Working… Menu
Trial record 15 of 568 for:    TRAMADOL

Tramadol and Pain Sensitization (TRAMADOL)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00487175
Recruitment Status : Completed
First Posted : June 15, 2007
Last Update Posted : March 17, 2009
Information provided by:
University Hospital, Clermont-Ferrand

Brief Summary:
Tramadol is a largely used analgesic drug. Its role however on sensitization as occurs for example in neuropathic pain is not very well known. This protocol aims therefore at studying the effect of tramadol in a human pain model with sensitization induced by a cold stimulus, using evoked potentials to elucidate how pain is modified when tramadol is administered.

Condition or disease Intervention/treatment Phase
Pain Drug: Tramadol Phase 1

Detailed Description:
The study is a comparison of the analgesic of tramadol versus placebo in a pain model using evoked potentials. Evaluation criteria will be the amplitude of the evoked potential obtained defore and after treatment

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 12 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Tramadol and Pain Sensitization
Study Start Date : September 2007
Actual Primary Completion Date : December 2007
Actual Study Completion Date : March 2008

Resource links provided by the National Library of Medicine

Drug Information available for: Tramadol

Intervention Details:
  • Drug: Tramadol
    to compare of the analgesic of tramadol versus placebo in a pain model using evoked potentials

Primary Outcome Measures :
  1. Amplitude of the evoked potential elicited by a thermal stimulus on the arm with an induced hyperalgic area [ Time Frame: with an induced hyperalgic area ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy men
  • Between 18 and 40 years old
  • Written consent given

Exclusion Criteria:

  • Concomitant medication
  • Tramadol hypersensibility
  • Excessive consumption of alcohol, tobacco, coffee, tea or toxicomania

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00487175

Layout table for location information
Clermont-Ferrand, France, 63000
Sponsors and Collaborators
University Hospital, Clermont-Ferrand
Layout table for investigator information
Principal Investigator: PICKERING Gisèle, MCU-PH, pharmacology
Layout table for additonal information
Responsible Party: Gisèle PICKERING, CHU Clermont-Ferrand Identifier: NCT00487175    
Other Study ID Numbers: CHU63-0020
First Posted: June 15, 2007    Key Record Dates
Last Update Posted: March 17, 2009
Last Verified: March 2009
Keywords provided by University Hospital, Clermont-Ferrand:
Healthy volunteers and pain
Additional relevant MeSH terms:
Layout table for MeSH terms
Analgesics, Opioid
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents