Endovascular Treatment Key Technique and Emergency Work Flow Improvement of Acute Ischemic Stroke (ANGEL-ACT)
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Endovascular thrombectomy (EVT) is effective and safe for acute ischemic stroke (AIS) caused by large vessel occlusion (LVO) in major clinical trials. Whether the benefit of EVT in randomized trials could be generalized to clinical practice, especially in developing countries, remains unknown. The prospective Chinese ANGEL-ACT Registry (Endovascular Treatment Key Technique and Emergency Work Flow Improvement of Acute Ischemic Stroke) was established to evaluate the utilization, and subsequent outcomes of EVT treated AIS patients. This study is a multi-center, prospective registry study initiated by researchers, funded by National Key R&D Program of China. A total of 2,000 patients with acute ischemic stroke will undergo endovascular treatment. The hypothesis was that favorable outcomes from clinical trials could be achieved in clinical practice in China.
Condition or disease
Intracranial Artery Occlusion With Infarction (Disorder)
Functional independence at 90 days (modified Rankin Scale of 0-2) [ Time Frame: 90±7 days after enrollment ]
The range of modified Rankin Scale was from 0 to 6. 0-No symptoms;1-No significant disability;2-Slight disability;3-Moderate disability;4-Moderately severe disability;5-Severe disability;6 -Dead.A higher score indicates worse a outcome.
Symptomatic intracranial hemorrhage (sICH) within 12-36 hours after the procedure [ Time Frame: 12-36 hours after the procedure ]
Heidelberg Bleeding Classification): new intracranial hemorrhage detected by brain imaging associated with ≥4 points total National Institutes of Health Stroke Scale (NIHSS), ≥2 points in one NIHSS category, leading to intubation/ hemicraniectomy/ EVD placement or other major medical/surgical intervention, or absence of alternative explanation for deterioration
Time from symptom onset to recanalization [ Time Frame: The end of the procedure ]
Secondary Outcome Measures :
Recanalization rate at the end of the procedure [ Time Frame: at the end of the procedure ]
mTICI score 2b-3
Recanalization rate after the first attempt [ Time Frame: At baseline, during the procedure, after the first attempt of endovascular treatment ]
mTICI score 2b-3
Changes in NIHSS score immediately after the procedure [ Time Frame: within 2 hours after the procedure ]
difference between NIHSS score immediately after the procedure and baseline
Changes in NIHSS score 24 hours after the procedure [ Time Frame: 24 hours after the procedure ]
difference between NIHSS score 24 hours after the procedure and baseline
Changes in NIHSS score 7 days after the procedure or at discharge [ Time Frame: 7 days after the procedure or discharge ]
difference between NIHSS score 7 days after the procedure or discharge and baseline
EQ-5D 90 days after the procedure [ Time Frame: 90±7 days after the procedure ]
EQ-5D is a standardized instrument for measuring generic health status. Rated level can be coded as a number 1, 2, or 3, which indicates having no problems for 1, having some problems for 2, and having extreme problems for 3. As a result, a person's health status can be defined by a 5-digit number, ranging from 11111 (having no problems in all dimensions) to 33333 (having extreme problems in all dimensions).A higher score indicates a better outcome.
Barthel index (BI) 90 days after the procedure [ Time Frame: 90±7 days after the procedure ]
The BI has a score of 0-100. A higher score indicates a better outcome.
Parenchymal hematoma (PH2) [ Time Frame: 12-36 hours after the procedure ]
PH2 is defined as hematoma in >30% of infarct area
Any intracranial hemorrhage on imaging [ Time Frame: 12-36 hours after the procedure ]
All-cause mortality within 90 days [ Time Frame: 90±7 days after the procedure ]
Time from onset to arrival [ Time Frame: At baseline, after arrival at the hospital ]
Time from arrival to imaging [ Time Frame: At baseline, after taking any brain imaging ]
Time from imaging to puncture [ Time Frame: At baseline, during the procedure, after successful groin puncture ]
Time from puncture to recanalization [ Time Frame: At baseline, during the procedure, after successful recanalization ]
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients with acute ischemic stroke caused by large vessel occlusion and receiving endovascular treatment.