Role of Bone in Knee Osteoarthritis (OA)
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|ClinicalTrials.gov Identifier: NCT00850538|
Recruitment Status : Completed
First Posted : February 25, 2009
Results First Posted : December 4, 2015
Last Update Posted : December 4, 2015
|Condition or disease||Intervention/treatment|
|Osteoarthritis, Knee||Radiation: MRI Procedure: Primary Total Knee Replacement|
BACKGROUND AND SIGNIFICANCE:
Although the presence of bone marrow lesions (BML) on MRI is strongly associated with osteoarthritis (OA) progression and pain in some studies, the mechanism for this relation and the underlying pathology is not well established. The lack of knowledge on what these lesions constitute hampers their clinical utility both with regards to measurement and targeting for therapeutic intervention.
Our preliminary data has localized specific changes in bone mineralization, remodeling and defects within BML features that are adjacent to the subchondral plate. BMLs appear to be sclerotic compared to unaffected regions; however, the mineral density in these lesions is reduced and may render this area to be mechanically compromised, and thus susceptible to attrition. Limited histological analysis of BMLs reveal thrombi, diffuse fibrinoid necrosis and hyperplasia of blood vessel walls - all indicative of infarction-like pathology.
The aim of this research proposal is to create more specific targets and improve our understanding of the pathology in BMLs.
Specific Aim 1:
- To collect tissue to evaluate protein and gene expression of these tissues and cultured cells.
|Study Type :||Observational|
|Actual Enrollment :||101 participants|
|Official Title:||The Role of Bone and Its Measurement in Knee Osteoarthritis|
|Study Start Date :||July 2008|
|Actual Primary Completion Date :||April 2013|
|Actual Study Completion Date :||April 2013|
- Radiation: MRI
1.5T MRI exam of signal knee with knee coil (estimated time: 35 minutes)
- Procedure: Primary Total Knee Replacement
Fluid, bone, and meniscus specimens obtained from total joint replacement will be collected.
- Number of Participants With Viable Specimens for Genetic Analysis [ Time Frame: Tissue samples collected at time of surgery ]
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00850538
|Australia, New South Wales|
|University of Sydney|
|Sydney, New South Wales, Australia, 02120|
|Principal Investigator:||David Hunter, MD||University of Sydney|