Trial of Adjunctive Vitamin D in Tuberculosis Treatment
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Suspected smear positive pulmonary tuberculosis.
Age 18 years or older.
Written informed consent to participate.
Known intolerance of vitamin D or first-line anti-tuberculous therapy.
Taking antituberculous therapy for more than six days in the six months preceding enrolment.
Taking the following medication in the month preceding enrolment: oral corticosteroid therapy, immunosuppressant therapy or cytotoxic therapy.
Taking the following medication at enrolment: benzothiadiazine derivatives, cardiac glycosides or antituberculous therapy other than rifampicin, isoniazid, pyrazinamide and ethambutol.
Diagnosis of any of the following: sarcoidosis, hyperparathyroidism, nephrolithiasis, pulmonary silicosis, HIV infection, liver failure, renal failure or malignancy
Infection with rifampicin-resistant organism (as demonstrated by rapid molecular testing)
Biochemical disturbance at enrolment: serum corrected calcium >2.66 mmol/l, serum AST >120 IU/l, total serum bilirubin > 40 micromol/l or serum creatinine > 250 micromol/l