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Diagnostic Pilot Study of Dual Energy Absorptiometry in the Detection of Osteopenia or Osteoporosis in Patients With Thalassemia Major

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ClinicalTrials.gov Identifier: NCT00006138
Recruitment Status : Completed
First Posted : August 4, 2000
Last Update Posted : June 24, 2005
Sponsor:
Collaborator:
Children's Hospital of Philadelphia
Information provided by:
Office of Rare Diseases (ORD)

Study Description
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Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information
Brief Summary:

OBJECTIVES:

I. Determine the frequency and severity of osteopenia and osteoporosis in patients with thalassemia major who undergo dual energy x-ray absorptiometry, and correlate these findings with other relevant endocrinologic measurements.


Condition or disease
Osteoporosis Thalassemia Major Osteopenia

Detailed Description:

PROTOCOL OUTLINE:

Patients undergo dual energy x-ray absorptiometry for bone density measurements, height (sitting and standing) and weight measurements, comprehensive endocrinologic examination, and assessment of the severity of iron overload at baseline, and then at years 1 and 2.

Study Design
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Study Type : Observational
Enrollment : 35 participants
Study Start Date : June 1998
Study Completion Date : August 2000

Resource links provided by the National Library of Medicine


Groups and Cohorts
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Outcome Measures
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Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   6 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria
  • Diagnosis of thalassemia major with iron overload
  • Not pregnant
  • Negative pregnancy test
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00006138


Sponsors and Collaborators
National Center for Research Resources (NCRR)
Children's Hospital of Philadelphia
Investigators
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Study Chair: Alan Richard Cohen Children's Hospital of Philadelphia
More Information
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Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information
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ClinicalTrials.gov Identifier: NCT00006138    
Other Study ID Numbers: 199/15314
CHP-IRB-1998-6-1502
CHP-GCRC-1655
First Posted: August 4, 2000    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: October 2000
Keywords provided by Office of Rare Diseases (ORD):
disease-related problem/condition
genetic diseases and dysmorphic syndromes
hematologic disorders
 osteoporosis
rare disease
thalassemia major
Additional relevant MeSH terms:
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Osteoporosis
Bone Diseases, Metabolic
Thalassemia
beta-Thalassemia
Bone Diseases
Musculoskeletal Diseases
Metabolic Diseases
 Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Anemia
Hematologic Diseases
Hemoglobinopathies
Genetic Diseases, Inborn