The Effective Treatment of Oral Helicobacter Pylori With the Success Rate of Gastric Eradication
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|ClinicalTrials.gov Identifier: NCT01863823|
Recruitment Status : Completed
First Posted : May 29, 2013
Last Update Posted : May 29, 2013
- Gastric eradication has no effective on oral H. pylori infection.
- Treatment of oral infection increase success rate of eradication on stomach infection.
|Condition or disease||Intervention/treatment||Phase|
|Oral Helicobacter Pylori||Drug: Amoxicillin and Tetracyclines Drug: Mouth washing||Phase 1 Phase 2|
Objective: The present study was aimed to explore the relationship of Helicobacter pylori(H. pylori) of the oral cavity with the success rate eradication of gastric H. pylori infection.
Study Design and Setting: 202 symptomatic and 148 asymptomatic individuals were recruited and tested using Saliva H. pylori antigen tests (HPS), H. pylori flagellin (HPF), the urea breathe test (UBT) and the polymerase chain reaction (PCR) test. Test subjects also received various treatments.
We collected data of HPS, HPF , PCR and UBT before treatment on 202 symptomatic patients and 148 asymptomatic individual groups. After drug treatment, we run HPS, HPF, PCR and UBT tests. If the tests of HPS, HPF and PCR show negative that indicate success of oral H.pylori eradication. If the test of UBT show negative that indicate success of stomach H.pyloi eradication. We also compare the suceess rate of eradication on stomach infection with and without oral H. pylori infection.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||350 participants|
|Intervention Model:||Single Group Assignment|
|Official Title:||Director of Research Division|
|Study Start Date :||August 2011|
|Actual Primary Completion Date :||September 2012|
|Actual Study Completion Date :||September 2012|
Amoxicillin and Tetracyclines
Drug: Amoxicillin and Tetracyclines
202 symptomatic and 148 asymptomatic individuals were recruited and tested using Saliva H. pylori antigen tests (HPS), H. pylori flagellin (HPF), the urea breathe test (UBT) and the polymerase chain reaction (PCR) test. Test subjects also received various treatments.
Other Name: dBest
Drug: Mouth washing
Two time washing mouth per day
Other Name: dBest
- Success Rate [ Time Frame: 12 months ]
- Diagnostic [ Time Frame: 6 months ]
- Agreement of diagnostic and success rate of gastric eradication [ Time Frame: 12 months ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01863823
|Beijing University First Hospital|
|Beijiang, China, 1001|