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Marijuana for HIV-Related Peripheral Neuropathy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00046722
Recruitment Status : Completed
First Posted : October 3, 2002
Last Update Posted : June 14, 2007
Information provided by:
Center for Medicinal Cannabis Research

Brief Summary:
To evaluate whether smoked marijuana reduces pain in people with HIV-related peripheral neuropathy.

Condition or disease Intervention/treatment Phase
Peripheral Nervous System Diseases HIV Infections Drug: Smoked Marijuana Phase 1 Phase 2

Detailed Description:
The study will include subjects with peripheral neuropathy caused either by HIV-disease or antiretroviral medication for the treatment of HIV. A neurologist will conduct a neurological and pain evaluation to determine eligibility for the study. Subjects who meet all eligibility criteria will be admitted to the General Clinical Research Center at San Francisco General Hospital for seven days. Subjects will be randomized (like a toss of a coin) to smoke marijuana or a placebo (cigarettes with no THC).

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Study Type : Interventional  (Clinical Trial)
Enrollment : 50 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Effects of Marijuana on Neuropathic Pain in HIV-Related Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Study.
Study Start Date : January 2003
Study Completion Date : April 2005

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Change in level of HIV-related neuropathic pain as recorded on a 100mm Visual Analog Scale.

Secondary Outcome Measures :
  1. Change in level of experimentally-induced pain.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No


  • HIV positive.
  • Be 18 years or older.
  • Diagnosis of HIV-related painful neuropathy.
  • Stable antiretroviral therapy or no antiretroviral therapy for at least 8 weeks.
  • Prior use of marijuana, at least 6 occasions in their lifetime prior to enrollment.


  • Current use of smoked tobacco products.
  • Current methadone treatment.
  • Use of smoked marijuana within 30 days of enrollment.
  • Diagnosis of diabetes mellitus.
  • Currently receiving treatment with corticosteroids.
  • Use of INH, dapsone or metronidazole within 8 weeks prior to enrollment.
  • Severe heart disease, uncontrolled high blood pressure or lung disease.
  • Women who are pregnant or breastfeeding.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00046722

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United States, California
University of California, San Francisco Community Consortium
San Francisco, California, United States, 94110
Sponsors and Collaborators
Center for Medicinal Cannabis Research
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Principal Investigator: Donald I Abrams, M.D. UCSF Community Consortium
Additional Information:
Publications of Results:
Layout table for additonal information Identifier: NCT00046722    
Other Study ID Numbers: C00-SF-101
CC# 056
First Posted: October 3, 2002    Key Record Dates
Last Update Posted: June 14, 2007
Last Verified: June 2007
Keywords provided by Center for Medicinal Cannabis Research:
treatment experienced
complementary therapies
Peripheral Neuropathy
HIV-Related Peripheral Neuropathy
Additional relevant MeSH terms:
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Peripheral Nervous System Diseases
Nervous System Diseases
Neuromuscular Diseases