Ability of Changes in End Tidal Carbon Dioxide to Assess the Stroke Volume Effects of a Volume Expansion of 250ml of Crystalloid in the Operating Room (REVCO2)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT03635307|
Recruitment Status : Completed
First Posted : August 17, 2018
Last Update Posted : January 22, 2020
|Condition or disease||Intervention/treatment|
|Blood Volume Expansion||Other: End Tidal Carbon Dioxide measure|
The main objective of volume expansion is to increase stroke volume. Franck-Starling curve is schematically divided into two portions: a vertical portion which mean that an increase in preload secondary to volume expansion will induce an increase in stroke volume; and a flat portion which mean that a same increase in preload will not induce an increase in stroke volume. Perioperative optimization is based on stroke volume maximization using volume expansion. Despite national and international recommendations, stroke volume monitoring is clearly not widely adopted. This is mostly due to the cost and the invasiveness of the devices allowing stroke volume monitoring. End tidal carbon dioxide is monitored in all patients undergoing general anaesthesia and is totally non-invasive. Several studies evaluated the relationship between stroke volume and end tidal carbon dioxide and other studies evaluated the ability of changes in end tidal carbon dioxide to assess changes in stroke volume induced by volume expansion with discordant results. These studies included small sample size and were heterogeneous (intensive care unit and nor operating room, volume expansion or passive leg raising, crystalloid or colloid, 500ml and not 250 ml ….). Nowadays, it is not clear if changes in end tidal carbon dioxide can be considered as a surrogate of changes in stroke volume during a volume expansion in operating room patients. Thus, the aim of the present study is to determine if change in End Tidal Carbon Dioxide can assess the stroke volume effects of a volume expansion of 250ml of crystalloid in the operating room.
The follow up will be restricted to the duration of volume expansion. The last data will be collected just after the end of volume expansion.
|Study Type :||Observational|
|Actual Enrollment :||115 participants|
|Official Title:||Ability of Changes in End Tidal Carbon Dioxide to Assess the Stroke Volume Effects of a Volume Expansion of 250ml of Crystalloid in the Operating Room|
|Actual Study Start Date :||August 16, 2018|
|Actual Primary Completion Date :||February 13, 2019|
|Actual Study Completion Date :||February 13, 2019|
|Operated patients with volume expansion||
Other: End Tidal Carbon Dioxide measure
End Tidal Carbon Dioxide measures before and after a volume expansion of 250ml of crystalloid in the operating room.
- End Tidal Carbon Dioxide measure [ Time Frame: Beggining time of volume expansion of 250ml of crystalloid during surgery ]
- End Tidal Carbon Dioxide measure [ Time Frame: 1 minute after the end of volume expansion of 250ml of crystalloid during surgery ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03635307
|CHU de Bordeaux|