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AURORA: Phase 3 Study for the Efficacy and Safety of CVC for the Treatment of Liver Fibrosis in Adults With NASH

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03028740
Recruitment Status : Recruiting
First Posted : January 23, 2017
Last Update Posted : October 8, 2019
Sponsor:
Information provided by (Responsible Party):
Tobira Therapeutics, Inc.

Brief Summary:
The AURORA study will be conducted to confirm the efficacy and safety of cenicriviroc (CVC) for the treatment of liver fibrosis in adult subjects with NASH.

Condition or disease Intervention/treatment Phase
Nonalcoholic Steatohepatitis Drug: Cenicriviroc Drug: Placebo Phase 3

Detailed Description:
The AURORA study will be conducted in 2 parts. Part 1 will examine the surrogate endpoint of improvement in fibrosis of at least 1 stage (nonalcoholic steatohepatitis clinical research network [NASH CRN]) and no worsening of steatohepatitis at Month 12. Subjects from Part 1 will continue into Part 2 and additional subjects will be newly randomized in Part 2 to determine long-term clinical outcomes composed of histopathologic progression to cirrhosis, liver-related clinical outcomes, and all-cause mortality.

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 2000 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: AURORA: A Phase 3 Study to Evaluate the Efficacy and Safety of Cenicriviroc for the Treatment of Liver Fibrosis in Adult Subjects With Nonalcoholic Steatohepatitis
Actual Study Start Date : April 20, 2017
Estimated Primary Completion Date : October 14, 2021
Estimated Study Completion Date : October 28, 2028


Arm Intervention/treatment
Experimental: Drug: Cenicriviroc
150 mg cenicriviroc
Drug: Cenicriviroc
1 tablet QD
Other Name: CVC

Placebo Comparator: Drug: Placebo
Placebo
Drug: Placebo
1 tablet QD




Primary Outcome Measures :
  1. Superiority of CVC compared to placebo on liver histology at Month 12 relative to the Screening biopsy [ Time Frame: Measurements at Baseline and 12 months ]
    Proportion of subjects with improvement in fibrosis by at least 1 stage (NASH CRN system) AND no worsening of steatohepatitis

  2. Superiority of CVC compared to placebo on the composite endpoint of histopathologic progression to cirrhosis, liver-related clinical outcomes, and all-cause mortality [ Time Frame: Time to accrue a pre-specified number of adjudicated events, End of Study, estimated to be 5 years ]

Secondary Outcome Measures :
  1. Effect of CVC compared to placebo on liver histology at Month 60 relative to the Screening biopsy for the proportion of subjects with improvement in fibrosis by at least 1 stage AND no worsening of steatohepatitis [ Time Frame: Time to accrue a pre-specified number of adjudicated events, End of Study, estimated to be 5 years ]


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Male and female subjects aged between 18-75 years
  • Ability to understand and sign a written informed consent form (ICF)
  • Histological evidence of NASH based on central reading of the Screening biopsy
  • Subjects included in Part1 must have histopathological evidence of Stage 2 or 3 liver fibrosis per the NASH CRN System based on central reading of the Screening biopsy slides. Subjects newly randomized in Part 2 must have histological evidence of Stage 3 liver fibrosis per the NASH CRN System, based on central reading of the Screening period biopsy slides. Historical biopsy can be used, provided the criteria listed on Item 3a above are fulfilled.
  • Females of childbearing potential and males participating in the study must agree to use at least 2 approved methods of contraception throughout the duration of the study and for 30 days after stopping study drug. Females who are postmenopausal must have documentation of cessation of menses for ≥ 12 months and serum follicle-stimulating hormone (FSH) ≥ 30 mU/mL at Screening.

Exclusion Criteria:

  • Inability to undergo a liver biopsy
  • Hepatitis B surface antigen (HBsAg) positive
  • Hepatitis C antibody (HCVAb) positive
  • Human immunodeficiency virus (HIV)-1 or HIV-2 infection
  • Prior or planned liver transplantation
  • Other known causes of chronic liver disease
  • History or presence of cirrhosis and/or hepatic decompensation including ascites, hepatic encephalopathy or variceal bleeding
  • Alcohol consumption greater than 21 units/week for males or 14 units/week for females
  • AST > 200 IU/L in males and females at Screening
  • ALT > 250 IU/L in males and > 200 IU/L in females at Screening
  • HbA1c > 10% at Screening
  • Serum albumin < 3.5 g/dL at Screening
  • Estimated glomerular filtration rate (eGFR) < 50 mL/min/1.73 m2 according to the Modification of Diet in Renal Disease (MDRD) equation
  • Platelet count < 100,000/mm3
  • Total bilirubin > 1.5 mg/dL
  • International normalized ratio (INR) > 1.3
  • Model of end stage liver disease (MELD) score > 12
  • Weight reduction, defined as ≥ 7% of body weight, through bariatric surgery in the past 5 years or bariatric surgery planned during the conduct of the study (including gastric banding and sleeve surgery)
  • History of malignancy within the past 5 years or ongoing malignancy other than basal cell carcinoma, or resected noninvasive cutaneous squamous cell carcinoma
  • Active, serious infections that require parenteral antibiotic or antifungal therapy within 30 days prior to Screening Visit
  • Clinically significant cardiovascular or cerebrovascular disease within the past 3 months
  • Females who are pregnant or breastfeeding
  • Current or anticipated treatment with radiation therapy, cytotoxic chemotherapeutic agents and immunomodulating agents (eg, interleukins, interferons, cyclosporine, tacrolimus) except for vaccines or short-term corticosteroids
  • Receiving a glucagon-like peptide 1 (GLP-1) receptor agonist, a dipeptidyl peptidase 4 (DPP-4) inhibitor, a sodium-glucose cotransporter 2 (SGLT2) and/or SGLT1 inhibitor, or a thiazolidinedione (TZD) for less than 6 months prior to the Screening period liver biopsy. Subjects on a stable therapy with a GLP-1 receptor agonist, DPP-4 inhibitor, SGLT1 and/or SGLT2 inhibitor, or a TZD for at least 6 months prior to the Screening liver biopsy may be considered eligible. (Important Note: if a historical biopsy is to be used, subjects need to be on stable therapy for at least 6 months prior to the day historical liver biopsy was performed).

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03028740


Contacts
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Contact: Clinical Trials Registry Team 1-877-277-8566 IR-CTRegistration@allergan.com

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Locations
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United States, Alabama
Summit Internal Medicine Recruiting
Birmingham, Alabama, United States, 35243
Contact: Study Coordinator    205-419-7738      
University of Alabama at Birmingham Recruiting
Birmingham, Alabama, United States, 35294-0012
Contact: Study Coordinator    205-975-5676      
Cullman Clinical Trials Recruiting
Cullman, Alabama, United States, 35055
Contact: Study Coordinator    608-664-9000      
Digestive Health Specialists of the Southeast Recruiting
Dothan, Alabama, United States, 36305
Contact: Study Coordinator    919-781-2514      
Objective GI D/B/A North Alabama GI Research Center Recruiting
Madison, Alabama, United States, 35758
Contact: Study Coordinator    256-960-9445      
United States, Arizona
The Institute for Liver Health Recruiting
Chandler, Arizona, United States, 85224-5688
Contact: Study Coordinator    480-686-8874      
East Valley Family Physicians -Synexus Withdrawn
Chandler, Arizona, United States, 85224
Synexus-Family Practice Specialists Withdrawn
Phoenix, Arizona, United States, 85018
Central Phoenix Medical Clinic Withdrawn
Phoenix, Arizona, United States, 85020
Adobe Gastroenterology Research, LLC Recruiting
Tucson, Arizona, United States, 85712
Contact: Study Coordinator    520-318-1236      
Del Sol Research Management, LLC Recruiting
Tucson, Arizona, United States, 85712
Contact: Study Coordinator    480-426-1361      
Del Sol Research Management LLC Recruiting
Tucson, Arizona, United States, 85745
Contact: Study Coordinator    520-257-3881      
United States, Arkansas
ARcare Center for Clinical Research Recruiting
Augusta, Arkansas, United States, 72006
Contact: Study Coordinator    501-664-7200      
Arkansas Diagnostic Center Recruiting
Little Rock, Arkansas, United States, 72205
Contact: Study Coordinator    501-227-7688      
Preferred Research Partners, Inc. Recruiting
Little Rock, Arkansas, United States, 72211
Contact: Study Coordinator    501-553-9987      
United States, California
Anaheim Clinical Trials Withdrawn
Anaheim, California, United States, 92801
Franco Felizarta MD Recruiting
Bakersfield, California, United States, 93301
Contact: Study Coordinator    661-324-3128      
Hope Clinical Research, Inc. Recruiting
Canoga Park, California, United States, 91303
Contact: Study Coordinator    818-999-4673      
GW Research Recruiting
Chula Vista, California, United States, 91910
Contact: Study Coordinator    619-585-8882      
Precision Research Institute Recruiting
Chula Vista, California, United States, 92114
Contact: Study Coordinator    619-501-0371      
Southern California Research Center Recruiting
Coronado, California, United States, 92118
Contact: Study Coordinator    619-990-1698      
Citrus Valley Gastroenterology Recruiting
Covina, California, United States, 91722
Contact: Study Coordinator    562-228-1967      
University of San Francisco, Fresno Medical Education Program Recruiting
Fresno, California, United States, 93701
Contact: Study Coordinator    559-499-6639      
Fresno Clinical Research Center (FCRC) Recruiting
Fresno, California, United States, 93720
Contact: Study Coordinator    310-560-7217      
National Research Institute Recruiting
Huntington Park, California, United States, 90255
Contact: Study Coordinator    323-588-1968      
University of California San Diego Recruiting
La Jolla, California, United States, 92037
Contact: Study Coordinator    626-840-8292      
University of California San Diego Recruiting
La Jolla, California, United States, 92037
Contact: Study Coordinator    858-246-2259      
Irvine Center for Clinical Research 067 Not yet recruiting
La Jolla, California, United States, 92093-0698
eStudySite Recruiting
La Mesa, California, United States, 91942
Contact: Study Coordinator    619-567-1550      
Om Research Recruiting
Lancaster, California, United States, 93534
Contact: Study Coordinator    661-388-2239      
Southern California Kaiser Permanente, Los Angeles Medical Center Recruiting
Los Angeles, California, United States, 90027
Contact: Study Coordinator    323-783-8977      
Global Research Institute Recruiting
Los Angeles, California, United States, 90036
Contact: Study Coordinator    323-933-9400      
Ruane Medical and Liver Health Institute Recruiting
Los Angeles, California, United States, 90036
Contact: Study Coordinator    323-954-0400 ext Ext. 226      
Cedars-Sinai Medical Group Recruiting
Los Angeles, California, United States, 90048
Contact: Study Coordinator    310-423-8762      
National Research Institute Recruiting
Los Angeles, California, United States, 90057
Contact: Study Coordinator    213-413-2500      
GastroIntestinal Biosciences Recruiting
Los Angeles, California, United States, 90067-2015
Contact: Study Coordinator    310-282-0525      
Veterans Affairs Greater Los Angeles Healthcare System Recruiting
Los Angeles, California, United States, 90073
Contact: Study Coordinator    310-478-3711      
United Medical Doctors Recruiting
Murrieta, California, United States, 92563
Contact: Study Coordinator    951-566-5229      
eStudySite Recruiting
Oceanside, California, United States, 91911-6660
Contact: Study Coordinator    760-631-3056      
Odyssey Clinical Research, LLC Recruiting
Orange, California, United States, 92866
Contact: Study Coordinator    714-872-8882      
Palmtree Clinical Research Inc. Recruiting
Palm Springs, California, United States, 92262
Contact: Study Coordinator    760-778-7799      
Stanford School of Medicine, Center for Clinical Sciences Research Recruiting
Palo Alto, California, United States, 94304
Contact: Study Coordinator    650-721-8517      
Asclepes Research Centers Recruiting
Panorama City, California, United States, 91402
Contact: Study Coordinator    747-998-0394      
National Research Institute Recruiting
Panorama City, California, United States, 91402
Contact: Study Coordinator    818-532-6880      
Havana Research Institute LLC Recruiting
Pasadena, California, United States, 91105
Contact: Study Coordinator    626-395-7732      
Pasadena Liver Center Recruiting
Pasadena, California, United States, 91105
Contact: Study Coordinator    626-795-5769      
Dream Team Clinical Research Not yet recruiting
Pomona, California, United States, 91767
Alliance Clinical Research Recruiting
Poway, California, United States, 92064
Contact: Study Coordinator    949-973-3704      
Inland Empire Liver Foundation Recruiting
Rialto, California, United States, 92377-4697
Contact: Study Coordinator    909-883-2999      
UC Davis Medical Center Not yet recruiting
Sacramento, California, United States, 95817
UC Davis Not yet recruiting
Sacramento, California, United States, 95817
TriWest Research Associates Recruiting
San Diego, California, United States, 92020
Contact: Study Coordinator    619-334-4735      
Precision Research Institute Recruiting
San Diego, California, United States, 92114
Contact: Study Coordinator    619-501-0371      
Southern California Permanente Medical Group Recruiting
San Diego, California, United States, 92154
Contact: Study Coordinator    619-583-4293      
Quest Clinical Research Recruiting
San Francisco, California, United States, 94115
Contact: Study Coordinator    415-353-0800      
UCSF School of Medicine Recruiting
San Francisco, California, United States, 94143-0538
Contact: Study Coordinator    415-476-2777      
Southern California Permanente Medical Group Withdrawn
San Marcos, California, United States, 92078
Care Access Research LLC Recruiting
San Pablo, California, United States, 94806
Contact: Study Coordinator    510-255-0642      
Upland Clinical Research Recruiting
Upland, California, United States, 91786
Contact: Study Coordinator    909-939-4199      
Island View GI Recruiting
Ventura, California, United States, 93003
Contact: Study Coordinator    805-641-6525      
United States, Colorado
Peak Gastroenterology Associates Recruiting
Colorado Springs, Colorado, United States, 80907
Contact: Study Coordinator    719-362-2270      
Synexus Withdrawn
Colorado Springs, Colorado, United States, 80909
South Denver Gastroenterology, PC Recruiting
Englewood, Colorado, United States, 80113
Contact: Study Coordinator    303-788-8888      
Western States Clinical Research, Inc. Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Study Coordinator    303-573-9951      
United States, Connecticut
Gastroenterology Associates of Fairfield County Recruiting
Bridgeport, Connecticut, United States, 06606
Contact: Study Coordinator    203-333-3328      
Medical Research Center of Connecticut, LLC Not yet recruiting
Hamden, Connecticut, United States, 06518
Yale University - New Haven Recruiting
New Haven, Connecticut, United States, 06520
Contact: Study Coordinator    203-737-6063      
Naugatuck Valley Gastroenterology, LLC - Gen1 Research Recruiting
Prospect, Connecticut, United States, 06712
Contact: Study Coordinator    779-227-3916      
United States, District of Columbia
Medstar Georgetown University Hospital Recruiting
Washington, District of Columbia, United States, 20007
Contact: Study Coordinator    202-444-1085      
United States, Florida
Innovative Medical Research of South Florida, Inc. Recruiting
Aventura, Florida, United States, 33180
Contact: Study Coordinator    305-759-1881      
Xera Med Research Recruiting
Boca Raton, Florida, United States, 33478
Contact: Study Coordinator    561-962-5065      
Gastroenterology Consultants of Clearwater Recruiting
Clearwater, Florida, United States, 33756-3839
Contact: Study Coordinator    727-443-7700      
West Central Gatroenterology Recruiting
Clearwater, Florida, United States, 33761
Contact: Study Coordinator    727-347-0005      
All Medical Research, LLC Recruiting
Cooper City, Florida, United States, 33024
Contact: Study Coordinator    754-263-2000      
Hi Tech and Global Research, LLC Recruiting
Coral Gables, Florida, United States, 33134
Contact: Study Coordinator    786-717-7515      
Top Medical Research, Inc Recruiting
Cutler Bay, Florida, United States, 33189
Contact: Study Coordinator    305-971-6883      
ICR Sites Recruiting
Doral, Florida, United States, 33166
Contact: Study Coordinator    305-552-7660      
Qway Research, LLC Recruiting
Hialeah, Florida, United States, 33010
Contact: Study Coordinator    305-884-0134      
Direct Helpers Research Center Recruiting
Hialeah, Florida, United States, 33012
Contact: Study Coordinator    305-828-3555      
Palmetto Research, LLC Recruiting
Hialeah, Florida, United States, 33016
Contact: Study Coordinator    305-728-4974      
Gastroenterology Associates - Crystal River Recruiting
Inverness, Florida, United States, 34452
Contact: Study Coordinator    352-341-2100      
Mayo Clinic College of Medicine Recruiting
Jacksonville, Florida, United States, 32224
Contact: Study Coordinator    901-953-0614      
SIH Research LLC Recruiting
Kissimmee, Florida, United States, 34741
Contact: Study Coordinator    209-485-8181      
Meridien Research Recruiting
Lakeland, Florida, United States, 33805
Contact: Study Coordinator    941-747-7900      
Florida Digestive Health Specialists Recruiting
Lakewood Ranch, Florida, United States, 34211
Contact: Study Coordinator    800-844-9302      
Meridien Research Recruiting
Maitland, Florida, United States, 32751
Contact: Study Coordinator    407-644-1165      
Southwest Gastroenterology Recruiting
Maitland, Florida, United States, 32751
Contact: Study Coordinator    303-250-2012      
San Marcus Research Clinic Recruiting
Miami Lakes, Florida, United States, 33014
Contact: Study Coordinator    305-424-7420      
Clinical Pharmacology of Miami, LLC Recruiting
Miami, Florida, United States, 33014
Contact: Study Coordinator    305-817-2900      
Bruce W. Carter Department of Veterans Affairs Medical Center Recruiting
Miami, Florida, United States, 33125
Contact: Study Coordinator    305-575-7000 ext Ext. 4640      
Optimus U Corporation Recruiting
Miami, Florida, United States, 33125
Contact: Study Coordinator    305-702-0024      
University of Miami Hospital Recruiting
Miami, Florida, United States, 33136
Contact: Study Coordinator    305-689-1800 ext 2      
Invictus Clinical Research Group LLC Recruiting
Miami, Florida, United States, 33144
Contact: Study Coordinator    305-961-1180      
Regenerate Clinical Trials Recruiting
Miami, Florida, United States, 33155-6553
Contact: Study Coordinator    786-631-3890      
Gastroenterology Associates of Western Colorado Recruiting
Miami, Florida, United States, 33157
Contact: Study Coordinator    970-245-0990      
Sanchez Clinical Research, Inc Recruiting
Miami, Florida, United States, 33157
Contact: Study Coordinator    305-234-9484      
Genoma Research Group Inc. Recruiting
Miami, Florida, United States, 33165
Contact: Study Coordinator    305-392-1264      
Medical Professional Clinical Research Center, INC Recruiting
Miami, Florida, United States, 33165
Contact: Study Coordinator    786-801-1360      
Clinical Research Associates of South Florida Recruiting
Miami, Florida, United States, 33172
Contact: Study Coordinator    305-887-2252      
ProLive Medical Research Recruiting
Miami, Florida, United States, 33175
Contact: Study Coordinator    305-221-8001      
Med Research of Florida, LLC Not yet recruiting
Miami, Florida, United States, 33186
Advanced Research Institute, Inc. Recruiting
New Port Richey, Florida, United States, 34653
Contact: Study Coordinator    727-835-3261      
Orlando Immunology Center Terminated
Orlando, Florida, United States, 32803
Bioclinical Research Alliance Recruiting
Orlando, Florida, United States, 32806
Contact: Study Coordinator    407-426-9266      
Omega Research Maitland, LLC Recruiting
Orlando, Florida, United States, 32810
Contact: Study Coordinator    407-988-1075      
Innovation Medical Research Center Recruiting
Palmetto Bay, Florida, United States, 33157
Contact: Study Coordinator    305-300-2695      
Gastroenterology Associates of Pensacola Recruiting
Pensacola, Florida, United States, 32503
Contact: Study Coordinator    850-324-5361      
Advanced Medical Research Recruiting
Port Orange, Florida, United States, 32127
Contact: Study Coordinator    386-767-8800      
Advanced Research Institute, Inc Recruiting
Saint Petersburg, Florida, United States, 33710
Contact: Study Coordinator    727-835-3261      
Sensible Healthcare Recruiting
Summerfield, Florida, United States, 34491
Contact: Study Coordinator    407-654-2724      
Tampa General Hospital Recruiting
Tampa, Florida, United States, 33606
Contact: Study Coordinator    813-844-5690      
AdventHealth Tampa Recruiting
Tampa, Florida, United States, 33613
Contact: Study Coordinator    813-615-7068      
Guardian Angel Research Center Recruiting
Tampa, Florida, United States, 33614
Contact: Study Coordinator    813-512-7479      
Gastro Florida Recruiting
Tampa, Florida, United States, 33626
Contact: Study Coordinator    727-443-7700      
Bioclinica Research Recruiting
The Villages, Florida, United States, 32162
Contact: Study Coordinator    352-261-0904      
South Florida Center of Gastroenterology, PA Terminated
Wellington, Florida, United States, 33414
Cleveland Clinic Florida Not yet recruiting
Weston, Florida, United States, 33331
Florida Medical Clinic Recruiting
Zephyrhills, Florida, United States, 33542
Contact: Study Coordinator    813-780-8368      
United States, Georgia
Summit Clinical Research, LLC Recruiting
Athens, Georgia, United States, 30607
Contact: Study Coordinator    706-400-4262      
Consultative Gastroenterology Recruiting
Atlanta, Georgia, United States, 30308
Contact: Study Coordinator    404-881-8800      
Digestive Healthcare of Georgia - Atlanta Recruiting
Atlanta, Georgia, United States, 30309
Contact: Study Coordinator    404-355-3200      
Piedmont Healthcare Recruiting
Atlanta, Georgia, United States, 30309
Contact: Study Coordinator    404-605-2615      
WellStar Health System Not yet recruiting
Atlanta, Georgia, United States, 30312
Gastroenterology Associates of Central Georgia Recruiting
Macon, Georgia, United States, 31201
Contact: Study Coordinator    478-742-2040      
GI Specialists of Georgia - Marietta Office Recruiting
Marietta, Georgia, United States, 30060
Contact: Study Coordinator    678-819-4237      
Infinite Clinical Trials Not yet recruiting
Riverdale, Georgia, United States, 30274
Digestive Disease Specialist, Inc. Recruiting
Snellville, Georgia, United States, 30078
Contact: Study Coordinator    405-702-1246      
United States, Idaho
Grand Teton Research Group, PLLC Recruiting
Idaho Falls, Idaho, United States, 83404
Contact: Study Coordinator    208-528-4256      
United States, Illinois
Northwestern University Recruiting
Chicago, Illinois, United States, 60611
Contact: Study Coordinator    312-695-4837      
Rush University Medical Center Recruiting
Chicago, Illinois, United States, 60612
Contact: Study Coordinator    312-942-8910      
RxClinicals Recruiting
Crystal Lake, Illinois, United States, 60012
Contact: Study Coordinator    773-979-1096      
Georgia Clinical Research LLC Recruiting
New Lenox, Illinois, United States, 60451
Contact: Study Coordinator    678-822-5581      
Carle Foundation Hospital Recruiting
Urbana, Illinois, United States, 61801
Contact: Study Coordinator    217-383-4011      
Endoscopy Center of the North Shore LLC Recruiting
Wilmette, Illinois, United States, 60091
Contact: Study Coordinator    303-250-2012      
United States, Indiana
Investigators Research Group, LLC Recruiting
Brownsburg, Indiana, United States, 46112
Contact: Study Coordinator    317-852-8280      
Indianapolis Gastroenterology Research Foundation Recruiting
Indianapolis, Indiana, United States, 46143
Contact: Study Coordinator    317-865-2959      
Aquiant Research Recruiting
New Albany, Indiana, United States, 47150
Contact: Study Coordinator    812-945-0145 ext Ext. 134      
Digestive Research Alliance of Michiana Recruiting
South Bend, Indiana, United States, 46635
Contact: Study Coordinator    574-239-1576      
United States, Iowa
Iowa Digestive Disease Center Recruiting
Clive, Iowa, United States, 50325
Contact: Study Coordinator    515-225-6050      
University of Iowa Hospitals and Clinics Recruiting
Iowa City, Iowa, United States, 52242
Contact: Study Coordinator    319-338-0581      
United States, Kansas
University of Kansas Medical Center Recruiting
Kansas City, Kansas, United States, 66160
Contact: Study Coordinator    913-588-3708      
Kansas Medical Clinic-Gastroenterology Recruiting
Topeka, Kansas, United States, 66606
Contact: Study Coordinator    785-354-8518      
United States, Kentucky
University of Louisville Physicians - University Medical Associates (UMA) Recruiting
Louisville, Kentucky, United States, 40202
Contact: Study Coordinator    502-852-2906      
United States, Louisiana
Delta Research Partners, LLC Recruiting
Bastrop, Louisiana, United States, 71220
Contact: Study Coordinator    318-283-2177      
Gastroenterology Associates of Central Georgia Recruiting
Bastrop, Louisiana, United States, 71220
Avant Research Associates LLC Recruiting
Crowley, Louisiana, United States, 70526
Contact: Study Coordinator    337-942-7390      
Centex Studies, Inc. Recruiting
Lake Charles, Louisiana, United States, 70601
Contact: Study Coordinator    337-433-3441      
Tandem Clinical Research Recruiting
Marrero, Louisiana, United States, 70072
Contact: Study Coordinator    504-934-8424      
New Orleans Research Institute Recruiting
Metairie, Louisiana, United States, 70006
Contact: Study Coordinator    504-456-8020      
Tulane University School of Medicine Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Study Coordinator    504-988-3047      
Ochsner Medical Center Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Study Coordinator    504-842-3925      
Nola Research Works, LLC Recruiting
New Orleans, Louisiana, United States, 70125
Contact: Study Coordinator    504-891-3613      
Louisiana Research Center Recruiting
Shreveport, Louisiana, United States, 71105
Contact: Study Coordinator    318-213-3453      
Clinical Trials of America LA LLC Recruiting
West Monroe, Louisiana, United States, 71291
Contact: Study Coordinator    318-716-3113      
United States, Maryland
Mercy Medical Center Recruiting
Baltimore, Maryland, United States, 21202
Contact: Study Coordinator    410-332-9505      
Johns Hopkins University Recruiting
Baltimore, Maryland, United States, 21205
Contact: Study Coordinator    410-614-3530      
Walter Reed National Military Medical Center Withdrawn
Bethesda, Maryland, United States, 20889
Digestive Disease Associates Recruiting
Catonsville, Maryland, United States, 21228
Contact: Study Coordinator    410-247-7500      
Chevy Chase Clinical Research Terminated
Chevy Chase, Maryland, United States, 20815
Gastro Center of Maryland Recruiting
Columbia, Maryland, United States, 21045
Contact: Study Coordinator    410-290-6677 ext 27      
Woodholme Gastroenterology - Severn Recruiting
Glen Burnie, Maryland, United States, 21061
Contact: Study Coordinator    410-602-7782 ext ext. 175      
Victory Clinical Research Recruiting
Greenbelt, Maryland, United States, 20770
Contact: Study Coordinator    301-728-5004      
United States, Massachusetts
Massachusetts General Hospital Recruiting
Boston, Massachusetts, United States, 02114
Contact: Study Coordinator    617-724-0972      
Boston Medical Center Active, not recruiting
Boston, Massachusetts, United States, 02118
Beth Israel Deaconess Medical Center Recruiting
Boston, Massachusetts, United States, 02215
Contact: Study Coordinator    617-632-1086      
Commonwealth Clinical Studies Withdrawn
Brockton, Massachusetts, United States, 02302
Lahey Hospital & Medical Center Recruiting
Burlington, Massachusetts, United States, 01805
Contact: Study Coordinator    781-744-3367      
The Research Institute Recruiting
Springfield, Massachusetts, United States, 01105
Contact: Study Coordinator    413-747-5566      
Umass Memorial Medical Center Recruiting
Worcester, Massachusetts, United States, 01655
Contact: Study Coordinator    508-856-5275      
United States, Michigan
Henry Ford Health System Recruiting
Detroit, Michigan, United States, 48202
Contact: Study Coordinator    313-916-5960      
United States, Minnesota
Minnesota Gastroenterology Recruiting
Maplewood, Minnesota, United States, 55117
Contact: Study Coordinator    216-526-4444      
United States, Mississippi
National Diabetes and Obesity Research Institute Recruiting
Biloxi, Mississippi, United States, 39532
Contact: Study Coordinator    512-717-8610      
GastroIntestinal Associates Recruiting
Flowood, Mississippi, United States, 39232
Contact: Study Coordinator    601-863-0395      
University of Mississippi Medical Center Recruiting
Jackson, Mississippi, United States, 39216
Contact: Study Coordinator    601-815-5180      
United States, Missouri
Clinical Research Professionals Recruiting
Creve Coeur, Missouri, United States, 63141
Kansas City Veterans Affairs Medical Center Not yet recruiting
Kansas City, Missouri, United States, 64128
Saint Louis University Recruiting
Saint Louis, Missouri, United States, 63104
Contact: Study Coordinator    314-977-9410      
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Study Coordinator    314-474-1915      
United States, Nebraska
CHI Health Research Recruiting
Omaha, Nebraska, United States, 68128
Contact: Study Coordinator    402-343-8512      
United States, Nevada
Synexus Clinical Research/ Rita Chuang, MD Withdrawn
Henderson, Nevada, United States, 89052
Machuca Family Medicine Recruiting
Las Vegas, Nevada, United States, 89104
Contact: Study Coordinator    702-234-1691      
Jubilee Clinical Research, Inc. Recruiting
Las Vegas, Nevada, United States, 89106
Contact: Study Coordinator    702-631-5000      
Sierra Clinical Research Recruiting
Las Vegas, Nevada, United States, 89106
Contact: Study Coordinator    702-909-0217      
Excel Clinical Research Recruiting
Las Vegas, Nevada, United States, 89109
Contact: Study Coordinator    702-680-1500      
Las Vegas Medical Research Recruiting
Las Vegas, Nevada, United States, 89113
Contact: Study Coordinator    702-750-0222 ext Ext. 105      
Advanced Biomedical Research of America Recruiting
Las Vegas, Nevada, United States, 89123
Contact: Study Coordinator    702-898-2088      
Digestive Disease Specialist Recruiting
Las Vegas, Nevada, United States, 89128
Contact: Study Coordinator    702-371-7256      
United States, New Hampshire
Dartmouth Hitchcock Medical Center Recruiting
Lebanon, New Hampshire, United States, 03756
Contact: Study Coordinator    603-650-7890      
United States, New Jersey
Hassman Research Institute Recruiting
Berlin, New Jersey, United States, 08009
Contact: Study Coordinator    856-753-7335      
Garden State Endocrinology LLC Recruiting
Brick, New Jersey, United States, 08723
Contact: Study Coordinator    732-686-9144      
AGA Clinical Research Associates, LLC Recruiting
Egg Harbor Township, New Jersey, United States, 08234
Contact: Study Coordinator    609-407-1220      
Amici Clinical Research Recruiting
Martinsville, New Jersey, United States, 08836
Contact: Study Coordinator    732-369-3480      
Rutgers University New Jersey Medical School Not yet recruiting
Newark, New Jersey, United States, 07103
Coastal Healthcare Recruiting
Ocean Township, New Jersey, United States, 07712
Contact: Study Coordinator    732-776-2416      
United States, New York
New York Clinical Trials Recruiting
Brooklyn, New York, United States, 11201
Contact: Study Coordinator    516-545-0951      
New York Methodist Hospital Recruiting
Brooklyn, New York, United States, 11215
Contact: Study Coordinator    718-780-3851      
The State University of New York, University at Buffalo Recruiting
Buffalo, New York, United States, 14201
Contact: Study Coordinator    716-847-2441 ext 1837      
Sing Chan, MD Recruiting
Flushing, New York, United States, 11355
Contact: Study Coordinator    718-886-6292      
United Health Services Hospitals, Inc Recruiting
Johnson City, New York, United States, 13790
Digestive Disease Specialist Recruiting
New Hyde Park, New York, United States, 11040
Contact: Study Coordinator    512-717-8610      
Beth Israel Medical Center Recruiting
New York, New York, United States, 10003
Contact: Study Coordinator    603-277-1445      
Concorde Medical Group Withdrawn
New York, New York, United States, 10016
NYU Langone Health - Perlmutter Cancer Center Recruiting
New York, New York, United States, 10016
Contact: Study Coordinator    212-263-3643      
Weill Cornell Medical College Recruiting
New York, New York, United States, 10021
Contact: Study Coordinator    212-746-5454      
Mount Sinai Medical Center Recruiting
New York, New York, United States, 10029
Contact: Study Coordinator    212-659-9519      
Tandem Clinical Research Recruiting
New York, New York, United States, 10033
Contact: Study Coordinator         
Digestive Disease Associates of Rockland - Gen1 Research Recruiting
Pomona, New York, United States, 10970
Contact: Study Coordinator    303-250-2012      
New York Medical College Recruiting
Valhalla, New York, United States, 10595
Contact: Study Coordinator    914-493-7337      
United States, North Carolina
The University of North Carolina at Chapel Hill Recruiting
Chapel Hill, North Carolina, United States, 27599
Contact: Study Coordinator    919-843-5936      
Carolinas Medical Center Recruiting
Charlotte, North Carolina, United States, 28204
Contact: Study Coordinator    704-446-4862      
Northeast GI Research Division Recruiting
Concord, North Carolina, United States, 28027
Contact: Study Coordinator    980-565-9915      
Duke University Recruiting
Durham, North Carolina, United States, 27710
Contact: Study Coordinator    919-684-8111      
Cumberland Research Associates, LLC Recruiting
Fayetteville, North Carolina, United States, 28304
Contact: Study Coordinator    910-484-8163      
Carolina Research Recruiting
Greenville, North Carolina, United States, 27834
Contact: Study Coordinator    252-758-8181      
High Point Clinical Trials Center Withdrawn
High Point, North Carolina, United States, 27265
Wake Research Associates Recruiting
Raleigh, North Carolina, United States, 27612
Contact: Study Coordinator    919-781-2514      
PMG Research of Winston-Salem Recruiting
Winston-Salem, North Carolina, United States, 27103
Contact: Study Coordinator    336-768-8062      
United States, Ohio
Consultants for Clinical Research Recruiting
Cincinnati, Ohio, United States, 45219
Contact: Study Coordinator    513-872-4549      
Consultants for Clinical Research Recruiting
Cincinnati, Ohio, United States, 45249
Contact: Study Coordinator    513-751-6667      
MetroHealth Medical Center Recruiting
Cleveland, Ohio, United States, 44109
Contact: Study Coordinator    216-778-5278      
Endocrinology Research Associates Recruiting
Columbus, Ohio, United States, 43201
Contact: Study Coordinator    614-824-5865      
The Ohio University - Gastroenterology, Hepatology Recruiting
Columbus, Ohio, United States, 43210
Contact: Study Coordinator    614-366-6199      
Gastroenterology Research of Lima Not yet recruiting
Lima, Ohio, United States, 45806
Paramount Medical Research & Consulting, LLC Recruiting
Middleburg Heights, Ohio, United States, 44130
Contact: Study Coordinator    440-826-0742      
United States, Oklahoma
IMIC, Inc. Recruiting
Oklahoma City, Oklahoma, United States, 73112
Contact: Study Coordinator    786-310-7477      
Integris Baptist Medical Center Recruiting
Oklahoma City, Oklahoma, United States, 73112
Contact: Study Coordinator    405-713-7432      
Options Health Research Recruiting
Tulsa, Oklahoma, United States, 74104
Contact: Study Coordinator    918-513-3490      
Gastroenterology Specialists, Inc. Recruiting
Tulsa, Oklahoma, United States, 74135
Contact: Study Coordinator    918-743-4002      
Adult Gastroenterology Associates-Gen1 Research Recruiting
Tulsa, Oklahoma, United States, 74136
Contact: Study Coordinator    303-250-2012      
United States, Pennsylvania
Main Line Gastroenterology Associates, P.C. Not yet recruiting
Bala-Cynwyd, Pennsylvania, United States, 19004
Eastern Pennsylvania Gastroenterology and Liver Specialist Recruiting
Bethlehem, Pennsylvania, United States, 18017
Contact: Study Coordinator    610-433-4100      
UPMC -Center for Liver Diseases Recruiting
Pittsburgh, Pennsylvania, United States, 15213
Contact: Study Coordinator    412-802-6700      
VA Pittsburgh Healthcare System Recruiting
Pittsburgh, Pennsylvania, United States, 15240
Contact: Study Coordinator    412-480-6109      
Care Access Research, Pottsville Recruiting
Pottsville, Pennsylvania, United States, 17901
Contact: Study Coordinator    570-478-5120      
Digestive Disease Associates, LTD Recruiting
Wyomissing, Pennsylvania, United States, 19610
Contact: Study Coordinator    610-374-4401 ext Ext. 142      
United States, Rhode Island
Partners in Clinical Research Recruiting
Cumberland, Rhode Island, United States, 02864
Contact: Study Coordinator    401-658-2305      
University Medical Group Recruiting
North Providence, Rhode Island, United States, 02908
Contact: Study Coordinator    401-821-3200 ext 23      
University Gastroenterology Recruiting
Providence, Rhode Island, United States, 02905
Contact: Study Coordinator    401-421-8800      
Care Access Research-Warwick Recruiting
Warwick, Rhode Island, United States, 02886
Contact: Study Coordinator    401-773-7855      
United States, South Dakota
Rapid City Medical Center Recruiting
Rapid City, South Dakota, United States, 57701
Contact: Study Coordinator    605-721-8414      
United States, Tennessee
Mount Vernon Clinical Research Recruiting
Chattanooga, Tennessee, United States, 37421
Contact: Study Coordinator    423-698-4584      
Gastro One Recruiting
Germantown, Tennessee, United States, 38138
Contact: Study Coordinator    901-820-0090      
Digestive Health Research Recruiting
Hermitage, Tennessee, United States, 37076
Contact: Study Coordinator    615-499-4740      
East Tennessee Research Institute Recruiting
Johnson City, Tennessee, United States, 37604
Contact: Study Coordinator    423-578-1530      
GIA Clinical Trials LLC Recruiting
Knoxville, Tennessee, United States, 37909
Contact: Study Coordinator    865-588-5121      
Digestive Health Research Recruiting
Lebanon, Tennessee, United States, 37090
Contact: Study Coordinator    615-499-4740      
UT-Memphis, Methodist University Hospital Recruiting
Memphis, Tennessee, United States, 38104
Contact: Study Coordinator    901-448-2232      
Vanderbilt University Recruiting
Nashville, Tennessee, United States, 37232-5280
Contact: Study Coordinator    615-936-1571      
United States, Texas
Texas Clinical Research Institute Recruiting
Arlington, Texas, United States, 76012
Contact: Study Coordinator    817-471-1070      
Avant Research Associates Recruiting
Austin, Texas, United States, 78704
Contact: Study Coordinator    512-814-6038      
Clinical Trials of Texas Inc Recruiting
Austin, Texas, United States, 78733
Contact: Study Coordinator    210-949-0122      
Austin Center for Clinical Research Terminated
Austin, Texas, United States, 78758
Trinity Universal Research Associates, Inc Recruiting
Carrollton, Texas, United States, 75007
Contact: Study Coordinator    214-793-8341      
Methodist Dallas Medical Center Recruiting
Dallas, Texas, United States, 75203
Contact: Study Coordinator    214-947-4450      
Dallas Diabetes Research Center Recruiting
Dallas, Texas, United States, 75230
Contact: Study Coordinator    972-566-8631      
Meritus Center for Clinical Research Recruiting
Dallas, Texas, United States, 75230
Contact: Study Coordinator    301-665-4608      
Liver Center of Texas Recruiting
Dallas, Texas, United States, 75234
Contact: Study Coordinator    214-250-8201      
Synexus Withdrawn
Dallas, Texas, United States, 75234
Southwest Family Medicine Associates Recruiting
Dallas, Texas, United States, 75235
Contact: Study Coordinator    214-393-2940      
University of Texas Southwestern Medical Center Recruiting
Dallas, Texas, United States, 75390-8887
Contact: Study Coordinator    214-645-6216      
San Antonio Military Medical Center Recruiting
Fort Sam Houston, Texas, United States, 78234
Contact: Study Coordinator    210-916-9073      
Baylor Scott & White All Saints Medical Center - Ft. Worth Recruiting
Fort Worth, Texas, United States, 76104
Contact: Study Coordinator    817-912-8763      
Texas Digestive Disease Consultants - Fort Worth Recruiting
Fort Worth, Texas, United States, 76104
Contact: Study Coordinator    817-922-9968      
Therapeutic Concepts, PA Recruiting
Houston, Texas, United States, 77004
Contact: Study Coordinator    713-526-9821      
Liver Associates of Texas Recruiting
Houston, Texas, United States, 77030-3002
Contact: Study Coordinator    713-799-2667      
Baylor College of Medicine Recruiting
Houston, Texas, United States, 77030
Contact: Study Coordinator    713-798-5382      
Michael E. DeBakey VA Medical Center (MEDVAMC) Recruiting
Houston, Texas, United States, 77030
Contact: Study Coordinator    281-788-5112      
St. Luke's Medical Center Recruiting
Houston, Texas, United States, 77030
Contact: Study Coordinator    832-355-1400      
Biopharma Informatic, LLC Recruiting
Houston, Texas, United States, 77043
Contact: Study Coordinator    281-768-5879      
Centex Studies Recruiting
Houston, Texas, United States, 77058
Contact: Study Coordinator    281-282-0808      
Biopharma Informatic, LLC Recruiting
Houston, Texas, United States, 77084
Contact: Study Coordinator    281-944-3610      
Amir A. Hassan, MD, PA Recruiting
Houston, Texas, United States, 77089
Contact: Study Coordinator    281-944-3610      
Pioneer Research Solutions, Inc. Recruiting
Houston, Texas, United States, 77099
Contact: Study Coordinator    713-333-9323      
GI Specialists of Houston Recruiting
Humble, Texas, United States, 77346
Contact: Study Coordinator    832-930-0342      
Pinnacle Clinical Research Terminated
Live Oak, Texas, United States, 78233
Rio Grande Gastroenterology Recruiting
McAllen, Texas, United States, 78503
Contact: Study Coordinator    956-661-9300      
Centex Studies, Inc. Recruiting
McAllen, Texas, United States, 78504
Contact: Study Coordinator    832-993-4546      
LinQ Research, LLC Recruiting
Pearland, Texas, United States, 77584
Contact: Study Coordinator    713-366-2922      
ClinRx Research LLC Recruiting
Plano, Texas, United States, 75024
Contact: Study Coordinator    214-680-9321      
Synexus Clinical Research Not yet recruiting
Plano, Texas, United States, 75093
Digestive Health Associates of Texas-Rockwall Recruiting
Richardson, Texas, United States, 75082
Contact: Study Coordinator    972-265-8201      
American Research Corporation Recruiting
San Antonio, Texas, United States, 77030
Contact: Study Coordinator         
Quality Research Inc. Recruiting
San Antonio, Texas, United States, 78209
Contact: Study Coordinator    210-824-5678      
American Research Corporation Recruiting
San Antonio, Texas, United States, 78215
Contact: Study Coordinator    210-253-3426      
San Antonio Premier Internal Medicine Recruiting
San Antonio, Texas, United States, 78220
Contact: Study Coordinator    210-323-6303      
Diabetes & Glandular Disease Clinic, P.A. (DGD) Recruiting
San Antonio, Texas, United States, 78229
Contact: Study Coordinator    210-614-8612      
Endeavor Clinical Trials, LLC Recruiting
San Antonio, Texas, United States, 78229
Contact: Study Coordinator    210-949-0807      
Sagact Pllc Recruiting
San Antonio, Texas, United States, 78229
Contact: Study Coordinator    210-581-2812      
Synexus Withdrawn
San Antonio, Texas, United States, 78229
Anson Medicine Recruiting
San Antonio, Texas, United States, 78260
Contact: Study Coordinator    830-484-8019      
Texas Digestive Disease Consultants Not yet recruiting
Southlake, Texas, United States, 76092
Gastrointestinal and Liver disease consultants Recruiting
Sugar Land, Texas, United States, 77479
Contact: Study Coordinator    713-715-6410      
Mount Olympus Medical Research, LLC Recruiting
Sugar Land, Texas, United States, 77479
Contact: Study Coordinator    832-805-1197      
Texas Digestive Disease Consultants Recruiting
Webster, Texas, United States, 77598
Contact: Study Coordinator    832-905-5001      
Wichita Falls Gastroenterology Withdrawn
Wichita Falls, Texas, United States, 76301
United States, Utah
Physician's Research Options, LLC Recruiting
Draper, Utah, United States, 84020
Contact: Study Coordinator    801-352-9228      
Wasatch Peak Family Practice Withdrawn
Layton, Utah, United States, 84041
Intermountain Medical Center Recruiting
Murray, Utah, United States, 84107
Contact: Study Coordinator    801-507-3380      
Care Access Research, LLC Recruiting
Ogden, Utah, United States, 84403
Contact: Study Coordinator    385-474-6935      
Advanced Clinical Research - Center for Digestive Health Recruiting
Riverton, Utah, United States, 84065
Contact: Study Coordinator    801-542-8190      
Care Access Research LLC Recruiting
Salt Lake City, Utah, United States, 84124
Contact: Study Coordinator    385-474-6935      
University of Utah Recruiting
Salt Lake City, Utah, United States, 84132
Contact: Study Coordinator    801-587-3995      
United States, Virginia
University of Virginia Health Systems Not yet recruiting
Charlottesville, Virginia, United States, 22908
Gastroenterology Associates of Northern Virginia Recruiting
Fairfax, Virginia, United States, 22031-4652
Contact: Study Coordinator    703-776-1795      
Inova Fairfax Medical Campus Recruiting
Falls Church, Virginia, United States, 22042
Contact: Study Coordinator    703-776-3592      
Liver Institute of Virginia Recruiting
Newport News, Virginia, United States, 23602
Contact: Study Coordinator    804-977-8920      
Digestive and Liver Disease Specialists Recruiting
Norfolk, Virginia, United States, 23502
Contact: Study Coordinator    757-466-0165      
McGuire Veterans Affairs Medical Center Recruiting
Richmond, Virginia, United States, 23249
Contact: Study Coordinator    804-675-6407      
VCU Medical Center Recruiting
Richmond, Virginia, United States, 23298
Contact: Study Coordinator    804-828-6314      
Digestive Disease Care PC Recruiting
Roanoke, Virginia, United States, 24014
Contact: Study Coordinator    516-437-9000      
Gastroenterology Consultants of Southwest Virginia Recruiting
Roanoke, Virginia, United States, 24014
Contact: Study Coordinator    540-206-2899      
United States, Washington
Washington Gastroenterology Recruiting
Bellevue, Washington, United States, 98004
Contact: Study Coordinator    425-452-8547      
Virginia Mason Hospital Recruiting
Seattle, Washington, United States, 98101
Contact: Study Coordinator    206-223-2319      
Harborview Medical Center Recruiting
Seattle, Washington, United States, 98104
Contact: Study Coordinator    206-744-3402      
Swedish Medical Center Recruiting
Seattle, Washington, United States, 98104
Contact: Study Coordinator    206-386-6215      
University of Washington Medical Center Recruiting
Seattle, Washington, United States, 98195
Contact: Study Coordinator    206-598-7087      
United States, West Virginia
Marshall University Department of Clinical and Translational Sciences Recruiting
Huntington, West Virginia, United States, 25701
Contact: Study Coordinator    304-691-1840      
United States, Wisconsin
University of Wisconsin Hospital and Clinics Not yet recruiting
Madison, Wisconsin, United States, 53792-7375
Froedtert Hospital Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Study Coordinator    414-805-1010      
Argentina
Hospital Italiano de Buenos Aires Recruiting
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1199ABB
Contact: Study Coordinator    541149590200 ext 5174      
Centro de Hepatologia S.A. Recruiting
La Plata, Buenos Aires, Argentina, B1902AWL
Contact: Study Coordinator    +542214838537      
Hospital Universitario Austral Recruiting
Pilar, Buenos Aires, Argentina, B1629AHJ
Contact: Study Coordinator    +54230442881      
DIM Clinica Privada Recruiting
Ramos Mejia, Buenos Aires, Argentina, B1704ETD
Contact: Study Coordinator    +541146562828      
Hospital Provincial del Centenario Not yet recruiting
Rosario, Santa Fe, Argentina, 2000
Australia, New South Wales
Royal Prince Alfred Hospital Recruiting
Camperdown, New South Wales, Australia, 2050
Contact: Study Coordinator    +61295156006      
Nepean Hospital Withdrawn
Kingswood, New South Wales, Australia, 2747
Saint George Hospital Recruiting
Kogarah, New South Wales, Australia, 2217
Contact: Study Coordinator    +61291131023      
Australia, Queensland
Gallipoli Medical Research Foundation Recruiting
Greenslopes, Queensland, Australia, 4120
Contact: Study Coordinator    +61733946752      
Royal Brisbane and Women's Hospital Recruiting
Herston, Queensland, Australia, 4029
Contact: Study Coordinator    +61736461757      
Australia, South Australia
Royal Adelaide Hospital Recruiting
Adelaide, South Australia, Australia, 5000
Contact: Study Coordinator    +61870742190      
Flinders Medical Center Recruiting
Bedford Park, South Australia, Australia, 5042
Contact: Study Coordinator    +610882045511      
Australia, Victoria
Monash Medical Centre Recruiting
Clayton, Victoria, Australia, 3168
Contact: Study Coordinator    +61385722571      
Austin Health Recruiting
Heidelberg, Victoria, Australia, 3084
Contact: Study Coordinator    +61394965582      
Australia, Western Australia
Royal Perth Hospital Recruiting
Perth, Western Australia, Australia, 6000
Contact: Study Coordinator    +61892242186      
Austria
Medizinische Universität Graz Recruiting
Graz, Styria, Austria, 8036
Contact: Study Coordinator    +43031638514388      
Medizinische Universität Innsbruck Recruiting
Innsbruck, Tyrol, Austria, 6020
Contact: Study Coordinator    +4305050423539      
Klinikum Wels-Grieskirchen Recruiting
Wels, Upper Austria, Austria, 4600
Contact: Study Coordinator    +4306763144204      
Wilhelminenspital der Stadt Wien Recruiting
Wien, Vienna, Austria, A-1160
Contact: Study Coordinator    +431491502401      
Belgium
Universitair Ziekenhuis Antwerpen Recruiting
Edegem, Antwerpen, Belgium, 2650
Contact: Study Coordinator    +3238213324      
Algemeen Ziekenhuis Maria Middelares Recruiting
Gent, Oost-Vlaanderen, Belgium, 9000
Contact: Study Coordinator    +32 9 246 71 41      
Universitair Ziekenhuis Gent Recruiting
Gent, Oost-Vlaanderen, Belgium, 9000
Contact: Study Coordinator    +3293324870      
Hôpital Erasme Recruiting
Brussels, Belgium, 1070
Contact: Study Coordinator    +3225553111      
Cliniques Universitaires Saint-Luc Recruiting
Brussels, Belgium, 1200
Contact: Study Coordinator    +3227642823      
Centre Hospitalier Chretien CHC Recruiting
Liege, Belgium, 4000
Contact: Study Coordinator    +3242248588      
Brazil
Hospital Universitário Professor Edgard Santos Withdrawn
Salvador, Bahia, Brazil, 40110-060
Hospital São Rafael-Monte Tabor Recruiting
Salvador, Bahia, Brazil, 41253-190
Contact: Study Coordinator    557132816464      
Instituto Goiano de Gastroenterologia e Endoscopia Digestiva Withdrawn
Goiânia, Goias, Brazil, 74535-170
Hospital das Clínicas da Universidade Federal de Minas Gerais Recruiting
Belo Horizonte, Minas Gerais, Brazil, 30130-100
Contact: Study Coordinator    +553134099746      
Hospital Universitário Gafrée e Guinle Withdrawn
Tijuca, Rio De Janeiro, Brazil, 20270-004
Irmandade da Santa Casa de Misericórdia de Porto Alegre Withdrawn
Porto Alegre, Rio Grande Do Sul, Brazil, 91350-200
Hospital das Clínicas da Faculdade de Medicina da Riberao Preto da Universidade de São Paulo Recruiting
Ribeirão Preto, Sao Paulo, Brazil, 14048-900
Contact: Study Coordinator    551636022760      
Faculdade de Medicina de São José do Rio Preto Hospital de Base Recruiting
São José do Rio Preto, Sao Paulo, Brazil, 15090-000
Contact: Study Coordinator    551732015054      
UNIFESP Universidade Federal De São Paulo Withdrawn
São Paulo, Sao Paulo, Brazil, 04040-003
Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro Recruiting
Rio de Janeiro, Brazil, 21941-913
Contact: Study Coordinator    55 21 9 9473-8592      
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo Recruiting
Sao Paulo, Brazil, 05403-000
Contact: Study Coordinator    +551130617301      
Canada, Alberta
University of Calgary Liver Unit Recruiting
Calgary, Alberta, Canada, T2N 4Z6
Contact: Study Coordinator    1 (403) 220-8966      
Bailey Health Clinic Recruiting
Edmonton, Alberta, Canada, T5H 4B9
Contact: Study Coordinator    1 (780) 429-3050      
Canada, British Columbia
Liver and Intestinal Research Centre Recruiting
Vancouver, British Columbia, Canada, V5Z 1H2
Contact: Study Coordinator    1 (604) 876-5122 ext Ext. 2227      
Vancouver General Hospital Recruiting
Vancouver, British Columbia, Canada, V5Z 1M9
Contact: Study Coordinator    1 (604) 875-5223      
GI Research (GIRI) Withdrawn
Vancouver, British Columbia, Canada, V6Z 2K5
Canada, Ontario
William Osler Health Centre, Brampton Memorial Hospital Campus Recruiting
Brampton, Ontario, Canada, L6R 3J7
Contact: Study Coordinator    905-494-2120 ext Ext. 57994      
London Health Sciences Centre University Hospital Withdrawn
London, Ontario, Canada, N6A 5A5
Ottawa Hospital Not yet recruiting
Ottawa, Ontario, Canada, K1H 8L6
Toronto Liver Centre Recruiting
Toronto, Ontario, Canada, M6H 3M1
Contact: Study Coordinator    1 (416) 652-2512      
Canada, Quebec
Ecogene-21 Recruiting
Chicoutimi, Quebec, Canada, G7H 7K9
Contact: Study Coordinator    418-545-1252      
MUHC Royal Victoria Hospital Not yet recruiting
Montreal, Quebec, Canada, H4A 3J1
Chile
Hospital Universidad Católica de Chile Not yet recruiting
Santiago, Santiago Metropolitan Region, Chile, 8333-0024
Hospital Clinico San Borja Arriaran Withdrawn
Santiago de Chile, Santiago, Chile, 8320000
Centro de Investigaciones Clínicas Viña del Mar Recruiting
Viña del Mar, Valparaiso, Chile, 25240364
Contact: Study Coordinator    56991333780      
France
CHU de Strasbourg Recruiting
Strasbourg cedex, Alsace, France, 67091
Contact: Study Coordinator    +33388116768      
Centre Hospitalier Universitaire Estaing Recruiting
Clermont-Ferrand, Aubergne, France, 63003
Contact: Study Coordinator    +33473750523      
Centre Hospitalier Universitaire de Caen - Hôpital Côte de Nacre Recruiting
Caen, Basse-Normandie, France, 14000
Centre HospitalierUniversitaire de Caen - Hopital Cote de Nacre Recruiting
Caen, Basse-Normandie, France, 14033
Contact: Study Coordinator    +33 2 31 06 45 43      
Hopital Pontchaillou Recruiting
Rennes, Bretagne, France, 35033
Contact: Study Coordinator    +33299284321      
Centre Hospitalier Regional et Universitaire de Besançon Hôpital Jean-Minjoz Recruiting
Besançon cedex, Franche-Comte, France, 25030
Contact: Study Coordinator    +33381668166      
Hôpital Jean Verdier Bondy Recruiting
Bondy, Ile-De-France, France, 93143
Contact: Study Coordinator    +33148026666      
Hôpital Beaujon Withdrawn
Clichy, Ile-De-France, France, 92110
Hôpital Beaujon Active, not recruiting
Clichy, Ile-De-France, France
Centre Hospitalier Universitaire Hopital Henri Mondor Recruiting
Creteil Cedex, Ile-De-France, France, 94010
Contact: Study Coordinator    +33149812111      
Hôpital Saint Antoine Recruiting
Paris Cedex 12, Ile-de-France, France, 75571
Contact: Study Coordinator    +33689981070      
Groupe Hospitalier - Hôpitaux Universitaires Pitie-Salpetriere - Charles-Foix - Pitie-Salpetriere Recruiting
Paris Cedex 13, Ile-De-France, France, 75651
Contact: Study Coordinator    +33142161020      
Centre Médical Odysseum Recruiting
Montpellier cedex 2, Languedoc-Roussillon, France, 34960
CHU de Montpellier Recruiting
Montpellier cedex 5, Languedoc-Roussillon, France, 34295
Contact: Study Coordinator    +33467337504      
Hôpital Dupuytren Recruiting
Limoges, Limousin, France, 87000
Contact: Study Coordinator    +33555056684      
Centre hospitalier universitaire de Poitiers Recruiting
Rouen, Normandie, France, 76031
Contact: Study Coordinator    +33-5-49 44 34 13      
Center Hospitalier Universitaire d'Angers Recruiting
Angers, Pays De La Loire, France, 49000
Contact: Study Coordinator    +33241353637      
CHU Amiens-Picardie Recruiting
Amiens Cedex 1, Picardie, France, 80054
Contact: Study Coordinator    +33322668000      
Centre Hospitalier Universitaire de Nice Hôpital l'Archet Recruiting
Nice Cedex 3, Provence Alpes Cote D'Azur, France, 06202
Contact: Study Coordinator    +33492037777      
Centre Hospitalier Universitaire Grenoble Recruiting
Grenoble Cedex 09, Rhone-Alpes, France, 38043
Contact: Study Coordinator    +33476549414      
Institut Bergonié Recruiting
Bordeaux, France, 33604
Contact: Study Coordinator    +33689981070      
Centre Hospitalier Universitaire de Rouen CHU de Rouen Hopital Charles-Nicolle Recruiting
Poitiers, France, 86021
Contact: Study Coordinator    +33-232 88 66 33      
Germany
Medizinische Universitätsklinik IV (Krehl Klinik) Abt. Gastroenterologie und Infektionskrankhen Recruiting
Heidelberg, Baden-Wuerttemberg, Germany, 69120
Contact: Study Coordinator    +4962215638102      
Universitätsmedizin Mannheim Recruiting
Mannheim, Baden-Wuerttemberg, Germany, 68167
Contact: Study Coordinator    +49 621 3833284      
Universitätsklinikum Tübingen Recruiting
Tübingen, Baden-Wuerttemberg, Germany, 72076
Contact: Study Coordinator    +4970712982723      
Synexus Clinical Research GmbH, Prüfzentrum Frankfurt Recruiting
Frankfurt, Hessen, Germany, 60313
Contact: Study Coordinator    +49 69 247 419 600      
Philipps-Universität und Universitätsklinikum Gießen und Marburg GmbH Recruiting
Marburg, Hessen, Germany, 35043
Contact: Study Coordinator    +49040741034806      
Medizinische Hochschule Hannover Recruiting
Hannover, Niedersachsen, Germany, 30625
Contact: Study Coordinator    +495115323305      
Universität Bonn Recruiting
Bonn, Nordhein-Westfalen, Germany, 53127
Contact: Study Coordinator    +4922828715260      
Gastroenterologische Gemeinschaftspraxis Recruiting
Herne, Nordhein-Westfalen, Germany, 44623
Contact: Study Coordinator    +492323946220      
Uniklinik RWTH Aachen Recruiting
Aachen, Nordrhein-Westfalen, Germany, 52074
Contact: Study Coordinator    +492418035848      
Uniklinik Köln Recruiting
Köln, Nordrhein-westfalen, Germany, 50937
Contact: Study Coordinator    +4922147823344470      
Universitätsmedizin der Johannes Gutenberg Universität Mainz Recruiting
Mainz, Rheinland-Pfalz, Germany, 55131
Contact: Study Coordinator    +4906131172717      
Gemeinschaftspraxis Drs. Denger und Pfitzner Recruiting
Friedrichsthal, Saarland, Germany, 66299
Contact: Study Coordinator    +49689798190      
Universitätsklinikum des Saarlandes Recruiting
Homburg, Saarland, Germany, 66427
Contact: Study Coordinator    +4968411623211      
EUGASTRO GmbH Withdrawn
Leipzig, Sachsen, Germany, 04103
Universitätsklinikum Leipzig Recruiting
Berlin, Germany, 04103
Contact: Study Coordinator    +493419712330      
Praxis Driesener Strasse Recruiting
Berlin, Germany, 10439
Contact: Study Coordinator    +49304519889415      
Leberzentrum am Checkpoint -Berlin Recruiting
Berlin, Germany, 10969
Contact: Study Coordinator    +4930259306471      
Synexus Clinical Research GmbH, Prüfzentrum Berlin Recruiting
Berlin, Germany, 12627
Contact: Study Coordinator    +49 (0) 30 5858 44 500      
Charité Universitätsmedizin Berlin Recruiting
Berlin, Germany, 13353
Contact: Study Coordinator    +4930450565207      
Universitätsklinikum Hamburg Eppendorf Recruiting
Hamburg, Germany, 20246
Contact: Study Coordinator    +49040741034806      
Greece
University Hospital of Ioannina Recruiting
Ioannina, Epirus, Greece, 45500
General Hospital of Thessaloniki PAPAGEORGIOU Withdrawn
Thessaloniki, Macedoni, Greece, 54636
Hippokratio Hospital Not yet recruiting
Thessaloniki, Macedoni, Greece, 54642
Hippokratio Hospital Recruiting
Thessaloniki, Macedoni, Greece, 54642
Contact: Study Coordinator    +302310892040      
University General Hospital of Patras Panagia I Voithia Recruiting
Patra, Peloponnese, Greece, 26504
University General Hospital of Alexandroupolis Recruiting
Alexandroupoli, Thrace, Greece, 68100
Hong Kong
Humanity and Health Research Centre Withdrawn
Hong Kong, Hong Kong, 00852
Queen Mary Hospital Active, not recruiting
Hong Kong, Hong Kong, 00852
Prince of Wales Hospital, Dept. of Medicine and Therapeutics Active, not recruiting
Hong Kong, Hong Kong
Alice Ho Miu Ling Nethersole Hospital Not yet recruiting
Tai Po, Hong Kong
Tuen Mun Hospital Not yet recruiting
Tuen Mun, Hong Kong, 00852
Hungary
Somogy Megyei Kaposi Mór Oktató Kórház Recruiting
Kaposvár, Somogy, Hungary, 7400
Contact: Study Coordinator    +36822501300      
SYNEXUS Magyarország Kft. - Budapest DRS Recruiting
Budapest, Hungary, 1036
Contact: Study Coordinator    +36706141291      
Egyesitett Szent Istvan es Szent Laszlo Korhaz - Rendelointezet; Szent Laszlo Korhaz Recruiting
Budapest, Hungary, 1097
Contact: Study Coordinator    +3614558100      
Synexus Magyarorszag Egeszsegugyi Szolgaltato Kft Recruiting
Debrecen, Hungary, 4025
Contact: Study Coordinator    +3652487717      
SYNEXUS Magyarország Kft. - Gyula DRS Recruiting
Gyula, Hungary, 5700
Contact: Study Coordinator    +36304079242      
Pécsi Tudományegyetem, Klinikai Központ, I.sz.Belgyógyászati Klinika Recruiting
Pécs, Hungary, 7624
Contact: Study Coordinator    +36309798674      
India
Sunshine Hospitals Withdrawn
Secunderabad, Andhra Pradesh, India, 500003
Surat Institute of Digestive Sciences Withdrawn
Surat, Gujarat, India, 395002
BAPS Pramukh Swami Hospital Withdrawn
Surat, Gujarat, India, 395009
Artemis Hospitals Withdrawn
Gurgaon, Haryana, India, 122001
Victoria Hospital (Bangalore Medical College) Withdrawn
Bangalore, Karnataka, India, 560002
KLES Prabhakar Kore Hospital and Medical Research Centre Withdrawn
Belgaum, Karnataka, India, 590010
Kasturba Medical College Hospital Withdrawn
Mangalore, Karnataka, India, 575 001
Global Hospital - Super Speciality and Transplant Centre Withdrawn
Mumbai, Maharashtra, India
B.J. Medical College and Sassoon General Hospital Withdrawn
Pune, Maharashtra, India, 411001
Post Graduate Institute of Medical Education and Research (PGIMER) Withdrawn
Chandigarh, Punjab, India, 160012
Sawai Man Singh Hospital Withdrawn
Jaipur, Rajashthan, India, 302004
KRM Hospital and Research Center Withdrawn
Lucknow, Uttar Pradesh, India, 226024
Om Research Center, Om Surgical Center and Maternity Home Withdrawn
Varanasi, Uttar Pradesh, India, 221 007
Israel
EMMS MC Withdrawn
Nazareth, Jerusalem, Israel, 91031
Rambam Health Care Campus - Rambam Medical Center Recruiting
Haifa, Israel, 3109601
Carmel Medical Center Recruiting
Haifa, Israel, 3436212
Shaare Zedek Medical Center Recruiting
Jerusalem, Israel, 9103102
Hadassah Medical Center Recruiting
Jerusalem, Israel, 91120
Galilee Medical Center Recruiting
Nahariya, Israel, 22100
Tel Aviv Sourasky Medical Center Recruiting
Tel Aviv, Israel, 64239
Sheba Medical Center at Tel Hashomer Recruiting
Tel-Hashomer, Israel, 52621
Italy
Ospedale Casa Sollievo della Sofferenza Recruiting
San Giovanni Rotondo, Foggia, Italy, 71013
Polo Universitario - L'Azienda Ospedaliera Luigi Sacco Active, not recruiting
Milan, Milano, Italy, 20157
Istituto Clinico Humanitas Active, not recruiting
Rozzano, Milano, Italy, 20089
Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona Not yet recruiting
Ancona, Italy
Ospedali Riuniti di Bergamo Not yet recruiting
Bergamo, Italy
Azienda Ospedaliera S. Orsola - Malpighi Not yet recruiting
Bologna, Italy, 40138
Azienda Ospedaliera Universitaria Careggi Recruiting
Firenze, Italy, 501 34
Ente Ospedaliero Ospedali Galliera Recruiting
Genova, Italy, 16128
Azienda Ospedaliera Universitaria San Martino Not yet recruiting
Genova, Italy, 16132
IRCCS Azienda Ospedaliera Universitaria San Martino Recruiting
Genova, Italy, 16132
Contact: Study Coordinator    +39 010 353 7950      
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Recruiting
Milano, Italy, 20122
Ospedale San Giuseppe Withdrawn
Milano, Italy, 20123
Ospedale San Raffaele Withdrawn
Milano, Italy, 20127
ASST Santi Paolo e Carlo Recruiting
Milano, Italy, 20142
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda Recruiting
Milano, Italy, 20162
Azienda Ospedaliero-Universitaria "Maggiore della Carità" Recruiting
Novara, Italy, 28100
Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone Recruiting
Palermo, Italy, 90127
Fondazione Policlinico Tor Vergata Recruiting
Roma, Italy, 00133
Fondazione Policlinico Universitario Agostino Gemelli Recruiting
Roma, Italy, 00168
Policlinico Umberto I di Roma Not yet recruiting
Roma, Italy
Mexico
Consultorio Médico Dr. Alma Laura Ladron de Guevara Recruiting
Mexico, Distrito Federal, Mexico, 06700
Contact: Study Coordinator    52015552298400      
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Withdrawn
México City, Distrito Federal, Mexico, 14080
Consultorio Rosario Arechavaleta Terminated
Guadalajara, Jalisco, Mexico, 44600
JM Research - Cuernavaca Recruiting
Cuernavaca, Morelos, Mexico, 62290
Investigaciones Medicas Cisneros Recruiting
Monterrey, Nuevo Leon, Mexico, 64000
Contact: Study Coordinator    520183471010 ext 6195      
Consultorio Dra. Maria Sarai Gonzalez Huezo Recruiting
Metepec, Mexico, 52140
Hospital Punta Sur Terminated
Queretaro, Mexico, 76090
New Zealand
Auckland City Hospital Recruiting
Grafton, Auckland, New Zealand, 1148
Contact: Study Coordinator    +649307494923579      
Middlemore Clinical Trials Recruiting
Papatoetoe, Auckland, New Zealand, 2025
Contact: Study Coordinator    +6492760044 ext Ext: 52976      
Bay of Plenty Clinical School Withdrawn
Tauranga, Bay Of Plenty, New Zealand, 3134
Christchurch Hospital Withdrawn
Christchurch, New Zealand, 8011
Dunedin Hospital Withdrawn
Dunedin, New Zealand, 9016
Norway
Oslo Universitetssykehus-Ullevål Hospital Recruiting
Oslo, Norway, 0424
Contact: Study Coordinator    +4791502770      
Peru
Hospital Nacional Arzobispo Loayza Recruiting
Lima, Lima 01, Peru, 15082
Hospital Nacional Guillermo Almenara Irigoyen Withdrawn
La Victoria, Lima, Peru, 15033
Clínica Delgado Withdrawn
Miraflores, Lima, Peru, 15074
SANNA - Clínica San Borja Withdrawn
San Borja, Lima, Peru, 15036
Hospital Nacional Dos de Mayo Withdrawn
Lima, Peru, 01
Hospital Nacional Edgardo Rebagliati Martins Withdrawn
Lima, Peru, 15073
Poland
Centrum Badan Klinicznych Piotr Napora Lekarze Spólka Partnerska Recruiting
Wroclaw, Dolnoslaskie, Poland, 50-349
Contact: Study Coordinator    +48602639169      
EMC Instytut Medyczny Recruiting
Wroclaw, Dolnoslaskie, Poland, 54-144
Contact: Study Coordinator    +48721 295 002      
VitaMED Recruiting
Bydgoszcz, Kujawsko-Pomorskie, Poland, 85-079
Contact: Study Coordinator    +48525257777      
Wojewódzki Specjalistyczny Szpital im. dr Wl. Bieganskiego w Lodzi Recruiting
Lódz, Lodzkie, Poland, 91-347
Contact: Study Coordinator    +48606181969      
Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji w Warszawie Active, not recruiting
Warszawa, Mazowieckie, Poland, 02-507
Szpital Specjalistyczny Nr 1 w Bytomiu Recruiting
Bytom, Slaskie, Poland, 41-902
Contact: Study Coordinator    +48668665775      
Specjalistyczna Praktyka Lekarska WAMED Zawiercie Active, not recruiting
Jaworze, Slaskie, Poland, 43-384
Niepubliczny Zaklad Opieki Zdrowotnej All-Medicus Active, not recruiting
Katowice, Slaskie, Poland, 40-659
Centrum Medycyny i Stomatologii Silesia Med Recruiting
Katowice, Slaskie, Poland, 40-752
Contact: Study Coordinator    +48338191717      
ID Clinic Arkadiusz Pisula Recruiting
Myslowice, Slaskie, Poland, 41-400
Contact: Study Coordinator    +48326161394      
Portugal
Hospital Professor Doutor Fernando Fonseca Recruiting
Amadora, Lisboa, Portugal, 2720-276
Contact: Study Coordinator    +351214345552      
Hospital da Senhora da Oliveira - Guimarães Recruiting
Guimaraes, Portugal, 4835-044
Contact: Study Coordinator    +351253540330      
Centro Hospitalar Lisboa Central - Hospital Capuchos Recruiting
Lisboa, Portugal, 1169-050
Contact: Study Coordinator    +351968018682      
Centro Hospitalar de São João Recruiting
Porto, Portugal, 4200-319
Contact: Study Coordinator    +351225512100      
Hospital de São Bernardo Recruiting
Setúbal, Portugal, 2910-446
Contact: Study Coordinator    +351265549000      
Hospital Santa Luzia de Viana do Castelo Recruiting
Viana do Castelo, Portugal, 4904-858
Contact: Study Coordinator    +351258802100      
Centro Hospitalar de Trás-os-Montes e Alto Douro EPE Withdrawn
Vila Real, Portugal, 5000-508
Puerto Rico
Clinical Research Puerto Rico Recruiting
San Juan, Puerto Rico, 00909-1711
Contact: Study Coordinator    787-723-5945      
Fundacion de Investigacion De Diego Recruiting
San Juan, Puerto Rico, 00927
Contact: Study Coordinator    1 (787) 722-1248      
Romania
Institutul Regional de Gastroenterologie si Hepatologie Prof. Dr. O Fodor Recruiting
Cluj-Napoca, Cluj, Romania, 400162
Contact: Study Coordinator    +40727343098      
Centrul Medical Tuculanu SRL Recruiting
Timisoara, Timis, Romania, 300158
Contact: Study Coordinator    +40722468168      
Policlinica Dr. Citu Recruiting
Timisoara, Timis, Romania, 300594
Contact: Study Coordinator    +400256494619      
Spitalul Clinic Jude¿ean de Urgen¿a Cluj-Napoca Recruiting
Cluj, Romania, 400006
Contact: Study Coordinator    +40722329204      
Russian Federation
Clinic of Professor Gorbakov Not yet recruiting
Krasnogorsk, Moscow, Russian Federation, 143405
Infection Center Not yet recruiting
Koltsovo, Novosibirsk, Russian Federation
Clinical Hospital #1-Smolensk Not yet recruiting
Smolensk, Solensk, Russian Federation, 214016
I.M. Sechenov First Moscow State Medical University Not yet recruiting
Moscow, Russian Federation, 119435
Modern Medicine Clinic Not yet recruiting
Moscow, Russian Federation, 121170
Sklifosovsky Scientific Research Institution of Emergency Care Not yet recruiting
Moscow, Russian Federation, 196143
Novosibirsk State Regional Clinical Hospital Not yet recruiting
Novosibirsk, Russian Federation, 630087
Stavropol State Medical University Not yet recruiting
Novosibirsk, Russian Federation, 630091
Union Clinic Not yet recruiting
Saint Petersburg, Russian Federation, 191119
ECO Bezopasnost Not yet recruiting
Saint Petersburg, Russian Federation, 768828
Research Institute of Influenza Not yet recruiting
Saint-Petersburg, Russian Federation, 197376
Smolensk City Hospital 1 Recruiting
Smolensk, Russian Federation, 214006
Contact: Study Coordinator    +79107871811      
Stavropol Regional Clinical Hospital Recruiting
Stavropol, Russian Federation, 355002
Contact: Study Coordinator    +79624452246      
Stavropol Regional Clinical Hospital Not yet recruiting
Stavropol, Russian Federation, 355017
Singapore
National University Hospital Active, not recruiting
Singapore, Singapore, 119074
Singapore General Hospital Active, not recruiting
Singapore, Singapore, 169608
Khoo Teck Puat Hospital Withdrawn
Singapore, Singapore, 768828
Slovenia
Univerzitetni klinicni center Ljubljana (University Clinical Center Ljubljana) Active, not recruiting
Ljubljana, Slovenia, 1000
Univerzitetni klinicni center Maribor Withdrawn
Maribor, Slovenia, 2000
Splošna bolnišnica Dr. Franca Derganca Nova Gorica Withdrawn
Šempeter pri Gorici, Slovenia, 5290
Spain
Hospital Universitario Donostia Recruiting
San Sebastian, Guipuzcoa, Spain, 20014
Contact: Study Coordinator    +34943007000      
Hospital Santa Creu i Sant Pau Recruiting
Barcelona, Spain, 00841
Contact: Study Coordinator    +34935565920      
Hospital del Mar Recruiting
Barcelona, Spain, 08003
Contact: Study Coordinator    +34933160400      
Hospital Universitari Vall d'Hebrón Recruiting
Barcelona, Spain, 08035
Contact: Study Coordinator    +34932746140      
Hospital General Universitario Gregorio Marañon Recruiting
Madrid, Spain, 28007
Contact: Study Coordinator    +34915868308      
Hospital Universitario Ramón Y Cajal Recruiting
Madrid, Spain, 28034
Contact: Study Coordinator    +34913368313      
Hospital Clínico Universitario Virgen de la Victoria Recruiting
Málaga, Spain, 29010
Contact: Study Coordinator    +34951032058      
Hospital Universitario Marqués de Valdecilla Recruiting
Santander, Spain, 39008
Contact: Study Coordinator    +34942213106      
Hospital Universitario Virgen del Rocio Recruiting
Sevilla, Spain
Contact: Study Coordinator    +34933160400      
Consorci Hospital General Universitari de València Recruiting
Valencia, Spain, 46018
Contact: Study Coordinator    +34963615550      
Hospital Universitari i Politecnic La Fe de Valencia Recruiting
Valencia, Spain, 46026
Contact: Study Coordinator    +34961245856      
Switzerland
Kantonspital Sankt Gallen Recruiting
St. Gallen, Saint Gallen, Switzerland, 9007
Contact: Study Coordinator    +410714941111      
Inselspital Recruiting
Bern, Switzerland, 3010
Contact: Study Coordinator    +41 31 632 80 26      
Taiwan
Chia-Yi Christian Hospital Active, not recruiting
Chiayi City, Chiayi, Taiwan, 60002
China Medical University Hospital Active, not recruiting
Taichung, Taichung City, Taiwan, 40447
National Cheng Kung University Hospital Not yet recruiting
Tainan, Tainan City, Taiwan, 70403
National Taiwan University Hospital Active, not recruiting
Taipei, Taipei City, Taiwan, 10002
Kaohsiung Medical University Hospital Withdrawn
Kaohsiung, Taiwan, 807
Cathay General Hospital Not yet recruiting
Taipei, Taiwan, 10630
Chang Gung Medical Foundation-LinKou Branch Active, not recruiting
Taoyuan, Taiwan, 333
United Kingdom
University Hospitals Birmingham NHS Foundation Trust Recruiting
Birmingham, England, United Kingdom, B15 2GW
Contact: Study Coordinator    +441214158700      
Addenbrookes Hospital Withdrawn
Cambridge, England, United Kingdom, CB2 0QQ
Gloucestershire Hospitals NHS Foundation Trust Recruiting
Gloucester, England, United Kingdom, GL53 7AN
Synexus North Teesside Clinical Research Centre Recruiting
Hardwick, England, United Kingdom, TS19 8PE
Contact: Study Coordinator    +44 (0)16 42 60 23 81      
Synexus Hexham Clinical Research Centre Recruiting
Hexham, England, United Kingdom, NE46 1QJ
Contact: Study Coordinator    +44 (0)16 42 344 674      
Hull and East Yorkshire Hospitals NHS Trust Recruiting
Hull, England, United Kingdom, HU3 2JZ
Contact: Study Coordinator    +441482816797      
Royal Free London NHS Foundation Trust Recruiting
London, England, United Kingdom, NW3 2QG
Contact: Study Coordinator    +4402077940500      
Guy's and Saint Thomas' NHS Foundation Trust Withdrawn
London, England, United Kingdom, SE1 7EH
Kings College Hospital NHS Foundation Trust Recruiting
London, England, United Kingdom, SE5 9RS
Contact: Study Coordinator    +442072342730      
Chelsea and Westminster Hospital NHS Foundation Trust Recruiting
London, England, United Kingdom, SW10 9NH
Contact: Study Coordinator    +442033158321      
Synexus Manchester Clinical Research Centre Recruiting
Manchester, England, United Kingdom, M15 6SE
Contact: Study Coordinator    +44 (0) 161 608 7790      
University Hospital of South Manchester NHS Foundation Trust Recruiting
Manchester, England, United Kingdom, M23 9LT
Contact: Study Coordinator    +441619987070      
Newcastle Upon the Tyne Hospitals Recruiting
Newcastle, England, United Kingdom, NE2 4HH
Contact: Study Coordinator    +4401912336161      
Norfolk and Norwich University Hospitals NHS Foundation Trust Recruiting
Norwich, England, United Kingdom, NR4 7UQ
Contact: Study Coordinator    +441603647330      
Plymouth Hospitals NHS Trust Recruiting
Plymouth, England, United Kingdom, PL6 8DH
Contact: Study Coordinator    +441752792725      
Portsmouth Hospitals NHS Trust Withdrawn
Portsmouth, England, United Kingdom, PO6 3LY
University Hospitals of North Midlands NHS Trust Recruiting
Stoke-on-Trent, England, United Kingdom, ST4 6QG
Contact: Study Coordinator    +441782672704      
Swansea Bay UHB Recruiting
Swansea, Wales, United Kingdom, SA2 8PP
St James's University Hospital Recruiting
Leeds, West Yorkshire, United Kingdom, LS9 7TF
Luton and Dunstable Hospital NHS Foundation Trust Recruiting
Luton, United Kingdom, LU4 0DZ
Contact: Study Coordinator    +441582491166      
Nottingham Digestive Diseases Biomedical Research Unit Recruiting
Nottingham, United Kingdom, NG7 2UH
Contact: Study Coordinator    +441159249924      
Sponsors and Collaborators
Tobira Therapeutics, Inc.
Investigators
Layout table for investigator information
Study Director: Eduardo B Martins Allergan

Additional Information:
Layout table for additonal information
Responsible Party: Tobira Therapeutics, Inc.
ClinicalTrials.gov Identifier: NCT03028740     History of Changes
Other Study ID Numbers: 3152-301-002
2016-004566-26 ( EudraCT Number )
1001 ( Registry Identifier: Registro Nacional Estudios Clinicos (RNEC) )
First Posted: January 23, 2017    Key Record Dates
Last Update Posted: October 8, 2019
Last Verified: October 2019

Layout table for additional information
Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
Layout table for MeSH terms
Fatty Liver
Liver Cirrhosis
Non-alcoholic Fatty Liver Disease
Liver Diseases
Digestive System Diseases
TAK-652
CCR5 Receptor Antagonists
Molecular Mechanisms of Pharmacological Action
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents