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Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer (TAILOR RT)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03488693
Recruitment Status : Recruiting
First Posted : April 5, 2018
Last Update Posted : September 12, 2019
Sponsor:
Collaborators:
Alliance for Clinical Trials in Oncology
Eastern Cooperative Oncology Group
NRG Oncology
Southwest Oncology Group
Information provided by (Responsible Party):
Canadian Cancer Trials Group

Brief Summary:
The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming back.

Condition or disease Intervention/treatment Phase
Breast Cancer Radiation: Radiation Other: No Radiation Not Applicable

Detailed Description:
Women with node positive breast cancer normally will receive endocrine therapy and some may receive chemotherapy to help prevent the cancer from coming back. Many women will also receive radiotherapy to the whole breast/chest area and the surrounding lymph glands (called regional radiotherapy). No one really knows whether patients with low risk breast cancer need to receive regional radiotherapy. Some women may be getting regional radiotherapy who do not need it. These women may be exposed to the side effects of their treatment without benefit.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 2140 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer
Actual Study Start Date : May 30, 2018
Estimated Primary Completion Date : September 1, 2027
Estimated Study Completion Date : December 30, 2027

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Breast Cancer

Arm Intervention/treatment
Active Comparator: No Regional Radiotherapy
A. Whole Breast Irradiation (WBI) following BCS or; B. No Radiotherapy (RT) following mastectomy
Radiation: Radiation
Radiotherapy given

Other: No Radiation
No radiotherapy given

Active Comparator: Regional Radiotherapy
A. WBI plus RT to the regional nodes (supraclavicular, non-dissected axillary, and internal mammary) following BCS or; B. RT to the chestwall and regional nodes (supraclavicular, non-dissected axillary, and internal mammary) following mastectomy
Radiation: Radiation
Radiotherapy given




Primary Outcome Measures :
  1. compare the breast cancer recurrence-free interval (BCRFI) between patients that received regional RT or not [ Time Frame: 9.5 years ]
    Defined as time from randomization to time of invasive recurrent disease in the ipsilateral chestwall, breast, regional nodes, distant sites or death due to BC.


Secondary Outcome Measures :
  1. Compare the invasive disease-free survival between patients that received regional RT or not. [ Time Frame: 9.5 years ]
    Defined as time from randomization to time of invasive recurrent disease in the ipsilateral chestwall, breast, regional nodes, distant sites or death due to BC

  2. Compare the breast cancer mortality between patients that received regional RT or not. [ Time Frame: 9.5 years ]
    Defined as death due to BC

  3. Compare the overall survival (OS) between patients that received regional RT or not [ Time Frame: 9.5 years ]
    Defined as the time from randomization to the time of death from any cause

  4. Compare the locoregional recurrence-free interval (LRRFI) between patients that received regional RT or not. [ Time Frame: 9.5 years ]
    Defined as time from randomization to time of invasive recurrent disease in the ipsilateral chestwall, breast or regional nodes, or death to due to BC

  5. Compare the distant recurrence-free interval (DRFI) between patients that received regional RT or not. [ Time Frame: 9.5 years ]
    Defined as time from randomization to time of invasive recurrent disease in distant sites or death due to BC

  6. Number and severity of adverse events using the current CTCAE version 4 [ Time Frame: 9.5 years ]
  7. Compare arm volume and mobility measurements between patients that received regional RT or not [ Time Frame: 9.5 years ]
    A Fisher's Exact Test will be used to compare lymphedema and arm abduction deficit between two arms. Defined as a difference in arm abduction of 10% or greater in the comparison of the ipsilateral to the contralateral arm.

  8. Compare patient-reported outcomes (PROs) and the quality of life (QOL) between patients that received regional RT or not [ Time Frame: 9.5 years ]
    using the NSABP Questionnaire for patients treated by BCS or mastectomy.

  9. Compare the quality of life (QOL) between patients that received regional RT or not [ Time Frame: 9.5 years ]
    Overall QOL (EORTC QLQ-C30) will be compared between the two treatment groups using a similar approach.

  10. Compare the cost-effectiveness between patients that received regional RT or not [ Time Frame: 9.5 years ]
    Costs will be expressed in $US and $CAN base currencies based on the final year of the study. An average cost per study subject by treatment arm for an overall mean cost per study arm will be generated

  11. Compare the quality of life (QOL) between patients that received regional RT or not [ Time Frame: 9.5 years ]
    breast symptoms (NSABP B32 Questionnaire) will be compared between the two treatment groups using a similar approach.

  12. Compare the quality of life (QOL) between patients that received regional RT or not [ Time Frame: 9.5 years ]
    skin symptoms and fatigue (EORTC QLQ-BR23) will be compared between the two treatment groups using a similar approach.



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   40 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Gender Based Eligibility:   Yes
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients must have newly diagnosed histologically proven invasive carcinoma of the breast with no evidence of metastases.
  • Patients must have been treated by BCS or mastectomy.
  • Patients treated by BCS or mastectomy and axillary dissection must have 1-3 positive axillary nodes (macrometastases, > 2 mm).
  • Patients treated by BCS and SLNB alone must have only 1-2 positive axillary nodes (macrometastases, > 2 mm).
  • Patients treated by mastectomy and SLNB alone must have only 1 positive axillary node (macrometastases, > 2 mm).
  • Patients must be ER ≥ 1% and HER2 negative on local testing
  • Patients must have an Oncotype DX recurrence score <18
  • Patient must consent to provision of, and investigator(s) must confirm access to and agree to submit to the CCTG Central Tumour Bank, a representative formalin fixed paraffin block of tumour tissue in order that the specific correlative marker assays described in the protocol may be conducted
  • Patient must consent to provision of samples of blood in order that the specific correlative marker assays described in the protocol may be conducted.
  • Patients must have had endocrine therapy initiated or planned for ≥ 5 years. Endocrine therapy can be given concurrently or following RT.
  • Patients may or may not have had adjuvant chemotherapy.
  • RT must be administered within 12 weeks of definitive surgery if the patient is not treated with chemotherapy. If adjuvant chemotherapy is given, RT must begin within 2-8 weeks after the last dose.
  • Patient's ECOG performance status must be 0, 1 or 2.
  • Patient's age must be ≥ 40 years.
  • Patient's life expectancy is ≥10 years
  • For the first 736 eligible English or French-speaking subjects who have agreed to optional questionnaire completion: Patient is able (i.e. sufficiently fluent) and willing to complete the quality of life, health utilities and lost productivity questionnaires in either English or French
  • Patient consent must be appropriately obtained in accordance with applicable local and regulatory requirements
  • Patients must be accessible for treatment and follow-up. Investigators must assure themselves the patients randomized on this trial will be available for complete documentation of the treatment, adverse events, and follow-up.
  • In accordance with CCTG policy, protocol treatment is to begin within 3 weeks of patient randomization.
  • Women of childbearing potential must have agreed to use an effective contraceptive method. A woman is considered to be of "childbearing potential" if she has had menses at any time in the preceding 12 consecutive months.

Exclusion Criteria:

  • Patients with nodal disease limited to micrometastases (pN1Mi, > 0.2 mm and ≤ 2 mm) or isolated tumour cells (pN0i+ < 0.2 mm).
  • Any prior history, not including the index cancer, of ipsilateral invasive breast cancer or ipsilateral DCIS treated with radiation therapy. (Patients with synchronous or previous ipsilateral LCIS are eligible.)
  • Synchronous or previous contralateral invasive breast cancer. (Patients with contralateral DCIS not treated with radiation are eligible.)
  • History of non-breast malignancies except adequately treated non-melanoma skin cancers, in situ cancers treated by local excision or other cancers curatively treated with no evidence of disease for ≥ 5 years.
  • Patients with pT3 or pT4 disease.
  • Patients who are pregnant.
  • Patients that have had prior ipsilateral chestwall/thoracic radiation.
  • Patients treated with neoadjuvant chemo or endocrine therapy for breast cancer.
  • Patients with serious non-malignant disease (e.g. cardiovascular, scleroderma etc.) which would preclude RT.
  • Patients with any serious active or co-morbid medical conditions, laboratory abnormality, psychiatric illness, active or uncontrolled infections, or serious illnesses or medical conditions that would prevent the patient from participating or to be managed according to the protocol (according to investigator's decision).

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03488693


Contacts
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Contact: Wendy Parulekar 613-533-6430 wparulekar@ctg.queensu.ca

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Locations
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United States, Arkansas
University of Arkansas for Medical Sciences Recruiting
Little Rock, Arkansas, United States, 72205
Contact: Site Public Contact    501-686-8274      
Principal Investigator: Thomas Kim         
United States, California
Alta Bates Summit Medical Center-Herrick Campus Recruiting
Berkeley, California, United States, 94704
Contact: Site Public Contact    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: Edmund W. Tai         
City of Hope Comprehensive Cancer Center Recruiting
Duarte, California, United States, 91010
Contact: Site Public Contact    800-826-4673    becomingapatient@coh.org   
Principal Investigator: Nayana L. Vora         
Fresno Cancer Center Recruiting
Fresno, California, United States, 93720
Contact: Site Public Contact    877-642-4691    Kpoct@kp.org   
Principal Investigator: Samantha A. Seaward         
Kaiser Permanente Oakland-Broadway Recruiting
Oakland, California, United States, 94611
Contact: Site Public Contact    877-642-4691    Kpoct@kp.org   
Principal Investigator: Samantha A. Seaward         
Kaiser Permanente-Rancho Cordova Cancer Center Recruiting
Rancho Cordova, California, United States, 95670
Contact: Site Public Contact    877-642-4691    Kpoct@kp.org   
Principal Investigator: Samantha A. Seaward         
Rohnert Park Cancer Center Recruiting
Rohnert Park, California, United States, 94928
Contact: Site Public Contact    877-642-4691    Kpoct@kp.org   
Principal Investigator: Samantha A. Seaward         
The Permanente Medical Group-Roseville Radiation Oncology Recruiting
Roseville, California, United States, 95678
Contact: Site Public Contact    877-642-4691    Kpoct@kp.org   
Principal Investigator: Samantha A. Seaward         
Kaiser Permanente Medical Center - Santa Clara Recruiting
Santa Clara, California, United States, 95051
Contact: Site Public Contact    877-642-4691    Kpoct@kp.org   
Principal Investigator: Samantha A. Seaward         
City of Hope South Pasadena Recruiting
South Pasadena, California, United States, 91030
Contact: Site Public Contact    800-826-4673    becomingapatient@coh.org   
Principal Investigator: Nayana L. Vora         
Kaiser Permanente Cancer Treatment Center Recruiting
South San Francisco, California, United States, 94080
Contact: Site Public Contact    877-642-4691    Kpoct@kp.org   
Principal Investigator: Samantha A. Seaward         
Sutter Solano Medical Center/Cancer Center Recruiting
Vallejo, California, United States, 94589
Contact: Site Public Contact    415-209-2686    bernicl@sutterhealth.org   
Principal Investigator: Edmund W. Tai         
United States, Colorado
University of Colorado Hospital Recruiting
Aurora, Colorado, United States, 80045
Contact: Site Public Contact    720-848-0650      
Principal Investigator: Rachel A. Rabinovitch         
Penrose-Saint Francis Healthcare Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Site Public Contact    308-398-6518    clinicaltrials@sfmc-gi.org   
Principal Investigator: Richard L. Deming         
UCHealth Memorial Hospital Central Recruiting
Colorado Springs, Colorado, United States, 80909
Contact: Site Public Contact    719-365-2406      
Principal Investigator: Rachel A. Rabinovitch         
Memorial Hospital North Recruiting
Colorado Springs, Colorado, United States, 80920
Contact: Site Public Contact    719-364-6700      
Principal Investigator: Rachel A. Rabinovitch         
Poudre Valley Hospital Recruiting
Fort Collins, Colorado, United States, 80524
Contact: Site Public Contact    970-297-6150      
Principal Investigator: Rachel A. Rabinovitch         
North Colorado Medical Center Recruiting
Greeley, Colorado, United States, 80631
Contact: Site Public Contact    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
McKee Medical Center Recruiting
Loveland, Colorado, United States, 80539
Contact: Site Public Contact    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
SCL Health Lutheran Medical Center Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Site Public Contact    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
United States, Connecticut
Yale University Recruiting
New Haven, Connecticut, United States, 06520
Contact: Site Public Contact    203-785-5702    canceranswers@yale.edu   
Principal Investigator: Christin A. Knowlton         
Lawrence and Memorial Cancer Center Recruiting
Waterford, Connecticut, United States, 06385
Contact: Site Public Contact    203-785-5702    canceranswers@yale.edu   
Principal Investigator: Christin A. Knowlton         
United States, Delaware
Helen F Graham Cancer Center Recruiting
Newark, Delaware, United States, 19713
Contact: Site Public Contact    302-623-4450    KDempsey@christianacare.org   
Principal Investigator: Gregory A. Masters         
Christiana Care Health System-Christiana Hospital Recruiting
Newark, Delaware, United States, 19718
Contact: Site Public Contact    302-623-4450    KDempsey@christianacare.org   
Principal Investigator: Gregory A. Masters         
United States, Florida
UM Sylvester Comprehensive Cancer Center at Coral Gables Recruiting
Coral Gables, Florida, United States, 33146
Contact: Site Public Contact    305-243-2647      
Principal Investigator: Cristiane Takita         
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Recruiting
Deerfield Beach, Florida, United States, 33442
Contact: Site Public Contact    305-243-2647      
Principal Investigator: Cristiane Takita         
Broward Health Medical Center Recruiting
Fort Lauderdale, Florida, United States, 33316
Contact: Site Public Contact    954-355-5346      
Principal Investigator: Marshal E. Lieberfarb         
Memorial Regional Hospital/Joe DiMaggio Children's Hospital Recruiting
Hollywood, Florida, United States, 33021
Contact: Site Public Contact    954-265-1847    OHR@mhs.net   
Principal Investigator: Ignacio Castellon         
University of Miami Miller School of Medicine-Sylvester Cancer Center Recruiting
Miami, Florida, United States, 33136
Contact: Site Public Contact    305-243-2647      
Principal Investigator: Cristiane Takita         
UF Cancer Center at Orlando Health Recruiting
Orlando, Florida, United States, 32806
Contact: Site Public Contact    321-841-7246    CancerClinicalTrials@orlandohealth.com   
Principal Investigator: Patrick Kelly         
Memorial Hospital West Recruiting
Pembroke Pines, Florida, United States, 33028
Contact: Site Public Contact    954-265-4325      
Principal Investigator: Ignacio Castellon         
Moffitt Cancer Center Recruiting
Tampa, Florida, United States, 33612
Contact: Site Public Contact    800-679-0775    canceranswers@moffitt.org   
Principal Investigator: Iman R. Washington         
United States, Georgia
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Recruiting
Savannah, Georgia, United States, 31405
Contact: Site Public Contact    912-819-5704    underberga@sjchs.org   
Principal Investigator: Howard A. Zaren         
United States, Idaho
Saint Alphonsus Cancer Care Center-Boise Recruiting
Boise, Idaho, United States, 83706
Contact: Site Public Contact    734-712-3671    stephanie.couch@stjoeshealth.org   
Principal Investigator: John M. Schallenkamp         
United States, Illinois
Northwestern University Recruiting
Chicago, Illinois, United States, 60611
Contact: Site Public Contact    312-695-1301    cancer@northwestern.edu   
Principal Investigator: Eric D. Donnelly         
Rush University Medical Center Recruiting
Chicago, Illinois, United States, 60612
Contact: Site Public Contact    312-942-5498    clinical_trials@rush.edu   
Principal Investigator: Parul N. Barry         
University of Illinois Recruiting
Chicago, Illinois, United States, 60612
Contact: Site Public Contact    312-355-3046      
Principal Investigator: Kent F. Hoskins         
Swedish Covenant Hospital Recruiting
Chicago, Illinois, United States, 60625
Contact: Site Public Contact    773-878-8200      
Principal Investigator: Elyse A. Lambiase         
Advocate Illinois Masonic Medical Center Recruiting
Chicago, Illinois, United States, 60657
Contact: Site Public Contact    773-296-5360      
Principal Investigator: Santosh V. Yajnik         
Decatur Memorial Hospital Recruiting
Decatur, Illinois, United States, 62526
Contact: Site Public Contact    217-876-4740    rhamrick@dmhhs.org   
Principal Investigator: Bryan A. Faller         
Northwestern Medicine Lake Forest Hospital Recruiting
Lake Forest, Illinois, United States, 60045
Contact: Site Public Contact       cancertrials@northwestern.edu   
Principal Investigator: Eric D. Donnelly         
OSF Saint Francis Medical Center Recruiting
Peoria, Illinois, United States, 61637
Contact: Site Public Contact    309-243-3605    andersonj@illinoiscancercare.com   
Principal Investigator: Bryan A. Faller         
Memorial Medical Center Recruiting
Springfield, Illinois, United States, 62781
Contact: Site Public Contact    217-788-3528      
Principal Investigator: Bryan A. Faller         
Carle Cancer Center Recruiting
Urbana, Illinois, United States, 61801
Contact: Site Public Contact    800-446-5532    Research@carle.com   
Principal Investigator: Sinisa Stanic         
United States, Indiana
IU Health West Hospital Recruiting
Avon, Indiana, United States, 46123
Contact: Site Public Contact    317-278-5632    iutrials@iu.edu   
Principal Investigator: Richard C. Zellars         
IU Health Central Indiana Cancer Centers-Fishers Recruiting
Fishers, Indiana, United States, 46037
Contact: Site Public Contact    317-356-2422      
Principal Investigator: Richard C. Zellars         
Indiana University/Melvin and Bren Simon Cancer Center Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Site Public Contact    317-278-5632    iutrials@iu.edu   
Principal Investigator: Richard C. Zellars         
IU Health Methodist Hospital Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Site Public Contact    317-278-5632    iutrials@iu.edu   
Principal Investigator: Richard C. Zellars         
Community Cancer Center East Recruiting
Indianapolis, Indiana, United States, 46219
Contact: Site Public Contact    317-497-2823    lcheri@ecommunity.com   
Principal Investigator: Daniel W. Weed         
Community Cancer Center South Recruiting
Indianapolis, Indiana, United States, 46227
Contact: Site Public Contact    317-497-2823    lcheri@ecommunity.com   
Principal Investigator: Daniel W. Weed         
Community Cancer Center North Recruiting
Indianapolis, Indiana, United States, 46256
Contact: Site Public Contact    317-497-2823    lcheri@ecommunity.com   
Principal Investigator: Daniel W. Weed         
IU Health Ball Memorial Hospital Recruiting
Muncie, Indiana, United States, 47303
Contact: Site Public Contact    765-751-5850      
Principal Investigator: Yunjie X. Lin         
United States, Iowa
Mercy Cancer Center-West Lakes Recruiting
Clive, Iowa, United States, 50325
Contact: Site Public Contact    308-398-6518    clinicaltrials@sfmc-gi.org   
Principal Investigator: Richard L. Deming         
Greater Regional Medical Center Suspended
Creston, Iowa, United States, 50801
Mercy Medical Center - Des Moines Recruiting
Des Moines, Iowa, United States, 50314
Contact: Site Public Contact    308-398-6518    clinicaltrials@sfmc-gi.org   
Principal Investigator: Richard L. Deming         
United States, Kansas
University of Kansas Cancer Center Recruiting
Kansas City, Kansas, United States, 66160
Contact: Site Public Contact    913-945-7552    ctnursenav@kumc.edu   
Principal Investigator: Shane R. Stecklein         
University of Kansas Cancer Center-Overland Park Recruiting
Overland Park, Kansas, United States, 66210
Contact: Site Public Contact    913-945-7552    ctnursenav@kumc.edu   
Principal Investigator: Shane R. Stecklein         
Ascension Via Christi Hospitals Wichita Recruiting
Wichita, Kansas, United States, 67214
Contact: Site Public Contact    800-362-0070    Keisha.humphries@ascension.org   
Principal Investigator: Pavan S. Reddy         
United States, Kentucky
Saint Elizabeth Medical Center South Recruiting
Edgewood, Kentucky, United States, 41017
Contact: Site Public Contact    859-301-5473    darla.hehman@stelizabeth.com   
Principal Investigator: Bradley J. Huth         
The James Graham Brown Cancer Center at University of Louisville Recruiting
Louisville, Kentucky, United States, 40202
Contact: Site Public Contact    502-562-3429      
Principal Investigator: Harriet Eldredge-Hindy         
United States, Maine
MaineHealth Coastal Cancer Treatment Center Recruiting
Bath, Maine, United States, 04530
Contact: Site Public Contact    888-823-5923    ctsucontact@westat.com   
Principal Investigator: Matthew D. Cheney         
Lafayette Family Cancer Center-EMMC Recruiting
Brewer, Maine, United States, 04412
Contact: Site Public Contact    800-987-3005      
Principal Investigator: Sarah J. Sinclair         
Maine Medical Center-Bramhall Campus Recruiting
Portland, Maine, United States, 04102
Contact: Site Public Contact    207-885-7565      
Principal Investigator: Matthew D. Cheney         
MaineHealth Cancer Care Center of York County Recruiting
Sanford, Maine, United States, 04073
Contact: Site Public Contact    207-459-1600      
Principal Investigator: Matthew D. Cheney         
Maine Medical Center- Scarborough Campus Recruiting
Scarborough, Maine, United States, 04074
Contact: Site Public Contact    207-396-8090    wrighd@mmc.org   
Principal Investigator: Matthew D. Cheney         
United States, Maryland
Anne Arundel Medical Center Recruiting
Annapolis, Maryland, United States, 21401
Contact: Site Public Contact    443-481-1320    kbodenhorn@aahs.org   
Principal Investigator: Mary E. Young         
Greater Baltimore Medical Center Recruiting
Baltimore, Maryland, United States, 21204
Contact: Site Public Contact    443-849-3706      
Principal Investigator: Matthew Boyer         
United States, Massachusetts
Lahey Hospital and Medical Center Recruiting
Burlington, Massachusetts, United States, 01805
Contact: Site Public Contact    781-744-8027      
Principal Investigator: Andrea B. McKee         
Lowell General Hospital Recruiting
Lowell, Massachusetts, United States, 01854
Contact: Site Public Contact    978-788-7084    ghincks@lowellgeneral.org   
Principal Investigator: Matthew S. Katz         
United States, Michigan
University of Michigan Comprehensive Cancer Center Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Site Public Contact    800-865-1125      
Principal Investigator: Reshma Jagsi         
Beaumont Hospital ? Dearborn Recruiting
Dearborn, Michigan, United States, 48124
Contact: Site Public Contact    248-551-7695      
Principal Investigator: Joshua T. Dilworth         
Beaumont Hospital - Farmington Hills Recruiting
Farmington Hills, Michigan, United States, 48336
Contact: Site Public Contact    248-551-7695      
Principal Investigator: Joshua T. Dilworth         
Spectrum Health at Butterworth Campus Recruiting
Grand Rapids, Michigan, United States, 49503
Contact: Site Public Contact    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Mercy Health Mercy Campus Recruiting
Muskegon, Michigan, United States, 49444
Contact: Site Public Contact    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
Ascension Providence Hospitals - Novi Recruiting
Novi, Michigan, United States, 48374
Contact: Site Public Contact    248-849-5332    karen.fife@ascension.org   
Principal Investigator: Cynthia M. Vakhariya         
William Beaumont Hospital-Royal Oak Recruiting
Royal Oak, Michigan, United States, 48073
Contact: Site Public Contact    248-551-7695      
Principal Investigator: Joshua T. Dilworth         
Ascension Providence Hospitals - Southfield Recruiting
Southfield, Michigan, United States, 48075
Contact: Site Public Contact    248-849-5332    karen.fife@ascension.org   
Principal Investigator: Cynthia M. Vakhariya         
Munson Medical Center Recruiting
Traverse City, Michigan, United States, 49684
Contact: Site Public Contact    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
William Beaumont Hospital - Troy Recruiting
Troy, Michigan, United States, 48085
Contact: Site Public Contact    248-551-7695      
Principal Investigator: Joshua T. Dilworth         
Metro Health Hospital Recruiting
Wyoming, Michigan, United States, 49519
Contact: Site Public Contact    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Kathleen J. Yost         
United States, Minnesota
Sanford Joe Lueken Cancer Center Recruiting
Bemidji, Minnesota, United States, 56601
Contact: Site Public Contact    218-333-5000    OncologyClinicalTrialsFargo@sanfordhealth.org   
Principal Investigator: Preston D. Steen         
Hennepin County Medical Center Recruiting
Minneapolis, Minnesota, United States, 55415
Contact: Site Public Contact    952-993-1517    mmcorc@healthpartners.com   
Principal Investigator: David M. King         
United States, Mississippi
Baptist Memorial Hospital and Cancer Center-Desoto Recruiting
Southhaven, Mississippi, United States, 38671
Contact: Site Public Contact    901-226-1366    BCCclintrials@bmhcc.org   
Principal Investigator: Angela H. Wortham         
United States, Missouri
Saint Francis Medical Center Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: Site Public Contact    573-334-2230    sfmc@sfmc.net   
Principal Investigator: Bryan A. Faller         
The University of Kansas Cancer Center-North Recruiting
Kansas City, Missouri, United States, 64154
Contact: Site Public Contact    913-945-7552    ctnursenav@kumc.edu   
Principal Investigator: Shane R. Stecklein         
The University of Kansas Cancer Center-Lee's Summit Recruiting
Lee's Summit, Missouri, United States, 64064
Contact: Site Public Contact    913-945-7552    ctnursenav@kumc.edu   
Principal Investigator: Shane R. Stecklein         
Missouri Baptist Medical Center Recruiting
Saint Louis, Missouri, United States, 63131
Contact: Site Public Contact    314-996-5569      
Principal Investigator: Bryan A. Faller         
United States, Montana
Benefis Healthcare- Sletten Cancer Institute Recruiting
Great Falls, Montana, United States, 59405
Contact: Site Public Contact    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: John M. Schallenkamp         
United States, Nebraska
University of Nebraska Medical Center Recruiting
Omaha, Nebraska, United States, 68198
Contact: Site Public Contact    402-559-6941    unmcrsa@unmc.edu   
Principal Investigator: Andrew O. Wahl         
United States, New Hampshire
New Hampshire Oncology Hematology PA-Concord Recruiting
Concord, New Hampshire, United States, 03301
Contact: Site Public Contact    603-224-2556      
Principal Investigator: Douglas J. Weckstein         
Wentworth-Douglass Hospital Recruiting
Dover, New Hampshire, United States, 03820
Contact: Site Public Contact    603-740-2150      
Principal Investigator: Jeffrey M. Lemons         
New Hampshire Oncology Hematology PA-Hooksett Recruiting
Hooksett, New Hampshire, United States, 03106
Contact: Site Public Contact    800-339-6484      
Principal Investigator: Douglas J. Weckstein         
United States, New Jersey
The Cancer Institute of New Jersey Hamilton Recruiting
Hamilton, New Jersey, United States, 08690
Contact: Site Public Contact    609-631-6946      
Principal Investigator: Nisha Ohri         
Rutgers Cancer Institute of New Jersey Recruiting
New Brunswick, New Jersey, United States, 08903
Contact: Site Public Contact    732-235-8675      
Principal Investigator: Nisha Ohri         
Robert Wood Johnson University Hospital Somerset Recruiting
Somerville, New Jersey, United States, 08876
Contact: Site Public Contact    908-685-2481      
Principal Investigator: Kathleen C. Toomey         
United States, New Mexico
University of New Mexico Cancer Center Recruiting
Albuquerque, New Mexico, United States, 87102
Contact: Site Public Contact    505-925-0366    LByatt@nmcca.org   
Principal Investigator: David Y. Lee         
Lovelace Radiation Oncology Recruiting
Albuquerque, New Mexico, United States, 87109
Contact: Site Public Contact    505-272-0530    AYost@nmcca.org   
Principal Investigator: David Y. Lee         
New Mexico Oncology Hematology Consultants Recruiting
Albuquerque, New Mexico, United States, 87109
Contact: Site Public Contact    505-272-0530    CLee@nmcca.org   
Principal Investigator: David Y. Lee         
Memorial Medical Center - Las Cruces Recruiting
Las Cruces, New Mexico, United States, 88011
Contact: Site Public Contact    575-556-6545    Kim.Hoffman@lpnt.net   
Principal Investigator: David Y. Lee         
United States, New York
Montefiore Medical Center-Einstein Campus Recruiting
Bronx, New York, United States, 10461
Contact: Site Public Contact    718-379-6866    aaraiza@montefiore.org   
Principal Investigator: Jana L. Fox         
Montefiore Medical Center - Moses Campus Recruiting
Bronx, New York, United States, 10467
Contact: Site Public Contact    718-379-6866    aaraiza@montefiore.org   
Principal Investigator: Jana L. Fox         
New York-Presbyterian/Brooklyn Methodist Hospital Suspended
Brooklyn, New York, United States, 11215
Mount Sinai Union Square Recruiting
New York, New York, United States, 10003
Contact: Site Public Contact    212-824-7309    CCTO@mssm.edu   
Principal Investigator: Sheryl Green         
Mount Sinai Chelsea Recruiting
New York, New York, United States, 10011
Contact: Site Public Contact    212-824-7309    CCTO@mssm.edu   
Principal Investigator: Sheryl Green         
Laura and Isaac Perlmutter Cancer Center at NYU Langone Recruiting
New York, New York, United States, 10016
Contact: Site Public Contact    212-263-4434    prmc.coordinator@nyumc.org   
Principal Investigator: Naamit K. Gerber         
Mount Sinai Hospital Recruiting
New York, New York, United States, 10029
Contact: Site Public Contact    212-824-7309    CCTO@mssm.edu   
Principal Investigator: Sheryl Green         
Stony Brook University Medical Center Recruiting
Stony Brook, New York, United States, 11794
Contact: Site Public Contact    800-862-2215      
Principal Investigator: Alexander M. Stessin         
United States, North Carolina
Mission Hospital Inc-Memorial Campus Recruiting
Asheville, North Carolina, United States, 28801
Contact: Site Public Contact    828-213-4150    leslie.verner@msj.org   
Principal Investigator: William M. McCollough         
Hope Women's Cancer Centers-Asheville Recruiting
Asheville, North Carolina, United States, 28816
Contact: Site Public Contact    828-670-8403    courtney.trafford@msj.org   
Principal Investigator: William M. McCollough         
CaroMont Regional Medical Center Recruiting
Gastonia, North Carolina, United States, 28054
Contact: Site Public Contact    704-834-2810    tammy.cozad@caromonthealth.org   
Principal Investigator: Robert M. Doline         
United States, North Dakota
Sanford Bismarck Medical Center Recruiting
Bismarck, North Dakota, United States, 58501
Contact: Site Public Contact    701-323-5760    OncologyClinicalTrialsFargo@sanfordhealth.org   
Principal Investigator: Preston D. Steen         
United States, Ohio
Mercy Medical Center Recruiting
Canton, Ohio, United States, 44708
Contact: Site Public Contact    888-293-4673      
Principal Investigator: Edward J. Walsh         
Aultman Health Foundation Recruiting
Canton, Ohio, United States, 44710
Contact: Site Public Contact    330-363-7274    ClinicalReserachDept@aultman.com   
Principal Investigator: Shruti Trehan         
Ohio State University Comprehensive Cancer Center Recruiting
Columbus, Ohio, United States, 43210
Contact: Site Public Contact    800-293-5066    Jamesline@osumc.edu   
Principal Investigator: Julia R. White         
The Mark H Zangmeister Center Recruiting
Columbus, Ohio, United States, 43219
Contact: Site Public Contact    614-488-2118    sheree@columbusccop.org   
Principal Investigator: Timothy D. Moore         
United States, Oklahoma
University of Oklahoma Health Sciences Center Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: Site Public Contact    405-271-8777    ou-clinical-trials@ouhsc.edu   
Principal Investigator: Christina Henson         
United States, Pennsylvania
Bryn Mawr Hospital Recruiting
Bryn Mawr, Pennsylvania, United States, 19010
Contact: Site Public Contact    484-476-2649    turzoe@mlhs.org   
Principal Investigator: Albert S. DeNittis         
Christiana Care Health System-Concord Health Center Recruiting
Chadds Ford, Pennsylvania, United States, 19317
Contact: Site Public Contact    302-623-4450    KDempsey@christianacare.org   
Principal Investigator: Gregory A. Masters         
Saint Vincent Hospital Recruiting
Erie, Pennsylvania, United States, 16544
Contact: Site Public Contact    814-452-5000      
Principal Investigator: James A. Betler         
Jefferson Hospital Recruiting
Jefferson Hills, Pennsylvania, United States, 15025
Contact: Site Public Contact    412-359-3043    ddefazio@wpahs.org   
Principal Investigator: James A. Betler         
Riddle Memorial Hospital Recruiting
Media, Pennsylvania, United States, 19063
Contact: Site Public Contact    484-476-2649    turzoe@mlhs.org   
Principal Investigator: Albert S. DeNittis         
Forbes Hospital Recruiting
Monroeville, Pennsylvania, United States, 15146
Contact: Site Public Contact    412-858-7746      
Principal Investigator: James A. Betler         
Paoli Memorial Hospital Recruiting
Paoli, Pennsylvania, United States, 19301
Contact: Site Public Contact    484-476-2649    turzoe@mlhs.org   
Principal Investigator: Albert S. DeNittis         
Thomas Jefferson University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Site Public Contact    215-955-6084      
Principal Investigator: Nicole L. Simone         
Allegheny General Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15212
Contact: Site Public Contact    877-284-2000      
Principal Investigator: James A. Betler         
West Penn Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15224
Contact: Site Public Contact    412-578-5000      
Principal Investigator: James A. Betler         
Wexford Health and Wellness Pavilion Recruiting
Wexford, Pennsylvania, United States, 15090
Contact: Site Public Contact    412-359-3043    ddefazio@wpahs.org   
Principal Investigator: James A. Betler         
Lankenau Medical Center Recruiting
Wynnewood, Pennsylvania, United States, 19096
Contact: Site Public Contact    484-476-2649    turzoe@mlhs.org   
Principal Investigator: Albert S. DeNittis         
United States, Rhode Island
Women and Infants Hospital Recruiting
Providence, Rhode Island, United States, 02905
Contact: Site Public Contact    401-274-1122      
Principal Investigator: William M. Sikov         
United States, South Carolina
Greenville Health System Cancer Institute-Faris Recruiting
Greenville, South Carolina, United States, 29605
Contact: Site Public Contact    864-241-6251    kwilliams8@ghs.org   
Principal Investigator: Jeffrey K. Giguere         
Saint Francis Cancer Center Recruiting
Greenville, South Carolina, United States, 29607
Contact: Site Public Contact    864-603-6213    meissa_beckman@bshsi.org   
Principal Investigator: Jeremy M. Kilburn         
Greenville Health System Cancer Institute-Eastside Recruiting
Greenville, South Carolina, United States, 29615
Contact: Site Public Contact    864-241-6251    kwilliams8@ghs.org   
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute-Greer Recruiting
Greer, South Carolina, United States, 29650
Contact: Site Public Contact    864-241-6251    kwilliams8@ghs.org   
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute-Seneca Recruiting
Seneca, South Carolina, United States, 29672
Contact: Site Public Contact    864-241-6251    kwilliams8@ghs.org   
Principal Investigator: Jeffrey K. Giguere         
Greenville Health System Cancer Institute-Spartanburg Recruiting
Spartanburg, South Carolina, United States, 29307
Contact: Site Public Contact    864-241-6251    kwilliams8@ghs.org   
Principal Investigator: Jeffrey K. Giguere         
Lexington Medical Center Recruiting
West Columbia, South Carolina, United States, 29169
Contact: Site Public Contact    803-936-8050      
Principal Investigator: Steven A. Madden         
United States, South Dakota
Sanford USD Medical Center - Sioux Falls Recruiting
Sioux Falls, South Dakota, United States, 57117-5134
Contact: Site Public Contact    605-312-3320    OncologyClinicalTrialsSF@SanfordHealth.org   
Principal Investigator: Preston D. Steen         
United States, Tennessee
Baptist Memorial Hospital and Cancer Center-Memphis Recruiting
Memphis, Tennessee, United States, 38120
Contact: Site Public Contact    901-226-1366    BCCclintrials@bmhcc.org   
Principal Investigator: Angela H. Wortham         
United States, Texas
UT Southwestern/Simmons Cancer Center-Dallas Recruiting
Dallas, Texas, United States, 75390
Contact: Site Public Contact    214-648-7097    canceranswerline@UTSouthwestern.edu   
Principal Investigator: Ann M. Leitch         
University of Texas Health Science Center at San Antonio Recruiting
San Antonio, Texas, United States, 78229
Contact: Site Public Contact    210-450-3800    phoresearchoffice@uthscsa.edu   
Principal Investigator: Zheng (Jane) Shi         
United States, Utah
Farmington Health Center Recruiting
Farmington, Utah, United States, 84025
Contact: Site Public Contact    888-424-2100    cancerinfo@hci.utah.edu   
Principal Investigator: Matthew M. Poppe         
Huntsman Cancer Institute/University of Utah Recruiting
Salt Lake City, Utah, United States, 84112
Contact: Site Public Contact    888-424-2100    cancerinfo@hci.utah.edu   
Principal Investigator: Matthew M. Poppe         
South Jordan Health Center Recruiting
South Jordan, Utah, United States, 84009
Contact: Site Public Contact    888-424-2100    cancerinfo@hci.utah.edu   
Principal Investigator: Matthew M. Poppe         
United States, Virginia
Augusta Health Center for Cancer and Blood Disorders Recruiting
Fishersville, Virginia, United States, 22939
Contact: Site Public Contact    540-332-5960      
Principal Investigator: Robert M. Kyler         
United States, Wisconsin
Langlade Hospital and Cancer Center Recruiting
Antigo, Wisconsin, United States, 54409
Contact: Site Public Contact    715-623-9869    Juli.Alford@aspirus.org   
Principal Investigator: Christopher S. Platta         
Marshfield Medical Center-EC Cancer Center Recruiting
Eau Claire, Wisconsin, United States, 54701
Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org   
Principal Investigator: Bevan Ly         
Aurora Cancer Care-Grafton Recruiting
Grafton, Wisconsin, United States, 53024
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Saint Vincent Hospital Cancer Center Green Bay Recruiting
Green Bay, Wisconsin, United States, 54301
Contact: Site Public Contact    920-433-8889    Christy.Gilchrist@hshs.org   
Principal Investigator: Matthew L. Ryan         
Saint Vincent Hospital Cancer Center at Saint Mary's Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Site Public Contact    920-433-8889    Christy.Gilchrist@hshs.org   
Principal Investigator: Matthew L. Ryan         
Aurora BayCare Medical Center Recruiting
Green Bay, Wisconsin, United States, 54311
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Aurora Cancer Care-Kenosha South Recruiting
Kenosha, Wisconsin, United States, 53142
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
University of Wisconsin Hospital and Clinics Recruiting
Madison, Wisconsin, United States, 53792
Contact: Site Public Contact    800-622-8922      
Principal Investigator: Bethany M. Anderson         
Aurora Bay Area Medical Group-Marinette Recruiting
Marinette, Wisconsin, United States, 54143
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Marshfield Medical Center-Marshfield Recruiting
Marshfield, Wisconsin, United States, 54449
Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org   
Principal Investigator: Bevan Ly         
Aurora Saint Luke's Medical Center Recruiting
Milwaukee, Wisconsin, United States, 53215
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Aurora Sinai Medical Center Recruiting
Milwaukee, Wisconsin, United States, 53233
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Marshfield Clinic-Minocqua Center Recruiting
Minocqua, Wisconsin, United States, 54548
Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org   
Principal Investigator: Bevan Ly         
Vince Lombardi Cancer Clinic - Oshkosh Recruiting
Oshkosh, Wisconsin, United States, 54904
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Marshfield Medical Center-Rice Lake Recruiting
Rice Lake, Wisconsin, United States, 54868
Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org   
Principal Investigator: Bevan Ly         
HSHS Saint Nicholas Hospital Recruiting
Sheboygan, Wisconsin, United States, 53081
Contact: Site Public Contact    920-433-8889    Christy.Gilchrist@hshs.org   
Principal Investigator: Matthew L. Ryan         
Vince Lombardi Cancer Clinic-Sheboygan Recruiting
Sheboygan, Wisconsin, United States, 53081
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Marshfield Clinic Stevens Point Center Recruiting
Stevens Point, Wisconsin, United States, 54482
Contact: Site Public Contact    800-782-8581    oncology.clinical.trials@marshfieldresearch.org   
Principal Investigator: Bevan Ly         
Saint Vincent Hospital Cancer Center at Sturgeon Bay Recruiting
Sturgeon Bay, Wisconsin, United States, 54235-1495
Contact: Site Public Contact    920-433-8889    Christy.Gilchrist@hshs.org   
Principal Investigator: Matthew L. Ryan         
Aurora Medical Center in Summit Recruiting
Summit, Wisconsin, United States, 53066
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Vince Lombardi Cancer Clinic-Two Rivers Recruiting
Two Rivers, Wisconsin, United States, 54241
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Aspirus Regional Cancer Center Recruiting
Wausau, Wisconsin, United States, 54401
Contact: Site Public Contact    877-405-6866      
Principal Investigator: Christopher S. Platta         
Aurora West Allis Medical Center Recruiting
West Allis, Wisconsin, United States, 53227
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Diagnostic and Treatment Center Recruiting
Weston, Wisconsin, United States, 54476
Contact: Site Public Contact    888-799-3989    oncology.clinical.trials@marshfieldresearch.org   
Principal Investigator: Bevan Ly         
Aspirus UW Cancer Center Suspended
Wisconsin Rapids, Wisconsin, United States, 54494
Canada, Alberta
Tom Baker Cancer Centre Recruiting
Calgary, Alberta, Canada, T2N 4N2
Contact: Site Public Contact    403-521-3433      
Principal Investigator: Jeffrey Q. Cao         
Cross Cancer Institute Recruiting
Edmonton, Alberta, Canada, T6G 1Z2
Contact: Site Public Contact    780-432-8500      
Principal Investigator: Susan M. Chafe         
Canada, British Columbia
BCCA-Abbotsford Cancer Centre Recruiting
Abbotsford, British Columbia, Canada, V2S 1K2
Contact: Site Public Contact    604-851-4710      
Principal Investigator: Maha Almahmudi         
BCCA-Cancer Centre for the Southern Interior Recruiting
Kelowna, British Columbia, Canada, V1Y 5L3
Contact: Site Public Contact    250-712-3900      
Principal Investigator: Angela Lin         
BCCA-Cancer Centre for the North Recruiting
Prince George, British Columbia, Canada, V2M 7E9
Contact: Site Public Contact    855-775-7300      
Principal Investigator: Robert A. Olson         
BCCA-Fraser Valley Cancer Centre Recruiting
Surrey, British Columbia, Canada, V3V 1Z2
Contact: Site Public Contact    604-930-2098      
Principal Investigator: Hamid Raziee         
BCCA-Vancouver Cancer Centre Recruiting
Vancouver, British Columbia, Canada, V5Z 4E6
Contact: Site Public Contact    888-939-3333      
Principal Investigator: Alan M. Nichol         
BCCA-Vancouver Island Cancer Centre Recruiting
Victoria, British Columbia, Canada, V8R 6V5
Contact: Site Public Contact    604-877-6010      
Principal Investigator: Tanya S. Berrang         
Canada, Newfoundland and Labrador
Doctor H. Bliss Murphy Cancer Centre Recruiting
St. John's, Newfoundland and Labrador, Canada, A1B 3V6
Contact: Site Public Contact    709-777-7589      
Principal Investigator: Craig M. Pochini         
Canada, Nova Scotia
QEII Health Sciences Centre/Nova Scotia Health Authority Recruiting
Halifax, Nova Scotia, Canada, B3H 2Y9
Contact: Site Public Contact    902-473-6000      
Principal Investigator: Wladyslawa Cwajna         
Canada, Ontario
Royal Victoria Regional Health Centre Recruiting
Barrie, Ontario, Canada, L4M 6M2
Contact: Site Public Contact    705-739-5661      
Principal Investigator: Christiaan S. Stevens         
Juravinski Cancer Centre at Hamilton Health Sciences Recruiting
Hamilton, Ontario, Canada, L8V 5C2
Contact: Site Public Contact    905-387-9495      
Principal Investigator: Timothy J. Whelan         
Grand River Regional Cancer Centre at Grand River Hospital Recruiting
Kitchener, Ontario, Canada, N2G 1G3
Contact: Site Public Contact    519-749-4300 ext 2307      
Principal Investigator: Sundeep Shahi         
London Regional Cancer Program Recruiting
London, Ontario, Canada, N6A 4L6
Contact: Site Public Contact    519-685-8600      
Principal Investigator: Francisco E. Perera         
Trillium Health Partners - Credit Valley Hospital Recruiting
Mississauga, Ontario, Canada, L5M 2N1
Contact: Site Public Contact    905-813-4040      
Principal Investigator: Senti S. Senthelal         
Ottawa Hospital and Cancer Center-General Campus Recruiting
Ottawa, Ontario, Canada, K1H 8L6
Contact: Site Public Contact    613-761-4395      
Principal Investigator: Lynn Chang         
Niagara Health System-Saint Catharines General Recruiting
Saint Catharines, Ontario, Canada, L2S 0A9
Contact: Site Public Contact    905-682-6451      
Principal Investigator: Abhirami Hallock         
Algoma District Cancer Program Sault Area Hospital Recruiting
Sault Ste Marie, Ontario, Canada, P6B 0A8
Contact: Site Public Contact    705-759-3434      
Principal Investigator: Silvana Spadafora         
Health Sciences North Recruiting
Sudbury, Ontario, Canada, P3E 5J1
Contact: Site Public Contact    706-522-6237 ext 2401    japaquette@hrsrh.on.ca   
Principal Investigator: Julie L. Bowen         
Odette Cancer Centre- Sunnybrook Health Sciences Centre Recruiting
Toronto, Ontario, Canada, M4N 3M5
Contact: Site Public Contact    416-480-5000      
Principal Investigator: Eileen Rakovitch         
University Health Network-Princess Margaret Hospital Recruiting
Toronto, Ontario, Canada, M5G 2M9
Contact: Site Public Contact    416-946-4501    clinical.trials@uhn.on.ca   
Principal Investigator: Christine A. Koch         
Canada, Quebec
Hopital de la Cite-de-la-Sante Recruiting
Laval, Quebec, Canada, H7M 3L9
Contact: Site Public Contact    450-975-5359      
Principal Investigator: Isabelle Roy         
CHUM - Centre Hospitalier de l'Universite de Montreal Recruiting
Montreal, Quebec, Canada, H2X 3E4
Contact: Site Public Contact    514-890-8000 ext 12725    info.cr.chum@ssss.gouv.qc.ca   
Principal Investigator: Pierre Rousseau         
The Research Institute of the McGill University Health Centre (MUHC) Recruiting
Montreal, Quebec, Canada, H3H 2R9
Contact: Site Public Contact    514-934-1934 ext 48354    evelyn.ortega@muhc.mcgill.ca   
Principal Investigator: Tarek Hijal         
Jewish General Hospital Recruiting
Montreal, Quebec, Canada, H3T 1E2
Contact: Site Public Contact    514-340-8222 ext 8248      
Principal Investigator: Thierry M. Muanza         
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ) Recruiting
Quebec City, Quebec, Canada, G1R 2J6
Contact: Site Public Contact       rechclinique@crchuq.ulaval.ca   
Principal Investigator: Valerie Theberge         
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont Recruiting
Sherbrooke, Quebec, Canada, J1H 5N4
Contact: Site Public Contact    819-820-6480    crcinformation.chus@ssss.gouv.qc.ca   
Principal Investigator: Sawyna Provencher         
Canada, Saskatchewan
Allan Blair Cancer Centre Recruiting
Regina, Saskatchewan, Canada, S4T 7T1
Contact: Site Public Contact    306-766-2213      
Principal Investigator: Derek Suderman         
Saskatoon Cancer Centre Recruiting
Saskatoon, Saskatchewan, Canada, S7N 4H4
Contact: Site Public Contact    306-655-2914      
Principal Investigator: Kate J. Johnson         
Sponsors and Collaborators
Canadian Cancer Trials Group
Alliance for Clinical Trials in Oncology
Eastern Cooperative Oncology Group
NRG Oncology
Southwest Oncology Group
Investigators
Layout table for investigator information
Study Chair: Timothy Whelan Juravinski Cancer Centre at Hamilton Health Sciences, Ontario Canada

Layout table for additonal information
Responsible Party: Canadian Cancer Trials Group
ClinicalTrials.gov Identifier: NCT03488693     History of Changes
Other Study ID Numbers: CCTG MA.39
NCI-2017-02047 ( Other Identifier: NCI CTRP )
First Posted: April 5, 2018    Key Record Dates
Last Update Posted: September 12, 2019
Last Verified: June 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

Layout table for additional information
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: Yes
Device Product Not Approved or Cleared by U.S. FDA: No
Pediatric Postmarket Surveillance of a Device Product: No
Product Manufactured in and Exported from the U.S.: No
Additional relevant MeSH terms:
Layout table for MeSH terms
Breast Neoplasms
Neoplasms by Site
Neoplasms
Breast Diseases
Skin Diseases