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PERG and mfPERG in Band Atrophy

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ClinicalTrials.gov Identifier: NCT00553761
Recruitment Status : Completed
First Posted : November 6, 2007
Last Update Posted : August 8, 2011
Sponsor:
Collaborator:
Fundação de Amparo à Pesquisa do Estado de São Paulo
Information provided by:
University of Sao Paulo

Study Description
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Brief Summary:
The study is designed to evaluate the ability of pattern electroretinogram (PERG) and multifocal pattern electroretinogram (mfPERG) to measure and identify the pattern of band atrophy of the optic nerve in patients with long standing chiasmal lesions. The hypothesis is that these electrophysiological tests were able to identify this such pattern. The idea is to investigate the ability of the these electrophysiological technics in detecting the neural loss from chiasmal compression and to evaluate the ability of PERG and mfPERG parameters to differentiate between eyes with band atrophy of the optic nerve and healthy eyes.

Condition or disease Intervention/treatment
Band Atrophy Device: Pattern electroretinogram

Study Design
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Study Type : Observational
Estimated Enrollment : 30 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Pattern Electroretinogram and Multifocal Pattern Electroretinogram For the Detection of Neural Loss in Patients With Permanent Temporal Visual Field Defect From Chiasmal Compression
Study Start Date : August 2006
Actual Primary Completion Date : July 2008
Actual Study Completion Date : July 2009
Groups and Cohorts
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Intervention Details:
  • Device: Pattern electroretinogram
    Full field and hemifield (nasal and temporal) stimulation transient pattern electroretinogram (PERG) were recorded both in patients and controls.

Outcome Measures
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Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with band atrophy from chismal compression and controls
Criteria

Inclusion Criteria:

  1. Visual acuity better than 20/30
  2. Refractive error less 5 spherical diopter and 3 cylinder diopter
  3. Temporal field defect

Exclusion Criteria:

  1. Presence of glaucoma and optic nerve anomalies
  2. Anormal nasal field
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00553761


Locations
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Brazil
Universidade de São Paulo
São Paulo, Brazil, 05403-000
Sponsors and Collaborators
University of Sao Paulo
Fundação de Amparo à Pesquisa do Estado de São Paulo
Investigators
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Study Chair: Mário Luiz R Monteiro, PhD University of Sao Paulo
More Information
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Additional Information:

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

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Responsible Party: Mario Luiz Ribeiro Monteiro/University of Sao Paulo, University of Sao Paulo
ClinicalTrials.gov Identifier: NCT00553761    
Other Study ID Numbers: 654/06
FAPESP 06/61549-6; 07/54142-0)
First Posted: November 6, 2007    Key Record Dates
Last Update Posted: August 8, 2011
Last Verified: November 2007
Keywords provided by University of Sao Paulo:
Band atrophy
Pattern electroretinogram
Chiasmal compression
Neural loss
Electrophysiological tests
Additional relevant MeSH terms:
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Atrophy
Pathological Conditions, Anatomical