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Study of Optimal Treatment Plan in Hypertensives With Anti-AT1-Receptor Autoantibody

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ClinicalTrials.gov Identifier: NCT00360763
Recruitment Status : Unknown
Verified August 2006 by Huazhong University of Science and Technology.
Recruitment status was:  Recruiting
First Posted : August 7, 2006
Last Update Posted : August 7, 2006
Sponsor:
Information provided by:
Huazhong University of Science and Technology

Study Description
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Brief Summary:
The autoantibodies against AT1 receptor (ATR-AA), behaving like an agonist were detected in patients with hypertension. ATR-AA which can blocked by ARB may play a role in the pathogenesis of hypertension. The present study is to explore whether AT1 receptor blocker has superior anti-hypertensive effect in patients with positive ATR-AA hypertension. Patients with 2 grade hypertension were recruited and ATR-AA was assayed by ELISA. A study was carried out and the efficacy of anti-hypertension was compared between candesartan cilexetil and ACE inhibitor imidapril.

Condition or disease Intervention/treatment Phase
Hypertension Drug: candesartan cilexetil Phase 4

Study Design
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Study Type : Interventional  (Clinical Trial)
Enrollment : 600 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Study Completion Date : December 2006

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Arms and Interventions
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Outcome Measures
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Eligibility Criteria
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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Hypertension (2 grade)

Exclusion Criteria:

  • Secondary hypertension
  • Known sensitivity or intolerance to an angiotensin II receptor antagonist or ACE inhibitor
  • Pregnancy
Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00360763


Locations
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China, Hubei
Department of Cardiology, Wuhan Union Hospital Recruiting
Wuhan, Hubei, China, 430022
Contact: Yu-Hua Liao, Doctor    00862785726376    yumiaowei@vip.sina.com   
Sponsors and Collaborators
Huazhong University of Science and Technology
Investigators
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Study Director: Yu-Hua Liao Union Hospital, Tongji Medical College
More Information
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Publications:

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

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ClinicalTrials.gov Identifier: NCT00360763    
Other Study ID Numbers: UH-01
First Posted: August 7, 2006    Key Record Dates
Last Update Posted: August 7, 2006
Last Verified: August 2006
Additional relevant MeSH terms:
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Hypertension
Vascular Diseases
Cardiovascular Diseases
Candesartan
Candesartan cilexetil
 Antihypertensive Agents
Angiotensin II Type 1 Receptor Blockers
Angiotensin Receptor Antagonists
Molecular Mechanisms of Pharmacological Action