Genetic of Aortic Valve Stenosis - Clinical and Therapeutic Implications (GENERAC)
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ClinicalTrials.gov Identifier: NCT00647088 |
Recruitment Status : Unknown
Verified February 2016 by Assistance Publique - Hôpitaux de Paris.
Recruitment status was: Recruiting
First Posted : March 31, 2008
Last Update Posted : March 1, 2017
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Condition or disease |
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Aortic Valve Stenosis |
Study Type : | Observational |
Estimated Enrollment : | 2200 participants |
Observational Model: | Case-Control |
Time Perspective: | Prospective |
Official Title: | Genetic of Aortic Valve Stenosis - Clinical and Therapeutic Implications |
Study Start Date : | March 2008 |
Estimated Primary Completion Date : | December 2017 |
Estimated Study Completion Date : | December 2017 |

Group/Cohort |
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aortic stenosis
various age and disease severity
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Controls
Controls free of valvular disease
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- Identification of genetic polymorphisms of fetuin-A, matrix-GLA protein, vitamin D receptor [ Time Frame: end of the study ]
- Identification of other genetic polymorphisms [ Time Frame: End of the Study ]
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Patients:
Inclusion criteria :
- Age >=18 years
- Pure isolated degenerative aortic valve stenosis
Exclusion criteria :
- Rheumatic, congenital or post-radiation aortic stenosis
- Severe renal insufficiency (clearance < 30 ml/min)
- Aortic insufficiency > or = grade 2/4
- Other valve disease > or = grade 2/4
Controls
Inclusion criteria :
- Age >=18 years
Exclusion criteria :
- Known first degree relative with aortic valve stenosis
- Severe renal insufficiency (clearance < 30 ml/min)
- Any valve disease > or = grade 2/4

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00647088
France | |
Assistance Publique - Hôpitaux de Paris, Bichat Hospital | Recruiting |
Paris, France, 75018 | |
Contact: David MESSIKA-ZEITOUN, MD 01 40 25 66 01 ext 00 33 david.messika-zeitoun@bch.aphp.fr | |
Principal Investigator: David Messika-Zeitoun |
Principal Investigator: | David Messika-Zeitoun, MD | Assistance Publique - Hôpitaux de Paris |
Responsible Party: | Assistance Publique - Hôpitaux de Paris |
ClinicalTrials.gov Identifier: | NCT00647088 |
Other Study ID Numbers: |
P070141 |
First Posted: | March 31, 2008 Key Record Dates |
Last Update Posted: | March 1, 2017 |
Last Verified: | February 2016 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Aortic Valve stenosis Genetic Mineralisation inhibitors |
Aortic Valve Stenosis Constriction, Pathologic Pathological Conditions, Anatomical Aortic Valve Disease |
Heart Valve Diseases Heart Diseases Cardiovascular Diseases Ventricular Outflow Obstruction |