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Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC (TALAPRO-2)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03395197
Recruitment Status : Recruiting
First Posted : January 10, 2018
Last Update Posted : February 6, 2020
Sponsor:
Collaborator:
Astellas Pharma Inc
Information provided by (Responsible Party):
Pfizer

Brief Summary:
This study compares rPFS in men with mCRPC treated with talazoparib plus enzalutamide vs. enzalutamide after confirmation of the starting dose of talazoparib in combination with enzalutamide.

Condition or disease Intervention/treatment Phase
mCRPC Drug: Talazoparib with enzalutamide Drug: Placebo with enzalutamide Phase 3

Detailed Description:
Part 1 is an open-label, non-randomized, safety and PK run-in study designed to confirm the starting dose of talazoparib in combination with enzalutamide through assessment of target safety events and PK at select sites. Part 2 is a randomized, double-blind, placebo-controlled, multinational study comparing talazoparib plus enzalutamide vs. placebo plus enzalutamide in patients with mCRPC.

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 1037 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Intervention Model Description: To assess radiographic PFS in men with mCRPC (with no systemic treatments initiated after documentation of mCRCP) treated with talazoparib and enzalutamide vs. placebo plus enzalutamide
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Masking Description: Double-blind.
Primary Purpose: Treatment
Official Title: A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF TALAZOPARIB WITH ENZALUTAMIDE IN METASTATIC CASTRATION-RESISTANT PROSTATE CANCER
Actual Study Start Date : December 18, 2017
Estimated Primary Completion Date : August 22, 2021
Estimated Study Completion Date : November 25, 2024

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Combination arm
Talazoparib plus enzalutamide
Drug: Talazoparib with enzalutamide
Talazoparib 0.5 mg/day plus enzalutamide 160mg/day

Active Comparator: Monotherapy arm
Ezalutamide plus placebo
Drug: Placebo with enzalutamide
Placebo plus enzalutamide 160 mg/day




Primary Outcome Measures :
  1. Confirm the dose of Talazoparib (part 1) [ Time Frame: Day 1 up to 28 days ]
    determined based on the safety profile

  2. Radiographic PFS (part 2) in unselected patients and in patients harboring DDR deficiencies [ Time Frame: randomization up to 25 months ]
    time from the date of randomization to first objective evidence of radiographic progression by blinded independent review, or death (occurring within 168 days of treatment discontinuation), whichever occurs first


Secondary Outcome Measures :
  1. Overall survival (part 2) in unselected patients and in patients harboring DDR deficiencies [ Time Frame: randomization up to 47 months ]
    time from randomization to death from any cause

  2. Objective response in measurable soft tissue disease (part 2) in unselected patients and in patients harboring DDR deficiencies [ Time Frame: baseline up to 6 months ]
    proportion of patients with measurable soft tissue disease at baseline with objective response per RECIST 1.1

  3. Duration of soft tissue response (part 2) in unselected patients and in patients harboring DDR deficiencies [ Time Frame: baseline up to 25 months ]
    duration of responses in patients with measurable soft tissue disease at baseline per RECIST 1.1

  4. PSA response (part 2) in unselected patients and in patients harboring DDR deficiencies [ Time Frame: baseline up to 25 months ]
    proportion of patients with PSA response grater than or equal to 50%

  5. Time to PSA progression (part 2) in unselected patients and in patients harboring DDR deficiencies [ Time Frame: baseline up to 25 months ]
    time from baseline to PSA progression

  6. Time to initiation of cytotoxic chemotherapy (part 2) in unselected patients and in patients harboring DDR deficiencies [ Time Frame: randomization up to 47 months ]
    time from randomization to initiation of cytotoxic chemotherapy

  7. Time to initiation of antineoplastic therapy (part 2) in unselected patients and in patients harboring DDR deficiencies [ Time Frame: randomization up to 47 months ]
    time from randomization to initiation of antineoplastic treatment

  8. Time to first symptomatic skeletal event (part 2) in unselected patients and in patients harboring DDR deficiencies [ Time Frame: randomization up to 47 months ]
    time from randomization to first symptomatic skeletal event (symptomatic fractures, spinal cord compression, surgery or radiation to the bone whichever is first)

  9. PFS on next line of therapy (PFS2) in unselected patients and in patients harboring DDR deficiencies [ Time Frame: randomization up to 47 months ]
    PFS2 based on investigator assessment

  10. Opiate use for cancer pain (part 2) in unselected patients and in patients harboring DDR deficiencies [ Time Frame: randomization up to 47 months ]
    time from randomization to opiate use for prostate cancer pain

  11. Incidence of adverse events (part 1 and 2) [ Time Frame: Day 1 up to 26 months ]
    AEs and SAEs incidence by type and severity (graded by NCI CTCAE version 4.03)

  12. Pharmacokinetic assessment of talazoparib (part 1) [ Time Frame: Week 1, 5, 9, and 13 ]
    plasma concentration of talazoparib

  13. Pharmacokinetic assessment of talazoparib (part 2) [ Time Frame: week 3, 5, 9 13, and 17 ]
    plasma concentration of talazoparib

  14. Pharmacokinetic assessment of enzalutamide (part 1) [ Time Frame: week 1, 5, 9, and 13 ]
    plasma concentration of enzalutamide

  15. Pharmacokinetic assessment of enzalutamide (part 2) [ Time Frame: week 3, 5, 9 13, and 17 ]
    plasma concentration of enzalutamide

  16. Patient-reported outcome:pain symptoms (part 2) in unselected patients and in patients harboring DDR deficiencies [ Time Frame: baseline up to 47 months ]
    change from baseline in patient-reported pain symptoms per Brief Pain Inventory Short Form (BPI-SF)

  17. Patient-reported outcome: pain symptoms (part 2) in unselected patients and in patients harboring DDR deficiencies [ Time Frame: baseline up to 47 months ]
    time to deterioration in patient-reported pain symptoms per Brief Pain Inventory Short Form (BPI-SF)

  18. Patient-reported outcome: cancer specific global health status/QoL, functioning, and symptoms (part 2) in unselected patients and in patients harboring DDR deficiencies [ Time Frame: baseline up to 47 months ]
    change from baseline in patient-reported Global health status/QoL per EORTC QLQ-C30

  19. Patient-reported outcome: cancer specific global health status/QoL, functioning, and symptoms (part 2) in unselected patients and in patients harboring DDR deficiencies [ Time Frame: baseline up to 47 months ]
    time to definitive deterioration in patient-reported global health status/QoL per EORTC QLQ-C30

  20. Patient-reported outcome: general health status (part2) in unselected patients and patients harboring DDR deficiencies [ Time Frame: baseline up to 47 months ]
    change from baseline in patient-reported general health status per EQ-5D-5L

  21. Patient-reported outcome: general health status (part 2) in unselected patients and patients harboring DDR deficiencies [ Time Frame: baseline up to 47 months ]
    time to definitive deterioration in patient-reported disease-specific urinary symptoms per EORTC QLQ-PR25



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Gender Based Eligibility:   Yes
Gender Eligibility Description:   Men at least 18 years of age. For Japan, at least 20 years of age.
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Histologically or cytologically confirmed adenocarcinoma of the prostate withoutsmall cell or signet cell features

Asymptomatic or mildly symptomatic metastatic castration resistant prostate cancer (mCRPC) (score on BPI-SF Question #3 must be < 4).

For enrollment into Part 2 only (optional in Part 1): assessment of DDR mutation status

Consent to a saliva sample collection for a germline comparator unless prohibited by local regulations or ethics committee decision (optional for patients in Part 1).

Surgically or medically castrated, with serum testosterone ≤ 50 ng/dL (≤ 1.73 nmol/L) at screening.

Metastatic disease in bone documented on bone scan or in soft tissue documented on CT/MRI scan.

Progressive disease at study entry in the setting of medical or surgical castration as defined by 1 or more of the following 3 criteria:

  • Prostate specific antigen (PSA) progression defined by a minimum of 2 rising PSA values from 3 consecutive assessments with an interval of at least 7 days between assessments..
  • Soft tissue disease progression as defined by RECIST 1.1.
  • Bone disease progression defined by Prostate Cancer Working Group 3 (PCWG3) with 2 or more new metastatic bone lesions on a whole body radionuclide bone scan.

Ongoing bisphosphonate or denosumab use prior to Day 1 (Part 1) or randomization (Part 2) is allowed but not mandatory.

Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1.

Life expectancy ≥ 12 months as assessed by the investigator.

Able to swallow the study drug and have no known intolerance to study drugs or excipients.

Must agree to use a condom when having sex with a partner from the time of the first dose of study drug through 4 months after last dose of study treatment. Must also agree for female partner of childbearing potential to use an additional highly effective form of contraception from the time of the first dose of study treatment through 4 months after last dose of study treatment when having sex with a non pregnant female partner of childbearing potential.

Must agree not to donate sperm from the first dose of study drug to 4 months after the last dose of study drug.

Evidence of a personally signed and dated informed consent document (and molecular prescreening consent if appropriate) indicating that the patient [or a legally acceptable representative/legal guardian] has been informed of all pertinent aspects of the study.

Willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures

Exclusion Criteria:

Any prior systemic cancer treatment initiated in in the non metastatic CRPC and mCRPC disease state.

Patients whose only evidence of metastasis is adenopathy below the aortic bifurcation.

Prior treatment with second-generation androgen receptor inhibitors (enzalutamide, apalutamide, and darolutamide), a PARP inhibitor, cyclophosphamide, or mitoxantrone for prostate cancer.

Prior treatment with platinum-based chemotherapy within 6 months (from the last dose) prior to Day 1 (Part 1) or randomization (Part 2), or any history of disease progression on platinum-based therapy within 6 months (from the last dose).

Treatment with cytotoxic chemotherapy, biologic therapy including sipuleucel T, or radionuclide therapy received in the castration-sensitive prostate cancer is NOT exclusionary if discontinued in the 28 days prior to Day 1 (Part 1) or randomization (Part 2).

Treatment with any investigational agent within 4 weeks before Day 1 (Part 1) or randomization (Part 2).

Prior treatment with opioids for pain related to either primary prostate cancer or metastasis within 28 days prior to Day 1 (Part 1) or randomization (Part 2).

Current use of potent P-gp inhibitors within 7 days prior to Day 1 (Part 1) or randomization (Part 2).

Major surgery (as defined by the investigator) within 2 weeks before Day 1 (Part 1) or randomization (Part 2), or palliative localized radiation therapy within 3 weeks before randomization (Part 2).

Clinically significant cardiovascular disease

Significant renal dysfunction as defined by any of the following laboratory abnormalities:

• Renal: eGFR < 30 mL/min/1.73 m2 by the MDRD equation (available via www.mdrd.com).

Patients enrolled in Part 1 only: Moderate renal impairment (eGFR 30-59 mL/min/1.73 m2) at screening.

Significant hepatic dysfunction as defined by any of the following laboratory abnormalities on screening labs:

  • Total serum bilirubin >1.5 times the upper limit of normal (ULN) (>3 × ULN for patients with documented Gilbert syndrome or for whom indirect bilirubin concentrations suggest an extrahepatic source of elevation).
  • Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) >2.5 times ULN (>5 × ULN if liver function abnormalities are due to hepatic metastasis).
  • Albumin <2.8 g/dL

Absolute neutrophil count < 1500/µL, platelets < 100,000/µL, or hemoglobin < 9 g/dL (may not have received growth factors or blood transfusions within 14 days before obtaining the hematology values at screening).

Known or suspected brain metastasis or active leptomeningeal disease.

Symptomatic or impending spinal cord compression or cauda equina syndrome.

Any history of myelodysplastic syndrome, acute myeloid leukemia, or prior malignancy except for the following:

  • Carcinoma in situ or non melanoma skin cancer
  • A cancer diagnosed and treated ≥ 5 years before randomization with no subsequent evidence of recurrence
  • American Joint Committee on Cancer Stage 0 or Stage 1 cancer that has a remote probability of recurrence in the opinion of the investigator and the sponsor

Gastrointestinal disorder affecting absorption.

Fertile male subjects who are unwilling or unable to use highly effective methods of contraception for the duration of the study and for 4 months after the last dose of investigational product.

Investigator site staff members directly involved in the conduct of the study and their family members, site staff members otherwise supervised by the investigator, or patients who are Pfizer employees, including their family members, directly involved in the conduct of the study.

Other acute or chronic medical (concurrent disease, infection, or comorbidity) or psychiatric condition including recent (within the past year) or active suicidal ideation or behavior or laboratory abnormality that interferes with ability to participate in the study, may increase the risk associated with study participation or investigational product administration, or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the patient inappropriate for entry into this study.

History of seizure or any condition that may predispose to seizure (eg, prior cortical stroke, significant brain trauma). Also, history of loss of consciousness or transient ischemic attack within 12 months of randomization (Part 2).


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03395197


Contacts
Layout table for location contacts
Contact: Pfizer CT.gov Call Center 1-800-718-1021 ClinicalTrials.gov_Inquiries@pfizer.com

Locations
Hide Hide 343 study locations
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United States, Alaska
Alaska Urological Institute dba Alaska Clinical Research Center Recruiting
Anchorage, Alaska, United States, 99503
United States, Arizona
Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers Recruiting
Chandler, Arizona, United States, 85224
Banner Gateway Medical Center Not yet recruiting
Gilbert, Arizona, United States, 85234
Banner MD Anderson Cancer Center Not yet recruiting
Gilbert, Arizona, United States, 85234
Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers Recruiting
Gilbert, Arizona, United States, 85297
Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers Recruiting
Mesa, Arizona, United States, 85202
Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers Recruiting
Mesa, Arizona, United States, 85206
Ironwood Physicians P.C. dba Ironwood Cancer & Research Centers Recruiting
Scottsdale, Arizona, United States, 85260
Urological Associates of Southern Arizona, PC Recruiting
Tucson, Arizona, United States, 85715
Urological Associates of Southern Arizona, P.C. Recruiting
Tucson, Arizona, United States, 85741
United States, California
Beverly Hills Cancer Center Recruiting
Beverly Hills, California, United States, 90211
South County Hematology/Oncology Not yet recruiting
Chula Vista, California, United States, 91911
Sharp Rees-Stealy Not yet recruiting
Chula Vista, California, United States, 91913
Glendale Adventist Medical Center Recruiting
Glendale, California, United States, 91206
Marin Cancer Care, Inc. Recruiting
Greenbrae, California, United States, 94904
Cancer Center Oncology Medical Group Not yet recruiting
La Mesa, California, United States, 91942
San Diego Clinical Trials Recruiting
La Mesa, California, United States, 91942
Loma Linda University Cancer Center - Records Management Only Not yet recruiting
Loma Linda, California, United States, 92350
Loma Linda University Cancer Center - Hematology/Oncology Clinic Not yet recruiting
Loma Linda, California, United States, 92354
Loma Linda University Medical Center Not yet recruiting
Loma Linda, California, United States, 92354
VA Long Beach Healthcare System Not yet recruiting
Long Beach, California, United States, 90822
Tower Urology Recruiting
Los Angeles, California, United States, 90048
UCLA Clark Urology Center Not yet recruiting
Los Angeles, California, United States, 90095
UCLA Medical Center Not yet recruiting
Los Angeles, California, United States, 90095
Stanford Cancer Institute Not yet recruiting
Palo Alto, California, United States, 94304
Desert Hematology Oncology Medical Group, Incorporation Not yet recruiting
Rancho Mirage, California, United States, 92270
San Diego Clinical Trials Recruiting
San Diego, California, United States, 92120
Medical Oncology Associates-SD Not yet recruiting
San Diego, California, United States, 92123
Sharp Memorial Hospital Investigational Pharmacy Not yet recruiting
San Diego, California, United States, 92123
Sharp Rees-Stealy Not yet recruiting
San Diego, California, United States, 92123
United States, Colorado
University of Colorado Denver CTO/CTRC Recruiting
Aurora, Colorado, United States, 80045
University of Colorado Hospital - Anschutz Cancer Pavilion Recruiting
Aurora, Colorado, United States, 80045
University of Colorado Hospital- Anschutz Inpatient Pavilion Recruiting
Aurora, Colorado, United States, 80045
University of Colorado Hospital- Anschutz Outpatient Pavilion Recruiting
Aurora, Colorado, United States, 80045
University of Colorado Hospital Recruiting
Aurora, Colorado, United States, 80045
The Urology Center of Colorado Recruiting
Denver, Colorado, United States, 80211
United States, Connecticut
Danbury Hospital Not yet recruiting
Danbury, Connecticut, United States, 06810
New Milford Hospital Not yet recruiting
New Milford, Connecticut, United States, 06776
Norwalk Hospital Not yet recruiting
Norwalk, Connecticut, United States, 06856
United States, Florida
Florida Cancer Specialists Not yet recruiting
Altamonte Springs, Florida, United States, 32701
Florida Cancer Specialists Not yet recruiting
Brandon, Florida, United States, 33511
Florida Cancer Specialists Not yet recruiting
Clearwater, Florida, United States, 33761
Florida Cancer Specialists Not yet recruiting
Daytona Beach, Florida, United States, 32117
21st Century Oncology Not yet recruiting
Fort Myers, Florida, United States, 33908
Florida Cancer Specialists Not yet recruiting
Gainesville, Florida, United States, 32605
Lakeland Regional Health Hollis Cancer Center Not yet recruiting
Lakeland, Florida, United States, 33805
Florida Cancer Specialists Not yet recruiting
Largo, Florida, United States, 33770
Florida Cancer Specialists Not yet recruiting
Lecanto, Florida, United States, 34461
Florida Cancer Specialists Not yet recruiting
New Port Richey, Florida, United States, 34655
Florida Cancer Specialists Not yet recruiting
Ocala, Florida, United States, 34471
Florida Cancer Specialists Not yet recruiting
Orange City, Florida, United States, 32763
Florida Cancer Specialists Not yet recruiting
Orlando, Florida, United States, 32806
Florida Cancer Specialists Not yet recruiting
Saint Petersburg, Florida, United States, 33705
Florida Cancer Specialists Not yet recruiting
Spring Hill, Florida, United States, 34608
Florida Cancer Specialists Not yet recruiting
Tampa, Florida, United States, 33607
Florida Cancer Specialists Not yet recruiting
Tavares, Florida, United States, 32778
Florida Cancer Specialists Not yet recruiting
The Villages, Florida, United States, 32159
Florida Cancer Specialists Not yet recruiting
Vero Beach, Florida, United States, 32960
Florida Cancer Specialists Not yet recruiting
Wellington, Florida, United States, 33414
Florida Cancer Specialists Not yet recruiting
West Palm Beach, Florida, United States, 33401
Florida Cancer Specialists Not yet recruiting
Winter Park, Florida, United States, 32792
United States, Georgia
University Cancer & Blood Center, LLC Not yet recruiting
Athens, Georgia, United States, 30607
Piedmont Cancer Institute Recruiting
Atlanta, Georgia, United States, 30318
Piedmont Cancer Institute Recruiting
Fayetteville, Georgia, United States, 30214
Piedmont Cancer Institute Recruiting
Newnan, Georgia, United States, 30265
Southeastern Regional Medical Center Not yet recruiting
Newnan, Georgia, United States, 30265
United States, Illinois
Cook County Health (CCH) Recruiting
Chicago, Illinois, United States, 60612
AMITA Health Cancer Institute Not yet recruiting
Hinsdale, Illinois, United States, 60521
Midwestern Regional Medical Center Not yet recruiting
Zion, Illinois, United States, 60099
United States, Indiana
First Urology, PSC Recruiting
Jeffersonville, Indiana, United States, 47130
United States, Kansas
Advanced Cancer Therapies Not yet recruiting
Wichita, Kansas, United States, 67206
Wichita Urology Group Not yet recruiting
Wichita, Kansas, United States, 67226
United States, Kentucky
First Urology, PSC Recruiting
Louisville, Kentucky, United States, 40207
United States, Louisiana
Ochsner Clinic Foundation Not yet recruiting
New Orleans, Louisiana, United States, 70121
Regional Urology Oncology & Radiation Center Not yet recruiting
Shreveport, Louisiana, United States, 71106
Regional Urology, LLC Not yet recruiting
Shreveport, Louisiana, United States, 71106
United States, Maryland
University of Maryland Greenebaum Comprehensive Cancer Center Not yet recruiting
Baltimore, Maryland, United States, 21201
United States, Michigan
Michigan Institute of Urology Not yet recruiting
Troy, Michigan, United States, 48084
United States, Missouri
VA Saint Louis Healthcare System Not yet recruiting
Saint Louis, Missouri, United States, 63106
United States, Montana
St. Vincent Healthcare Not yet recruiting
Billings, Montana, United States, 59101
St. Vincent Frontier Cancer Center Not yet recruiting
Billings, Montana, United States, 59102
United States, Nebraska
Oncology Hematology West, PC dba Nebraska Cancer Specialists Not yet recruiting
Omaha, Nebraska, United States, 68114
Oncology Hematology West, PC dba Nebraska Cancer Specialists Not yet recruiting
Omaha, Nebraska, United States, 68124
GU Research Network/Urology Cancer Center Recruiting
Omaha, Nebraska, United States, 68130
Oncology Hematology West, PC dba Nebraska Cancer Specialists Not yet recruiting
Omaha, Nebraska, United States, 68130
United States, New Jersey
New Jersey Cancer Care and Blood Disorders Recruiting
Belleville, New Jersey, United States, 07109
New Jersey Urology, LLC Recruiting
Voorhees, New Jersey, United States, 08043
United States, New Mexico
Urology Group of New Mexico Recruiting
Albuquerque, New Mexico, United States, 87109
San Juan Oncology Associates Not yet recruiting
Farmington, New Mexico, United States, 87401
United States, New York
Montefiore Medical Center - Montefiore Medical Park Recruiting
Bronx, New York, United States, 10461
Premier Medical Group of the Hudson Valley PC Recruiting
Poughkeepsie, New York, United States, 12601
Associated Medical Professionals of New York, PLLC Recruiting
Syracuse, New York, United States, 13210
United States, Ohio
TriState urologic Services PSC Inc., dba The Urology Group Recruiting
Cincinnati, Ohio, United States, 45212
Clinical Research Solutions Recruiting
Middleburg Heights, Ohio, United States, 44130
United States, Oklahoma
Stephenson Cancer Center (clinic) Not yet recruiting
Oklahoma City, Oklahoma, United States, 73104
Stephenson Cancer Center (infusion) Not yet recruiting
Oklahoma City, Oklahoma, United States, 73104
Stephenson Cancer Center Not yet recruiting
Oklahoma City, Oklahoma, United States, 73104
United States, Oregon
Kaiser Permanente Sunnyside Medical Center Not yet recruiting
Clackamas, Oregon, United States, 97015-9303
Providence Cancer Institute Clackamas Clinic Not yet recruiting
Clackamas, Oregon, United States, 97015
Cascade View Medical Building Not yet recruiting
Corvallis, Oregon, United States, 97330
Good Samaritan Hospital - Corvallis Not yet recruiting
Corvallis, Oregon, United States, 97330
Kaiser Permanente Westside Medical Center Not yet recruiting
Hillsboro, Oregon, United States, 97124
Providence Cancer Institute Newberg Clinic Not yet recruiting
Newberg, Oregon, United States, 97132
Providence Cancer Institute Franz Clinic Not yet recruiting
Portland, Oregon, United States, 97213
Providence Oncology and Hematology Care Clinic - Westside Not yet recruiting
Portland, Oregon, United States, 97225
Kaiser Permanente Northwest Not yet recruiting
Portland, Oregon, United States, 97227
United States, Pennsylvania
UPMC Hillman Cancer Center - Altoona Recruiting
Altoona, Pennsylvania, United States, 16601
UPMC Hillman Cancer Center - Upper St. Clair Recruiting
Bethel Park, Pennsylvania, United States, 15102
UPMC Hillman Cancer Center - Arnold Palmer - Mt View Recruiting
Greensburg, Pennsylvania, United States, 15601
Lancaster Urology Recruiting
Lancaster, Pennsylvania, United States, 17604
UPMC Hillman Cancer Center - Monroeville Recruiting
Monroeville, Pennsylvania, United States, 15146
Eastern Regional Medical Center, Inc. Not yet recruiting
Philadelphia, Pennsylvania, United States, 19124
UPMC Hillman Cancer Center Recruiting
Pittsburgh, Pennsylvania, United States, 15232
UPMC Hillman Cancer Center - Passavant (HOA) Recruiting
Pittsburgh, Pennsylvania, United States, 15237
UPMC Hillman Cancer Center - Passavant (OHA) Recruiting
Pittsburgh, Pennsylvania, United States, 15237
UPMC Hillman Cancer Center - Northwest Recruiting
Seneca, Pennsylvania, United States, 16346
UPMC Hillman Cancer Center - Uniontown Recruiting
Uniontown, Pennsylvania, United States, 15401
UPMC Hillman Cancer Center - Washington Recruiting
Washington, Pennsylvania, United States, 15301
United States, South Carolina
Carolina Urologic Research Center Recruiting
Myrtle Beach, South Carolina, United States, 29572
United States, Tennessee
Sarah Cannon Research Institute Recruiting
Chattanooga, Tennessee, United States, 37404
Tennessee Oncology, PLLC Recruiting
Chattanooga, Tennessee, United States, 37404
Tennesse Oncology, PLLC Recruiting
Cleveland, Tennessee, United States, 37311
Tennessee Cancer Specialists-Harrogate Not yet recruiting
Harrogate, Tennessee, United States, 37752
Tennessee Cancer Specialists-Jefferson City Not yet recruiting
Jefferson City, Tennessee, United States, 37760
Center for Biomedical Research Not yet recruiting
Knoxville, Tennessee, United States, 37909
Tennessee Cancer Specialists Not yet recruiting
Knoxville, Tennessee, United States, 37909
Tennessee Cancer Specialists-Morristown Not yet recruiting
Morristown, Tennessee, United States, 37813
Urology Associates P.C. Recruiting
Nashville, Tennessee, United States, 37209
The Vanderbilt Clinic Recruiting
Nashville, Tennessee, United States, 37232
Vanderbuilt University Medical Center, Department of Urology Recruiting
Nashville, Tennessee, United States, 37232
United States, Texas
Rio Grande Urology, P.A. Recruiting
El Paso, Texas, United States, 79912
Houston Metro Urology Recruiting
Houston, Texas, United States, 77027
Baylor Scott and White Medical Center-Temple Not yet recruiting
Temple, Texas, United States, 76508
United States, Utah
Farmington Health Center -University of Utah Recruiting
Farmington, Utah, United States, 84025
Huntsman Cancer Hospital Recruiting
Salt Lake City, Utah, United States, 84112
University of Utah, Huntsman Cancer Institute Recruiting
Salt Lake City, Utah, United States, 84112
Redwood Health Center-University of Utah Recruiting
Salt Lake City, Utah, United States, 84119
South Jordan Health Center -University of Utah Recruiting
South Jordan, Utah, United States, 84095
United States, Virginia
Inova Schar Cancer Institute Infusion Pharmacy Not yet recruiting
Fairfax, Virginia, United States, 22031
Inova Schar Cancer Institute Not yet recruiting
Fairfax, Virginia, United States, 22031
United States, Wisconsin
University of Wisconsin Clinical Science Center Recruiting
Madison, Wisconsin, United States, 53792
University of Wisconsin Hospital & Clinics Recruiting
Madison, Wisconsin, United States, 53792
Argentina
Centro de Investigacion Pergamino SA - Clinica Pergamino SA Recruiting
Pergamino, Buenos Aires, Argentina, B2700CPM
Instituto de Oncologia de Rosario Recruiting
Rosario, Santa FE, Argentina, S2000KZE
Centro de Urologia-CDU Not yet recruiting
Caba, Argentina, C1120AAT
Hospital Británico de Buenos Aires Recruiting
Caba, Argentina, C1280AEB
Centro de Educacion Medica e Investigaciones Clinicas "Norberto Quirno" Cemic Recruiting
Caba, Argentina, C1431FWO
Clinica Universitaria Reina Fabiola Recruiting
Cordoba, Argentina, X5004FHP
Hospital Privado Centro Medico de Cordoba Recruiting
Cordoba, Argentina, X5016KEH
Australia, New South Wales
Chris O'Brien Lifehouse Recruiting
Camperdown, New South Wales, Australia, 2050
St Vincent's Hospital Sydney Recruiting
Darlinghurst, New South Wales, Australia, 2010
Epic Pharmacy Recruiting
Port Macquarie, New South Wales, Australia, 2444
Port Macquarie Base Hospital Recruiting
Port Macquarie, New South Wales, Australia, 2444
Australia, Queensland
ICON Cancer Centre Wesley Recruiting
Auchenflower, Queensland, Australia, 4066
River City Pharmacy Recruiting
Auchenflower, Queensland, Australia, 4066
Princess Alexandra Hospital Recruiting
Brisbane, Queensland, Australia, 4102
ICON Cancer Centre Chermside Recruiting
Chermside, Queensland, Australia, 4032
ICON Cancer Centre South Brisbane Recruiting
South Brisbane, Queensland, Australia, 4101
Integrated Clinical Oncology Network Pty Ltd (ICON) Recruiting
South Brisbane, Queensland, Australia, 4101
ICON Cancer Centre Southport Recruiting
Southport, Queensland, Australia, 4215
Australia, Victoria
Peter MacCallum Cancer Centre Recruiting
Melbourne, Victoria, Australia, 3000
Peter MacCallum Cancer Centre Recruiting
North Melbourne, Victoria, Australia, 3051
Belgium
AZ Klina Not yet recruiting
Brasschaat, Belgium, 2930
A.Z. Sint-Lucas Recruiting
Gent, Belgium, 9000
UZ Gent Recruiting
Gent, Belgium, 9000
AZ Groeninge Recruiting
Kortrijk, Belgium, 8500
Clinique Saint-Pierre Ottignies Not yet recruiting
Ottignies, Belgium, 1340
CHU UCL Namur site Godinne Recruiting
Yvoir, Belgium, 5530
Brazil
Associacao Hospital de Caridade de Ijui Not yet recruiting
Ijui, RS, Brazil, 98700-000
Fundacao Pio XII - Hospital de Cancer de Barretos Not yet recruiting
Barretos, SP, Brazil, 14784-400
Canada, Alberta
Tom Baker Cancer Centre - Alberta Health Services Not yet recruiting
Calgary, Alberta, Canada, T2N 4N2
Canada, Ontario
The Ottawa Hospital Cancer Center Not yet recruiting
Ottawa, Ontario, Canada, K1H 8L6
Canada, Quebec
Centre integre universitaire de sante et de services sociaux du Saguenay-Lac-Saint-Jean Not yet recruiting
Chicoutimi, Quebec, Canada, G7H 5H6
CHUM - Pharmacie du CRCHUM Not yet recruiting
Montreal, Quebec, Canada, H2X 1R9
CHUM - Centre Hospitalier de l'Universite de Montreal Not yet recruiting
Montreal, Quebec, Canada, H2X 3E4
Jewish General Hospital Not yet recruiting
Montreal, Quebec, Canada, H3T 1E2
Centre integre universitaire de sante et de services sociaux de I'Estrie Not yet recruiting
Sherbrooke, Quebec, Canada, J1H 5N4
Chile
Sociedad Prosalud Montes y Orlandi Ltda. Not yet recruiting
Santiago, Metropolitana, Chile, 7500006
Sociedad Prosalud Montes y Orlandi Ltda. Fantasy name (Orlandi Oncologia) Not yet recruiting
Santiago, Metropolitana, Chile, 7500713
Centro de Investigacion Clinica del Sur Recruiting
Temuco, Region DE LA Araucania, Chile, 4781156
Sociedad de Investigaciones Medicas Ltda (SIM) Not yet recruiting
Temuco, Region DE LA Araucania, Chile, 4810469
Centro de Investigaciones Clinicas Vina del Mar Recruiting
Vina del Mar, Valparaiso, Chile, 2540488-2540364
China, Jiangsu
Nanjing Drum Tower Hospital , The Affiliated Hospital of Nanjing University Medical School Not yet recruiting
Nanjing, Jiangsu, China, 210008
Czechia
Fakultní nemocnice Hradec Králové Not yet recruiting
Hradec Kralove, Czechia, 500 05
Fakultní nemocnice Hradec Králové Not yet recruiting
Hradec Králové, Czechia, 500 05
Fakultni nemocnice Ostrava Recruiting
Ostrava-Poruba, Czechia, 708 52
Multiscan s.r.o. Not yet recruiting
Pardubice, Czechia, 530 02
Multiscan Pharma Not yet recruiting
Pardubice, Czechia, 532 03
Multiscan s.r.o. Not yet recruiting
Pardubice, Czechia, 532 03
Fakultní nemocnice Královské Vinohrady Not yet recruiting
Praha 10, Czechia, 100 34
Masarykova nemocnice v Usti nad Labem, o.z. Krajska zdravotni a.s. Not yet recruiting
Usti nad Labem, Czechia, 401 13
Finland
HUS Helsinki University Hospital Recruiting
Helsinki, Finland, 00029
Docrates Cancer Center Recruiting
Helsinki, Finland, 00180
HUS Pharmacy, Clinical Trials Recruiting
Helsinki, Finland, 00290
OYS apteekki Recruiting
Kempele, Finland, 90440
Kuopio University Hospital Recruiting
Kuopio, Finland, 70029
Kuopio University Hospital Recruiting
Kuopio, Finland, 70210
Oulun yliopistollinen sairaala Recruiting
Oulu, Finland, 90220
Pirkanmaan sairaanhoitopiiri/Sairaala-apteekki/Tutkimusfarmaseutti Recruiting
Tampere, Finland, 33520
Tampere University Hospital Recruiting
Tampere, Finland, 33520
Turku University Hospital Recruiting
Turku, Finland, 20520
France
Centre d'Oncologie du Pays-Basque Not yet recruiting
Bayonne, France, 64100
Clinique CAPIO Belharra Not yet recruiting
Bayonne, France, 64100
Hopital Saint Andre Not yet recruiting
Bordeaux CEDEX, France, 33075
Hopital Saint Andre - CHU de Bordeaux Not yet recruiting
Bordeaux, France, 33075
CHD Vendée Recruiting
LA ROCHE SUR YON cedex 9, France, 85925
Clinique Victor Hugo-Centre Jean Bernard Not yet recruiting
Le Mans, France, 72000
Clinique Victor Hugo Not yet recruiting
Le Mans, France, 72015 Cedex 02
CHU Montpellier-Hopital Saint Eloi Not yet recruiting
Montpellier cedex 5, France, 34295
Hopital Europeen Georges Pompidou Not yet recruiting
Paris Cedex 15, France, 75908
Hopital Saint Louis Not yet recruiting
Paris, France, 75010
Hopital Saint-Louis Not yet recruiting
Paris, France, 75010
Hopital Europeen Georges Pompidou Not yet recruiting
Paris, France, 75015
Clinique Sainte Anne Not yet recruiting
Strasbourg, France, 67000
Hopitaux Universitaires de Strasbourg - Hopital Civil Not yet recruiting
Strasbourg, France, 67091
Nouvel Hopital Civil Not yet recruiting
Strasbourg, France, 67091
Hopital Foch Recruiting
Suresnes Cedex, France, 92151
Hopital Foch Recruiting
Suresnes, France, 92150
Institut Gustave Roussy Recruiting
VILLEJUIF cedex, France, 94805
Germany
Universitaetsklinikum Erlangen, Urologische und Kinderurologische Klinik Not yet recruiting
Erlangen, Germany, 91054
Diagnostikzentrum Recruiting
Kirchheim, Germany, 73230
Universitaetsklinikum Muenster Recruiting
Muenster, Germany, 48149
Studienpraxis Urologie Recruiting
Nuertingen, Germany, 72622
Labor Dr. Gartner Recruiting
Ravensburg, Germany, 88212
Laborgemeinschaft Reutlingen Recruiting
Reutlingen, Germany, 72770
Kliniken Nordoberpfalz AG Not yet recruiting
Weiden, Germany, 92637
Hungary
Semmelweis Egyetem Urologiai Klinika Not yet recruiting
Budapest, Hungary, 1082
Orszagos Onkologiai Intezet Recruiting
Budapest, Hungary, 1122
Országos Onkológiai Intézet Recruiting
Budapest, Hungary, 1122
Uzsoki Utcai Korhaz Recruiting
Budapest, Hungary, 1145
Uzsoki Utcai Kórház Recruiting
Budapest, Hungary, 1145
Debreceni Egyetem Klinikai Kozpont Klinikai Gyogyszertar Recruiting
Debrecen, Hungary, 4032
Debreceni Egyetem Klinikai Kozpont Recruiting
Debrecen, Hungary, 4032
Pecsi Tudomanyegyetem Klinikai Kozpont Gyogyszereszeti Intezet es Klinikai Kozponti Gyogyszertar Recruiting
Pecs, Hungary, 7624
Pecsi Tudomanyegyetem Klinikai Kozpont Onkoterapias Intezet Recruiting
Pecs, Hungary, 7624
Israel
Bnai Zion Medical Center Not yet recruiting
Haifa, Israel, 3104802
Rambam Health Care Campus Not yet recruiting
Haifa, Israel, 3109601
Shaare Zedek Medical Center Not yet recruiting
Jerusalem, Israel, 9103102
Rabin Medical Center, Beilinson Hospital Not yet recruiting
Petah Tikva, Israel, 4941492
Department of Oncology, Tel Aviv Sourasky Medical Center Recruiting
Tel Aviv, Israel, 6423906
Tel Aviv Sourasky Medical Center Recruiting
Tel Aviv, Israel, 6423906
Italy
Azienda Ospedaliera universitaria di Bologna Policlinico S. Orsola Malpighi Not yet recruiting
Bologna, BO, Italy, 40138
Azienda Ospedaliero-Universitaria Policlinico Sant' Orsola Malpighi Not yet recruiting
Bologna, BO, Italy, 40138
ASST di Cremona Recruiting
Cremona, CR, Italy, 26100
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS Recruiting
Meldola, FC, Italy, 47014
Azienda Ospedaliera S. Maria Recruiting
Terni, TN, Italy, 05100
Ospedale Santa Chiara Not yet recruiting
Trento, TN, Italy, 38122
AOU San Luigi Gonzaga Recruiting
Orbassano, TO, Italy, 10043
ASST-Spedali Civili di Brescia Not yet recruiting
Brescia, Italy, 25123
A.O.R.N. "A. Cardarelli" Not yet recruiting
Napoli, Italy, 80131
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale - Napoli Recruiting
Napoli, Italy, 80131
Japan
Nagoya University Hospital Recruiting
Nagoya, Aichi, Japan, 466-8560
Hirosaki University School of Medicine & Hospital Recruiting
Hirosaki, Aomori, Japan, 036-8563
National Cancer Center Hospital East Recruiting
Kashiwa, Chiba, Japan, 277-8577
National Hospital Organization Hokkaido Cancer Center Recruiting
Sapporo, Hokkaido, Japan, 003-0804
Hokkaido University Hospital Recruiting
Sapporo, Hokkaido, Japan, 060-8648
Kanazawa University Hospital Recruiting
Kanazawa, Ishikawa, Japan, 920-8641
Yokohama City University Medical Center Recruiting
Yokohama, Kanagawa, Japan, 232-0024
Yokosuka Kyosai Hospital Recruiting
Yokosuka, Kanagawa, Japan, 238-8558
Osaka International Cancer Institute Recruiting
Osaka-shi, Osaka, Japan, 5418567
Kindai University Hospital Recruiting
Osakasayama, Osaka, Japan, 589-8511
Osaka University Hospital Recruiting
Suita, Osaka, Japan, 565-0871
Hamamatsu University School of Medicine, University Hospital Recruiting
Hamamatsu, Shizuoka, Japan, 431-3192
National Hospital Organization Tokyo Medical Center Recruiting
Meguro-ku, Tokyo, Japan, 152-8902
Keio University Hospital Recruiting
Shinjuku-ku, Tokyo, Japan, 160-8582
Chiba Cancer Center Recruiting
Chiba, Japan, 260-8717
National Hospital Organization Kyushu Cancer Center Recruiting
Fukuoka, Japan, 811-1395
Kagoshima University Hospital Recruiting
Kagoshima, Japan, 890-8520
National Hospital Organization Kumamoto Medical Center Recruiting
Kumamoto, Japan, 860-0008
Tokushima University Hospital Recruiting
Tokushima, Japan, 770-8503
Yamagata Prefectural Central Hospital Recruiting
Yamagata, Japan, 990-2292
Korea, Republic of
Clinical Trial Pharmacy, National Cancer Center Recruiting
Goyang-si, Gyeonggi-do, Korea, Republic of, 10408
National Cancer Center Recruiting
Goyang-si, Gyeonggi-do, Korea, Republic of, 10408
Pusan National University Hospital Recruiting
Busan, Korea, Republic of, 49241
Kyungpook National University Chilgok Hospital Recruiting
Daegu, Korea, Republic of, 41404
Seoul National University Hospital Recruiting
Seoul, Korea, Republic of, 03080
Clinical Trial Center, Severance Hospital, yonsei University Health System Recruiting
Seoul, Korea, Republic of, 03722
Severance Hospital, Yonsei University Health System Recruiting
Seoul, Korea, Republic of, 03722
Asan Medical Center Recruiting
Seoul, Korea, Republic of, 05505
Cancer Center Clinical Trial, Asan Medical Center Recruiting
Seoul, Korea, Republic of, 05505
Clinical Trials Center Pharmacy Recruiting
Seoul, Korea, Republic of, 06351
Samsung Medical Center Recruiting
Seoul, Korea, Republic of, 06351
Clinical Trial Pharmacy, The Catholic University of Korea Recruiting
Seoul, Korea, Republic of, 06591
The Catholic University of Korea, Seoul St. Mary's Hospital Recruiting
Seoul, Korea, Republic of, 06591
New Zealand
Tauranga Urology Research Limited Recruiting
Tauranga, BAY OF Plenty, New Zealand, 3112
Christchurch Public Hospital Recruiting
Christchurch, Canterbury, New Zealand, 8011
Canterbury District Health Board Recruiting
Christchurch, Canterbury, New Zealand, 8140
Waikato Hospital Recruiting
Hamilton, Waikato, New Zealand, 3204
Auckland City Hospital Recruiting
Auckland, New Zealand, 1023
Norway
Sykehusapoteket Ostfold, Kalnes Not yet recruiting
Gralum, Norway, 1712
Ostfold County Hospital, Kalnes Not yet recruiting
Gralum, Norway, 1714
Akershus University Hospital Recruiting
Lorenskog, Norway, 1478
Sykehusapoteket Ahus Lorenskog Recruiting
Norbyhagen, Norway, 1474
Oslo University Hospital -Ullevål & Radiumhospitalet Recruiting
Oslo, Norway, 0379
Sykehusapoteket Oslo Recruiting
Oslo, Norway, 0379
St. Olavs Hospital, Trondheim University Hospital Recruiting
Trondheim, Norway, 7030
Sykehusapoteket i Trondheim Recruiting
Trondheim, Norway, 7030
Peru
Clinica Monte Carmela S.C.R.LTDA Recruiting
Arequipa, Peru
Hospital Militar Central "Coronel Luis Arias Schreiber" Recruiting
Lima, Peru, Lima 11
Instituto Nacional de Enfermedades Neoplasicas Not yet recruiting
Lima, Peru, Lima 34
Clinica Internacional Sede San Borja Recruiting
Lima, Peru, Lima 41
Clinica Oncosalud Recruiting
Lima, Peru, Lima 41
Poland
Szpital Specjalistczny W Brzozowie Podkarpack I Osrodek Onkologiczny im. Ks. B Markiewicza Not yet recruiting
Brzozow, Poland, 36-200
Szpitale Pomorskie Sp. z o.o. Oddzial Onkologii i Radioterapii Recruiting
Gdynia, Poland, 81-519
Przychodnia Lekarska "Komed" Roman Karaszewski Not yet recruiting
Konin, Poland, 62-500
Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina Recruiting
Otwock, Poland, 05-400
NZOZ Szpital Mazovia; Oddzial urologiczny Recruiting
Warszawa, Poland, 02-797
Portugal
Centro Clínico Académico - Braga, Associação (2CABraga) Not yet recruiting
Braga, Portugal, 4710-243
Hospital do Espirito Santo de Evora Not yet recruiting
Evora, Portugal, 7000-811
Fundação Champalimaud Not yet recruiting
Lisboa, Portugal, 1400-038
South Africa
Cancercare Langenhoven Drive Oncology Centre Recruiting
Port Elizabeth, Eastern CAPE, South Africa, 6045
Wits Clinical Research Charlotte Maxeke Johannesburg Academic Hospital (CMJAH), Clinical Trial Site Not yet recruiting
Johannesburg, Gauteng, South Africa, 2193
Wits Clinical Research Not yet recruiting
Johannesburg, Gauteng, South Africa, 2193
The Medical Oncology Centre of Rosebank Not yet recruiting
Johannesburg, Gauteng, South Africa, 2196
CancerCare Rondebosch Oncology Recruiting
Cape Town, Western CAPE, South Africa, 7700
Outeniqua Cancercare Oncology Unit Recruiting
George, Western CAPE, South Africa, 6530
Cape Town Oncology Trials Recruiting
Kraaifontein, Cape Town, Western CAPE, South Africa, 7570
Spain
Hospital Clinico Universitario de Santiago de Compostela Recruiting
Santiago de Compostela, A Coruna, Spain, 15706
Hospital General Universitario de Elche Not yet recruiting
Elche, Alicante, Spain, 03203
Institut Catala d'Oncologia - ICO L'Hospitalet Recruiting
L'Hospitalet de Llobregat, Barcelona, Spain, 08908
Institut Catala d'Oncologia ICO L'Hospitalet Recruiting
L'Hospitalet de Llobregat, Barcelona, Spain, 08908
Corporacio Sanitaria i Universitaria Parc Tauli Recruiting
Sabadell, Barcelona, Spain, 08208
Hospital Universitari Vall d'Hebron Recruiting
Barcelona, Spain, 08035
Hospital Clinic de Barcelona Not yet recruiting
Barcelona, Spain, 08036
Hospital Universitario La Princesa Not yet recruiting
Madrid, Spain, 28006
Hospital General Universitario Gregorio Maranon Not yet recruiting
Madrid, Spain, 28009
MD Anderson Cancer Center Not yet recruiting
Madrid, Spain, 28033
Hospital Universitario 12 De Octubre Not yet recruiting
Madrid, Spain, 28041
Sweden
ApoEx AB NKS, Kliniska provningar Recruiting
Solna, Sweden, 171 64
Patientomrade Backencancer, Tema Cancer Recruiting
Stockholm, Sweden, 171 76
Cancercentrum Recruiting
Umeå, Sweden, 901 85
Sjukhusapoteket Umeå Recruiting
Umeå, Sweden, 907 37
Akademiska University Hospital Not yet recruiting
Uppsala, Sweden, 751 85
Akademiska sjukhuset, Kliniska prövingar Not yet recruiting
Uppsala, Sweden, 75185
United Kingdom
University Hospitals Plymouth NHS Trust Not yet recruiting
Plymouth, Devon, United Kingdom, PL6 8DH
Royal Cornwall Hospitals NHS Trust Recruiting
Cornwall, United Kingdom, TR1 3LJ
Royal Cornwall Hospitals NHS Trust Recruiting
Cronwall, United Kingdom, TR1 3LJ
NHS Greater Glasgow and Clyde, The Beatson West of Scotland Cancer Centre Recruiting
Glasgow, United Kingdom, G12 0YN
NHS Greater Glasgow and Clyde Recruiting
Glasgow, United Kingdom, G12 0YN
Imperial College Healthcare NHS Trust Recruiting
London, United Kingdom, W12 0HS
Imperial College Healthcare NHS Trust Recruiting
London, United Kingdom, W2 1NY
Imperial College Healthcare NHS Trust, Charing Cross Hospital Recruiting
London, United Kingdom, W6 8RF
Oxford University Hospitals NHS Trust Not yet recruiting
Oxford, United Kingdom, OX3 7LE
Sponsors and Collaborators
Pfizer
Astellas Pharma Inc
Investigators
Layout table for investigator information
Study Director: Pfizer CT.gov Call Center Pfizer

Additional Information:
Layout table for additonal information
Responsible Party: Pfizer
ClinicalTrials.gov Identifier: NCT03395197    
Other Study ID Numbers: C3441021
2017-003295-31 ( EudraCT Number )
TALAPRO-2 ( Other Identifier: Alias Study Number )
First Posted: January 10, 2018    Key Record Dates
Last Update Posted: February 6, 2020
Last Verified: January 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes
Plan Description: Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.
URL: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests

Layout table for additional information
Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Pfizer:
mCRPC (metastatic castration-resistant prostate cancer)
Additional relevant MeSH terms:
Layout table for MeSH terms
Talazoparib
Poly(ADP-ribose) Polymerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents