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Massage Therapy for Cancer-Related Fatigue

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00039793
Recruitment Status : Completed
First Posted : June 13, 2002
Last Update Posted : August 18, 2006
Information provided by:
National Center for Complementary and Integrative Health (NCCIH)

Brief Summary:
The purpose of this study is to develop methods for studying the effect of bodywork therapy on symptoms of fatigue in patients undergoing cancer chemotherapy.

Condition or disease Intervention/treatment Phase
Breast Neoplasms Ovarian Neoplasms Prostatic Neoplasms Colorectal Neoplasms Procedure: Moderate-intensity and low-intensity bodywork therapy Phase 2

Detailed Description:

The proposed project is a randomized pilot trial of a Swedish-style massage therapy intervention for the treatment of fatigue in patients who are undergoing cancer chemotherapy. Fatigue is the most common complaint of patients receiving treatment for cancer, but is often difficult to treat and causes a substantial decrement in patients' quality of life. Massage therapy is a non-invasive intervention used in many patients with cancer for symptom control. Prior small studies have suggested some efficacy of bodywork therapies in conditions characterized by fatigue, such as fibromyalgia and chronic fatigue syndrome. Based on these results, massage therapy may provide an important adjunct in ameliorating fatigue and enhancing cancer patients' well being.

The proposed study is a 12-week, randomized, three-arm, parallel-comparison clinical trial comparing the effects of a Swedish-style massage regimen to a sham bodywork control and a usual-care group for fatigue reduction in cancer patents undergoing chemotherapy. Patients with breast, ovarian, prostate, or colo-rectal cancer will be enrolled; the primary outcome measure is a quantitative assessment of fatigue symptoms. This study will determine efficacy, functioning, perceptions of fatigue, and quality of life. This study should provide not only important data on the potential efficacy of massage therapy for the treatment of fatigue, but also advance the methodology for studying CAM interventions for difficult-to-treat symptomatic conditions.

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Study Type : Interventional  (Clinical Trial)
Enrollment : 45 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Massage Therapy for Cancer-Related Fatigue
Study Start Date : March 2001
Study Completion Date : March 2004

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Fatigue

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion criteria:

  • Confirmed tissue diagnosis of cancer of the breast, ovary, prostate or colo-rectum
  • Have an anticipated completion of chemotherapy no more than 2 weeks before the last bodywork session.
  • Have a primary oncologist
  • Currently receiving chemotherapy or completed chemotherapy treatment within the past 6 months

Exclusion criteria:

  • Active skin rash or open cutaneous lesions.
  • History of venous thrombosis (or symptomatic varicosity)
  • Identification of a thrombosis using an ultrasound test of the legs.
  • Long term (> 3 months) steroid medications for other medical conditions in past 5 years
  • Plans to move out of the study region within 6 months
  • Thyroid-stimulating hormone (TSH) level above the upper limit of normal
  • Hematocrit <25%
  • Platelet count of < 50,000
  • Patients who have been receiving regular (i.e. at least twice a month) bodywork over the past 6 months.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00039793

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United States, California
Osher Center for Integrative Medicine
San Francisco, California, United States, 94143
Sponsors and Collaborators
National Center for Complementary and Integrative Health (NCCIH)
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Principal Investigator: Andrew Avins, MD, MPH Osher Center for Integrative Medicine, University of California, San Francisco
OverallOfficial: Shelley Adler, PhD Osher Center for Integrative Medicine, University of California, San Francisco
OverallOfficial: Michael Patterson, MS Osher Center for Integrative Medicine, University of California, San Francisco
Additional Information:
Publications automatically indexed to this study by Identifier (NCT Number):
Layout table for additonal information Identifier: NCT00039793    
Obsolete Identifiers: NCT00058513
Other Study ID Numbers: R21AT000348-01 ( U.S. NIH Grant/Contract )
First Posted: June 13, 2002    Key Record Dates
Last Update Posted: August 18, 2006
Last Verified: July 2006
Keywords provided by National Center for Complementary and Integrative Health (NCCIH):
Cancer-related fatigue
alternative medicine
cancer rehabilitation /care
human therapy evaluation
physical therapy
neoplasm /cancer chemotherapy
neoplasm /cancer palliative treatment
Additional relevant MeSH terms:
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Breast Neoplasms
Colorectal Neoplasms
Prostatic Neoplasms
Ovarian Neoplasms
Neoplasms by Site
Breast Diseases
Skin Diseases
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases
Genital Neoplasms, Male
Urogenital Neoplasms
Prostatic Diseases
Endocrine Gland Neoplasms
Ovarian Diseases
Adnexal Diseases
Genital Neoplasms, Female
Endocrine System Diseases
Gonadal Disorders