Working...
ClinicalTrials.gov
ClinicalTrials.gov Menu
Trial record 1 of 1 for:    ea9131
Previous Study | Return to List | Next Study

Simplified Patient Care Strategy in Decreasing Early Death in Patients With Acute Promyelocytic Leukemia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT03253848
Recruitment Status : Recruiting
First Posted : August 18, 2017
Last Update Posted : November 21, 2018
Sponsor:
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Eastern Cooperative Oncology Group ( ECOG-ACRIN Cancer Research Group )

Brief Summary:
This clinical trial studies how well simplified patient care strategy works in decreasing early death in patients with acute promyelocytic leukemia. Implementing simplified acute promyelocytic leukemia guidelines along with support from acute promyelocytic leukemia experts may decrease deaths and improve survival.

Condition or disease Intervention/treatment
Acute Promyelocytic Leukemia With PML-RARA t(15;17) Other: Best Practice Other: Laboratory Biomarker Analysis Procedure: Supportive Care

Detailed Description:

PRIMARY OBJECTIVES:

I. To evaluate if the proposed patient care strategy, that includes use of simplified guidelines along with acute promyelocytic leukemia (APL) expert support, decreases the one-month induction mortality rate from 30% to under 15%.

SECONDARY OBJECTIVES:

I. To assess the overall survival 1 year after accrual is completed. II. To assess incidence and severity of differentiation syndrome. III. To correlate outcomes with time to initiation of all-trans retinoic acid (ATRA) from diagnosis or suspicion of diagnosis.

IV. To compare outcomes between academic and community centers separately. V. To evaluate factors associated with outcome.

OUTLINE:

Patients receive standard of care treatment for APL. Patients? doctors regularly discuss with an APL expert to identify and mange treatment.

After diagnosis, patients are followed up for 1 year.


Layout table for study information
Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: A Simplified Patient Care Strategy to Decrease Early Deaths in Acute Promyelocytic Leukemia (APL)
Actual Study Start Date : August 16, 2017
Estimated Primary Completion Date : August 18, 2022
Estimated Study Completion Date : August 18, 2025

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Leukemia

Group/Cohort Intervention/treatment
Observational (simplified guidelines and support)
Patients receive standard of care treatment for APL. Patients? doctors regularly discuss with an APL expert to identify and mange treatment.
Other: Best Practice
Discussion between doctors and APL expert
Other Names:
  • standard of care
  • standard therapy

Other: Laboratory Biomarker Analysis
Correlative studies

Procedure: Supportive Care
Receive simplified guidelines and support
Other Names:
  • Supportive Therapy
  • Symptom Management
  • Therapy, Supportive




Primary Outcome Measures :
  1. Mortality rate [ Time Frame: At 1 month ]
    Will be estimated by dividing total number of deaths within one month of study entry by total number of cases with at least one-month follow up data. 95% repeated confidence interval will be provided.


Secondary Outcome Measures :
  1. Compliance with treatment guidelines [ Time Frame: Up to 1 year ]
    Will be assessed as binary outcome and the successful compliance rate will be described with 95% confidence interval. A regression model will be developed to evaluate the factors associated with outcome. Data items such as age, risk status, comorbidity will be collected and evaluated.

  2. Length of hospital stay [ Time Frame: Up to 1 year ]
    Will be associated with toxicity measures. Will be dichotomized as ?mild? versus (vs.) ?severe? and the length of hospital stay will be compared using the two-sample t-test.

  3. Mortality rate [ Time Frame: At 1 month ]
    Will be compared between patients with long time or short time from diagnosis to treatment using the Fisher?s exact test. Will also be compared between lead institutions and outlying centers.

  4. Overall survival [ Time Frame: At 1 month ]
    Will be compared between the lead institutions and outlying centers and two-sided p-values will be reported.

  5. Overall survival (OS) [ Time Frame: At 1 year ]
    Will be described using the method of Kaplan-Meier. The median OS and one-year OS rate will be estimated and 95% confidence interval (CI) will be provided.

  6. Severity and duration of coagulopathy, bleeding, infections, and differentiation syndrome [ Time Frame: Up to 1 year ]
    Will be measured based on the Common Terminology Criteria for Adverse Events version 4.0. Analysis of the safety data will be mostly descriptive. The proportion of patients with the worst degree toxicity of grade 3 or higher will be assessed and presented with 95% CI.

  7. Time from diagnosis and initiation of treatment [ Time Frame: Up to 1 year ]
    Will be assessed and dichotomized as ?short? vs. ?long? using the median value.



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with confirmed APL 18 years and over.
Criteria

Inclusion Criteria:

  • Confirmed to have a diagnosis of APL, which is defined as:

    • Positive t(15:17) by fluorescence in situ hybridization (FISH) or conventional karyotype
    • Positive promyelocytic leukemia/retinoic acid receptor PML/RAR alpha by polymerase chain reaction (PCR)
  • Patients must accept treatment and supportive care guidelines
  • Referrals must be made as early as possible but no later than 5 calendar days after ATRA therapy is initiated; consent can be obtained up till day 7 or earlier
  • Co-management can be started as soon as referral is made including weekends; the physician at the outlying facility should make every effort to call the APL expert at the first suspicion of APL

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03253848


  Hide Study Locations
Locations
Layout table for location information
United States, California
Kaiser Permanente-Deer Valley Medical Center Recruiting
Antioch, California, United States, 94531
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Fremont Recruiting
Fremont, California, United States, 94538
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Fresno Cancer Center Recruiting
Fresno, California, United States, 93720
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente Recruiting
Fresno, California, United States, 93720
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Modesto Recruiting
Modesto, California, United States, 95356
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente Oakland-Broadway Recruiting
Oakland, California, United States, 94611
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Oakland Recruiting
Oakland, California, United States, 94611
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Rancho Cordova Cancer Center Recruiting
Rancho Cordova, California, United States, 95670
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Redwood City Recruiting
Redwood City, California, United States, 94063
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Richmond Recruiting
Richmond, California, United States, 94801
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Rohnert Park Cancer Center Recruiting
Rohnert Park, California, United States, 94928
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Roseville Recruiting
Roseville, California, United States, 95661
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
The Permanente Medical Group-Roseville Radiation Oncology Recruiting
Roseville, California, United States, 95678
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-South Sacramento Recruiting
Sacramento, California, United States, 95823
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
South Sacramento Cancer Center Recruiting
Sacramento, California, United States, 95823
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente - Sacramento Recruiting
Sacramento, California, United States, 95825
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-San Francisco Recruiting
San Francisco, California, United States, 94115
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Santa Teresa-San Jose Recruiting
San Jose, California, United States, 95119
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente San Leandro Recruiting
San Leandro, California, United States, 94577
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente Medical Center - Santa Clara Recruiting
Santa Clara, California, United States, 95051
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Santa Rosa Recruiting
Santa Rosa, California, United States, 95403
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente Cancer Treatment Center Recruiting
South San Francisco, California, United States, 94080
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-South San Francisco Recruiting
South San Francisco, California, United States, 94080
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Stockton Recruiting
Stockton, California, United States, 95210
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente Medical Center-Vacaville Recruiting
Vacaville, California, United States, 95688
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Vallejo Recruiting
Vallejo, California, United States, 94589
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
Kaiser Permanente-Walnut Creek Recruiting
Walnut Creek, California, United States, 94596
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
United States, Colorado
Rocky Mountain Cancer Centers-Aurora Recruiting
Aurora, Colorado, United States, 80012
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Boulder Community Hospital Recruiting
Boulder, Colorado, United States, 80301
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Boulder Recruiting
Boulder, Colorado, United States, 80304
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Denver Health Medical Center Recruiting
Denver, Colorado, United States, 80204
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
National Jewish Health-Main Campus Recruiting
Denver, Colorado, United States, 80206
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
The Women's Imaging Center Recruiting
Denver, Colorado, United States, 80209
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Colorado Blood Cancer Institute Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Presbyterian - Saint Lukes Medical Center - Health One Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Midtown Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
SCL Health Saint Joseph Hospital Recruiting
Denver, Colorado, United States, 80218
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Rose Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Rose Medical Center Recruiting
Denver, Colorado, United States, 80220
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Comprehensive Cancer Care and Research Institute of Colorado LLC Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Swedish Medical Center Recruiting
Englewood, Colorado, United States, 80113
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
National Jewish Health-Western Hematology Oncology Recruiting
Golden, Colorado, United States, 80401
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
North Colorado Medical Center Recruiting
Greeley, Colorado, United States, 80631
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Greenwood Village Recruiting
Greenwood Village, Colorado, United States, 80111
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Littleton Recruiting
Littleton, Colorado, United States, 80120
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Rocky Mountain Cancer Centers-Sky Ridge Recruiting
Lone Tree, Colorado, United States, 80124
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
McKee Medical Center Recruiting
Loveland, Colorado, United States, 80539
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
National Jewish Health-Northern Hematology Oncology Recruiting
Thornton, Colorado, United States, 80260
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
SCL Health Lutheran Medical Center Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
United States, Florida
Mayo Clinic in Florida Not yet recruiting
Jacksonville, Florida, United States, 32224-9980
Contact: James M. Foran    904-953-7292    foran.james@mayo.edu   
Principal Investigator: James M. Foran         
United States, Hawaii
Kaiser Permanente Moanalua Medical Center Recruiting
Honolulu, Hawaii, United States, 96819
Contact: Louis Fehrenbacher    626-564-3455      
Principal Investigator: Louis Fehrenbacher         
United States, Illinois
Illinois CancerCare-Bloomington Recruiting
Bloomington, Illinois, United States, 61704
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Illinois CancerCare-Canton Recruiting
Canton, Illinois, United States, 61520
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Memorial Hospital of Carbondale Recruiting
Carbondale, Illinois, United States, 62902
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
SIH Cancer Institute Recruiting
Carterville, Illinois, United States, 62918
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Illinois CancerCare-Carthage Recruiting
Carthage, Illinois, United States, 62321
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Centralia Oncology Clinic Recruiting
Centralia, Illinois, United States, 62801
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Northwestern University Not yet recruiting
Chicago, Illinois, United States, 60611
Contact: Jessica K. Altman    312-503-1817    j-altman@northwestern.edu   
Principal Investigator: Jessica K. Altman         
Cancer Care Center of Decatur Recruiting
Decatur, Illinois, United States, 62526
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Decatur Memorial Hospital Recruiting
Decatur, Illinois, United States, 62526
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Crossroads Cancer Center Recruiting
Effingham, Illinois, United States, 62401
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Illinois CancerCare-Eureka Recruiting
Eureka, Illinois, United States, 61530
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Illinois CancerCare-Galesburg Recruiting
Galesburg, Illinois, United States, 61401
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Western Illinois Cancer Treatment Center Recruiting
Galesburg, Illinois, United States, 61401
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Illinois CancerCare-Kewanee Clinic Recruiting
Kewanee, Illinois, United States, 61443
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Illinois CancerCare-Macomb Recruiting
Macomb, Illinois, United States, 61455
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Illinois CancerCare-Ottawa Clinic Recruiting
Ottawa, Illinois, United States, 61350
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Illinois CancerCare-Pekin Recruiting
Pekin, Illinois, United States, 61554
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Recruiting
Pekin, Illinois, United States, 61554
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Methodist Medical Center of Illinois Recruiting
Peoria, Illinois, United States, 61603
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Illinois CancerCare-Peoria Recruiting
Peoria, Illinois, United States, 61615
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Recruiting
Peoria, Illinois, United States, 61615
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
OSF Saint Francis Medical Center Recruiting
Peoria, Illinois, United States, 61637
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Illinois CancerCare-Peru Recruiting
Peru, Illinois, United States, 61354
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Valley Radiation Oncology Recruiting
Peru, Illinois, United States, 61354
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Illinois CancerCare-Princeton Recruiting
Princeton, Illinois, United States, 61356
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Southern Illinois University School of Medicine Recruiting
Springfield, Illinois, United States, 62702
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Springfield Clinic Recruiting
Springfield, Illinois, United States, 62702
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Memorial Medical Center Recruiting
Springfield, Illinois, United States, 62781
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Cancer Care Specialists of Illinois-Swansea Recruiting
Swansea, Illinois, United States, 62226
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Memorial and Saint Elizabeth's Health Care Services LLP Recruiting
Swansea, Illinois, United States, 62226
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
United States, Iowa
Mary Greeley Medical Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
McFarland Clinic PC-William R Bliss Cancer Center Recruiting
Ames, Iowa, United States, 50010
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
McFarland Clinic PC-Boone Recruiting
Boone, Iowa, United States, 50036
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
McFarland Clinic PC-Trinity Cancer Center Recruiting
Fort Dodge, Iowa, United States, 50501
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
McFarland Clinic PC-Jefferson Recruiting
Jefferson, Iowa, United States, 50129
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
McFarland Clinic PC-Marshalltown Recruiting
Marshalltown, Iowa, United States, 50158
Contact: Joseph J. Merchant    515-239-2621      
Principal Investigator: Joseph J. Merchant         
United States, Minnesota
Sanford Clinic North-Bemidgi Recruiting
Bemidji, Minnesota, United States, 56601
Contact: Preston D. Steen    712-252-0088      
Principal Investigator: Preston D. Steen         
Essentia Health Saint Joseph's Medical Center Recruiting
Brainerd, Minnesota, United States, 56401
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Essentia Health Cancer Center Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Essentia Health Saint Mary's Medical Center Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Miller-Dwan Hospital Recruiting
Duluth, Minnesota, United States, 55805
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Lake Region Healthcare Corporation-Cancer Care Recruiting
Fergus Falls, Minnesota, United States, 56537
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Mayo Clinic Not yet recruiting
Rochester, Minnesota, United States, 55905
Contact: Mark R. Litzow    507-266-0523    litzow.mark@mayo.edu   
Principal Investigator: Mark R. Litzow         
United States, Missouri
Parkland Health Center-Bonne Terre Recruiting
Bonne Terre, Missouri, United States, 63628
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Saint Francis Medical Center Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Southeast Cancer Center Recruiting
Cape Girardeau, Missouri, United States, 63703
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Capital Region Medical Center-Goldschmidt Cancer Center Recruiting
Jefferson City, Missouri, United States, 65109
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Missouri Baptist Medical Center Recruiting
Saint Louis, Missouri, United States, 63131
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Sainte Genevieve County Memorial Hospital Recruiting
Sainte Genevieve, Missouri, United States, 63670
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Missouri Baptist Sullivan Hospital Recruiting
Sullivan, Missouri, United States, 63080
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
Missouri Baptist Outpatient Center-Sunset Hills Recruiting
Sunset Hills, Missouri, United States, 63127
Contact: James L. Wade    309-243-3605      
Principal Investigator: James L. Wade         
United States, New York
Memorial Sloan-Kettering Cancer Center Not yet recruiting
New York, New York, United States, 10065
Contact: Martin S. Tallman    212-639-3842    tallmanm@mskcc.org   
Principal Investigator: Martin S. Tallman         
United States, North Dakota
Sanford Bismarck Medical Center Recruiting
Bismarck, North Dakota, United States, 58501
Contact: Preston D. Steen    712-252-0088      
Principal Investigator: Preston D. Steen         
Essentia Health Cancer Center-South University Clinic Recruiting
Fargo, North Dakota, United States, 58103
Contact: Bret E. Friday    888-203-7267      
Principal Investigator: Bret E. Friday         
Roger Maris Cancer Center Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen    712-252-0088      
Principal Investigator: Preston D. Steen         
Sanford Broadway Medical Center Recruiting
Fargo, North Dakota, United States, 58122
Contact: Preston D. Steen    712-252-0088      
Principal Investigator: Preston D. Steen         
United States, Pennsylvania
ECOG-ACRIN Cancer Research Group Not yet recruiting
Philadelphia, Pennsylvania, United States, 19103
Contact: Anand P. Jillella    404-778-1900    ajillel@emory.edu   
Principal Investigator: Anand P. Jillella         
University of Pennsylvania/Abramson Cancer Center Not yet recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Selina M. Luger    215-662-6348    selina.luger@uphs.upenn.edu   
Principal Investigator: Selina M. Luger         
United States, South Dakota
Sanford Cancer Center-Oncology Clinic Recruiting
Sioux Falls, South Dakota, United States, 57104
Contact: Preston D. Steen    712-252-0088      
Principal Investigator: Preston D. Steen         
Sanford USD Medical Center - Sioux Falls Recruiting
Sioux Falls, South Dakota, United States, 57117-5134
Contact: Preston D. Steen    712-252-0088      
Principal Investigator: Preston D. Steen         
United States, Tennessee
Baptist Memorial Hospital and Cancer Center-Memphis Recruiting
Memphis, Tennessee, United States, 38120
Contact: Salil Goorha    901-226-3077      
Principal Investigator: Salil Goorha         
United States, Wyoming
Cheyenne Regional Medical Center-West Recruiting
Cheyenne, Wyoming, United States, 82001
Contact: Keren Sturtz    303-777-2663    ccrp@co-cancerresearch.org   
Principal Investigator: Keren Sturtz         
Sponsors and Collaborators
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)
Investigators
Layout table for investigator information
Principal Investigator: Anand Jillella ECOG-ACRIN Cancer Research Group

Layout table for additonal information
Responsible Party: ECOG-ACRIN Cancer Research Group
ClinicalTrials.gov Identifier: NCT03253848     History of Changes
Other Study ID Numbers: EA9131
NCI-2016-01123 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
EA9131 ( Other Identifier: ECOG-ACRIN Cancer Research Group )
ECOG-ACRIN-EA9131 ( Other Identifier: DCP )
EA9131 ( Other Identifier: CTEP )
UG1CA189828 ( U.S. NIH Grant/Contract )
U10CA037403 ( U.S. NIH Grant/Contract )
First Posted: August 18, 2017    Key Record Dates
Last Update Posted: November 21, 2018
Last Verified: November 2018

Additional relevant MeSH terms:
Layout table for MeSH terms
Leukemia
Leukemia, Promyelocytic, Acute
Neoplasms by Histologic Type
Neoplasms
Leukemia, Myeloid, Acute
Leukemia, Myeloid