral saturation, Change in quality of CPR [ Time Frame: During resuscitation ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Adult population >18 years of age with cardiac arrest

Inclusion Criteria:

  • cardiac arrest
  • > 18 years of age

Exclusion Criteria:

  • < 18 years of age

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00951704

Layout table for location information
Tampere University Hospital
Tampere, Pirkanmaa, Finland, 33521
Department of Anesthesiology and Intensive Care, Turku University Hospital
Turku, Finland, 20100
Sponsors and Collaborators
Tampere University Hospital
Turku University Hospital
Uppsala University
Layout table for investigator information
Study Director: Jyrki Tenhunen, MD, PhD Critical Care Medicine Research Group
Principal Investigator: Sanna Hoppu, MD, PhD Tampere University Hospital
Principal Investigator: Marko Sainio, MD Turku University Hospital
Study Director: Klaus Olkkola, MD, PhD Department of Anesthesiology and Intensive Care, Helsinki University Hospital
Principal Investigator: Heidi Hellevuo, MD Tampere University Hospital
Principal Investigator: Piritta Setälä, MD Tampere University Hospital
Study Director: Ilkka Virkkunen, MD, PhD Tampere University Hospital
Principal Investigator: Heidi Kangasniemi, MD Tampere University Hospital
Principal Investigator: Joonas Tamminen Tampere University Hospital
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Layout table for additonal information
Responsible Party: Tampere University Hospital
ClinicalTrials.gov Identifier: NCT00951704    
Other Study ID Numbers: R08116
First Posted: August 4, 2009    Key Record Dates
Last Update Posted: December 13, 2018
Last Verified: December 2018
Keywords provided by Tampere University Hospital:
Tissue Perfusion
invasive arterial pressure
exhaled carbon dioxide
Quality of life
Quality of chest compressions
Epidemiology of sudden cardiac arrest(OHCA)
Additional relevant MeSH terms:
Layout table for MeSH terms
Heart Arrest
Heart Diseases
Cardiovascular Diseases