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Trial record 91 of 465 for:    KETOROLAC

Intranasal Desmopressin vs IV Ketorolac in Renal Colic Pain Control

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ClinicalTrials.gov Identifier: NCT02937896
Recruitment Status : Completed
First Posted : October 19, 2016
Last Update Posted : October 19, 2016
Sponsor:
Information provided by (Responsible Party):
Kambiz Nasiri, Shahid Beheshti University of Medical Sciences

Brief Summary:
The aim of this study is the comparison of efficacy of intravenous ketorolac and intranasal desmopressin in renal colic patients pain control.

Condition or disease Intervention/treatment Phase
Renal Colic Drug: Desmopressin Drug: Ketorolac Drug: Normal Saline Not Applicable

Detailed Description:
40 renal colic patients have been divided into 2 groups randomly, one group has been received 30mg intravenous Ketorolac and 4 puffs nasal Normal Saline while other has been received 40 micrograms nasal Desmopressin and 1cc intravenous Normal Saline. Pain Score before drug administration,also 10, 30 and 60 minutes after drug administration has been measured bye Visual Analogue Scale ( VAS ).

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Treatment
Official Title: Comparison of Intranasal Desmopressin vs IV Ketorolac in Renal Colic Patients
Study Start Date : January 2015
Actual Primary Completion Date : February 2016
Actual Study Completion Date : April 2016

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Ketorolac
30mg ketorolac administrated intravenous and 4 puffs nasal Normal Saline.
Drug: Ketorolac
30mg intravenous Ketorolac.
Other Name: Toradol

Drug: Normal Saline
4 puffs nasal Normal Saline.
Other Name: NaCl

Active Comparator: Desmopressin
40 microgram nasal desmopressin administrated and 1cc Normal Saline intravenous
Drug: Desmopressin
40 micrograms Nasal Desmopressin.
Other Name: Ddavp

Drug: Normal Saline
1cc intravenous Normal Saline.
Other Name: NaCl




Primary Outcome Measures :
  1. Pain score [ Time Frame: Pain score change from baseline pain score before intervention 10, 30 and 60 minutes after intervention ]


Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years to 50 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • renal colic patients

Exclusion Criteria:

  • history of hypertension and cardiac disease
  • pregnant patients
  • use of analgesic within 4 hours before intervention

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Responsible Party: Kambiz Nasiri, Emergency Medicine Resident, Shahid Beheshti University of Medical Sciences
ClinicalTrials.gov Identifier: NCT02937896     History of Changes
Other Study ID Numbers: 688
First Posted: October 19, 2016    Key Record Dates
Last Update Posted: October 19, 2016
Last Verified: October 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

Additional relevant MeSH terms:
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Ketorolac
Ketorolac Tromethamine
Colic
Renal Colic
Infant, Newborn, Diseases
Pain
Neurologic Manifestations
Signs and Symptoms
Deamino Arginine Vasopressin
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Hemostatics
Coagulants
Antidiuretic Agents
Natriuretic Agents