Cognitive Function and Emotional Possessing in Bilateral Facial Palsy
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|ClinicalTrials.gov Identifier: NCT02179450|
Recruitment Status : Completed
First Posted : July 1, 2014
Last Update Posted : July 1, 2014
Based on recent findings that botulinum toxin injections in the cranial muscles might reduce emotional processing (Havas 2011), an increasing number of popular newspaper tabloids are suggesting a negative effect on cognition. The underlying research articles address the "facial feedback hypothesis". The hypothesis indicates that expressive behaviour, including facial mimic expressions influences the subject's brain via feedback. (Alam 2008) Other systemic neurological diseases, e.g of inflammatory origin, may lead to temporary bilateral facial nerve palsy (BF). During recovery process, the palsy usually remits completely.
The effect of bilateral facial muscle palsy on cognition and emotional possessing has never been evaluated.
The results of this pilot study might provide new information about the effect bilateral facial palsy on emotional processing and cognition and the facial feedback hypothesis.
The aim of this controlled pilot study is to assess cognitive function and emotional processing in patients with bilateral facial palsy. In addition, differences in cognitive function and emotional processing in patients with different manifestations of dystonia should be evaluated.
According to the facial feedback theory, paralysed mimic muscles might alter emotional processing. Therefore, investigators compare patients with bilateral facial muscle palsy and healthy controls. Investigators expect no influence of facial muscle palsy on cognitive functions in any of the tested groups; the investigators expect a mild impairment of emotional processing only in the patients group with bilateral facial muscle palsy (BEB and BF). In addition, the investigators expect no difference in emotional processing in patients with different manifestations of dystonia (BEB and CD) at remission. There might be a slight difference of emotional processing in patients with different manifestations of dystonia (BEB and CD) at time of prominent facial palsy.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||84 participants|
|Observational Model:||Case Control|
|Official Title:||Pilot Study Assessing Cognitive Function and Emotional Possessing in Patients With Bilateral Facial Palsy|
|Study Start Date :||August 2012|
|Actual Primary Completion Date :||May 2013|
|Actual Study Completion Date :||December 2013|
Patients suffering from Blepharospasm
Patients suffering from cervical dystonia
Bilateral facial palsy
Patients suffering from bilateral facial palsy of inflammatory origin
- I-S-T-2000R- (intelligence-structure-test 2000R) [ Time Frame: up to four weeks ]
Test to evaluate Intelligence
- Subtest "Matrixes"
- Subtest "Analogies"
- Beck's depression-inventory-II [ Time Frame: up to four weeks ]Evaluation of depression (BDI-II; Hautzinger et al., 2009)
- Apathy Evaluation Scale [ Time Frame: up to four weeks ]Evaluation of apathy (AES; Luecken et al., 2006)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02179450
|Department of Neurology, Medical University of Vienna|
|Vienna, Austria, 1090|
|Principal Investigator:||Eduard Auff, Prof., MD||Department of Neurology, Medical University of Vienna|