Myocardial Flow Reserve in Severe AS Without Obstructive Coronary Artery Disease
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT02575768 |
Recruitment Status :
Completed
First Posted : October 15, 2015
Last Update Posted : October 15, 2015
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Exertional angina is common symptom in patients with severe aortic stenosis (AS) without obstructive coronary artery disease (CAD). Although reduced myocardial flow reserve is one of the proposed explanations for angina, little is known about the pathophysiology.
This study aimed that adenosine-stress cardiac magnetic resonance can be used for the assessment of myocardial perfusion reserve and suggest the pathophysiology of development of angina in patients with severe AS without obstructive CAD.
Condition or disease | Intervention/treatment |
---|---|
Chest Pain Severe Aortic Stenosis | Other: Adenosine-stress cardiac magnetic resonance imaging |
Study Type : | Observational |
Actual Enrollment : | 104 participants |
Observational Model: | Case-Control |
Time Perspective: | Prospective |
Official Title: | Reduced Myocardial Flow Reserve in Exertional Angina With Severe Aortic Stenosis and Normal Coronary Arteries: Insight From Prospective Observational Adenosine-stress Cardiac Magnetic Resonance Imaging Study |
Study Start Date : | June 2012 |
Actual Primary Completion Date : | April 2015 |
Actual Study Completion Date : | April 2015 |

Group/Cohort | Intervention/treatment |
---|---|
Severe AS: asymptomatic
Asymptomatic
|
Other: Adenosine-stress cardiac magnetic resonance imaging
undergoing adenosine-stress cardiac magnetic resonance imaging |
Severe AS: pure angina
Presence of exertional chest pain
|
Other: Adenosine-stress cardiac magnetic resonance imaging
undergoing adenosine-stress cardiac magnetic resonance imaging |
Normal controls
Healthy controls
|
Other: Adenosine-stress cardiac magnetic resonance imaging
undergoing adenosine-stress cardiac magnetic resonance imaging |
- Values of the myocardial perfusion reserve index (MPRI) [ Time Frame: Day 1 ]Signal intensity-time curves were generated for all segments and the maximum upslope of the LV myocardium divided by the maximum upslope of the LV cavity. MPRI [upslopestress(corrected)/upsloperest(corrected)] was calculated dividing the segmental upslope value during adenosine and rest. Whole (average of all myocardial segments) MPRI were calculated.

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Probability Sample |
Inclusion Criteria:
- severe AS
- normal LV ejection fraction (EF ≥ 50%)
Exclusion Criteria:
- age <18
- LVEF < 50% in echocardiography
- concomitant other valvular disease of moderate or severe severity
- previous aortic valve replacement
- symptomatic patients other than chest pain
- obstructive CAD (>30% luminal stenosis in at least one coronary artery on coronary angiography)
- history of myocardial infarction or acute coronary syndrome
- contraindication to adenosine
- any absolute contraindication to CMR
- estimated glomerular filtration rate <30 mL/min/1.73m2.
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Samsung Medical Center |
ClinicalTrials.gov Identifier: | NCT02575768 |
Other Study ID Numbers: |
2012-01-014 |
First Posted: | October 15, 2015 Key Record Dates |
Last Update Posted: | October 15, 2015 |
Last Verified: | June 2012 |
Adenosine Aortic Valve Stenosis Constriction, Pathologic Chest Pain Pathological Conditions, Anatomical Heart Valve Diseases Heart Diseases Cardiovascular Diseases Ventricular Outflow Obstruction Pain Neurologic Manifestations |
Analgesics Sensory System Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Arrhythmia Agents Vasodilator Agents Purinergic P1 Receptor Agonists Purinergic Agonists Purinergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action |