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Evaluation of the Effectiveness and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo and Adalimumab, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Have Active Disease (CREDO 2)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT02760407
Recruitment Status : Recruiting
First Posted : May 3, 2016
Last Update Posted : December 3, 2018
Quintiles, Inc.
OCT Clinical Trials
Information provided by (Responsible Party):

Brief Summary:
The purpose of this study is to determine how safe and effective the study drug Olokizumab is, in patients with Rheumatoid Arthritis (RA) who are already receiving, but not fully responding to treatment with methotrexate (MTX).

Condition or disease Intervention/treatment Phase
Rheumatoid Arthritis Drug: Olokizumab 64mg q4w Drug: Olokizumab 64mg q2w Drug: Adalimumab 40mg q2w Drug: Placebo q2w Phase 3

Detailed Description:
The goal of this Phase III study is to assess the safety, tolerability, and efficacy of OKZ in subjects with moderately to severely active RA who have responded inadequately to MTX. The primary endpoint of the trial is at Week 12. Olokizumab is expected to reduce the disease activity and improve physical function. The study is expected to provide safety information in a large group of subjects over at least a 24 week period. Adalimumab 40 mg q2w SC has been included as the active comparator for assay sensitivity and non inferiority evaluations.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 1575 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Treatment
Official Title: A Randomized, Double-Blind, Parallel-Group, Placebo- and Active-Controlled, Multicenter Phase III Study of the Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis Inadequately Controlled by Methotrexate Therapy
Study Start Date : May 2016
Estimated Primary Completion Date : December 2019
Estimated Study Completion Date : May 2020

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Arm 1: Olokizumab q4w + Methotrexate
Experimental, Olokizumab 64mg q4w Subcutaneous + Methotrexate (oral)
Drug: Olokizumab 64mg q4w
Experimental: Arm 2: Olokizumab q2w + Methotrexate
Experimental, Olokizumab 64mg q2w Subcutaneous + Methotrexate (oral)
Drug: Olokizumab 64mg q2w
Active Comparator: Arm 3: Adalimumab q2w + Methotrexate
Active Comparator, Adalimumab 40mg q2w Subcutaneous + Methotrexate (oral)
Drug: Adalimumab 40mg q2w
Other Name: Humira

Placebo Comparator: Arm 4: Placebo q2w + Methotrexate
Placebo Comparator, Placebo q2w Subcutaneous + Methotrexate (oral)
Drug: Placebo q2w

Primary Outcome Measures :
  1. ACR20 response [ Time Frame: at Week 12 ]
    Where a responder is defined as any subject satisfying ACR20 criteria and remaining on randomized treatment and in the study at Week 12. This endpoint will serve to demonstrate that the efficacy of OKZ is superior to placebo

Secondary Outcome Measures :
  1. ACR20 response and to demonstrate that the efficacy of OKZ is non-inferior to adalimumab [ Time Frame: at Week 12 ]
    Where a responder is defined as any subject satisfying ACR20 criteria and remaining on randomized treatment and in the study at Week 12. This endpoint will serve to demonstrate that the efficacy of OKZ is non-inferior to adalimumab, provided that superiority of adalimumab to placebo (assay sensitivity) is demonstrated concurrently based on the same endpoint.

  2. Difference between OKZ and placebo in the percentage of subjects achieving low disease activity [ Time Frame: at Week 12 ]
    Defined as DAS28 (CRP) <3.2, and remaining on randomized treatment and in the study at Week 12

  3. Difference between OKZ and placebo in the improvement of physical ability [ Time Frame: Baseline to Week 12 ]
    measured by the Health Assessment Questionnaire Disability Index (HAQ DI)

  4. ACR50 response [ Time Frame: at Week 24 ]
    Difference between OKZ and placebo in the percentage of subjects achieving an ACR50 response and remaining on randomized treatment and in the study at Week 24

  5. Simplified Disease Activity Index (SDAI) ≤3.3 (remission) [ Time Frame: at Week 24 ]
    Difference between OKZ and placebo in the percentage of subjects with SDAI ≤3.3 (remission) and remaining on randomized treatment and in the study at Week 24.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Subjects willing and able to sign informed consent
  • Subjects must have a diagnosis of adult onset RA classified by ACR/EULAR 2010 revised classification criteria for RA for at least 12 weeks prior to Screening.
  • Inadequate response to treatment with MTX for at least 12 weeks prior to Screening at a dose of 15 to 25 mg/week (or ≥10 mg/week if intolerant to higher doses)
  • The dose and means of administering MTX must have been stable for at least 6 weeks prior to Screening.
  • Subjects must be willing to take folic acid or equivalent throughout the study.
  • Subjects must have moderately to severely active RA disease as defined by all of the following:

    • ≥6 tender joints (68 joint count) at Screening and baseline; and
    • ≥6 swollen joints (66 joint count) at Screening and baseline; and
    • CRP above ULN at Screening based on the central laboratory results

Exclusion Criteria:

  • Diagnosis of any other inflammatory arthritis or systemic rheumatic disease (e.g., gout, psoriatic or reactive arthritis, Crohn's disease, Lyme disease, juvenile idiopathic arthritis, or systemic lupus erythematosus)
  • Prior exposure to any licensed or investigational compound directly or indirectly targeting IL 6 or IL 6R (including tofacitinib or other Janus kinases and spleen tyrosine kinase [SYK] inhibitors)
  • Prior treatment with cell depleting therapies including anti CD20 or investigational agents (e.g., CAMPATH, anti CD4, anti CD5, anti CD3, and anti CD19)
  • Prior use of bDMARDs
  • Use of oral glucocorticoids greater than 10 mg/day prednisone (or equivalent) or change in dosage within 2 weeks prior to baseline
  • Prior history of no response to hydroxychloroquine and sulfasalazine
  • Prior use of cDMARDs (other than MTX) within the following windows prior to baseline (cDMARDs should not be discontinued to facilitate a subject's participation in the study, but should instead have been previously discontinued as part of a subject's medical management of RA):

    1. 4 weeks for sulfasalazine, azathioprine, cyclosporine, hydroxychloroquine, chloroquine, gold, penicillamine, minocycline, or doxycycline
    2. 12 weeks for leflunomide unless the subject has completed the following elimination procedure at least 4 weeks prior to baseline: Cholestyramine at a dosage of 8 grams 3 times daily for at least 24 hours, or activated charcoal at a dosage of 50 grams 4 times daily for at least 24 hours
    3. 24 weeks for cyclophosphamide
  • Participation in any other investigational drug study within 30 days or 5 times the terminal half-life of the investigational drug, whichever is longer, prior to baseline
  • Other treatments for RA (e.g., Prosorba Device/Column) within 6 months prior to baseline
  • Abnormal laboratory values
  • Subjects with concurrent acute or chronic viral hepatitis B or C infection
  • Subjects with HIV infection
  • Subjects with:

    1. Current active TB disease or a history of active TB disease.
    2. Close contact with an individual with active TB within 1.5 years prior to Screening
    3. History of untreated latent TB infection (LTBI), regardless of IGRA result at Screening
    4. Positive interferon-gamma release assay (IGRA) result at Screening. If indeterminate, the IGRA can be repeated once during the Screening Period. If there is a second indeterminate result, the subject will be excluded.
  • Concurrent malignancy or a history of malignancy within the last 5 years
  • Uncontrolled diabetes mellitus
  • History of chronic alcohol or drug abuse as judged by the Investigator
  • Female subjects who are pregnant, currently lactating
  • Female subjects of childbearing potential who are not willing to use a highly effective method of contraception during the study OR Male subjects with partners of childbearing potential not willing to use a highly effective method of contraception during the study
  • Subjects with a known hypersensitivity to any component of the OKZ drug product, adalimumab, or placebo
  • Other exclusion criteria may apply

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02760407

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United States, Alabama
Rheumatology Associates Of North Alabama- RANA Withdrawn
Huntsville, Alabama, United States, 35801
United States, Arizona
Arizona Arthritis & Rheumatology Associates, P.C. Recruiting
Glendale, Arizona, United States, 85304
Contact: Saima Chohan    480-443-8400   
Contact: Anna Bermudez    480-626-6657   
Principal Investigator: Saima Chohan         
Arizona Arthritis & Rheumatology Research, PLLC Not yet recruiting
Glendale, Arizona, United States, 85306
Contact: Nehad Soloman   
Contact: Jeanell Halverson    602-386-4972   
Principal Investigator: Nehad Soloman         
Arizona Arthritis & Rheumatology Research, PLLC Not yet recruiting
Glendale, Arizona, United States, 85306
Contact: Ramina Jajoo    480-443-8400   
Contact: Samer Salama    602-926-9742   
Principal Investigator: Ramina Jajoo         
Arizona Arthritis & Rheumatology Associates, P.C. Recruiting
Mesa, Arizona, United States, 85202
Contact: Daniel Kreutz    480-321-8580   
Contact: Tannaz Besharatian    480-626-6656   
Arizona Arthritis & Rheumatology Research, PLLC Withdrawn
Phoenix, Arizona, United States, 85032-9384
Radiant Research, Inc. Withdrawn
Scottsdale, Arizona, United States, 85251
United States, Arkansas
CHI St. Vincent Hot Springs Withdrawn
Hot Springs, Arkansas, United States, 71913
CHI St. Vincent Hot Springs Recruiting
Hot Springs, Arkansas, United States, 71913
Contact: Ratinder Kaur    501-627-1800   
Contact: Jonathan Wright    501-520-5476 ext 128   
Principal Investigator: Ratinder Kaur         
Little Rock Diagnostic Clinic, PA Withdrawn
Little Rock, Arkansas, United States, 72205
United States, California
Medvin Clinical Research Recruiting
Covina, California, United States, 91722
Contact: Samy Metyas    626-966-1909   
Contact: Ruby Espinosa    626-869-5730   
TriWest Research Associates, LLC Recruiting
El Cajon, California, United States, 92020-4124
Contact: Arthur Mabaquiao    619-334-4735   
Contact: Lizenia Hernandez    619-334-4735   
Principal Investigator: Arthur Mabaquiao         
Aviva Research Not yet recruiting
Escondido, California, United States, 92025
Contact: James Schultz    760-999-2011   
Contact: Diane O'Grady    760-999-2011   
Rheumatology Center of San Diego Recruiting
Escondido, California, United States, 92025
Contact: Tania Rivera    858-336-2810   
Contact: Joy Pauley    858-336-2810   
Principal Investigator: Tania Rivera         
Saint Jude Heritage Medical Grp Withdrawn
Fullerton, California, United States, 92835
MD Med Corp. Recruiting
Hemet, California, United States, 92543
Contact: Chandrakant Mehta    951-652-5000   
Contact: Linda Stallman    951-652-5000   
Principal Investigator: Chandrakant Mehta         
Advanced Medical Research, LLC Recruiting
La Palma, California, United States, 90623
Contact: Gerald Ho    562-867-8195   
Contact: Ray Beshai    562-867-8195   
Principal Investigator: Gerald Ho         
Valerius Medical Group Recruiting
Los Alamitos, California, United States, 90720
Contact: Rebekah Neal    562-794-9801   
Principal Investigator: Rebekah Neal         
Orange Orthopedic Medical Group Recruiting
Orange, California, United States, 92868
Contact: Eric Lee    909-296-8700   
Contact: Amalia Ellis    909-296-8754   
Principal Investigator: Eric Lee         
Riverside Medical Clinic Recruiting
Riverside, California, United States, 92506
Contact: Andre Babajanians    951-321-6473   
Contact: Eryka Sarzotti    951-321-6473   
Principal Investigator: Andre Babajanians         
East Bay Rheumatology Medical Group, Inc. Recruiting
San Leandro, California, United States, 94578
Contact: Clark Neuwelt    510-357-1303   
Contact: Shannon Radillo    510-357-1040   
Principal Investigator: Clark Neuwelt         
Nazanin Firooz, MD Inc. Not yet recruiting
West Hills, California, United States, 91307
Contact: Firooz Nazanin    818-598-0000   
Contact: Sharzad Firooz    818-598-0000   
Principal Investigator: Firooz Nazanin         
Medvin Clinical Research Recruiting
Whittier, California, United States, 90602
Contact: Tien-I Karleen Su    562-758-6600   
Contact: Negrete Nereyda    562-758-6600 ext 5   
Principal Investigator: Tien-I Karleen Su         
United States, Colorado
Denver Arthritis Clinic Recruiting
Denver, Colorado, United States, 80230
Contact: Christopher Antolini    303-394-2828   
Contact: Theresa Hernandez    303-394-2828 ext 177   
Principal Investigator: Christopher Antolini         
United States, Connecticut
Arthritis & Osteoporosis Center PC Withdrawn
Hamden, Connecticut, United States, 06518
New England Research Associates LLC Recruiting
Trumbull, Connecticut, United States, 06611
Contact: Geoffrey Gladstein    203-374-9816   
Contact: Lindsey Sutton    203-374-9816   
Principal Investigator: Geoffrey Gladstein         
United States, Delaware
Delaware Arthritis Suspended
Lewes, Delaware, United States, 19958
Javed Rheumatology Associates Not yet recruiting
Newark, Delaware, United States, 19713
Contact: Sheerin Javed    302-633-9033   
Contact: Fran Miller    302-633-9033 ext 109   
Principal Investigator: Sheerin Javed         
United States, Florida
RASF - Clinical Research Center Recruiting
Boca Raton, Florida, United States, 33486
Contact: Joseph Forstot    561-361-6547   
Contact: Heather Gliatta    561-361-6547   
Principal Investigator: Joseph Forstot         
Reliable Clinical Research, LLC Not yet recruiting
Hialeah, Florida, United States, 33012
Contact: Gilberto Perez    786-536-4177   
Contact: Frank Aguirre    786-536-4177   
Principal Investigator: Gilberto Perez         
Pharmax Research Clinic, Inc. Recruiting
Miami, Florida, United States, 33126
Contact: Henry Paez    305-262-4321   
Contact: Yailin Martin    305-262-4321   
Principal Investigator: Henry Paez         
Suncoast Research Recruiting
Miami, Florida, United States, 33135
Contact: Mark Kutner    305-631-6704   
Contact: Richard Garcia    305-631-6704 ext 127   
Principal Investigator: Mark Kutner         
Medical Research Center of Miami Recruiting
Miami, Florida, United States, 33144
Contact: Nayvis Iglesias    305-677-9267   
Contact: Jesdit Diaz    305-249-1183 ext 102   
Principal Investigator: Nayvis Iglesias         
Suncoast Clinical Research Inc. Recruiting
New Port Richey, Florida, United States, 34652
Contact: Farrukh Zaidi    727-849-4131   
Contact: Barbara Fox    727-849-4131   
Principal Investigator: Farrukh Zaidi         
Arthritis & Osteoporosis Treatment Center, P.A. Withdrawn
Orange Park, Florida, United States, 32073
Omega Research Consultants Recruiting
Orlando, Florida, United States, 32810
Contact: Ayesu Kwabena    407-271-8030   
Contact: Aracely Gonzalez    407-271-8030   
Principal Investigator: Ayesu Kwabena         
Arthritis Center Not yet recruiting
Palm Harbor, Florida, United States, 34684
Contact: Karen Zagar    727-789-2784   
Contact: Tricia Hanson    727-789-2784   
Principal Investigator: Karen Zagar         
Arthritis Research of Florida, Inc. Recruiting
Palm Harbor, Florida, United States, 34684
Contact: Anthony Sebba    727-210-2555   
Contact: Anita McNeil    727-210-2555   
Principal Investigator: Anthony Sebba         
Family Clinical Trials, LLC. Recruiting
Pembroke Pines, Florida, United States, 33026
Contact: Jeanne-Elyse Cedeno    954-842-3147   
Contact: Lisbel Gonzalez    954-842-3147   
Principal Investigator: Jeanne-Elyse Cedeno         
McIlwain Medical Group, PA Recruiting
Tampa, Florida, United States, 33613
Contact: Harris McIlwain    813-345-2393   
Contact: Dianne Morales    813-345-2382   
Principal Investigator: Harris McIlwain         
Lovelace Scientific Resources, Inc. Not yet recruiting
Venice, Florida, United States, 34292
Contact: Jeffrey Kaine    941-485-8314   
Contact: Mandy Burdine    941-485-8314   
Principal Investigator: Jeffrey Kaine         
United States, Georgia
Arthritis Center of North Georgia Not yet recruiting
Gainesville, Georgia, United States, 30501
Contact: Marta Bognar   
Contact: Laura Corn    678-677-8824   
Principal Investigator: Marta Bognar         
Marietta Rheumatology Associates, PC Not yet recruiting
Marietta, Georgia, United States, 30060
Contact: Roel Querubin    770-667-0220   
Contact: Emily Enlemann    770-372-3962   
Principal Investigator: Roel Querubin         
United States, Idaho
Advanced Clinical Research Recruiting
Boise, Idaho, United States, 83642
Contact: Mark Turner    208-377-8653   
Contact: Audra Weslowski    208-377-8653 ext 211   
Principal Investigator: Mark Turner         
Institute of Arthritis Research Recruiting
Idaho Falls, Idaho, United States, 83404
Contact: Craig Scoville    208-542-9080   
Contact: Carolina Saldana    208-542-9080   
Principal Investigator: Craig Scoville         
United States, Illinois
Rush University Medical Center Not yet recruiting
Chicago, Illinois, United States, 60612
Contact: Joel Block    312-942-8268   
Contact: Joshlean Fair    3125632955   
Principal Investigator: Joel Block         
Springfield Clinic, LLP Not yet recruiting
Springfield, Illinois, United States, 62703
Contact: Michael Pick    217-528-7541 ext 4434   
Contact: Jodie Galloway    217-525-4538   
Principal Investigator: Michael Pick         
United States, Indiana
Deaconess Clinic Withdrawn
Evansville, Indiana, United States, 47713-1227
United States, Kansas
University of Kansas Medical Center Research Institute, Inc. Withdrawn
Kansas City, Kansas, United States, 66160
Via Christi Research, a division of Via Christi Hospitals Wichita, Inc. Withdrawn
Wichita, Kansas, United States, 67208
United States, Kentucky
Graves Gilbert Clinic Recruiting
Bowling Green, Kentucky, United States, 42101
Contact: Asad Fraser    270-393-2786   
Contact: Mary Jo Marr    270-393-2786   
Principal Investigator: Asad Fraser         
Research Integrity, LLC. Withdrawn
Owensboro, Kentucky, United States, 42303
United States, Louisiana
The Arthritis & Diabetes Clinic, Inc. Recruiting
Monroe, Louisiana, United States, 71203
Contact: Jyothi Mallepalli    318-388-5830   
Contact: Leslie Hughes    318-812-1250   
Principal Investigator: Jyothi Mallepalli         
United States, Maine
Rheumatology Associates Withdrawn
Portland, Maine, United States, 04102
United States, Maryland
Klein and Associates, M.D., P.A. Recruiting
Cumberland, Maryland, United States, 21502
Contact: Steven Klein    301-724-4337   
Contact: Janie VanSkiver    301-724-4337 ext 1220   
Principal Investigator: Steven Klein         
Arthritis Treatment Center Withdrawn
Frederick, Maryland, United States, 21702
Klein and Associates, M.D., P.A. Recruiting
Hagerstown, Maryland, United States, 21740
Contact: Mary Howell    301-791-6680 ext 1131   
Contact: Richard Robinson II    301-791-6680 ext 1131   
Principal Investigator: Mary Howell         
The Center for Rheumatology and Bone Research Recruiting
Wheaton, Maryland, United States, 20902
Contact: Herbert Baraf    301-942-6610   
Contact: Meghan Lormore    301-942-6610   
Principal Investigator: Herbert Baraf         
United States, Michigan
AA MRC LLC Ahmed Arif Medical Research Center Recruiting
Grand Blanc, Michigan, United States, 48439
Contact: Ali Karrar    810-953-8700   
Contact: Iman Abdelrahman    810-694-0082   
Principal Investigator: Ali Karrar         
United States, Mississippi
North MS Medical Clinics, Inc. Not yet recruiting
Tupelo, Mississippi, United States, 38801
Contact: Charles King    662-377-5131   
Contact: Lara Blake    662-377-5131   
Principal Investigator: Charles King         
United States, Missouri
St. Louis Center for Clinical Research Withdrawn
Saint Louis, Missouri, United States, 63128
United States, Montana
Glacier View Research Instutute-Rheumatology Recruiting
Kalispell, Montana, United States, 59901
Contact: Roger Diegel    406-755-1460   
Contact: Jaime Wyatt    406-755-1460   
Principal Investigator: Roger Diegel         
United States, Nevada
Allied Clinical Research Recruiting
Reno, Nevada, United States, 89519
Contact: Bryan Wolf    775-800-6999   
Contact: Serafin Herrera    7758006999   
Principal Investigator: Bryan Wolf         
United States, New Jersey
Arthritis & Osteoporosis Associates, PA Recruiting
Freehold, New Jersey, United States, 07728
Contact: Hisham El-Kadi    732-780-7650   
Contact: Tara Lowenburg    732-410-4737   
Principal Investigator: Hisham El-Kadi         
United States, New Mexico
Lovelace Scientific Resources, Inc. Recruiting
Albuquerque, New Mexico, United States, 87108
Contact: Michael McGuire    505-348-9700   
Contact: Bonnie Gutierrez    505-348-9523   
Principal Investigator: Michael McGuire         
United States, New York
Weill Cornell Brain & Spine Center Recruiting
New York, New York, United States, 10021
Contact: David Goddard    929-455-2399   
Contact: Debra London    929-455-2585   
Principal Investigator: David Goddard         
United States, North Carolina
Medication Management, LLC Recruiting
Greensboro, North Carolina, United States, 27408
Contact: Mishra Nilamadhab    336-501-1761   
Contact: Casey Roberts    336-890-6015   
Principal Investigator: Mishra Nilamadhab         
Cape Fear Arthritis Care Recruiting
Leland, North Carolina, United States, 28451
Contact: David Snow    608-848-8900   
Contact: Olivia Anderson    710-679-3217   
Principal Investigator: David Snow         
Carolina Arthritis Associates Recruiting
Wilmington, North Carolina, United States, 28401
Contact: Mark Harris    910-762-1182   
Contact: Jodi Daniel    910-762-1182 ext 1022   
Principal Investigator: Mark Harris         
United States, North Dakota
Trinity Medical Group Recruiting
Minot, North Dakota, United States, 58701
Contact: Erdal Diri    701-857-2510   
Contact: Janelle Rostad    701-857-2510   
Principal Investigator: Erdal Diri         
United States, Ohio
STAT Research, Inc. Recruiting
Dayton, Ohio, United States, 45417
Contact: Sanford Wolfe    937-223-4229   
Contact: Lynette Tipton    937-223-4229   
Principal Investigator: Sanford Wolfe         
Clinical Research Source, Inc. Recruiting
Perrysburg, Ohio, United States, 43551
Contact: Edward Goldberger    419-873-1532   
Contact: Denise Coressel    419-873-1532   
Principal Investigator: Edward Goldberger         
United States, Oklahoma
Health Research of Oklahoma, PLLC Not yet recruiting
Oklahoma City, Oklahoma, United States, 73103
Contact: Christine Codding    405-702-6770   
Contact: Crista Bowling    405-702-6770   
Principal Investigator: Christine Codding         
Lynn Health Science Institute Recruiting
Oklahoma City, Oklahoma, United States, 73112
Contact: William Schnitz    405-602-3927   
Contact: Kim Hamilton    405-602-3939 ext 145   
Principal Investigator: William Schnitz         
United States, Pennsylvania
Altoona Center for Clinical Research, P.C. Recruiting
Duncansville, Pennsylvania, United States, 16635
Contact: Frederick Murphy    814-693-0300   
Contact: Kimberly Gates    800-924-7790   
Principal Investigator: Frederick Murphy         
Arthritis Group Recruiting
Philadelphia, Pennsylvania, United States, 19152
Contact: James Udell    215-725-1710   
Contact: Donah Crawford    215-725-1710   
Principal Investigator: James Udell         
United States, South Carolina
Low Country Rheumatology, PA Recruiting
North Charleston, South Carolina, United States, 29406
Contact: William Edwards    843-572-4840   
Contact: Kellean Van Cleef    843-572-1818   
Principal Investigator: William Edwards         
United States, Tennessee
Center for Inflammatory Disease Recruiting
Nashville, Tennessee, United States, 37203-2032
Contact: Robert LaGrone    615-690-0300   
Contact: Debra Jones    6153213277   
Principal Investigator: Robert LaGrone         
United States, Texas
Allergy Asthma Rheumatology Treatment Specialist (ARTS) Recruiting
Amarillo, Texas, United States, 79124
Contact: Constantine Saadeh    806-353-7000   
Contact: Kelly Witcher    806-352-2453   
Principal Investigator: Constantine Saadeh         
Austin Regional Clinic, P.A. Recruiting
Austin, Texas, United States, 78731
Contact: Tina Bunch    512-344-0362   
Contact: Vivian Mills    512-344-0362   
Principal Investigator: Tina Bunch         
Accurate Clinical Management LLC Recruiting
Baytown, Texas, United States, 77521
Contact: Sabeen Najam    832-672-7973   
Contact: Jorge Gonzalez    832-500-8169   
Principal Investigator: Sabeen Najam         
Diagnostic Group of Southeast Texas Withdrawn
Beaumont, Texas, United States, 77701
Pioneer Research Solutions, Inc. Not yet recruiting
Beaumont, Texas, United States, 77702
Contact: Vijay Kumar    713-333-9323   
Contact: Roselyn Bianco    409-833-1748   
Principal Investigator: Vijay Kumar         
Precision Comprehensive Clinical Research Solutions Not yet recruiting
Grapevine, Texas, United States, 76051
Contact: Dhiman Basu    972-299-8399   
Contact: Ashwin Boda    972-299-8399   
Principal Investigator: Dhiman Basu         
Accurate Clinical Management LLC Withdrawn
Houston, Texas, United States, 77004
Rheumatic Disease Clinical Research Center, LLC Withdrawn
Houston, Texas, United States, 77004
Accurate Clinical Research, Inc. Recruiting
Houston, Texas, United States, 77034
Contact: Philip Waller    281-481-8557   
Contact: Syed Saad    832-500-8169   
Principal Investigator: Philip Waller         
Accurate Clinical Research, Inc. Recruiting
Houston, Texas, United States, 77034
Contact: Amber Khan    281-422-7179   
Contact: Christopher Kurien    832-500-8169   
Principal Investigator: Amber Khan         
Rheumatology Clinic of Houston, P.A. Recruiting
Houston, Texas, United States, 77065
Contact: Qaiser Rehman    832-237-8585   
Contact: Kemal Baloch    (832) 237-8585   
Principal Investigator: Qaiser Rehman         
Houston Institute For Clinical Research Withdrawn
Houston, Texas, United States, 77074
Advanced Rheumatology of Houston Recruiting
Houston, Texas, United States, 77090
Contact: Tamar Brionez    281-766-7886   
Contact: Rizwana Nouman    936-681-4882   
Principal Investigator: Tamar Brionez         
Pioneer Research Solutions, Inc. Recruiting
Houston, Texas, United States, 77099
Contact: Asif Cochinwala    713-333-9323   
Contact: Khurram Shah    713-333-9323   
Principal Investigator: Asif Cochinwala         
West Texas Clinical Research Not yet recruiting
Lubbock, Texas, United States, 79410
Contact: Jitendra Vasandani    806-993-1040   
Contact: Brenda Parrish    806-993-1040   
Principal Investigator: Jitendra Vasandani         
Arthritis & Osteoporosis Associates LLP Withdrawn
Lubbock, Texas, United States, 79424
Accurate Clinical Research, Inc. Recruiting
Nassau Bay, Texas, United States, 77058
Contact: Prashanth Sunkureddi    713-677-0086   
Contact: Jose Zamora    832-500-8169   
Principal Investigator: Prashanth Sunkureddi         
Dr. Alex De Jesus Rheumatology, P.A. Recruiting
San Antonio, Texas, United States, 78229
Contact: Alex De Jesus    210-762-6577   
Contact: Lisa Sanchez    832-500-8169   
Principal Investigator: Alex De Jesus         
DM Clinical Research Not yet recruiting
Tomball, Texas, United States, 77375
Contact: Shaikh Arif Ali    281-517-0550   
Contact: Shivani Shah    281-517-0550 ext 403   
Principal Investigator: Shaikh Arif Ali         
Advanced Rheumatology of Houston Recruiting
Woodville, Texas, United States, 77382
Contact: Tamar Brionez    832-452-7249   
Contact: Rizwana Nouman    936-681-4882   
Principal Investigator: Tamar Brionez         
United States, Virginia
The Center For Arthritis and Rheumatic Diseases Withdrawn
Chesapeake, Virginia, United States, 23320
United States, Washington
Arthritis Northwest, PLLC Recruiting
Spokane, Washington, United States, 99204
Contact: Howard Kenney    509-838-6500   
Contact: Flori Mantello    509-838-6500 ext 192   
Principal Investigator: Howard Kenney         
The Vancouver Clinic Withdrawn
Vancouver, Washington, United States, 98664
United States, West Virginia
West Virginia Research Institute Recruiting
South Charleston, West Virginia, United States, 25309
Contact: Suzanne Gharib    304-389-4455   
Contact: Tammy Estep    304-389-4455   
Principal Investigator: Suzanne Gharib         
Hospital Italiano Regional del Sur Not yet recruiting
Bahia Blanca, Buenos Aires, Argentina, B8001HXM
Contact: Fabian Risueño    +542914557273   
Principal Investigator: Fabian Risueño         
Centro de Investigaciones Medicas Mar del Plata Not yet recruiting
Mar del Plata, Buenos Aires, Argentina, B7600FYK
Contact: Gladys Alicia Testa    +542234942575   
Principal Investigator: Gladys Alicia Testa         
Instituto de Investigaciones Clinicas-Mar del Plata Not yet recruiting
Mar del Plata, Buenos Aires, Argentina, B7600FZ
Contact: Juan Pablo Gulin    +542234963224   
Principal Investigator: Juan Pablo Gulin         
Instituto Medico CER Not yet recruiting
Quilmes, Buenos Aires, Argentina, B1878DVB
Contact: Benito Jorge Velasco Zamora    +541143509600   
Principal Investigator: Benito Jorge Velasco Zamora         
Instituto de Investigaciones Clinicas Quilmes Not yet recruiting
Quilmes, Buenos Aires, Argentina, B1878GEG
Contact: Jose Luis Velasco Zamora    +541142531337   
Principal Investigator: Jose Luis Velasco Zamora         
IARI Withdrawn
San Fernando, Buenos Aires, Argentina, 1646
Sanatorio Delta Withdrawn
Rosario, Santa Fe, Argentina, S2000BIF
Sanatorio Parque S.A. Withdrawn
Rosario, Santa Fe, Argentina, S2000DSV
Clinica de Higado y Aparato Digestivo Not yet recruiting
Rosario, Santa Fe, Argentina
Contact: Judith Carrio    +5493414215777   
Principal Investigator: Judith Carrio         
Sanatorio San Martin Not yet recruiting
Venado Tuerto, Santa Fe, Argentina, S2600KUE
Contact: Rosana Gallo    +543462155617485   
Principal Investigator: Rosana Gallo         
Centro Medico Privado de Reumatologia Not yet recruiting
San Miguel de Tucuman, Tucuman, Argentina, T4000AXL
Contact: Alberto Jorge Spindler    +543814200180   
Principal Investigator: Alberto Jorge Spindler         
Centro de Investigaciones Reumatológicas Not yet recruiting
San Miguel de Tucuman, Tucuman, Argentina, T4000BRD
Contact: Eleonora del Valle Lucero    +543814301098   
Principal Investigator: Eleonora del Valle Lucero         
Organizacion Medica de Investigacion (OMI) Not yet recruiting
Ciudad Autonoma Buenos Aires, Argentina, C1015ABO
Contact: Patricio Tate    +541143720308   
Principal Investigator: Patricio Tate         
APRILLUS Not yet recruiting
Ciudad Autonoma Buenos aires, Argentina, C1046AAQ
Contact: Pablo Alejandro Mannucci    +541149512763   
Principal Investigator: Pablo Alejandro Mannucci         
Centro de Investigacion en Enfermedades Reumaticas CIER Withdrawn
Ciudad Autonoma Buenos Aires, Argentina, C1055AAF
Expertia S.A- Mautalen Salud e Investigación Withdrawn
Ciudad Autonoma Buenos Aires, Argentina, C1128AAE
Instituto Centenario Not yet recruiting
Ciudad Autonoma Buenos Aires, Argentina, C1204AAD
Contact: Cecilia Asnal    +541149810256   
Principal Investigator: Cecilia Asnal         
Hospital General de Agudos Dr. J. M. Ramos Mejia Not yet recruiting
Ciudad Autonoma Buenos Aires, Argentina, C1221ADC
Contact: Eduardo Kerzberg    +541149311178   
Principal Investigator: Eduardo Kerzberg         
Atencion Integral en Reumatologia (AIR) Not yet recruiting
Ciudad Autonoma Buenos Aires, Argentina, C1426AAL
Contact: Horacio Oscar Venarotti    +541147812499   
Principal Investigator: Horacio Oscar Venarotti         
Consultora Integral de Salud S.R.L. Withdrawn
Cordoba, Argentina, 5004
Instituto Reumatológico Strusberg Withdrawn
Cordoba, Argentina, X5000EDC
Instituto DAMIC Fundacion Rusculleda Not yet recruiting
Cordoba, Argentina, X5003DCE
Contact: Gisela Constanza Subils    +543514888230   
Principal Investigator: Gisela Constanza Subils         
Centro Polivalente de Asistencia e Inv. Clinica CER Not yet recruiting
San Juan, Argentina, J5402DIL
Contact: Jose Luis Cristian Moreno    +542644211086;   
Principal Investigator: Jose Luis Cristian Moreno         
HUWC - UFC - Hospital Universitário Walter Cantídio - Universidade Federal do Ceará Not yet recruiting
Fortaleza, Ceará, Brazil, 60430-370
Contact: Leonardo Ribeiro Sampaio    +558533668590   
Principal Investigator: Leonardo Ribeiro Sampaio         
CEDOES - Diagnóstico e Pesquisa Not yet recruiting
Vitória, Espírito Santo, Brazil, 29055-450
Contact: Celso Ricardo Emerich de Abreu    +552721250220;   
Principal Investigator: Celso Ricardo Emerich de Abreu         
CIP - Centro Internacional de Pesquisa Not yet recruiting
Goiânia, Goiás, Brazil, 74110-120
Contact: Antônio Carlos Ximenes    +556232293280   
Principal Investigator: Antônio Carlos Ximenes         
CMiP - Centro Mineiro de Pesquisa Not yet recruiting
Juiz de Fora, Minas Gerais, Brazil, 36010-570
Contact: Antônio Scafuto Scotton    +553233128900 ;   
Principal Investigator: Antônio Scafuto Scotton         
CETI - Centro de Estudos em Terapias Inovadoras Ltda. Not yet recruiting
Curitiba, Paraná, Brazil, 80030-110
Contact: Sebastião Cézar Radominski    +554130223482   
Principal Investigator: Sebastião Cézar Radominski         
Clinilive - Clínica do Idoso e Pesquisa Clínica Not yet recruiting
Maringá, Paraná, Brazil, 87014-250
Contact: Antônio Carlos da Silva    +554430293004 ;   
Principal Investigator: Antônio Carlos da Silva         
Hospital Bruno Born Not yet recruiting
Lajeado, Rio Grande Do Sul, Brazil, 95900-000
Contact: Jussara Marilu Bohn    +555137147500XX377   
Principal Investigator: Jussara Marilu Bohn         
LMK Serviços Médicos S/S Ltda Not yet recruiting
Porto Alegre, Rio Grande Do Sul, Brazil, 90480-000
Contact: Mauro Waldemar Keiserman    +555133205057   
Principal Investigator: Mauro Waldemar Keiserman         
Faculdade de Medicina do ABC Not yet recruiting
Santo André, Sao Paulo, Brazil, 09060-650
Contact: Sônia Maria Alvarenga Anti Loduca Lima    +551149935606 ;   
Principal Investigator: Sônia Maria Alvarenga Anti Loduca Lima         
Hospital Estadual Mário Covas Not yet recruiting
Santo André, Sao Paulo, Brazil, 09190-610
Contact: Anna Maura Ferreira Fernandes    +551128295148 ;   
Principal Investigator: Anna Maura Ferreira Fernandes         
HUCFF-UFRJ - Hospital Universitário Clementino Fraga Filho - Universidade Federal do Rio de Janeiro Not yet recruiting
Rio de Janeiro, Brazil, 21941-913
Contact: Luís Roimicher    +552125626241   
Principal Investigator: Luís Roimicher         
CCBR Brasil Centro de Pesquisas e Análises Clínicas Ltda. Not yet recruiting
Rio de Janeiro, Brazil
Contact: Ana Cláudia Cauceglia Melazzi    +552125277979   
Principal Investigator: Ana Cláudia Cauceglia Melazzi         
CPCLIN - Centro de Pesquisas Clínicas Ltda. Not yet recruiting
São Paulo, Brazil, 01244-030
Contact: Flora Maria D'Andrea Marcolino    +551127110298 ; ;   
Principal Investigator: Flora Maria D'Andrea Marcolino         
Hospital Abreu Sodré - AACD Not yet recruiting
São Paulo, Brazil, 04023-000
Contact: Morton Aaron Scheinberg    +551159048078   
Principal Investigator: Morton Aaron Scheinberg         
MHAT-Plovdiv AD Recruiting
Plovdiv, Bulgaria, 4002
Contact: Ivan Goranov    +35932906177 0000 00 000000   
Principal Investigator: Ivan Goranov         
MHAT - Ruse, AD Recruiting
Ruse, Bulgaria, 7002
Contact: Nadezhda Kapandjieva    +359888411725   
Principal Investigator: Nadezhda Kapandjieva         
Medizinski Zentar-1-Sevlievo EOOD Recruiting
Sevlievo, Bulgaria, 5400
Contact: Mariyana Mihaylova    +359884344961   
Principal Investigator: Mariyana Mihaylova         
MHAT - Shumen, AD Recruiting
Shumen, Bulgaria, 9700
Contact: Stoyan Todorov    +35954855755   
Principal Investigator: Stoyan Todorov         
NMTH "Tsar Boris III" Recruiting
Sofia, Bulgaria, 1233
Contact: Antoaneta Toncheva    +35929311650   
Principal Investigator: Antoaneta Toncheva         
MHAT "Lyulin", EAD Recruiting
Sofia, Bulgaria, 1336
Contact: Emil Dimitrov    +359887617210   
Principal Investigator: Emil Dimitrov         
Medical Center "Excelsior", OOD Recruiting
Sofia, Bulgaria, 1407
Contact: Tsvetanka Petranova    +35928620601   
Principal Investigator: Tsvetanka Petranova         
MDHAT 'Dr. Stefan Cherkezov', AD Recruiting
Veliko Tarnovo, Bulgaria, 5000
Contact: Svetla Kopcheva    +35962640921   
Principal Investigator: Svetla Kopcheva         
Centro de Reumatologia y Ortopedia SAS Not yet recruiting
Barranquilla, Colombia, 080020
Contact: Juan Jose Jaller Raad    +5753450085   
Principal Investigator: Juan Jose Jaller Raad         
Fundacion Hospital Universidad del Norte Not yet recruiting
Barranquilla, Colombia
Contact: Carlo Caballero    +5753587496   
Principal Investigator: Carlo Caballero         
Fundacion Instituto de Reumatologia Fernando Chalem Not yet recruiting
Bogota, Colombia
Contact: Philippe Chalem    +5713466423   
Principal Investigator: Philippe Chalem         
Centro de Investigacion en Reumatologia y Especialidades Medicas SAS. CIREEM Not yet recruiting
Bogotá, Colombia
Contact: Patricia Julieta Velez Sanchez    +5716109131   
Principal Investigator: Patricia Julieta Velez Sanchez         
Medicity S.A.S. Not yet recruiting
Bucaramanga, Colombia
Contact: Diego Luis Saaibi    +575776399661   
Principal Investigator: Diego Luis Saaibi         
Clinica de Artritis Temprana S.A. Not yet recruiting
Cali, Colombia
Contact: Carlos Enrique Toro    +5725240885   
Principal Investigator: Carlos Enrique Toro         
Hospital Pablo Tobón Uribe Not yet recruiting
Medellín, Colombia, 050034
Contact: Javier Dario Marquez Hernandez    +5744459067   
Principal Investigator: Javier Dario Marquez Hernandez         
IMEDICA s.r.o. Withdrawn
Brno, Czechia, 602 00
Revmatologie s.r.o. Recruiting
Brno, Czechia, 638 00
Contact: Leona Prochazkova    +420545214556   
Principal Investigator: Leona Prochazkova         
Revmatologicka ambulance Recruiting
Jihlava, Czechia, 586 01
Contact: Andrea Houzarova    +420696982264   
Principal Investigator: Andrea Houzarova         
Revmatologicka a interni ambulance Recruiting
Kladno, Czechia, 272 01
Contact: Gabriela Simkova    +420312684223   
Principal Investigator: Gabriela Simkova         
Revmatologie MUDr. Klara Sirova s.r.o. Recruiting
Ostrava - Moravska Ostrava, Czechia, 702 00
Contact: Klara Sirova    +420596123011   
Principal Investigator: Klara Sirova         
Artroscan s.r.o. Recruiting
Ostrava - Trebovice, Czechia, 722 00
Contact: Ladislav Bortlik    +420596938950   
Principal Investigator: Ladislav Bortlik         
Vesalion s.r.o. Recruiting
Ostrava, Czechia, 70200
Contact: Libor Novosad    +420595044402   
Principal Investigator: Libor Novosad         
Clintrial, s.r.o. Recruiting
Praha 10, Czechia, 100 00
Contact: Vlasta Gollerova    +420487824287      
Principal Investigator: Vlasta Gollerova         
Revmatologicka ambulance Recruiting
Praha 4 Nusle, Czechia, 140 00
Contact: Zuzana Urbanova    +420261225638   
Principal Investigator: Zuzana Urbanova         
Nuselska poliklinika Recruiting
Praha 4, Czechia, 140 00
Contact: Zuzana Stejfova    +420234091145   
Principal Investigator: Zuzana Stejfova         
Fakultni nemocnice v Motole Recruiting
Praha 5, Czechia, 150 06
Contact: Rudolf Horvath    +420224433828   
Principal Investigator: Rudolf Horvath         
Affidea Praha, s.r.o. Recruiting
Praha, Czechia, 148 00
Contact: Jan Rosa    +420267090863   
Principal Investigator: Jan Rosa         
MEDICAL PLUS s.r.o. Recruiting
Uherske Hradiste, Czechia, 686 01
Contact: Eva Dokoupilova    +420572551850   
Principal Investigator: Eva Dokoupilova         
PV - Medical, s.r.o. Recruiting
Zlin, Czechia, 760 01
Contact: Petr Vitek    +420577221686   
Principal Investigator: Petr Vitek         
East Tallinn Central Hospital Recruiting
Tallinn, Estonia, 11312
Contact: Triin Savi    +3726067779   
Principal Investigator: Triin Savi         
Medita Kliinik OÜ Recruiting
Tartu, Estonia, 50107
Contact: Mart Kull    +3725220420   
Principal Investigator: Mart Kull         
Kerckhoff-Klinik gGmbH Recruiting
Bad Nauheim, Hessen, Germany, 61231
Contact: Ramona Koenig    +4960329962112   
Principal Investigator: Ramona Koenig         
CIRI - Centrum für Innovative Diagnostik und Therapie GmbH Recruiting
Frankfurt, Hessen, Germany, 60528
Contact: Frank Behrens    +496963017302   
Principal Investigator: Frank Behrens         
Rheumazentrum Prof. Dr. G. Neeck Withdrawn
Bad Doberan, Mecklenburg Vorpommern, Germany, 18209
SMO.MD GmbH Recruiting
Magdeburg, Sachsen Anhalt, Germany, 39120
Contact: Cornelia Kuehne    +493916119511   
Principal Investigator: Cornelia Kuehne         
Rheumapraxis Dr. med. Reiner Kurthen Recruiting
Aachen, Germany, 52064
Contact: Reiner Kurthen    +4924123276   
Charité Universitätsmedizin Berlin Dpt. of Dermatology Venerology and Allergology Recruiting
Berlin, Germany, 10117
Contact: Gerd-Ruediger Burmester    +4930450513061   
Principal Investigator: Gerd-Ruediger Burmester         
Klinische Forschung Berlin-Mitte GmbH Recruiting
Berlin, Germany, 10117
Contact: Andrei Khariouzov    +493094892368   
Principal Investigator: Andrei Khariouzov         
HRF Hamburger Rheuma Forschungszentrum Recruiting
Hamburg, Germany, 20095
Contact: Andrea Everding    +491785262647   
Principal Investigator: Andrea Everding         
Schoen Klinik Hamburg Eilbek Withdrawn
Hamburg, Germany, 22081
Studienambulanz Dr. Wassenberg Recruiting
Northeim, Germany, 40882
Contact: Siegfried Wassenberg    +4921025533788   
Principal SMO Kft. Recruiting
Baja, Hungary, 6500
Contact: Eva Somos    +3679422233X1413   
Principal Investigator: Eva Somos         
DRC Gyogyszervizsgalo Kozpont Kft. Recruiting
Balatonfured, Hungary, 8230
Contact: Gabriella Sulyok    +3687481616   
Principal Investigator: Gabriella Sulyok         
Clinexpert Egeszsegugyi Szolg. es Ker. Kft. Recruiting
Budapest, Hungary, 1033
Contact: Eszter Simoncsics    +3612108139   
Principal Investigator: Eszter Simoncsics         
Obudai Egeszsegugyi Centrum Recruiting
Budapest, Hungary, 1036
Contact: Magdolna Nagy    +3614367344   
Principal Investigator: Magdolna Nagy         
Debreceni Egyetem Klinikai Kozpont Not yet recruiting
Debrecen, Hungary, 4032
Contact: Sandor Szanto    +3652411600X56362   
Principal Investigator: Sandor Szanto         
Kiskunhalasi Semmelweis Korhaz Not yet recruiting
Kiskunhalas, Hungary, 6400
Contact: Katalin Takacs    +3677522074   
Principal Investigator: Katalin Takacs         
DRC Szekesfehervar Recruiting
Szekesfehervar, Hungary, 8000
Contact: Ildiko Rapolthy    +36302166170   
MAV Korhaz és Rendelointezet Not yet recruiting
Szolnok, Hungary, 5000
Contact: Attila Kovacs    +3656524654   
Principal Investigator: Attila Kovacs         
Vital Medical Center Recruiting
Veszprem, Hungary, 8200
Contact: Edit Drescher    +3688556280   
Principal Investigator: Edit Drescher         
Korea, Republic of
Pusan National University Hospital Not yet recruiting
Busan, Korea, Republic of, 49241
Contact: Seung-Geun Lee    82512407580   
Chonbuk National University Hospital Not yet recruiting
Chungbuk, Korea, Republic of, 54907
Contact: Wan Hee Yoo    +82632502579   
Chungnam National University Hospital Recruiting
Daejeon, Korea, Republic of, 35015
Contact: Seong Wook Kang    +82422808018 -00-000-0000   
Principal Investigator: Seong Wook Kang         
Eulji University Hospital Recruiting
Daejeon, Korea, Republic of, 35233
Contact: Mi-Kyoung Lim    +82426113150   
Principal Investigator: Mi-Kyoung Lim         
Chonnam National University Hospital Recruiting
Gwangju, Korea, Republic of, 61469
Contact: Shin-Seok Lee    +82622206590   
Principal Investigator: Shin-Seok Lee         
Jeju National University Hospital Not yet recruiting
Jeju, Korea, Republic of, 63241
Contact: Jinseok Kim    +82647171457   
Severance Hospital, Yonsei University Not yet recruiting
Seoul, Korea, Republic of, 03722
Contact: Yong-Beom Park    +8223935420   
Hanyang University Seoul Hospital Withdrawn
Seoul, Korea, Republic of, 04763
The Catholic University of Korea, Seoul St. Mary's Hospital Recruiting
Seoul, Korea, Republic of, 06591
Contact: Ji Hyeon Ju    +82222586893   
Principal Investigator: Ji Hyeon Ju         
Dr.Saulite-Kandevica Private Practice Recruiting
Liepaja, Latvia, LV-3401
Contact: Daina Saulite-Kandevica    +37129509038   
Principal Investigator: Daina Saulite-Kandevica         
GK Neuroklinika Not yet recruiting
Riga, Latvia, LV1011
Contact: Signe Zelca    +37129227961   
Principal Investigator: Signe Zelca         
Alytus Regional S. Kudirkos Hospital, Public Institution Recruiting
Alytus, Lithuania, 62114
Contact: Virginija Lietuvininkiene    +37068521009   
Principal Investigator: Virginija Lietuvininkiene         
Republican Kaunas Hospital, Public Institution Recruiting
Kaunas, Lithuania, 45130
Contact: Joana Dambrauskiene    +37037342062   
Principal Investigator: Joana Dambrauskiene         
Klaipeda University Hospital, Public Institution Recruiting
Klaipeda, Lithuania, 92288
Contact: Loreta Bukauskiene    +37068684485   
Principal Investigator: Loreta Bukauskiene         
Siauliai Republican Hospital, Public Institution Recruiting
Siauliai, Lithuania, 76231
Contact: Vida Basijokiene    +37068678245   
Principal Investigator: Vida Basijokiene         
Vilnius University Hospital Santariskiu Clinic, Public Institution Recruiting
Vilnius, Lithuania, LT-08661
Contact: Jelena Ranceva    +37052365201   
Principal Investigator: Jelena Ranceva         
Center Outpatient Clinic, Public Institution Recruiting
Vilnius, Lithuania, LT01117
Contact: Ruta Lauciuviene    +37069935268   
Principal Investigator: Ruta Lauciuviene         
Centro de Investigacion Clínica GRAMEL S.C Not yet recruiting
Mexico, DisMexicotrito Federal, Mexico, 03720
Contact: Luis Jara Quezada    +525552546698   
Principal Investigator: Luis Jara Quezada         
Clinicos Asociados BOCM S.C. Not yet recruiting
Mexico, Distrito Federal, Mexico, 03300
Contact: Angela Veronica Vicente Gonzalez    +525555115833   
Principal Investigator: Angela Veronica Vicente Gonzalez         
Comite Mexicano Para la Prevencion de Osteoporosis AC Not yet recruiting
Mexico, Distrito Federal, Mexico, 06100
Contact: Erika Vera Perez    +525555741900   
Principal Investigator: Erika Vera Perez         
Clinstile, S.A. de C.V. Not yet recruiting
Mexico, Distrito Federal, Mexico, 06700
Contact: Favio Edmundo Enriquez Sosa    +525555334180   
Principal Investigator: Favio Edmundo Enriquez Sosa         
Clinical Research Institute S.C. Not yet recruiting
Tlalnepantla, Estado De Mexico, Mexico, 54055
Contact: Miguel Saavedra Salinas    +525552651800x4330   
Principal Investigator: Miguel Saavedra Salinas         
Clinica de Investigacion en Reumatologia y Obesidad S.C. Not yet recruiting
Guadalajara, Jalisco, Mexico, 44650
Contact: Sergio Duran Barragan    +523338170562   
Principal Investigator: Sergio Duran Barragan         
Centro de Estudios de Investigacion Basica y Clinica SC Not yet recruiting
Guadalajara, Jalisco, Mexico, 44690
Contact: Ignacio Garcia Valladares    +523336165859   
Principal Investigator: Ignacio Garcia Valladares         
Accelerium S. de R.L. de C.V. Not yet recruiting
Monterrey, Nuevo León, Mexico, 64000
Contact: Edmundo De la Garza Ramos    +528183461160   
Principal Investigator: Edmundo De la Garza Ramos         
Hospital y Clinica OCA SA de CV Not yet recruiting
Monterrey, Nuevo León, Mexico, 64000
Contact: Arturo Villarreal Ortega    +528114777005   
Principal Investigator: Arturo Villarreal Ortega         
Universidad Autonoma de Nuevo Leon, Hospital Universitario Dr. Jose Eleuterio Gonzalez Not yet recruiting
Monterrey, Nuevo León, Mexico, 64460
Contact: Diana Flores Alvarado    +528183482015   
Principal Investigator: Diana Flores Alvarado         
Investigacion y Biomedicina de Chihuahua, S.C. Not yet recruiting
Chihuahua, Mexico, 31000
Contact: Cesar Pacheco Tena    +526144373002   
Principal Investigator: Cesar Pacheco Tena         
Centro de Alta Especialidad en Reumatología e Investigación del Potosí, S.C. Not yet recruiting
San Luis Potosi, Mexico, 78213
Contact: Juan Rizo Rodriguez    +524448084352   
Principal Investigator: Juan Rizo Rodriguez         
CERMED Recruiting
Bialystok, Poland, 15-270
Contact: Krystyna Kuc    +48603157778   
Principal Investigator: Krystyna Kuc         
NZOZ ZDROWIE Osteo-Medic Recruiting
Bialystok, Poland, 15-351
Contact: Artur Racewicz    +48856749013 0 0000 0000000   
Principal Investigator: Artur Racewicz         
Szpital Uniwersytecki nr 2 im.dr J. Biziela Recruiting
Bydgoszcz, Poland, 85-168
Contact: Iwona Dankiewicz-Fares    +48523655631   
Principal Investigator: Iwona Dankiewicz-Fares         
McBk S.C. Recruiting
Grodzisk Mazowiecki, Poland, 05-825
Contact: Krystyna Jedrychowicz-Rosiak    +48602184985   
Principal Investigator: Krystyna Jedrychowicz-Rosiak         
Polimedica Centrum Badań, Profilaktyki I Leczenia Recruiting
Kielce, Poland, 25-364
Contact: Mirella Wojtecka-Grabka    +48693163758   
Centrum Medyczne AMED Recruiting
Lodz, Poland, 91-347
Contact: Anna Dudek    +4848224004041   
Principal Investigator: Anna Dudek         
ETYKA Osrodek Badan Klinicznych Recruiting
Olsztyn, Poland, 10-117
Contact: Agnieszka Pawtel    +48608434310   
Principal Investigator: Agnieszka Pawtel         
Szpital Wojewodzki im. Prymasa Kardynala Stefana Wyszynskiego Recruiting
Sieradz, Poland, 98-200
Contact: Robert Kolacinski    +48602115037   
Principal Investigator: Robert Kolacinski         
CCBR - Lodz - PL Recruiting
Skierniewice, Poland, 96-100
Contact: Anna Strzelecka    +48468334910   
Principal Investigator: Anna Strzelecka         
Clinmedica Research Recruiting
Skierniewice, Poland, 96-100
Contact: Sylwia Olechnowicz-Tietz    +4842605680092   
Principal Investigator: Sylwia Olechnowicz-Tietz         
RCMed Recruiting
Sochaczew, Poland, 96-500
Contact: Monika Wronisz    +48468611390   
Principal Investigator: Monika Wronisz         
KO-MED Centra Kliniczne Staszow Recruiting
Staszow, Poland, 28-200
Contact: Krystyna Dworak    +48158641234   
Principal Investigator: Krystyna Dworak         
Samodzielny Publiczny ZOZ Tomaszow Lubelski Recruiting
Tomaszow Lubelski, Poland, 22-600
Contact: Andrzej Kaminski    +48609594722   
Principal Investigator: Andrzej Kaminski         
Niepubliczny Zaklad Opieki Zdrowotnej "Nasz Lekarz" Praktyka Grupowa Lekarzy Rodzinnych z Recruiting
Torun, Poland, 87-100
Contact: Slawomir Jeka    +48523655731   
Principal Investigator: Slawomir Jeka         
Medycyna Kliniczna Recruiting
Warszawa, Poland, 00-660
Contact: Agnieszka Zielinska    +48228346336   
Principal Investigator: Agnieszka Zielinska         
Rheuma Medicus Zaklad Opieki Zdrowotnej Recruiting
Warszawa, Poland, 02-118
Contact: Maria Rell-Bakalarska    +48224011028   
Principal Investigator: Maria Rell-Bakalarska         
McM Polimedica Recruiting
Wysokie Mazowieckie, Poland, 02777
Contact: Anna Rowinska-Osuch    +48224046878   
KO-MED Centra Kliniczne Zamosc Recruiting
Zamosc, Poland, 22-400
Contact: Agnieszka Rapa    +48846278887   
Principal Investigator: Agnieszka Rapa         
Santa Familia Centrum Badan, Profilaktyki i Leczenia Recruiting
Zgierz, Poland, 95-100
Contact: Jadwiga Burczynska    +48427174038   
Centrul Medical Sana SRL Withdrawn
Bucuresti, Romania, 011025
Spitalul Clinic Judetean de Urgenta "Sf. Apostol Andrei" Constanta Recruiting
Constanta, Romania, 900591
Contact: Ana Maria Ramazan    +40769657789   
Principal Investigator: Ana Maria Ramazan         
Mediab SRL Withdrawn
Targu Mures, Romania, 540142
Russian Federation
SPb SBHI "Clinical Rheumatological Hospital #25", Fourth Rheumatology Unit Recruiting
Saint Petersburg, Leningradskaya Oblast, Russian Federation, 190068
Contact: Galina Matsyevskaya    +79217465972   
Principal Investigator: Galina Matsyevskaya         
FSBEI HE "FMSMU n.a. I.M. Sechenov of MoH of RF", University Hospital #2, Departament of New Drugs Introduction Recruiting
Moscow, Moscovskaya Oblast, Russian Federation, 119991
Contact: Elena Smolyarchuk    +7 (916) 686-41-66   
Principal Investigator: Elena Smolyarchuk         
State Budgetary Healthcare Institution "City Clinical Hospital # 15 n.a O.M. Filatov" of Moscow Healtheare Department Recruiting
Moscow, Moscow Region, Russian Federation, 111539
Contact: Ivan Gordeev    +79265345912   
Principal Investigator: Ivan Gordeev         
SBHI of Nizhny Novgorod Region "Nizhny Novgorod Regional Clinical Hospital n.a.Semashko" Recruiting
Nizhniy Novgorod, Nizhegorodskaya Oblast, Russian Federation, 603126
Contact: Tatyana Plaksina    +7 (920) 298-25-89   
Principal Investigator: Tatyana Plaksina         
State Budgetary Healthcare Institution "Republican Clinical Hospital n.a. G.G. Kuvatov" Recruiting
Ufa, Republic Of Bashkortostan, Russian Federation, 450005
Contact: Rimma Kamalova    +79174502905   
Principal Investigator: Rimma Kamalova         
SBHI of Republic of Karelia "Republican Hospital named after V.A.Baranov" Recruiting
Petrozavodsk, Republic Of Karelia, Russian Federation, 185019
Contact: Natalia Vezikova    +79114014021   
Principal Investigator: Natalia Vezikova         
Non-govarnmental Healtheare Institution "Regional Clinical Hospital at Smolensk station of OJSC "Russian Railways" Recruiting
Smolensk, Smolenskaya Oblast, Russian Federation, 214025
Contact: Diana Krechikova    +79107896462   
Principal Investigator: Diana Krechikova         
State Budgetary Healthcare Institution of Sverdlovsk Region "Sverdlovsk Regional Clinical Hospital #1" Recruiting
Ekaterinburg, Sverdlovskaya Oblast, Russian Federation, 620102
Contact: Ludmila Evstigneeva    +7 (922) 204-97-85   
Principal Investigator: Ludmila Evstigneeva         
SBEI HPE "Ural State Medical University" of MoH of RF based MBI "Central City Clinical Hospital #6" Recruiting
Ekaterinburg, Sverdlovskaya Oblast, Russian Federation, 620149
Contact: Nadezhda Izmozherova    +79122899213   
Principal Investigator: Nadezhda Izmozherova         
State Autonomous Healthcare Institution "Republican Clinical Hospital of Ministry of Health of Tatarstan Republic Withdrawn
Kazan', The Republic Of Tatarstan, Russian Federation, 420064
FSBSI "Scientific Research Institute of Rheumatology n.a. V.A. Nasonova" Recruiting
Moscow, Russian Federation, 115522
Contact: Marina Stanislav    +79166920666   
Principal Investigator: Marina Stanislav         
China Medical University Hospital Recruiting
Taichung, Taiwan, 40447
Contact: Chung-Ming Huang    +8864220521213488 000000000   
Principal Investigator: Chung-Ming Huang         
Chi Mei Medical Center Recruiting
Tainan, Taiwan, 710
Contact: Hung-An Chen    +88662812811   
Principal Investigator: Hung-An Chen         
Tri-Service General Hospital Withdrawn
Taipei, Taiwan, 11490
Chang Gung Memorial Hospital, Linkou Recruiting
Taoyuan, Taiwan, 333
Contact: Lieh-Bang Liou    +886332812008812 00000000   
Principal Investigator: Lieh-Bang Liou         
United Kingdom
Derriford Hospital Withdrawn
Plymouth, Devon, United Kingdom, PL6 8DH
Torbay Hospital Not yet recruiting
Torquay, Devon, United Kingdom, TQ2 7AA
Contact: Catherine Gwynne    +441803654832   
Principal Investigator: Catherine Gwynne         
Christchurch Hospital Not yet recruiting
Christchurch, Dorset, United Kingdom, BH23 2JX
Contact: Jonathan Marks    +441202486361   
Principal Investigator: Jonathan Marks         
Queen's Hospital Withdrawn
Romford, Essex, United Kingdom, RM7 0AG
Whipps Cross University Hospital Recruiting
London, Greater London, United Kingdom, E11 1NR
Contact: Hasan Tahir    +442085356615   
Principal Investigator: Hasan Tahir         
Royal Free Hospital Not yet recruiting
London, Greater London, United Kingdom, NW3 2QG
Contact: Voon Ong    +442073177544   
Principal Investigator: Voon Ong         
Basingstoke and North Hampshire Hospital Not yet recruiting
Basingstoke, Hampshire, United Kingdom, RG24 9NA
Contact: Emma Williams    +447932785488   
Principal Investigator: Emma Williams         
Maidstone Hospital Recruiting
Maidstone, Kent, United Kingdom, ME16 9QQ
Contact: Michael Batley    +441622225265   
Arrowe Park Hospital Recruiting
Wirral, Merseyside, United Kingdom, CH49 5PE
Contact: Emmanuel George    +4415106047244   
Principal Investigator: Emmanuel George         
King's Mill Hospital Withdrawn
Nottingham, Nottinghamshire, United Kingdom, NG17 4JL
Glasgow Royal Infirmary Not yet recruiting
Glasgow, Strathclyde, United Kingdom, G4 0SF
Contact: Rajan Madhok    +441412114988   
Principal Investigator: Rajan Madhok         
Ninewells Hospital Not yet recruiting
Dundee, Tayside Region, United Kingdom, DD1 9SY
Contact: Vinod Kumar    +441382740089   
Principal Investigator: Vinod Kumar         
Sponsors and Collaborators
Quintiles, Inc.
OCT Clinical Trials
Layout table for investigator information
Study Director: Mikhail Samsonov R-Pharm

Layout table for additonal information
Responsible Party: R-Pharm Identifier: NCT02760407     History of Changes
Other Study ID Numbers: CL04041023
First Posted: May 3, 2016    Key Record Dates
Last Update Posted: December 3, 2018
Last Verified: November 2018
Keywords provided by R-Pharm:
moderate Rheumatoid Arthritis
severe Rheumatoid Arthritis
Additional relevant MeSH terms:
Layout table for MeSH terms
Arthritis, Rheumatoid
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases
Abortifacient Agents, Nonsteroidal
Abortifacient Agents
Reproductive Control Agents
Physiological Effects of Drugs
Antimetabolites, Antineoplastic
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Dermatologic Agents
Enzyme Inhibitors
Folic Acid Antagonists
Immunosuppressive Agents
Immunologic Factors
Antirheumatic Agents
Nucleic Acid Synthesis Inhibitors
Anti-Inflammatory Agents