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Where Culture Meets Genetics: Exploring Latinas Causal Attributions of Breast and Colon Cancer and Models of Disease Inheritance

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ClinicalTrials.gov Identifier: NCT02767986
Recruitment Status : Completed
First Posted : May 11, 2016
Last Update Posted : January 14, 2019
Sponsor:
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Human Genome Research Institute (NHGRI) )

Brief Summary:

Background:

Culture can affect the way a person thinks about illness. This can affect how they seek help for illness. It can also affect how they choose a treatment and follow it. This can lead to health disparities among certain groups of people. Breast and colon cancers are the most common cancers for Latinos. Even though they get these cancers at lower rates than other population groups, Latinos are more likely to be diagnosed with these cancers at advanced stages. Researchers want to study what Latina women immigrants believe causes breast and colon cancer and other factors they think play a role in disease. This understanding could lead to better interactions between Latinos and their doctors.

Objective:

To learn more about what Latina immigrants believe causes breast and colon cancer and other factors they think play a role in disease.

Eligibility:

Women ages 18 and older who:

Were born in Latin America

Speak Spanish

Have never had breast, ovarian, or colon cancer

Design:

Participants will be interviewed in person or over the phone. This will take up to an hour. The interview will be recorded. Participants will answer questions about:

Their family s cancer history

What they think causes breast and colon cancer

What they think plays a role in disease


Condition or disease
Colon Cancer Breast Cancer

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Detailed Description:

Research to understand the sources of health disparities has acknowledged that in addition to biomedical risk factors, culture plays an important role in differential health outcomes. Consequently, understanding cultural differences that may influence health behavior is key in working towards reducing these disparities. Causal attributions are a key component of individuals illness perceptions and thus impact health behaviors, which may present as health disparities at a population level. While research has explored non-Hispanic White women s causal attributions of breast cancer, less is known about Latina s beliefs about the causes of breast cancer, and little is known about causal attributions of colon cancer in any population. Understanding Latina s causal attributions of breast and colon cancer may provide insight into the determinants of cancer disparities in this population. Because a subset of both breast and colon cancers result from single gene mutations, which confer an increased risk of developing such cancers, understanding causal attributions in Latina populations is relevant to the field of genetics. This is especially true since Latinas have historically underutilized cancer genetic risk assessment counseling and testing services. As these services become a standard part of general healthcare provision, it will become increasingly important to understand ways in which different cultural groups interact with genetic information. One way this can be done is through investigating culturally informed mental models of disease risk and inheritance. This study seeks to describe causal attributions of breast and colon cancer and to explore mental models of disease inheritance among Latina immigrants. A qualitative exploratory design including interviews comprised of free-listing, ranking, and open-ended questions will be used. Participants will be recruited through the NIH Clinical Research Volunteer Program as well as using other resources within the Office of Participant Recruitment. First, we will describe Latina s causal attributions for these cancers. Next, we will use cultural consensus theory (CCT) to identify and describe common cultural models of causes of these cancers. Finally, we will explore Latina s mental models of disease inheritance using both free-listing and openended questions.

2. Objectives and specific aims.

The objective of this study is to describe the cultural models of Latina immigrants regarding causal attributions of breast and colon cancer as well as to explore this group s mental models of disease inheritance.

Aim #1: To identify the main causal attributions of breast and colon cancers among Latina immigrants.

Aim #2: To use cultural consensus analysis to identify the presence or absence of shared cultural models of causal attributions for breast and colon cancers among participants.

Aim #3: To describe the mental models of disease inheritance held by members of the Latina immigrant population.

3. Brief Rationale and Background:

Latinos in the United States

Hispanic or Latino is currently the largest minority group in the United States, constituting 17% of the population as of 2013 according to the U.S. Census Bureau. In Maryland specifically, the 2010 census found 8.3% of the population to be Hispanic or Latino, and as of July 2014, the U.S. Census Bureau estimates that 9.2% of the Maryland population is Hispanic or Latino. Notably, the absolute number of Hispanics or Latinos in Maryland doubled during the period 2000-2010, indicating the high level of growth in this segment of the population (http://quickfacts.census.gov/qfd/states/24000lk.html). The U.S. Office of Management and Budget (OMB) defines Hispanic or Latino as a person of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish culture or origin regardless of race (http://www.census.gov/topics/population/hispanic-origin/about.html). For the purposes of this proposal, the terms Latino/a will refer to people of Spanish-speaking countries of the Western hemisphere, and Latino/a immigrants will refer to persons born in one of these countries who have since immigrated to the United States. Notably, this working definition excludes people of Spanish or Brazilian nationality or descent, mainly due to the cultural focus of this investigation.


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Study Type : Observational
Actual Enrollment : 22 participants
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Where Culture Meets Genetics: Exploring Latinas' Causal Attributions of Breast and Colon Cancer and Mental Models of Disease Inheritance
Study Start Date : May 10, 2016
Actual Primary Completion Date : February 2, 2017
Actual Study Completion Date : February 2, 2017

Resource links provided by the National Library of Medicine


Group/Cohort
Spanish-speaking Latinas
Women who speak Spanish as their primary language



Primary Outcome Measures :
  1. casual attributions of breast cancer [ Time Frame: baseline ]
    participants' free lists of breast cancer causes

  2. causal attributions of breast cancer [ Time Frame: baseline ]
    participants' free lists of colon cancer causes

  3. mental modes of inheritance [ Time Frame: baseline ]
    qualitative descriptions of women's understanding/thoughts about inheritance



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Women who speak spanish as their primary language; living in the metropolitan Baltimore/Washington, DC region
Criteria
  • INCLUSION CRITERIA:
  • Are a woman, 18 years of age or older
  • Have immigrated to the United States from Latin America
  • Speak Spanish
  • Are able to meet in-person in the metro Washington, DC area

Puedes reunir los requisitos si:

  • Eres mujer y tienes 18 a(SqrRoot) os de edad o m(SqrRoot)(Degree)s
  • Has emigrado a los Estados Unidos desde Latinoam(SqrRoot)(Copyright)rica
  • Hablas el espa(SqrRoot) ol con fluidez
  • Puedes asistir en persona en la zona metropolitana de Washington, DC

EXCLUSION CRITERIA:

-NIH medical and research staff


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02767986


Locations
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United States, Maryland
National Human Genome Research Institute (NHGRI)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Human Genome Research Institute (NHGRI)
Investigators
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Principal Investigator: Lori Erby, Ph.D. National Human Genome Research Institute (NHGRI)

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Responsible Party: National Human Genome Research Institute (NHGRI)
ClinicalTrials.gov Identifier: NCT02767986     History of Changes
Other Study ID Numbers: 999916106
16-HG-N106
First Posted: May 11, 2016    Key Record Dates
Last Update Posted: January 14, 2019
Last Verified: January 4, 2019
Keywords provided by National Institutes of Health Clinical Center (CC) ( National Human Genome Research Institute (NHGRI) ):
Health Disparities
Mental Models
Hispanic
Health Belief Model
Cultural Consensus Theory
Cancer Genetics
Qualitative
Additional relevant MeSH terms:
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Colonic Neoplasms
Colorectal Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases