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Trial record 95 of 1197 for:    Adenosine

A Comparison Study of Apadenoson and Adenosine to Treadmill Exercise Stress.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00380198
Recruitment Status : Terminated (Business decision to end program)
First Posted : September 25, 2006
Last Update Posted : February 1, 2017
Information provided by:
Forest Laboratories

Brief Summary:
The purpose of this clinical research study is to compare Apadenoson and adenosine to treadmill exercise stress SPECT MPI

Condition or disease Intervention/treatment Phase
Coronary Artery Disease Drug: Apadenoson Phase 3

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Study Type : Interventional  (Clinical Trial)
Enrollment : 1500 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double
Primary Purpose: Diagnostic
Official Title: A Randomized, Double-Blind Comparison of Apadenoson and Adenosine to Treadmill Exercise Stress for Single-Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)
Study Start Date : July 2006
Actual Primary Completion Date : November 2006
Study Completion Date : November 2006

Resource links provided by the National Library of Medicine

Drug Information available for: Adenosine

Primary Outcome Measures :
  1. Agreement between MPI Summed Stress Scores for extent and severity of disease

Secondary Outcome Measures :
  1. Comparison of imaging data to 6 month event data or angiography

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • Clinically appropriate for exercise stress testing

Exclusion Criteria:

  • Contraindication to adenosine stress or inability to perform treadmill exercise test

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00380198

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Sponsors and Collaborators
Forest Laboratories
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Study Director: Robert Mittleman, MD Bristol-Myers Squibb

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Responsible Party: Amy Lankford, PhD, Sr. Manager, PGxHealth, LLC Identifier: NCT00380198     History of Changes
Other Study ID Numbers: BMS068645-305
EudraCT #2006-002222-31
First Posted: September 25, 2006    Key Record Dates
Last Update Posted: February 1, 2017
Last Verified: January 2017
Additional relevant MeSH terms:
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Coronary Artery Disease
Coronary Disease
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Arrhythmia Agents
Vasodilator Agents
Purinergic P1 Receptor Agonists
Purinergic Agonists
Purinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action