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Invasive Infections in Children With Hemoglobinopathies

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ClinicalTrials.gov Identifier: NCT00456443
Recruitment Status : Completed
First Posted : April 5, 2007
Last Update Posted : April 5, 2007
Sponsor:
Information provided by:
HaEmek Medical Center, Israel

Study Description
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Brief Summary:
Patients diagnosed as having hemoglobinopathies are exposed to serious bacterial infections, principally those patients that underwent splenectomy. Since the introduction of anti pneumococcal vaccine the incidence decreased significantly but other bacteria besides encapsulated bacteria takes place as principal cause of invasive infections. The purpose of this study is to analyse in a retrospective study the incidence of those infections in a group of patients suffering from thalassemia and sickle cell anemia treated in our clinic.

Condition or disease Intervention/treatment
Thalassemia Sickle Cell Anemia Procedure: Historical records

Study Design
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Study Type : Observational
Enrollment : 200 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Retrospective
Official Title: Invasive Infections in Children With Hemoglobinopathies. A Clinical Descriptive Retrospective Study.
Study Start Date : January 2006
Actual Study Completion Date : June 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Thalassemia

Groups and Cohorts
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Outcome Measures
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Eligibility Criteria
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Ages Eligible for Study:   up to 40 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • All patients treated in the Pediatric Hematology Unit.
Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00456443


Locations
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Israel
Pediatric Hematology Unit and Pediatric Dpt B - HaEmek Medical Center
Afula, Israel, 18101
Sponsors and Collaborators
HaEmek Medical Center, Israel
Investigators
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Study Director: Ariel Koren, MD Pediatric Hematology Unit, Ha'Emek Medical Center
Principal Investigator: Waheeb Sakran, MD Pediatric Dpt B - Ha'Emek Medical Center
More Information
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ClinicalTrials.gov Identifier: NCT00456443    
Other Study ID Numbers: 4140905.EMC
First Posted: April 5, 2007    Key Record Dates
Last Update Posted: April 5, 2007
Last Verified: April 2007
Keywords provided by HaEmek Medical Center, Israel:
Thalassemia
Sickle cell anemia
Splenectomy
Infections
Streptococcal Pneumonia
Additional relevant MeSH terms:
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Infection
Thalassemia
Anemia, Sickle Cell
Hemoglobinopathies
Anemia
 Hematologic Diseases
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Genetic Diseases, Inborn