Dental Caries Prevention by a Natural Product
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|ClinicalTrials.gov Identifier: NCT03763578|
Recruitment Status : Not yet recruiting
First Posted : December 4, 2018
Last Update Posted : December 4, 2018
|Condition or disease||Intervention/treatment||Phase|
|Dental Caries||Other: Licorice||Not Applicable|
Research hypothesis (Null hypothesis):
The present clinical trial will be conducted to reject or accept the null hypothesis that using Licorice extract mouth wash in addition to standard preventive measures will not differ from using standard preventive measures alone in preventing incidence of new carious lesions.
P: Population with high caries risk patients
I: Use of licorice.
I2: Use of chlorhexidine
C: Use of standard preventive measures (tooth brushing, tooth paste, interdental cleaning).
O.1: Primary outcome is incidence of new carious lesions
T: Time for measurement is 12 months
S: A Randomized controlled clinical trial (Parallel study)
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||81 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||Licorice Versus Standard Preventive Measures for the Prevention of Caries Incidence in Young Egyptian Adults: Randomized Controlled Trial|
|Estimated Study Start Date :||December 1, 2018|
|Estimated Primary Completion Date :||December 1, 2019|
|Estimated Study Completion Date :||January 1, 2020|
licorice is one of the natural products that is listed by the Food and Drug Administration (FDA) as GRAS (generally regarded as safe) when used as food flavoring and sweetening agent which has an antimicrobial, anti-inflammatory and antiviral activity.
Natural herbal product
Active Comparator: Chlorhexidine
The "gold standard" of oral therapeutics is Chlorhexidine due to its prolonged broad- spectrum antimicrobial effect.
Natural herbal product
No Intervention: Control Group
Participants in this group will follow only the standard preventive measures which is brushing twice a day after breakfast and before bed time and daily flossing interdentally before bed time. (No Mouthwash is used)
- Incidence of new carious lesions [ Time Frame: 12 months ]Appearance of new carious lesions within the study duration
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03763578
|Conservative and Esthetic Dentistry Department-Faculty of Dentistry- Cairo University||Not yet recruiting|
|Cairo, Choose Any State/Province, Egypt, 002|
|Contact: Sara Mady, Masters 00201004705764 firstname.lastname@example.org|
|Contact: Sara Mady, Masters 00201001181056 email@example.com|