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Trial record 1 of 1 for:    NCT02548351
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Randomized Global Phase 3 Study to Evaluate the Impact on NASH With Fibrosis of Obeticholic Acid Treatment (REGENERATE)

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ClinicalTrials.gov Identifier: NCT02548351
Recruitment Status : Recruiting
First Posted : September 14, 2015
Last Update Posted : January 24, 2018
Sponsor:
Information provided by (Responsible Party):
Intercept Pharmaceuticals

Brief Summary:
The primary objectives of this study are to evaluate the effect of Obeticholic Acid treatment compared to placebo on 1) histological improvement and 2) liver-related clinical outcomes in patients with non-cirrhotic nonalcoholic steatohepatitis (NASH) with liver fibrosis.

Condition or disease Intervention/treatment Phase
Non Alcoholic Steatohepatitis (NASH) Drug: Obeticholic Acid Drug: Placebo Phase 3

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 2370 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Phase 3, Double-Blind, Randomized, Long-Term, Placebo-Controlled, Multicenter Study Evaluating the Safety and Efficacy of Obeticholic Acid in Subjects With Nonalcoholic Steatohepatitis
Study Start Date : September 2015
Estimated Primary Completion Date : October 2022
Estimated Study Completion Date : October 2022


Arm Intervention/treatment
Experimental: 10 mg Obeticholic Acid
10 mg Obeticholic Acid daily for the remainder of the study
Drug: Obeticholic Acid
Experimental: 25 mg Obeticholic Acid
25 mg Obeticholic Acid daily for the remainder of the study
Drug: Obeticholic Acid
Placebo Comparator: Placebo
One tablet daily for the remainder of the study
Drug: Placebo



Primary Outcome Measures :
  1. To evaluate the effect of Obeticholic Acid compared to placebo on liver histology in non-cirrhotic nonalcoholic steatohepatitis (NASH) subjects with stage 2 or 3 fibrosis by assessing the following primary endpoints [ Time Frame: Measurements at Baseline and 18 months ]

    Primary endpoints include:

    • The proportion of Obeticholic Acid treated patients relative to placebo achieving at least one stage of liver fibrosis improvement with no worsening of NASH, or
    • The proportion of Obeticholic Acid treated patients relative to placebo achieving NASH resolution with no worsening of liver fibrosis.

  2. To evaluate the effect of Obeticholic Acid compared to placebo on all-cause mortality and liver-related clinical outcomes as measured by the time to first occurrence of any of the listed adjudicated events (clinical outcomes composite endpoint) [ Time Frame: Time to accrue a pre-specified number of adjudicated events, End of Study, estimated to be 7 years ]

    Primary endpoint events include:

    Death (all cause), model of end stage liver disease (MELD) score ≥15, liver transplant, hepatocellular carcinoma (HCC), ascites requiring medical intervention, histological progression to cirrhosis, hospitalization (as defined by a stay of ≥24 hours) for onset of: variceal bleed, hepatic encephalopathy, spontaneous bacterial peritonitis.



Secondary Outcome Measures :
  1. To evaluate the effect of Obeticholic Acid compared to placebo on liver histology in NASH [ Time Frame: Measurements at Baseline and 18 months up to 7 years ]
    • Improvement of fibrosis and NASH as a composite endpoint
    • Resolution of fibrosis



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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Histologic evidence of NASH upon central read of a liver biopsy obtained no more than 6 months before Day 1 defined by presence of all 3 key histological features of NASH with a score of at least 1 for each and a combined score of 4 or greater out of a possible 8 points according to NASH CRN criteria.
  2. Histologic evidence of fibrosis stage 2 (perisinusoidal and portal/periportal) or stage 3 (bridging fibrosis) as defined by the NASH CRN scoring of fibrosis, or

    Histologic evidence of fibrosis stage 1a or stage 1b (mild or moderate, zone 3 perisinusoidal) as defined by the NASH CRN scoring of fibrosis if accompanied by ≥1 of the following risk factors:

    • Obesity (BMI ≥30 kg/m2)
    • Type 2 diabetes diagnosed per 2013 American Diabetes Association criteria (hemoglobin A1c [HbA1c] ≥6.5%, fasting plasma glucose ≥126 mg/dL, 2-hour plasma glucose ≥200 mg/dL during oral glucose tolerance test, or random plasma glucose ≥200 mg/dL)
    • ALT >1.5× upper limit of normal (ULN).
  3. For subjects with a historical biopsy, is either not taking or is on stable doses of TZDs/glitazones or vitamin E for 6 months before Day 1.
  4. Stable body weight (ie, not varying by >10% for at least 3 months) before Day 1.
  5. Age ≥18 years.
  6. Female subjects of childbearing potential must use ≥1 effective method of contraception during the study and until 30 days following the last dose of investigational product. Effective methods of contraception are considered to be those listed below:

    • Barrier method, ie, condom (male or female) with spermicide or diaphragm with spermicide
    • Intrauterine device
    • Vasectomy (partner)
    • Hormonal (eg, contraceptive pill, patch, intramuscular implant or injection)
    • Abstinence (defined as refraining from heterosexual intercourse).
  7. Must provide written informed consent and agree to comply with the study protocol.

Exclusion Criteria:

  1. Current or history of significant alcohol consumption for a period of more than 3 consecutive months within 1 year before Screening (significant alcohol consumption is defined as more than 2 units/day for females and more than 4 units/day for males, on average).
  2. Prior (at any point) or planned (during the study period) ileal resection, or prior (within 5 years before Screening) or planned (during the study period) bariatric surgery (eg, gastric bands, gastroplasty, roux-en-Y gastric bypass).
  3. HbA1c >9.5% within 60 days before Day 1.
  4. Evidence of other forms of known chronic liver disease including:

    • Positive test result at Screening for hepatitis B surface antigen (hBsAg)
    • Active hepatitis C virus (HCV) infection (positive for HCV ribonucleic acid [RNA] at Screening) or history of positive HCV RNA test result
    • PBC, PSC, autoimmune hepatitis, or overlap syndrome
    • Alcoholic liver disease
    • Wilson's disease, hemochromatosis, or iron overload
    • Alpha-1-antitrypsin (A1AT) deficiency as defined by diagnostic features in liver histology (confirmed by A1AT level below the lower limit of normal [LLN] or exclusion at the Investigator's discretion)
    • Prior known drug-induced liver injury within 5 years before Day 1
    • Known or suspected HCC
    • History of liver transplant, current placement on a liver transplant list, or MELD score >12.
  5. Histological presence of cirrhosis.
  6. Total bilirubin >1.5 mg/dL (subjects with Gilbert's syndrome may be enrolled despite a total bilirubin level >1.5 mg/dL if their conjugated bilirubin is <1.5× ULN).
  7. Conjugated bilirubin ≥1.5 ULN.
  8. AST or ALT ≥10× ULN, international normalized ratio (INR) >1.5, or serum creatinine ≥1.5 mg/dL.
  9. Creatine phosphokinase >5x ULN.
  10. Platelet count <100 000/mm3.
  11. LDL ≥190 mg/dL and already on a stable dose of statin and/or proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor for ≥30 days at Screening.
  12. Inability to safely undergo a liver biopsy.
  13. History of biliary diversion.
  14. Known positivity for human immunodeficiency virus infection.
  15. Subjects with recent history (within 1 year of Day 1) of significant atherosclerotic cardiovascular disease (myocardial infarction, unstable angina, acute coronary syndrome, cerebrovascular accident [stroke], cerebrovascular ischemia, transient ischemic attack, or peripheral vascular disease requiring intervention). Such subjects may be identified by different means, including but not limited to, an abnormal ECG, a history or planned cardiovascular intervention such as coronary revascularization (eg, percutaneous coronary intervention or coronary artery bypass graft), coronary angioplasty, stenting, carotid atherectomy, or placement of a cardiac pacemaker or defibrillator.

    • Controlled hypertension without other recent manifestations of significant atherosclerotic cardiovascular disease and placement of cardiac pacemaker or defibrillator for reasons other than atherosclerotic cardiovascular disease (eg, for treatment of atrial fibrillation subsequent to nodal ablation) is not exclusionary.

  16. Other medical conditions that may diminish life expectancy to <2 years, including known cancers (except carcinomas in situ or other stable, relatively benign carcinomas).
  17. Known substance abuse in the year before Screening.
  18. Pregnancy, planned pregnancy, potential for pregnancy (ie, unwillingness to use effective birth control during the study), or current or planned breast feeding.
  19. Participated in a clinical research study with any investigational product being evaluated for the treatment of diabetes, weight loss, or NASH in the 6 months before Day 1.
  20. Received any investigational product not being evaluated for the treatment of diabetes, weight loss, or NASH from Screening to Day 1, within 30 days before Day 1, or within 5 half-lives of the compound (whichever was longer) before Day 1.
  21. Previous exposure to OCA.
  22. Mental instability or incompetence, such that the validity of informed consent or ability to be compliant with the study, is uncertain.
  23. History of known or suspected clinically significant hypersensitivity to OCA or any of its components.
  24. Any other condition that, in the opinion of the Investigator, would impede compliance or hinder completion of the study.
  25. Acute cholecystitis or acute biliary obstruction.
  26. BMI >45 kg/m2 with at least 1 of the following comorbidities:

    • Hypertension with blood pressure ≥140/90 mmHg if <60 years, ≥150/90 mmHg if ≥60 years, or on antihypertensive medication
    • Hyperlipidemia defined as LDL cholesterol ≥160 mg/dL, total cholesterol ≥200 mg/dL, or on lipid lowering medication
    • Type 2 diabetes per 2013 American Diabetes Association criteria

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02548351


Contacts
Contact: Szecho Lin, B.S. 858 832 4509 szecho.lin@interceptpharma.com

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Locations
United States, Alabama
University of Alabama at Birmingham Recruiting
Birmingham, Alabama, United States, 35294
Contact: Cassandra Ridgel    205-975-4016    cassandraridgel@uabmc.edu   
Principal Investigator: Ashwani Singal, MD         
Digestive Health Specialists of the Southeast Recruiting
Dothan, Alabama, United States, 36305
Contact: Ben Riedlinger    919-781-2514    briedlinger@wakeresearch.com   
Principal Investigator: William McLaughlin, MD         
University of South Alabama Recruiting
Mobile, Alabama, United States, 36688
Contact: Darlene Howard       drhoward@health.southalabama.edu   
Principal Investigator: Phillip Henderson, MD         
United States, Arizona
The Institute for Liver Health Recruiting
Chandler, Arizona, United States, 85294
Contact: Anita Kohli    602-406-2147    Anita.Kohli@DignityHealth.org   
Principal Investigator: Richard Manch, MD         
Banner - Advanced Liver Disease and Transplant Center Recruiting
Phoenix, Arizona, United States, 85006
Contact: Laura Wilkes    602-839-6211    LAURA.WILKES@BANNERHEALTH.COM   
Principal Investigator: Ester Little, MD         
St. Joseph's Hospital and Medical Center Recruiting
Phoenix, Arizona, United States, 85013
Contact: Emily Khoury    602-406-3614    emily.khoury@DignityHealth.org   
Principal Investigator: Anita Kohli, MD         
Mayo Clinic Recruiting
Phoenix, Arizona, United States, 85054
Contact: Kelly Clark    480-342-2536    clark.kelly2@mayo.edu   
Principal Investigator: Elizabeth Carey, MD         
United States, Arkansas
Liver Wellness Center Recruiting
Little Rock, Arkansas, United States, 72204
Contact: Lynn Frazier    501-687-9300    lfrazier@adclr.com   
Principal Investigator: Alonzo Williams, MD         
Arkansas Gastroenterology Recruiting
North Little Rock, Arkansas, United States, 72117
Contact: Amie Crow    501-945-9300    amie@arkgi.net   
Principal Investigator: Whitfield Knapple, MD         
United States, California
GW Research Inc. Recruiting
Chula Vista, California, United States, 91910
Contact: Judy Barron    619-585-8882    crc@gwresearch.net   
Principal Investigator: Gregory Wiener, MD         
Precision Research Institute Recruiting
Chula Vista, California, United States, 91910
Contact: Hakim Mohamed    619-861-5314    mhakim@oscmsandiego.com   
Principal Investigator: Cynthia L Schaeffer, MD         
eStudy Site Recruiting
Chula Vista, California, United States, 91911
Contact: May Tetangco    619-955-5246    mtetangco@estudysite.com   
Principal Investigator: Michael Water, MD         
Southern California Research Center Recruiting
Coronado, California, United States, 92118
Contact: Fatma Barakat    619-522-0330 ext 235    fbarakat@livercenters.com   
Principal Investigator: Tarek Hassanein, MD         
TriWest Research Associates Recruiting
El Cajon, California, United States, 92020
Contact: Nancy Moore    619-334-4735    nmoore@triwestresearch.com   
Principal Investigator: Donald Lipkis, MD         
UCSF Fresno Clinical Research Center Recruiting
Fresno, California, United States, 93701
Contact: Sonia Garcia    559-499-6637    sgarcia@fresno.ucsf.edu   
Principal Investigator: Bakht Roshan, MD         
Fresno Clinical Research Center (FCRC) Recruiting
Fresno, California, United States, 93720
Contact: Muhammad Sheikh, MD    559-393-6999    liverdisease@gmail.com   
Principal Investigator: Muhammad Sheikh, MD         
Citrus Valley Gastroenterology Recruiting
Glendora, California, United States, 91740
Contact: Sita Patel    714-726-7225    sita@abs-health.com   
Principal Investigator: Sartaj Marty Arora, MD         
Scripps Clinic Recruiting
La Jolla, California, United States, 92037
Contact: Marjory Simpson    858-652-5420    simpson.marjory@scrippshealth.org   
Principal Investigator: Paul J Pockros, MD         
University of California, San Diego Recruiting
La Jolla, California, United States, 92093-0063
Contact: Phirum Nguyen       psnguyen@mail.ucsd.edu   
Contact: Monica Gonzalez       mpg001@ucsd.edu   
Principal Investigator: Rohit Loomba, MD         
Loma Linda University Not yet recruiting
Loma Linda, California, United States, 92354
Contact: Ryan Evans    909-558-3870    KSelim@llu.edu   
Principal Investigator: Khaled Selim, MD         
Loma Linda Veterans Association for Research & Education Recruiting
Loma Linda, California, United States, 92357
Contact: Rebecca Lynne    909-583-6361    Rebecca.Ruybalid@va.gov   
Principal Investigator: Cindy Cai         
Keck Medical Center of USC Recruiting
Los Angeles, California, United States, 90033
Contact: Valentina Rodina, MD, MS, CCRP       valentina.rodina@med.usc.edu   
Principal Investigator: Liyun Yuan, MD         
Ruane Medical and Clinical Research Institute Recruiting
Los Angeles, California, United States, 90036
Contact: Dani Ain       dain@ruanemedical.com   
Principal Investigator: Peter Ruane, MD         
Cedars Sinai Medical Center Recruiting
Los Angeles, California, United States, 90048
Contact: Laura Sarmiento    310-423-4295    Laura.Sarmiento@cshs.org   
Principal Investigator: Vinay Sundaram, MD         
National Research Institute, Wilshire Recruiting
Los Angeles, California, United States, 90057
Contact: Lynn Frazier    501-687-9300    lfrazier@adclr.com   
Principal Investigator: Juan Frias, MD         
Gastrointestinal Biosciences Recruiting
Los Angeles, California, United States, 90067
Contact: David Streja       david@emclinical.com   
Principal Investigator: Nicholas Karyotakis, MD         
VA Greater Los Angeles Health Care System Recruiting
Los Angeles, California, United States, 90073
Contact: Elena Goncharova       elena.goncharova@va.gov   
Principal Investigator: Neville R Pimstone, MD         
David Geffen School of Medicine at UCLA Recruiting
Los Angeles, California, United States, 90095
Contact: Val Peacock       vpeacock@mednet.ucla.edu   
Principal Investigator: Francisco Durazo, MD         
Surinder Saini, M.D., Inc Recruiting
Newport Beach, California, United States, 92660
Contact: Christine Tran    562-861-5690    christinetran@macksresearch.com   
Principal Investigator: Surinder S Saini, MD         
Stanford University Recruiting
Palo Alto, California, United States, 94304
Contact: Pranali Suryavanshi    650-721-4288    pranali@stanford.edu   
Principal Investigator: Aijaz Ahmed, MD         
Inland Empire Liver Foundation Recruiting
Rialto, California, United States, 92377
Contact: Elaine Lopez    909-883-2999    elopez@ieliverfoundation.com   
Principal Investigator: Zeid Kayali, MD         
University of California Davis Medical Center Recruiting
Sacramento, California, United States, 95817
Contact: Sandeep Dhaliwal    916-734-8985    sandhaliwal@ucdavis.edu   
Principal Investigator: Christopher L Bowlus, MD         
Medical Associates Research Group Recruiting
San Diego, California, United States, 92123
Contact: Tina Delarosa    858-277-5678    tina.delarosa@marginc.com   
Principal Investigator: Michael Bennett, MD         
Kaiser Permanente Recruiting
San Diego, California, United States, 92154
Contact: Sandra Pantoja    619-662-5394    Sandra.X.Pantoja@kp.org   
Principal Investigator: Heather M Patton, MD         
University of California San Francisco (UCSF) / San Francisco General Hospital Recruiting
San Francisco, California, United States, 94110
Contact: Helen Park    415-206-3819    HeeEunHelen.Park@ucsf.edu   
Principal Investigator: Mandana Khalili, MD         
California Pacific Medical Center Recruiting
San Francisco, California, United States, 94115
Contact: Doug Troyer    415-600-1369    troyerd@cpmcri.org   
Principal Investigator: Raphael B Merriman, MD         
Quest Clinical Research Recruiting
San Francisco, California, United States, 94115
Contact: Nora Darago    415-353-0800 ext 27    ndarago@estudysite.com   
Principal Investigator: Maurizio Bonacini, MD         
University of California San Francisco Recruiting
San Francisco, California, United States, 94143
Contact: Rachel Mustain    415-476-6944    rachel.mustain@ucsf.edu   
Principal Investigator: Bilal Hameed, MD         
Silicon Valley Research Institute, San Jose Gastroenterology Recruiting
San Jose, California, United States, 95128
Contact: My Tops Ly    408-347-9001    mytops@sjgi.com   
Principal Investigator: Huy Trinh, MD         
United States, Colorado
University of Colorado, Denver Recruiting
Aurora, Colorado, United States, 80045
Contact: Sandra Boimbo    303-724-8892    SANDRA.BOIMBO@UCDENVER.EDU   
Principal Investigator: Amanda Wieland, MD         
South Denver Gastroenterology, PC Recruiting
Englewood, Colorado, United States, 80113
Contact: Kelley Braun, CRC    303-406-4288    kbraun@gutfeelings.com   
Principal Investigator: Marcelo Kugelmas, MD         
Rocky Mountain Clinical Research, LLC Recruiting
Wheat Ridge, Colorado, United States, 80033
Contact: Katie Health    303-279-1550    Katherine@rockymtcr.com   
Principal Investigator: John Goff, MD         
United States, Connecticut
Bridgeport Hospital Recruiting
Bridgeport, Connecticut, United States, 06610
Contact: Tina McCurry    203-384-4849    Tina.McCurry@bpthosp.org   
Principal Investigator: Caroline Loeser, MD         
Medical Research Center of Connecticut, LLC Not yet recruiting
Hamden, Connecticut, United States, 06518
Contact: Candace Cotto    203-281-5161    ccotto@gastrocenter.org   
Principal Investigator: Paul Feuerstadt, MD         
Yale University School of Medicine Recruiting
New Haven, Connecticut, United States, 06520
Contact: Claudia Bertuccio    203-785-2204    claudia.bertuccio@yale.edu   
Principal Investigator: Joseph K Lim, MD         
United States, District of Columbia
Georgetown University Hospital Recruiting
Washington, District of Columbia, United States, 20007
Contact: Teleah Davis    202-444-0652    teleah.g.davis@medstar.net   
Principal Investigator: Coleman Smith, MD         
United States, Florida
Integrity Clinical Research, LLC Recruiting
Doral, Florida, United States, 33166
Contact: Carlos Quintero, Esq    305-552-7660    cquintero@icrsites.com   
Principal Investigator: Linda Martinez, MD         
University of Florida (UF) Hepatology Research at CTRB Recruiting
Gainesville, Florida, United States, 32610-0272
Contact: Amy Gunnett    352-273-9470    amy.gunnett@medicine.ufl.edu   
Principal Investigator: Roberto J Firpi-Morell, MD         
Nature Coast Clinical Research Recruiting
Inverness, Florida, United States, 34452
Contact: Linda Gray, RN, CCRC    352-341-2100    lgray@encoredocs.com   
Principal Investigator: Paul A Hellstern, Jr, MD         
University of Florida Health - Jacksonville Recruiting
Jacksonville, Florida, United States, 32207
Contact: Kelly Jackman    904-633-0070    Kelly.Jackman@jax.ufl.edu   
Principal Investigator: James Scolapio, MD         
Mayo Clinic Recruiting
Jacksonville, Florida, United States, 32224
Contact: Jessica Sanders    904-953-8030    sanders.jessica1@mayo.edu   
Principal Investigator: Maria Yataco, MD         
Borland-Groover Clinic Recruiting
Jacksonville, Florida, United States, 32256
Contact: Courtney Tadewald    904-680-0871    ctadewald01@bgclinic.com   
Principal Investigator: Ana M Corregidor, MD         
Florida Digestive Health Specialist Research Institute Recruiting
Lakewood Ranch, Florida, United States, 34211
Contact: Pamela Browder    941-216-4835 ext 106    Pamela.browder@fdhs.com   
Principal Investigator: Guy W Neff, MD, MBA         
Sunrise Medical Research, Inc Recruiting
Lauderdale Lakes, Florida, United States, 33319
Contact: Yobanka Tapia    954-915-9991    research@sunrisemedresearch.com   
Principal Investigator: Jeffrey H Schneider, MD         
Meridien Research, Inc. Recruiting
Maitland, Florida, United States, 32751
Contact: Ginny McClanahan    407-644-1165    gmcclanahan@meridienresearch.net   
Principal Investigator: Eva-Maria Heurich, MD         
Bruce W. Carter Miami VA Medical Center Recruiting
Miami, Florida, United States, 33125
Contact: Rolando D Garcia-Rojas    305-575-7000 ext 4640    rolandogarciarojas@yahoo.com   
Principal Investigator: Lennox Jeffers, MD         
University of Miami, Schiff Center for Liver Disease Recruiting
Miami, Florida, United States, 33136
Contact: Andrea Elibero    305-243-6968    axe375@med.miami.edu   
Principal Investigator: Eugene R Schiff, MD         
Gastro Health Not yet recruiting
Miami, Florida, United States, 33173
Contact: Karla Gonzalez    786-456-8676    kgonzalez@gastrohealth.com   
Principal Investigator: Flavia Mendes, MD         
ProLive Medical Research Recruiting
Miami, Florida, United States, 33175
Contact: Laura Diaz       ldiaz@prolivemed.com   
Principal Investigator: Sandor Romero, MD         
Janus Clinical Research Recruiting
Miami, Florida, United States, 33186
Contact: Carlos Rodriguez    305-209-1291    carlos@januscr.net   
Principal Investigator: Jorge R Beato, MD         
Florida Hospital Transplant Institute Recruiting
Orlando, Florida, United States, 32819
Contact: Gladys Mendez    407-303-3637      
Principal Investigator: Ayman Koteish, MD         
South Florida Center of Gastroenterology, PA Recruiting
Wellington, Florida, United States, 33414
Contact: Donovan Mott    561-472-5648    dmottx1@gmail.com   
Principal Investigator: Mitchell N Davis, DO         
Cleveland Clinic Florida Recruiting
Weston, Florida, United States, 33331
Contact: Maria Mejia    954-659-5888    mejiagm@ccf.org   
Principal Investigator: John Rivas, MD         
Florida Medical Clinic, PA Recruiting
Zephyrhills, Florida, United States, 33542
Contact: William Johnston    813-780-8368    wjohnston@floridamedicalclinic.com   
Principal Investigator: Tawfik N Chami, MD         
United States, Georgia
Summit Clinical Research, LLC Recruiting
Athens, Georgia, United States, 30607
Contact: Barbara Wilson    706-461-5454    bwilson.scr@gmail.com   
Principal Investigator: Jeffrey M Williams, MD         
Atlanta Gastroenterology Associates (AGA), LLC Recruiting
Atlanta, Georgia, United States, 30308
Contact: Anne Taylor    404-881-1094    anne.taylor@atlantagastro.com   
Principal Investigator: Norman Gitlin, MD         
Digestive Healthcare of Georgia Recruiting
Atlanta, Georgia, United States, 30309
Contact: Debeeh Legaspi    678-686-5073    dlegaspi@digestivehealthcare.net   
Principal Investigator: Michael R Galambos, MD         
Piedmont Transplant Institute Recruiting
Atlanta, Georgia, United States, 30309
Contact: Stephen Spainhour    404-605-2347    Stephen.Spainhour@piedmont.org   
Principal Investigator: Raymond A Rubin, MD         
Emory University Hospital Recruiting
Atlanta, Georgia, United States, 30322
Contact: Elizabeth Ferry    404-712-1816    elizabeth.ferry@emoryhealthcare.org   
Principal Investigator: Ryan Ford, MD         
Georgia Regents University Not yet recruiting
Augusta, Georgia, United States, 30912
Principal Investigator: Sandeep Khurana, MBBS         
Columbus Regional Research Institute Not yet recruiting
Columbus, Georgia, United States, 31904
Contact: Mark Summers    706-321-0495    msummers@iacthealth.com   
Principal Investigator: Michael Steinbook, MD         
Gastrointestinal Specialists of Georgia, PC Recruiting
Marietta, Georgia, United States, 30060
Principal Investigator: Aasim M Sheikh, MD         
Georgia Clinical Research, LLC Recruiting
Snellville, Georgia, United States, 30078
Contact: Glenda Burton    678-822-5581    Mylaptop@tampabay.rr.com   
Principal Investigator: John D Lentz, III, MD         
United States, Hawaii
The Queen's Medical Center - Liver Center Recruiting
Honolulu, Hawaii, United States, 96813
Contact: Leslie Huddleston, RN, PA-C    808-691-1163    lhuddleston@queens.org   
Principal Investigator: Naoky Tsai, MD         
United States, Idaho
Grand Teton Research Group Recruiting
Idaho Falls, Idaho, United States, 83404
Contact: Ana Goetsch    208-528-4256    ana@gtrgi.org   
Principal Investigator: Larry C Evans, DO         
United States, Illinois
Norhwestern Memorial Hospital Recruiting
Chicago, Illinois, United States, 60611
Contact: Stanislava Milosevic    312-694-0326    s-milosevic@northwestern.edu   
Principal Investigator: Mary E Rinella, MD         
Rush University Medical Center Recruiting
Chicago, Illinois, United States, 60612
Contact: Diana Giczewski    312-563-3919    Diana_Giczewski@rush.edu   
Principal Investigator: Nikunj Shah, MD         
University of Chicago Recruiting
Chicago, Illinois, United States, 60637
Contact: Maria Newsome    773-702-2788    mnewsome1@bsd.uchicago.edu   
Principal Investigator: K. Gautham Reddy, MD         
Loyola University Medical Center Recruiting
Maywood, Illinois, United States, 60153
Contact: Jessica Shore    708-216-2027    jshore@luc.edu   
Principal Investigator: Natasha Von Roenn, MD         
United States, Indiana
Indiana University (IU) Health University Hospital Recruiting
Indianapolis, Indiana, United States, 46202
Contact: Rachel Lee    317-278-6266    lee352@iu.edu   
Principal Investigator: Raj Vuppalanchi, MD         
Indianapolis Gastroenterology Research Foundation Recruiting
Indianapolis, Indiana, United States, 46237
Contact: Sheila A Thompson    317-865-2959    sthompson@indygastro.com   
Principal Investigator: David C Pound, MD         
United States, Kansas
The University of Kansas Medical Center Recruiting
Kansas City, Kansas, United States, 66160
Contact: Brian Bridges    913-945-7830    bbridges@kumc.edu   
Principal Investigator: Winston Dunn, MD         
United States, Kentucky
Graves-Gilbert Clinic Recruiting
Bowling Green, Kentucky, United States, 42101
Contact: Carole Wood    270-780-0591    woodc@ggclinic.com   
Principal Investigator: Robert Emslie, MD         
Gastroenterology Associates of Hazard Recruiting
Hazard, Kentucky, United States, 41701
Principal Investigator: Uday Shankar, MD         
University of Kentucky Recruiting
Lexington, Kentucky, United States, 40536
Contact: Sylvia Nicholson    859-323-1086    sylvia.nicholson@uky.edu   
Principal Investigator: Alla Grigorian, MD         
University of Louisville Recruiting
Louisville, Kentucky, United States, 40202
Contact: Susan Rames    502-852-3383    Susan.rames@louisville.edu   
Principal Investigator: Matthew C Cave         
United States, Louisiana
Tulane University Medical Center Recruiting
New Orleans, Louisiana, United States, 70112
Contact: Delainna Bartholomew    504-988-6902    Delainna.Bartholomew@HCAhealthcare.com   
Principal Investigator: Fredric Regenstein, MD         
Ochsner Clinic Foundation Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Maria Gloth    504-842-8253    mgloth@ochsner.org   
Principal Investigator: Shoba Joshi, MD         
Louisiana Research Center, LLC Recruiting
Shreveport, Louisiana, United States, 71105
Contact: Veronica Greer    318-525-3227    vgreer@gis.md   
Principal Investigator: Humberto Aguilar, MD         
United States, Maryland
Investigative Clinical Research Recruiting
Annapolis, Maryland, United States, 21401
Contact: Robin Doremus    410-224-4887 ext 444    robin@icrmd.com   
Principal Investigator: Michael S Epstein, MD         
Mercy Medical Center, Institute for Digestive Health and Liver Disease Recruiting
Baltimore, Maryland, United States, 21202
Contact: Polly Robarts    410-843-2075    probarts@mdmercy.com   
Principal Investigator: Paul Thuluvath, MD         
John Hopkins Hospital Recruiting
Baltimore, Maryland, United States, 21205
Contact: Harry Luu    410-955-9695    hluu@jhmi.edu   
Principal Investigator: James Hamilton, MD         
Walter Reed National Military Medical Center Recruiting
Bethesda, Maryland, United States, 20889
Contact: Luz Kumpel    301-295-6127    luz.m.kumpel.ctr@mail.mil   
Principal Investigator: Dawn Torres, MD         
Digestive Disease Associates, PA Recruiting
Catonsville, Maryland, United States, 21228
Contact: Seema Shahi    410-737-0053    s.shahi@ddamd.com   
Principal Investigator: Natarajan Ravendhran, MD         
United States, Massachusetts
Massachusetts General Hospital Recruiting
Boston, Massachusetts, United States, 02114
Contact: Jenna Gustafson    617-724-3836    jlgustafson@partners.org   
Principal Investigator: Kathleen Corey, MD         
Boston University Medical Center Recruiting
Boston, Massachusetts, United States, 02118
Contact: Sherida Padilla    617-638-6527    Sherida.Padilla@bmc.org   
Principal Investigator: Michelle Long, MD         
Beth Israel Deaconess Medical Center Recruiting
Boston, Massachusetts, United States, 02215
Contact: Angelica Francescucci    617-632-1068    afrance1@bidmc.harvard.edu   
Principal Investigator: Michelle Lai, MD, MPH         
Commonwealth Clinical Studies Recruiting
Brockton, Massachusetts, United States, 02302
Contact: Estelle Crowley    508-588-9900    ecrowley@gisdoc.com   
Principal Investigator: Prithvi Sreenivasan, MD         
Lahey Hospital & Medical Center Recruiting
Burlington, Massachusetts, United States, 01805
Contact: Agnes Trabucco       agnes.trabucco@lahey.org   
Principal Investigator: Fredric Gordon, MD         
University of Massachusetts Medical School Recruiting
Worcester, Massachusetts, United States, 01655
Contact: Johanna Galindo de Laflin    774-441-8402    johanna.galindodelaflin@umassmemorial.org   
Principal Investigator: Gyongyi Szabo, MD         
United States, Michigan
Henry Ford Health System Recruiting
Detroit, Michigan, United States, 48202
Contact: Margaret French    313-916-3369    mfrench1@hfhs.org   
Principal Investigator: Stuart C Gordon, MD         
West Michigan Clinical Research Recruiting
Wyoming, Michigan, United States, 49519
Contact: Bridgett Klooster       bklooster@gastro-assoc-wm.com   
Principal Investigator: Allan Coates, DO         
Huron Gastroenterology Associates Recruiting
Ypsilanti, Michigan, United States, 48197
Contact: Ellen Dobrusin    734-714-0523    ellend@hurongastro.com   
Principal Investigator: Naresh Gunaratnam, MD         
United States, Minnesota
University of Minnesota Not yet recruiting
Minneapolis, Minnesota, United States, 55414
Contact: Muse Jama    612-624-5773    jamax165@umn.edu   
Principal Investigator: John Lake, MD         
Mayo Clinic - Rochester Recruiting
Rochester, Minnesota, United States, 55905
Contact: Thomas De Leeuw    507-538-8764    deleeuw.thomas@mayo.edu   
Principal Investigator: Kymberly D Watt, MD         
Minnesota Gastroenterology, P.A. Recruiting
Saint Paul, Minnesota, United States, 55114
Contact: Miriam Snyder    612-870-5664    miriam.snyder@mngastro.com   
Principal Investigator: Donald Zogg, MD         
United States, Mississippi
University of Mississippi Medical Center Recruiting
Jackson, Mississippi, United States, 39216
Contact: Rosemary Risen    601-815-5180    rrisen@umc.edu   
Principal Investigator: Brian B Borg, MD         
United States, Missouri
VA Medical Center Kansas City Recruiting
Kansas City, Missouri, United States, 64128
Contact: Amber Wolf    816-861-4700 ext 56579    amber.wolf@va.gov   
Principal Investigator: Prashant Pandya, DO         
Kansas City Research Institute Recruiting
Kansas City, Missouri, United States, 64131
Contact: Laurie Lynn    816-759-5274 ext 181    llynn@kcresearchinstitute.com   
Principal Investigator: Bradley Freilich, MD         
St. Louis University, Gastroenterology and Hepatology, Clinical Research Unit Recruiting
Saint Louis, Missouri, United States, 63104
Contact: Charles Horn    314-977-9400    charleshorn@slu.edu   
Principal Investigator: Brent Tetri, MD         
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Teresa Spitz    314-454-0058    tspitz@wustl.edu   
Principal Investigator: Kevin Korenblat, MD         
United States, Nebraska
CHI Research Center Recruiting
Omaha, Nebraska, United States, 68124
Contact: Tiffany Floro    402-343-8511    Tiffany.floro@alegent.org   
Contact       Tiffany.floro@alegent.org   
Principal Investigator: Sandeep Mukherjee, MD         
United States, New Jersey
AGA Clinical Research Associates, LLC Recruiting
Egg Harbor Township, New Jersey, United States, 08234
Contact: Theresa Stevens    609-407-1220 ext 1108    Theresa@atlanticgastro.com   
Principal Investigator: John J Santoro, DO         
Amici Clinical Research Recruiting
Martinsville, New Jersey, United States, 08836
Principal Investigator: Robert Falcone, MD         
Rutgers University New Jersey Medical School Recruiting
Newark, New Jersey, United States, 07103
Contact: Serban A Moroianu    973-972-1517    moroiasa@njms.rutgers.edu   
Principal Investigator: Nikolaos Pyrsopoulos, MD         
Saint Joseph's Regional Medical Center Recruiting
Paterson, New Jersey, United States, 07503
Contact: Ismael Castaneda    973-754-3811    castanei@sjhmc.org   
Principal Investigator: Andrew de la Torre, MD         
The Gastroenterology Group of South Jersey Recruiting
Vineland, New Jersey, United States, 08360
Contact: Allison Sacco    856-691-1400    asacco84@yahoo.com   
Principal Investigator: James Izanec, DO         
United States, New Mexico
AccumetRx Clinical Research Recruiting
Albuquerque, New Mexico, United States, 87109
Contact: Jeremy Kilburn    505-872-4091    jkilburn@accumetrx.com   
Principal Investigator: Antoine Jakiche, MD         
United States, New York
Montefiore Medical Center Recruiting
Bronx, New York, United States, 10467
Contact: Hayder Said    347-671-8216    hsaid@montefiore.org   
Principal Investigator: Samuel H Sigal, MD         
University of Buffalo Recruiting
Buffalo, New York, United States, 14203
Contact: Rick Rejman    716-878-3320    rmrejman@buffalo.edu   
Principal Investigator: Andrew Talal, MD         
North Shore University Hospital Recruiting
Manhasset, New York, United States, 11030
Contact: Sylwia Sobolewska    516-562-2060    ssobolewska@northwell.edu   
Principal Investigator: David E Bernstein, MD         
Mount Sinai Beth Israel Recruiting
New York, New York, United States, 10003
Contact: Olia Ali    212-844-6408    oali@CHPNET.ORG   
Principal Investigator: Ira Jacobson, MD         
Concorde Medical Group PLLC Recruiting
New York, New York, United States, 10016
Contact: Resmi Varughese    212-889-5544    rvarughese@concordemed.com   
Principal Investigator: Hillel Tobias, MD         
New York University (NYU) Langone Medical Center Recruiting
New York, New York, United States, 10016
Contact: Therese Capobianco    212-263-0155    therese.capobianco@nyumc.org   
Principal Investigator: James Park, MD         
Icahn School of Medicine at Mt. Sinai Recruiting
New York, New York, United States, 10029
Contact: Mekdes Mersha    212-241-0493    Mekdes.mersha@mssm.edu   
Principal Investigator: Meena Bansal, MD         
Columbia University Medical Center Recruiting
New York, New York, United States, 10032
Contact: Samina Munir    212-305-3839    sm3417@cumc.columbia.edu   
Principal Investigator: Julia J Wattacheril, MD, MPH         
Weill Cornell Medical College Recruiting
New York, New York, United States, 10065
Contact: Stephen Osei-Mensah    646-962-5370    sto2007@med.cornell.edu   
Principal Investigator: Sonal Kumar, MD         
Premier Medical Group of the Hudson Valley, PC Recruiting
Poughkeepsie, New York, United States, 12601
Contact: Alyson Cahill       acahill@premiermedicalhv.com   
Principal Investigator: Peter Varunok, MD         
University of Rochester Medical Center Recruiting
Rochester, New York, United States, 14642
Contact: Chelsea M Vallone    585-275-0803    chelsea_vallone@urmc.rochester.edu   
Principal Investigator: Jonathan Huang, MD         
United States, North Carolina
Asheville Gastroenterology Associates, PA Recruiting
Asheville, North Carolina, United States, 28801
Contact: Roberta Golden       roberta.golden@ashevillegastro.com   
Principal Investigator: Adam S Zivony, MD         
The University of North Carolina at Chapel Hill Recruiting
Chapel Hill, North Carolina, United States, 27599-7584
Contact: Renee Blanchard    919-843-5936    renee_blanchard@med.unc.edu   
Principal Investigator: A. Sidney Barritt, MD         
Carolinas Medical Center Recruiting
Charlotte, North Carolina, United States, 28204
Contact: Gale Groseclose    704-355-4875    Gale.Groseclose@carolinashealthcare.org   
Principal Investigator: Andrew S deLemos, MD         
Charlotte Gastroenterology & Hepatology, P.L.L.C Recruiting
Charlotte, North Carolina, United States, 28207
Contact: Beth Martinotti    704-602-6564    beth.martinotti@charlottegastro.com   
Principal Investigator: Jason Wilson, MD         
Duke University Medical Center Recruiting
Durham, North Carolina, United States, 27710
Contact: Mariko Kopping    919-684-4798    mariko.kopping@duke.edu   
Principal Investigator: Manal F Abdelmalek, MD, MPH         
Cumberland Research Associates, LLC Recruiting
Fayetteville, North Carolina, United States, 28304
Contact: Angela Person    910-484-8163    aperson@cumberlandresearchassociates.com   
Principal Investigator: John E Poulos, MD         
Wake Research Associates, LLC Recruiting
Raleigh, North Carolina, United States, 27612
Contact: Ben Riedlinger    919-781-2514    briedlinger@wakeresearch.com   
Principal Investigator: Charles Barish, MD         
Piedmont Healthcare, Carolinas Center for Liver Disease Recruiting
Statesville, North Carolina, United States, 28677
Contact: Anna Nash, RN, MSN    704-978-0044    anna.nash@piedmonthealthcare.com   
Principal Investigator: Robert W Reindollar, MD         
Digestive Health Specialists, PA Recruiting
Winston-Salem, North Carolina, United States, 27103
Contact: Stephanie Riggs    336-768-6211    stephanier@digestivehealth.ws   
Principal Investigator: Christopher Jue, MD         
United States, Ohio
Consultants for Clinical Research Recruiting
Cincinnati, Ohio, United States, 45249
Contact: Amanda Snow    513-587-0410    asnow@ccrstudy.com   
Principal Investigator: Ravi Ravinuthala, MD         
University of Cincinnati Physicians Company, LLC/Division of Digestive Diseases Recruiting
Cincinnati, Ohio, United States, 45267-0595
Contact: Elizabeth Stambrook, BSN, RN    513-584-2363    stambre@ucmail.uc.edu   
Principal Investigator: Kenneth E Sherman, MD, PhD         
University Hospitals Case Medical Center Recruiting
Cleveland, Ohio, United States, 44106
Contact: Guptha Baskaran    216-286-6668    Guptha.MunugoorBaskaran@UHhospitals.org   
Principal Investigator: Pierre Gholam, MD         
MetroHealth Medical Center Recruiting
Cleveland, Ohio, United States, 44109
Contact: Carla Viscomi, RN       cviscomi@metrohealth.org   
Principal Investigator: Hicham Khallafi, MD         
The Ohio State University (OSU) Wexner Medical Center Recruiting
Columbus, Ohio, United States, 43203
Contact: Amber Anaya    614-688-6257    amber.anaya@osumc.edu   
Principal Investigator: David Bradley, MD         
Center for Digestive Health Not yet recruiting
Mentor, Ohio, United States, 44059
Contact: Odessa Martin    440-205-5740 ext 71    OMartin@medicmgmt.com   
Principal Investigator: Franjo Vladic, MD         
Clinical Research Solutions Recruiting
Middleburg Heights, Ohio, United States, 44130
Contact: Brent Smith    440-340-9010    bsmith@crssites.com   
Principal Investigator: Bob Souder, MD         
United States, Oklahoma
INTEGRIS Baptist Medical Center Recruiting
Oklahoma City, Oklahoma, United States, 73112
Contact: William Synnott    405-949-6629    william.synnott@integrisok.com   
Principal Investigator: Joykumar Patel, MD         
United States, Oregon
Oregon Health & Science University (OHSU) Recruiting
Portland, Oregon, United States, 97239
Contact: Brian Booty    503-346-0812    bootyb@ohsu.edu   
Principal Investigator: Barry Schlansky, MD         
United States, Pennsylvania
Central Bucks Specialists-Gastroenterology Recruiting
Doylestown, Pennsylvania, United States, 18901
Contact: Timothy Madden, CRC    215-345-2517    tmadden@dh.org   
Principal Investigator: Victor Araya, MD         
Hershey Medical Center Recruiting
Hershey, Pennsylvania, United States, 17033
Contact: Laurie Peiffer    717-531-5226    lpeiffer@hmc.psu.edu   
Principal Investigator: Karen Krok, MD         
Main Line Gastroenterology Associates Recruiting
Perkasie, Pennsylvania, United States, 18944
Contact: Patty Lepley    215-723-8580    pattyl@mlga.net   
Principal Investigator: Scott A Fink, MD         
Hahnemann University Hospital/Drexel University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19102
Contact: Hemali Lala    267-507-6836    hlala@drexelmed.edu   
Principal Investigator: Vishal Patel, MD         
University of Pennsylvania Medical Center Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Christine M Gepty    215-349-8563    christine.gepty@uphs.upenn.edu   
Principal Investigator: K. Rajender Reddy, MD         
Thomas Jefferson University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Hannah Ott    215-955-7979    hannah.ott@jefferson.edu   
Principal Investigator: Dina Halegoua-De Marzio, MD         
Einstein Healthcare Network Recruiting
Philadelphia, Pennsylvania, United States, 19141
Contact: Marva James, RN, MHS    215-456-2004    JamesMar@einstein.edu   
Principal Investigator: Victor Navarro, MD         
University of Pittsburgh Medical Center Recruiting
Pittsburgh, Pennsylvania, United States, 15213
Contact: Amy Schmotzer    412-802-8567    schmotzerar@upmc.edu   
Principal Investigator: Jaideep Behari, MD         
United States, Rhode Island
University Gastroenterology, Liver Center Recruiting
Providence, Rhode Island, United States, 02905
Contact: Brandie Millovitsch    401-421-8800    bmillovitsch@yahoo.com   
Principal Investigator: Thomas E Sepe, MD         
United States, South Carolina
Medical University of South Carolina Recruiting
Charleston, South Carolina, United States, 29425
Contact: April Williams    843-876-4301    williamsa@musc.edu   
Principal Investigator: Ira Willner, MD         
Greenville Health System Recruiting
Greenville, South Carolina, United States, 29605
Contact: Donna West    864-455-2846    dwest3@ghs.org   
Principal Investigator: Gary Abrams, MD         
United States, South Dakota
Innovative Clinical Research Recruiting
Rapid City, South Dakota, United States, 57701
Contact: James Friend    303-913-8056    friendjt@rcmed.net   
Principal Investigator: Blake Jones, MD         
United States, Tennessee
ClinSearch, LLC Recruiting
Chattanooga, Tennessee, United States, 37421
Contact: Christy Schmeck    423-698-4584    cschmeck@clinsearch-us.com   
Principal Investigator: Richard A Krause, MD         
Gastro One Recruiting
Germantown, Tennessee, United States, 38138
Contact: Stephanie Walker    901-309-6030    swalker1@gastro1.com   
Principal Investigator: Ziad Younes, MD         
Methodist Healthcare, University Hospital Recruiting
Memphis, Tennessee, United States, 38104
Contact: Carol Jones    901-516-8078    Carol.Jones@mlh.org   
Principal Investigator: Sanjaya Satapathy, MD         
Nashville Medical Research Institute Recruiting
Nashville, Tennessee, United States, 37205
Contact: George Telfer    615-383-1727    gtelfer@nmri.co   
Principal Investigator: Ronald E Pruitt, MD         
Quality Medical Research, PLLC Recruiting
Nashville, Tennessee, United States, 37211
Contact: Christy Swope    615-832-5530    cswope@qualitymedicalresearch.com   
Principal Investigator: Robert W Herring, Jr., MD         
Vanderbilt University Medical Center - Digestive Disease Center Recruiting
Nashville, Tennessee, United States, 37212
Contact: Tina Higginbotham    615-322-4643    tina.higginbotham@vanderbilt.edu   
Principal Investigator: Michael Porayko, MD         
United States, Texas
Texas Clinical Research Institute Recruiting
Arlington, Texas, United States, 76012
Contact: Jo Swearingen    817-471-1070    joswear@aol.com   
Principal Investigator: Reem Ghalib, MD         
Austin Center for Clinical Research Recruiting
Austin, Texas, United States, 78756
Contact: Olia Nayor    512-371-7702    olia.nayor@acclinicalresearch.com   
Principal Investigator: Imtiaz Alam, MD         
The Liver Institute at Methodist Dallas Medical Center Recruiting
Dallas, Texas, United States, 75203
Contact: Cynthia Uberu    214-947-1287    CynthiaUberu@mhd.com   
Principal Investigator: Parvez Mantry, MD         
Liver Center of Texas Recruiting
Dallas, Texas, United States, 75234
Contact: Heema Marwah    972-354-1520    HeemaM@acrctrials.com   
Principal Investigator: Abdullah Mubarak, MD         
Texas Digestive Disease Consultants Recruiting
Dallas, Texas, United States, 75246
Contact: Chris Fourment, M.D.       cfourment@tddctx.com   
Principal Investigator: James Trotter, MD         
University of Texas Southwestern Medical Center Recruiting
Dallas, Texas, United States, 75390-9151
Contact: Griselda Soto    214-648-2725    griselda.soto@utsouthwestern.edu   
Principal Investigator: Marlyn Mayo, MD         
MedResearch, Inc. Recruiting
El Paso, Texas, United States, 79935
Contact: Isaac Patino    915-307-4669    ipatino@epmedresearch.com   
Principal Investigator: Ruben Ramirez-Vega, MD         
Brooke Army Medical Center (Geneva Foundation) Recruiting
Fort Sam Houston, Texas, United States, 78234
Contact: Reaber Neal-Bryant    210-916-2746    Reaber.d.nealbryant.ctr@mail.mil   
Principal Investigator: Angelo Paredes, MD         
Baylor All Saints Medical Center Recruiting
Fort Worth, Texas, United States, 76104
Contact: Trista Bachand    817-922-2585    Trista.Bachand@BSWHealth.org   
Principal Investigator: Apurva A Modi, MD         
VA Medical Center Houston Recruiting
Houston, Texas, United States, 77021
Contact: Dianna Castillo    713-440-4403      
Principal Investigator: Hashem El-Serag, MD         
Baylor College of Medicine - Ben Taub Hospital Recruiting
Houston, Texas, United States, 77030
Contact: Valeria Hernandez       valehn_3@comcast.net   
Principal Investigator: Maya Balakrishnan, MD         
Baylor St. Luke's Medical Center, Advanced Liver Therapies Recruiting
Houston, Texas, United States, 77030
Contact: Jana Lee    713-798-5382    janal@bcm.edu   
Principal Investigator: John M Vierling, MD         
Houston Methodist Hospital Recruiting
Houston, Texas, United States, 77030
Contact: Susan Dorman, RN, CCRC    713-441-6316    SADorman@HoustonMethodist.org   
Principal Investigator: David W Victor, III, MD         
Liver Associates of Texas, P.A. Recruiting
Houston, Texas, United States, 77030
Contact: Herman Ortiz    713-799-2667    hortiz@liverassoctx.com   
Principal Investigator: Victor Ankoma-Sey, MD         
University of Texas Health Science Center, Houston Recruiting
Houston, Texas, United States, 77030
Contact: Urvashi Patel-Knox       urvashi.patelknox@uth.tmc.edu   
Principal Investigator: Moises Nevag Rubin, MD         
Centex Studies, Inc. Recruiting
Houston, Texas, United States, 77058
Principal Investigator: Joe E Pouzar, MD         
Gulf Coast Research Group Recruiting
Houston, Texas, United States, 77096
Contact: Trayce Zelt    832-526-3597    tzelt@gulfcoastresearchgroup.com   
Principal Investigator: Andrea Duchini, MD         
Gastroenterology Consultants of San Antonio Recruiting
Live Oak, Texas, United States, 78233
Contact: Rose Gomez    210-614-1234 ext 435    rgomez@gastroconsa.com   
Principal Investigator: Stephen Harrison, MD         
Centex Studies - McAllen Recruiting
McAllen, Texas, United States, 78504
Contact: Blake Torrence       blaketorrence@centexstudies.com   
Principal Investigator: Joel Solis, MD         
American Research Corporation, The Texas Liver Institute Recruiting
San Antonio, Texas, United States, 78215
Contact: Nicole Forsyth    210-253-3426    nforsyth@txliver.com   
Principal Investigator: Eric J Lawitz, MD         
Texas Digestive Disease Consultants- San Marcos Recruiting
San Marcos, Texas, United States, 78666
Contact: Chris Fourment, MD    817-310-4473    cfourment@tddctx.com   
Principal Investigator: Thomas Kepczyk, MD         
United States, Utah
Intermountain Medical Center Recruiting
Murray, Utah, United States, 84107
Contact: Jake Krong    801-507-9333    Jake.Krong@imail.org   
Principal Investigator: Michael Charlton, MD         
University of Utah Hospital Recruiting
Salt Lake City, Utah, United States, 84132
Contact: Tiffany Tomkinson    801-585-9155    Tiffany.Tomkinson@hsc.utah.edu   
Principal Investigator: Juan Gallegos-Orozco, MD         
United States, Vermont
The University of Vermont Medical Center Recruiting
Burlington, Vermont, United States, 05401
Contact: Joanna Pierce       Joanna.Pierce@med.uvm.edu   
Principal Investigator: Steven Lidofsky, MD, PhD         
United States, Virginia
University of Virginia Recruiting
Charlottesville, Virginia, United States, 22908
Contact: Jennifer Greene, RN    434-982-0709    jag7fh@hscmail.mcc.virginia.edu   
Principal Investigator: Stephen Caldwell, MD         
Inova Fairfax Hospital Recruiting
Falls Church, Virginia, United States, 22042
Contact: Mariam Afendy    703-776-2056    mariam.afendy@inova.org   
Principal Investigator: Nila Rafiq, MD         
Digestive and Liver Disease Specialists Recruiting
Norfolk, Virginia, United States, 23502
Contact: Pamela Hoisington, CCRP    757-961-1110    pamelah@dlds.org   
Principal Investigator: Michael J Ryan, MD         
Bon Secours Liver Institute of Virginia Recruiting
Richmond, Virginia, United States, 23226
Contact: Susan Vollum, RN, CCRP    804-977-8921    Susan_Vollum@bshsi.org   
Principal Investigator: Mitchell Shiffman, MD         
McGuire DVAMC Recruiting
Richmond, Virginia, United States, 23249
Contact: Edie Gavis, RN    804-675-5584      
Principal Investigator: Michael Fuchs, MD         
Virginia Commonwealth University Recruiting
Richmond, Virginia, United States, 23298
Contact: Jolene Schlosser    804-828-9195    jolene.schlosser@vcuhealth.org   
Principal Investigator: Arun Sanyal, MD, MBBS         
United States, Washington
Virginia Mason Medical Center Recruiting
Seattle, Washington, United States, 98101
Contact: Sara Ackermann    206-341-1295    sarah.ackermann@virginiamason.org   
Principal Investigator: Asma Siddique, MD         
Swedish Organ Transplant and Liver Center Recruiting
Seattle, Washington, United States, 98104
Contact: Adel Islam    206-215-6532    adel.islam@swedish.org   
Principal Investigator: Kris V Kowdley, MD         
University of Washington Recruiting
Seattle, Washington, United States, 98195
Contact: Robin Smith    206-543-0826    rsmith@medicine.washington.edu   
Principal Investigator: Kiran Bambha, MD         
United States, Wisconsin
University of Wisconsin, School of Medicine Recruiting
Madison, Wisconsin, United States, 53705
Contact: Jenny Vue    608-262-5404    jxvue@medicine.wisc.edu   
Principal Investigator: Adnan Said, MD         
Australia
Royal Adelaide Hospital Recruiting
Adelaide, Australia, 5000
Contact: Megan Phelps    +61 8 8222 4248    Megan.Phelps@sa.gov.au   
Principal Investigator: John Bate, Dr         
Flinders Medical Centre Recruiting
Bedford Park, Australia, 5042
Contact: Rachel Wundke    +61 8 8204 6989    Rachel.Wundke@sa.gov.au   
Principal Investigator: Jeyamani Ramachandran, Dr         
The Royal Brisbane Hospital Recruiting
Brisbane, Australia, 4029
Contact: Deborah D'Arcy       Deborah.DArcy@health.qld.gove.au   
Principal Investigator: Richard Skoein, Dr         
Gallipoli Medical Research Foundation Recruiting
Brisbane, Australia, 4120
Contact: Amanda Mason    +61 7 3394 7071    MasonAmanda@ramsayhealth.com.au   
Principal Investigator: Mark McCullen, MD         
Royal Prince Alfred Hospital Recruiting
Camperdown, Australia, 2050
Contact: Elizabeth Glynn    +61 2 9515 6006    Elizabeth.Glynn@sswahs.nsw.gov.au   
Principal Investigator: Simone Strasser, A/Prof         
Monash Medical Centre Recruiting
Clayton, Australia, 3168
Contact: Sherryne Warner    +61 3 9594 3039    Sherryne.warner@monash.edu   
Principal Investigator: Stephen Pianko, Dr         
Concord Repatriation General Hospital Recruiting
Concord, Australia, 2139
Principal Investigator: Alice Lee, Dr         
Austin Hospital Recruiting
Heidelberg, Australia, 3084
Contact: Brenda Morales    +61 3 9496 2787    Brenda.MORALES@austin.org.au   
Principal Investigator: Peter Angus, Professor         
Nepean Hospital Recruiting
Kingswood, Australia, 2747
Contact: Gaaya Kanapathipillai    02 4734 2319    Gaaya.Kanapathipillai@health.nsw.gov.au   
Principal Investigator: Martin D Weltman, A/Prof         
Fiona Stanley Hospital Recruiting
Murdoch, Australia, 6150
Contact: Wendy Lam    +61 8 6151 1221    wendy.lam@health.wa.gov.au   
Principal Investigator: Oyekoya Ayonrinde, Dr         
Royal Melbourne Hospital Recruiting
Parkville, Australia, 3053
Contact: Virginia Bird       Virginia.Bird@mh.org.au   
Principal Investigator: Siddharth Sood, Dr         
The Alfred Hospital Recruiting
Prahran, Australia, 3181
Contact: Geneveive Murphy    +61 3 9076 5713    g.murphy@alfred.org.au   
Principal Investigator: Stuart Roberts, Prof         
Westmead Hospital Recruiting
Westmead, Australia, 2145
Contact: Kindness Bondezi       Kindness.Bondezi@health.nsw.gov.au   
Principal Investigator: Jacob George, Prof         
Austria
Medizinische Universität Innsbruck Recruiting
Innsbruck, Austria, 6020
Contact: Klemens Zotter       klemens.zotter@tirol-kliniken.at   
Principal Investigator: Wolfgang Vogel, Prof         
Klinikum Klagenfurt am Wörthersee Recruiting
Klagenfurt, Austria, 9020
Contact: Markus Peck-Radosavljevic, Prof    43 463 538 31103    markus@peck.at   
Principal Investigator: Markus Peck-Radosavljevic, Prof         
Krankenhaus der Elisabethinen Linz Recruiting
Linz, Austria, 4020
Contact: Andreas Maieron, Dr    +4373276764467    andreas.maieron@elisabethinen.or.at   
Principal Investigator: Andreas Maieron, Dr         
Medizinische Universität Wien - AKH Recruiting
Wien, Austria, 1090
Contact: Stefan Traussnigg       stefan.traussnigg@meduniwien.ac.at   
Principal Investigator: Michael Trauner, Prof         
Belgium
Universitair Ziekenhuis Antwerpen (UZA) Recruiting
Edegem, Antwerp, Belgium, 2650
Contact: Veronique Derwael       veronique.derwael@uza.be   
Principal Investigator: Sven Francque, Prof         
CUB Hôpital Erasme Recruiting
Brussels, Brabant, Belgium, 1070
Contact: Mia Persoons       mia.persoons@erasme.ulb.ac.be   
Principal Investigator: Christophe Moreno, Prof Dr         
University Hospitals Leuven, KU Leuven Recruiting
Leuven, Vlaams-Brabant, Belgium, 3000
Contact: Liliane Schrijvers    +32 1634 4299    liliane.schrijvers@uzleuven.be   
Principal Investigator: Len Verbeke, Prof Dr         
AZ Sint-Jan Brugge Oostende Not yet recruiting
Brugge, Belgium, B-8000
Contact: Deborah Van Massenhove    0032 50452554    Deborah.VanMassenhove@azsintjan.be   
Principal Investigator: Hans Orlent, Dr         
UCL Saint-Luc Recruiting
Brussels, Belgium, 1200
Contact: Arianne Demassieux    +32 2 764 1436    arianne.demassieux@uclouvain.be   
Principal Investigator: Yves Horsmans, Prof Dr         
Ziekenhuis Oost-Limburg Not yet recruiting
Genk, Belgium, B-3600
Contact: Anita Eevers    0032 8 932 65 19    Anita.Eevers@zol.be   
Principal Investigator: Geert Robaeys, Dr         
UZ Ghent Recruiting
Ghent, Belgium, 9000
Contact: Annemarie De Geyter    +32 9 332 5707    annemarie.degeyter@ugent.be   
Principal Investigator: Anja Geerts, Prof Dr         
Gastroenterologie AZ Nikolaas Recruiting
Sint-Niklaas, Belgium, 9100
Contact: Kirsten Can Camp    0032 037602032    Kirsten.VanCamp@aznikolaas.be   
Principal Investigator: Jeffrey Schouten, Dr         
Canada, Alberta
University of Alberta Recruiting
Edmonton, Alberta, Canada, T6G 2X8
Contact: Sharon Appelman-Eszczuk    780-492-8602    sharon.appelman@ualberta.ca   
Principal Investigator: Aldo J Montano-Loza, MD         
Canada
University of Calgary Recruiting
Calgary, Canada, T2N 4Z6
Contact: Pam Crotty    403-592-5076    pcrotty@ucalgary.ca   
Principal Investigator: Laura Stinton, Dr         
GI Medical Research Recruiting
Edmonton, Canada, T5H 4B9
Contact: Daphne Meyer       daphne@gastrodoc.org   
Principal Investigator: Robert J Bailey, MD         
London Health Sciences Centre - University Hospital Recruiting
London, Canada, N6A 5A5
Contact: Patsy Burns    519-685-8500 ext 32520    patsy.burns@lhsc.on.ca   
Principal Investigator: Paul Marotta, MD         
Centre de Recherche du Centre Hospitalier de l'Universite de Montreal (CRCHUM) Recruiting
Montreal, Canada, H2X 0A9
Contact: Christina Benjamin    514-890-8000 ext 35283    christina.benjamin.chum@ssss.gouv.qc.ca   
Principal Investigator: Catherine Vincent, MD         
The Research Institute of the McGill University Health Centre Recruiting
Montreal, Canada, H4A 3J1
Contact: Natacha Cotta-Grand    514-934-1934 ext 32547    natacha.cotta-grand@muhc.mcgill.ca   
Principal Investigator: Giada Sebastiani, MD         
Toronto Center for Liver Disease Recruiting
Toronto, Canada, M5G 2C4
Contact: Catalina Coltescu    416-340-4800 ext 6192    ccoltesc@uhnresearch.ca   
Principal Investigator: Keyur Patel, MD         
Toronto Liver Centre Recruiting
Toronto, Canada, M6H 3M1
Contact: Marzena Magnes       magnes.marzena8@gmail.com   
Principal Investigator: Magdy Elkhashab, MD         
LAIR Centre Recruiting
Vancouver, Canada, V5Z 1H2
Contact: Lori L Walston    604-876-5122    lwalston@laircentre.com   
Principal Investigator: Edward Tam, MD         
Gordon & Leslie Diamond Health Care Centre Recruiting
Vancouver, Canada, V5Z 1M9
Contact: Kirby Lau    604-875-5705    kirby.lau@vch.ca   
Principal Investigator: Eric Yoshida, MD         
GI Research Institute (GIRI) Recruiting
Vancouver, Canada, V6Z 2K5
Contact: Maria Schmit    6046886332    maria.a.schmit@gmail.com   
Principal Investigator: Alnoor Ramji, MD         
PerCuro Clinical Research Not yet recruiting
Victoria, Canada, V8V 3M9
Contact: Laila Peterson    250-382-6270    laila@percuro.ca   
Principal Investigator: Oscar Cruz Pereira, MD         
University of Manitoba Recruiting
Winnipeg, Canada, R3E 3P4
Contact: Kim Hawkins    204-789-3725    khawkins@exchange.hsc.mb.ca   
Principal Investigator: Kelly Kaita, MD         
Denmark
Aalborg University Hospital Recruiting
Aalborg, Denmark, 9001
Contact: Tove Nygaard    +45 9766 3568      
Principal Investigator: Peter Holland-Fischer, Prof         
Aarhus Universitetshospital Recruiting
Aarhus C, Denmark, 8000
Contact: Lisbet Gerdes    +45 7846 2814    lisbgerd@rm.dk   
Principal Investigator: Henning Grønbæk, Prof         
Copenhagen University Hospital Hvidovre Recruiting
Hvidovre, Denmark, 2650
Contact: Carina Blixt    +45 38625141    carina.margaretha.blixit@regionh.dk   
Principal Investigator: Lise Lotte Gluud, Dr         
Odense University Hospital Recruiting
Odense, Denmark, 5000
Contact: Annette Dam Fialla    +45 2464 3940    adam@health.sdu.dk   
Principal Investigator: Aleksander Krag, Prof         
Finland
Helsinki University Central Hospital Recruiting
Helsinki, Finland, 00290
Contact: Perttu Arkkila    +35 894 711    perttu.arkkila@hus.fi   
Principal Investigator: Perttu Arkkila, Prof         
Turku University Hospital Recruiting
Turku, Finland, 20520
Contact: Kimmo Salminen, Dr    +35823130691    kimmo.salminen@tyks.fi   
Principal Investigator: Kimmo Salminen, Dr         
France
CHU Amiens Picardie Recruiting
Amiens, France, 80054
Contact: Rachida Faham    +33 3 22 08 88 67    Faham.Rachida@chu-amiends.fr   
Principal Investigator: Eric Nguyen-Khac, Prof         
CHU Angers Recruiting
Angers, France, 49933
Contact: Sandra Girre       sagirre@chu-angers.fr   
Principal Investigator: Jerome Boursier, Dr         
Centre Endoscopie Nord Isere Recruiting
Bourgoin-Jallieu, France, 38300
Contact: Thierry Fontanges, Dr       tfontanges@orange.fr   
Principal Investigator: Thierry Fontanges, Dr         
CHU Caen, Hôpital Côte de Nacre Recruiting
Caen, France, 14033
Contact: Elise Vastel    +33 2 31 06 30 19    vastel-e@chu-caen.fr   
Principal Investigator: Marie-Astrid Piquet, Prof         
Hôpital Beaujon Recruiting
Clichy, France, 92110
Contact: Simplice Dzamitika       simplice.dzamitika-ext@aphp.fr   
Principal Investigator: Tarik Asselah, Prof         
Henri Mondor Hospital Recruiting
Creteil, France, 94000
Contact: Beatrice Lecomte    33149814324    beatrice.lecomte2@aphp.fr   
Principal Investigator: Christophe Hezode, Dr         
CHU Grenoble Recruiting
Grenoble, France, 38700
Contact: Laure Bordy    33 4 76 76 61 50    lbordy@chu-grenoble.fr   
Principal Investigator: Vincent Leroy, Dr         
Hôpital Claude Huriez CHRU Lille Recruiting
Lille, France, 59037
Contact: Virginie Suffys    +33 3 20 44 57 42    virginie.suffys@chru-lille.fr   
Principal Investigator: Philippe Mathurin, Prof         
Hôpital de la Croix Rousse Recruiting
Lyon, France, 69004
Contact: Mahe Raffin    +33 4 26 73 27 38    mahe.raffin@chu-lyon.fr   
Principal Investigator: Fabien Zoulim, Prof         
Hôpital Saint Joseph Recruiting
Marseille, France
Contact: Gaëlle Le Folgoc    +33 4 91 80 82 07    glefolgooc@hopital-saint-joseph.fr   
Principal Investigator: Marc Bourliére, Dr         
CHU de Nice Recruiting
Nice, France, 6202
Contact: Emmanuelle Mouraux       mouraux.e@chu-nice.fr   
Principal Investigator: Rodolphe Anty, Dr         
CHU Orléans Recruiting
Orléans, France, 45100
Contact: Barbara De Dieuleveult    +33 2 38 22 99 40    Barbara.de-dieuleveult@chr-orleans.fr   
Principal Investigator: Si Nafa Si Ahmed, Dr         
Hôpital Saint-Antoine Recruiting
Paris, France, 75012
Contact: Geneviève Haldric    +33 1 49 28 23 81    genevieve.haldric@sat.aphp.fr   
Principal Investigator: Lawrence Serfaty, Prof         
Hospital Cochin Recruiting
Paris, France, 75014
Contact: Mina Ahloulay    +33158412988    mina.ahloulay-ext@aphp.fr   
Principal Investigator: Stanislas Pol, Dr         
Hôpital de la pitié Salpétrère Recruiting
Paris, France, 75651
Contact: Carole Bernhardt    +33 1 42 16 10 62    cbernhardt@noos.fr   
Principal Investigator: Vlad Ratziu, Prof         
CHU de Bordeaux - Hôpital du Haut-Lévêque Recruiting
Pessac, France, 33604
Contact: Maude Charbonnier    +33 5 57 65 63 11    maude.charbonnier@chu-bordeaux.fr   
Principal Investigator: Victor de Lédinghen, Prof         
CHU de Rouen, Hôpital C Nicole Recruiting
Rouen, France, 76031
Contact: Anthony Gallego    +33 2 32 88 58 89    anthony.gallego@chu-rouen.fr   
Principal Investigator: Odile Goria, Dr         
CHU de Toulouse Recruiting
Toulouse, France, 31059
Contact: Careine Barret    +33561779906    barretc@chu-toulouse.fr   
Principal Investigator: Maeva Guillaume, Dr         
Centre Hospitalier Universitaire de Nancy Recruiting
Vandoeuvre-Lès-Nancy, France
Contact: Johanne Amoyel    +33 3 83 15 33 61    johanne.amoyel@yahoo.fr   
Principal Investigator: Jean-Pierre Bronowicki, Prof         
Hopital Paul Brousse Recruiting
Villejuif, France, 94800
Contact: Isabelle Ogier    +33 1 45 59 64 37    isabelle.ogier-ext@aphp.fr   
Principal Investigator: Didier Samuel, Prof         
Germany
Universitatsklinikum Heidelberg Recruiting
Heidelberg, Baden-Wurttemberg, Germany, 69120
Contact: Silvia Dykstra       silvia_dykstra@med.uni-heidelberg.de   
Principal Investigator: Anita Pathil-Warth, Dr         
Friedrich Alexander Universitat Erlangen Recruiting
Erlangen, Bavaria, Germany, 91054
Contact: Annette Remberg    +49 9131 85 35194    med1-studien@uk-erlangen.de   
Principal Investigator: Andreas Kremer, Dr         
Klinikum der Johann-Wolfgang Goethe Universitat Recruiting
Frankfurt, Hesse, Germany, 60590
Contact: Pascale Pecere       pascal.pecere@kgu.de   
Principal Investigator: Stefan Zeuzem, Prof Dr         
Universitatsmedizin Mainz Recruiting
Mainz, Rhineland-Palatinate, Germany, 55131
Contact: Susan Depoix       susan.depoix@unimedizin-mainz.de   
Principal Investigator: Joern Schattenberg, Dr         
Universitatsklinikum Leipzig Recruiting
Leipzig, Saxony, Germany, 04103
Contact: Yvonne Hausman       yvonne.hausman@medizin.uni-leipzig.de   
Principal Investigator: Thomas Berg, Prof Dr         
Universitätsklinikum Aachen Recruiting
Aachen, Germany, 52074
Contact: Daniela Kroy    +49 241 8085660      
Principal Investigator: Christian Trautwein, Prof         
Charite Universitätsmedizin Campus Virchow Recruiting
Berlin, Germany, 13353
Contact: Angelika Goebels       angelika.goebels@charite.de   
Principal Investigator: Eckart Schott, Prof         
St. Josef-Hospital, Ruhr University Bochum Recruiting
Bochum, Germany, 44791
Contact: Gaby Rohe    0049 234 509-2366    g.rohe@klinikum-bochum.de   
Principal Investigator: Wolfgang Schmidt, Dr         
Universitätskliniken Bonn AöR Recruiting
Bonn, Germany, 53127
Contact: Melanie Neuhaus    +49 228 28716789      
Principal Investigator: Ulrich Spengler, Prof         
University of Düsseldorf Recruiting
Düsseldorf, Germany, 40225
Contact: Sabine Tebbe    +49 211 81 07132    Sabine.Tebbe@med.uni-duesseldorf.de   
Principal Investigator: Dieter Häussinger, Prof         
Katholische Kliniken Ruhrhalbinsel GmbH Recruiting
Essen, Germany, 45147
Contact: Karoline Wieczorek    +49 201 455 1527    karoline.wieczorek@kkrh.de   
Principal Investigator: Susanne Beckebaum, Prof         
University Hospital Essen Recruiting
Essen, Germany, 45147
Contact: Jennifer Weinreich    +49 201 723 4410    jennifer.weinreich@uk-essen.de   
Principal Investigator: Ali Canbay, Prof         
Ifi- Studien und Projekte GmbH Recruiting
Hamburg, Germany, 20099
Contact: Petra Lange    +49402840760-201    lange@ifi-medizin.de   
Principal Investigator: Jorg Petersen, Prof         
Universitätsklinikum Hamburg- Eppendorf Recruiting
Hamburg, Germany, 20246
Contact: Nicole Fuge    +49 40 7410 57981    nfuge@uke.de   
Principal Investigator: Johannes Kluwe, Dr         
Medizinische Hochschule Hannover Recruiting
Hannover, Germany, 30625
Contact: Janina Kirschner       Kirschner.Janina@mh-hannover.de   
Principal Investigator: Michael Manns, Prof         
Gastroenterologische Gemeinschaftspraxis Recruiting
Herne, Germany, 44623
Contact: Jennifer Zemke    +49 2323 946238    Zemke@gastro-praxis-herne.de   
Principal Investigator: Heinz Hartmann, Prof Dr         
Universitätsklinikum des Saarlandes Recruiting
Homburg, Germany, 66421
Contact: Ute Kemnade    +49 6841 16 23201    ute.kemnade@uks.eu   
Principal Investigator: Frank Lammert, Dr         
Hepato-Gastroenterology Center Kiel Not yet recruiting
Kiel, Germany, 24146
Contact: Britta Schoepke    +49 431 530 38320      
Principal Investigator: Holger Hinrichsen, Dr         
Universitätsklinik Köln Recruiting
Köln, Germany, 50931
Contact: Bianca Jacobs    +49 221 478 7847    bianca.jacobs@uk-koeln.de   
Principal Investigator: Münevver Demir, Dr         
EUGASTRO GmbH Recruiting
Leipzig, Germany, 4103
Contact: Micheal Winkler       Michael.winkler@eugastro.de   
Principal Investigator: Ingolf Schiefke, Dr         
Universitatsklinikum Mannheim Recruiting
Mannheim, Germany, 68167
Contact: Ralf Jesenofsky    +49 621 383 3261    ralf.jesenofsky@umm.de   
Principal Investigator: Christoph Antoni, Dr         
Krankenhaus Barmherzige Brueder Munich Recruiting
Munich, Germany, 80639
Contact: Christine Koller    +49 89 1797 2401    christine.koller@barmherzige-muenchen.de   
Principal Investigator: Christian Rust, Prof         
Universitätsklinikum Würzburg Recruiting
Würzburg, Germany, 97080
Contact: Carolin Spielau-Geidies    +4993120140170    spielau_c@ukw.de   
Principal Investigator: Andreas Geier, Prof         
Hungary
Szent László Kórház - Központi Felnőtt Szakrendelő Recruiting
Budapest, Hungary, 1097
Contact: Edit Villert    +36 20 539 9796    villert@lamb.hu   
Principal Investigator: Mihály Makara, Dr         
Kenézy Gyula Kórház és Rendelőintézet, Infektológia és Hepatológiai Centrum Recruiting
Debrecen, Hungary, 4031
Contact: Erzsébet Komáromi    +36 30 857 58 66    e.komaromi@clintrial.hu   
Principal Investigator: István Várkonyi, Dr         
University of Debrecen Recruiting
Debrecen, Hungary, 4032
Contact: Istvan Tornai, Dr    +36 30 972 2826    itornai@med.unideb.hu   
Principal Investigator: Istvan Tornai, Dr         
University of Pécs Recruiting
Pécs, Hungary, 7624
Contact: Aron Vincze, Dr    +36 30 979 8674    vincze.aron@pte.hu   
Principal Investigator: Aron Vincze, Dr         
Israel
Carmel Medical Center Not yet recruiting
Haifa, Israel
Contact: Orly Azulai    97248250239    orlyaz@clalit.org.il   
Principal Investigator: Eli Zuckerman, Dr         
Rambam Health Care Campus Not yet recruiting
Haifa, Israel
Contact: Vered B Hakoon    972 502061650    v_ben_hakoon@rambam.health.gov.il   
Principal Investigator: Ella Veitsman, Dr         
West Galilee Hospital Not yet recruiting
Nahariya, Israel, 22100
Principal Investigator: Michal Carmiel, Dr         
Holy Family Hospital Not yet recruiting
Nazareth, Israel
Principal Investigator: Rifaat Safadi, Dr         
Italy
AOU Pol. S.Orsola-Malpighi di Bologna Recruiting
Bologna, Italy, 40138
Contact: Pietro Andreone, Prof    +39.051.2143618    pietro.andreone@unibo.it   
Principal Investigator: Pietro Andreone, Prof         
Università de Bologna Recruiting
Bologna, Italy, 40138
Contact: Francesco Azzaroli       frencesco.azzaroli@unibo.it   
Principal Investigator: Giuseppe Mazzella, Prof         
Università degli Studi di Firenze Recruiting
Firenze, Italy, 20139
Contact: Mirko Tarrochi, MD, PhD    +39-0552758115    mirko.tarocchi@unifi.it   
Principal Investigator: Andrea Galli, Dr         
Azienda Ospedaliera San Paolo Polo Universitario Milano Recruiting
Milano, Italy, 20142
Contact: Elena Finati    +39-02-81844447    ele.finati@gmail.com   
Principal Investigator: Massimo Zuin, Dr         
Fondazione IRCCS Ca' Granda Recruiting
Milano, Italy
Principal Investigator: Silvia Fargion, Dr         
Humanitas Research Hospital Recruiting
Milan, Italy, 20086
Contact: Ilaria Sogno    00390282247319    ilaria.sogno@humanitasresearch.it   
Principal Investigator: Savino Bruno, Prof         
Ospedale san Giuseppe Multimedica Recruiting
Milan, Italy, 20123
Contact: Mariagrazia Rumi, Dr       mariagrazia.Rumi@unimi.it   
Principal Investigator: Mariagrazia Rumi, Dr         
ASL di Modena Not yet recruiting
Modena, Italy, 41126
Contact: Amedeo Lonardo, Dr    +39 059 396 1895    a.lonardo@ausl.mo.it   
Principal Investigator: Amedeo Lonardo, Dr         
University of Naples Recruiting
Naples, Italy, 80131
Principal Investigator: Filomena Morisco, Dr         
University of Padova Recruiting
Padova, Italy, 35128
Contact: Irene Franceschet    +39 34984 22766    irene.franceschet@gmail.com   
Principal Investigator: Annarosa Floreani, Dr         
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccon" Not yet recruiting
Palermo, Italy, 90127
Contact: Salvatore Petta    +39 091 6552280    salvatore.petta@unipa.it   
Principal Investigator: Antonio Craxi, Prof         
University of Tor Vergata (Roma) Not yet recruiting
Roma, Italy, 00133
Contact: Alessandra Nistri       alessandra.nistri@ptvonline.it   
Principal Investigator: Mario Angelico, Dr         
Università Cattolica del Sacro Cuore Recruiting
Roma, Italy, 00168
Contact: Luca Miele    +39 06 3503 4726    luca.miele@rm.unicatt.it   
Principal Investigator: Antonio Grieco, Prof         
A.O.U. Città della Salute e della Scienza di Torino - Dipartimento di scienze mediche Recruiting
Torino, Italy, 10126
Contact: Elisabetta Bugianesi, Dr    +390116334605    elisabetta.bugianesi@unito.it   
Principal Investigator: Elisabetta Bugianesi, Dr         
Netherlands
Vrije Universiteit Medisch centrum Not yet recruiting
Amsterdam, Netherlands, 1081 HV
Contact: Margreet Voebel    +3120 4444304    m.voebel@vumc.nl   
Principal Investigator: Dewkoemar Ramsoekh, Dr         
University of Amsterdam Not yet recruiting
Amsterdam, Netherlands, 1100DD
Contact: Lowiek Hubers    +31 20 5662422    l.m.hubers@amc.uva.nl   
Principal Investigator: Ulrich Beuers, Prof         
Radboud University Nijmegen Medical Center Not yet recruiting
Nijmegen, Netherlands, 6526 GA
Principal Investigator: Joost Drenth, Prof         
University Medical Center Utrecht Not yet recruiting
Utrecht, Netherlands, 3584 CX
Contact: Janneke Van den Brink    +31 88 557004    j.vandenbrink@umcutrecht.nl   
Principal Investigator: Karel Van Erpecum, Dr         
New Zealand
Auckland City Hospital Recruiting
Grafton, Auckland, New Zealand, 1023
Contact: Julianne Brewer    +64 9 307 4949 ext 23579    JBrewer@adhb.govt.nz   
Principal Investigator: David Orr, MD         
Middlemore Clinical Trials Recruiting
Auckland, New Zealand, 2025
Contact: Jenny White    +64 9 276 0044 ext 8644    jenny.white@mmclintrials.nz   
Principal Investigator: Tien H Lim, Dr         
Dunedin Hospital Recruiting
Dunedin, New Zealand, 9016
Contact: Merrilee Williams       merrilee.williams@southerndhb.govt.nz   
Principal Investigator: Michael Schultz, A/Prof         
Poland
Uniwersytecki Szpital Kliniczny w Białymstoku Recruiting
Bialystok, Poland, 15-540
Contact: Robert Flisiak, Prof    +48857416921    robert.flisiak@umb.edu.pl   
Principal Investigator: Robert Flisiak, Prof         
Centrum Badań Klinicznych Recruiting
Gdansk, Poland, 80-546
Contact: Krzysztof Malinowski    +487604493464    kmalinowski@pihouse.pl   
Principal Investigator: Katarzyna Sikorska, Prof         
Samodzielny Publiczny Centralny Szpital Kliniczny im. prof. Kornela Gibinskiego Slaskiego Uniwersytetu Medycznego w Katowicach Recruiting
Katowice, Poland, 40-752
Contact: Marek Hartleb, Prof    +48 32 789 44 01    mhartleb@sum.edu.pl   
Principal Investigator: Marek Hartleb, Prof         
Klinika Chorob Zakaznych i Hepatologii UM Oddzial Chorob Zakaznych Recruiting
Lodz, Poland, 91-347
Contact: Anna Piekarska, Prof    +48422516098    annapiekar@op.pl   
Principal Investigator: Anna Piekarska, Prof         
Samodzielny Publiczny Szpital Kliniczny Nr 1 Recruiting
Lublin, Poland, 20-081
Contact: Krzysztof Tomasiewicz, Prof.    +48 815349414    Krzysztof.tomasiewicz@umlub.pl   
Principal Investigator: Krzysztof Tomasiewicz, Prof.         
Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie Recruiting
Lublin, Poland, 20-954
Contact: Halina Cichoz-Lach    +48 601 377 656    lach.halina@wp.pl   
Principal Investigator: Krzysztof Celinski, Prof         
Centrum Badań Klinicznych Piotr Napora lekarze spółka partnerska Recruiting
Wroclaw, Poland, 51-162
Contact: Monika Pazgan-Simon    +48 602 639 169      
Principal Investigator: Krzysztof Simon, Prof         
Portugal
Centro Hospitalar do Baixo Vouga, EPE Recruiting
Aveiro, Portugal, 3814-501
Contact: Diana Soares    351 2343 78365    diana.soares@10285@chbv.min-saude.pt   
Principal Investigator: Rosa Jorge, Dr         
Hospital José Joaquim Fernandesin Recruiting
Beja, Portugal, 7801-849
Contact: Carlos Monteverde, Dr         
Principal Investigator: Carlos Monteverde, Dr         
Centro Hosipitalar e Universitário de Coimbra Recruiting
Coimbra, Portugal, 3000-075
Contact: Rosalina Guedes    +351 239401045    guedes.rf@gmail.com   
Principal Investigator: Armando Carvalho, Prof         
Hospital de Santo Antonio Recruiting
Douro, Portugal, 4099-001
Principal Investigator: Jose Ferreira, Dr         
Hospital da Senhora da Oliveira - Guimarães Recruiting
Guimarães, Portugal, 4835-044
Contact: Joana Vale    +351 910120513    jvale@blueclinical.pt   
Principal Investigator: Joana Magalhães, MD         
CHLC, EPE - Hospital de Santo António dos Capuchos Not yet recruiting
Lisboa, Portugal, 1169-050
Contact: Filipe Calinas, Dr    +351 968018682    filipe.calinas@gmail.com   
Principal Investigator: Filipe Calinas, Dr         
Centro Hospitalar Lisboa Ocidental Recruiting
Lisbon, Portugal, 1349-019
Principal Investigator: Cristina Chagas, Dr         
CHLN - Hospital de Santa Maria Recruiting
Lisbon, Portugal, 1649-035
Contact: Celia Guterres    +351 926534571    celia.guterres@hsm.min-saude.pt   
Principal Investigator: Helena Cortez-Pinto, Prof         
Centro Hospitalar Trás-os-Montes e Alto Douro, EPE Recruiting
Lordelo, Portugal, 5000-508
Contact: Francisco Dias    +351 919153268    fdias@blueclinical.pt   
Principal Investigator: Jose Presa Ramos, Dr         
Centro Hospitalar São João, EPE -Hospital de São João Recruiting
Porto, Portugal, 4200-319
Contact: Sónia Barros    +35 1917501380    sonia.barros@hsjoao.min-saude.pt   
Principal Investigator: Guilherme Macedo, Prof         
Puerto Rico
University of Puerto Rico Recruiting
Ponce, Puerto Rico, 00716
Contact: Jessica Medina    787-842-0175    jessicamedina0306@gmail.com   
Principal Investigator: Barbara Rosado Carrion, MD         
Klinical Investigations Group, LLC Recruiting
San Juan, Puerto Rico, 00907
Contact: Jessica Carrion-Gonzalez    787-919-7868    jcarriongonz1983@gmail.com   
Principal Investigator: Federico Rodriguez-Perez, MD         
Hospital Auxilio Mutuo Recruiting
San Juan, Puerto Rico, 00919
Contact: Jacqueline Vazquez    787-758-2000 ext 9081    jvazquez@auxiliomutuo.com   
Principal Investigator: Jose Rivera-Acosta, MD         
Fundacion de Investigacion Recruiting
San Juan, Puerto Rico, 00927
Contact: Michelle Echeandia    787-722-1248    mecheandia@fdipr.com   
Principal Investigator: Grisell Ortiz-Lasanta, MD         
Serbia
Klinički Centar Srbije Recruiting
Belgrade, Serbia, 11000
Contact: Tamara Alempijevic       tamara.alempijevic@med.bg.ac.rs   
Principal Investigator: Miodrag Krstić, Prof         
Kliničko Bolnički Centar Zvezdara Recruiting
Belgrade, Serbia, 11000
Contact: Jelena Djordevic    +381 11380 9650    jelena.oxford@gmail.com   
Principal Investigator: Petar Svorcan, Prof         
University Hospital Center Bezanijska Kosa Recruiting
Belgrade, Serbia, 11080
Contact: Marija Brankovic, Dr    +381 64 0150022    manive23@gmail.com   
Principal Investigator: Marija Brankovic, Dr         
University Hospital Center Zemun Recruiting
Belgrade, Serbia, 11080
Contact: Predrag Dugalic, Prof    +381648543101    predrag.dugalic@yahoo.com   
Principal Investigator: Predrag Dugalic, Prof         
Clinical Center Nis Recruiting
Nis, Serbia, 18000
Contact: Aleksander Nagorni, Dr    +381691095002    nagornia@gmail.com   
Principal Investigator: Aleksander Nagorni, Dr         
Spain
Hospital Universitari Son Espases Recruiting
Palma de Mallorca, Baleares, Spain, 07120
Contact: Maria del Carmen La Bandera       pervotrefille@yahoo.es   
Principal Investigator: Lucia Bonet, Dr         
Hospital Universitario Puerta de Hierro Recruiting
Majadahonda, Madrid, Spain, 28222
Contact: Maca Gómez-Alonso       mgadelhuph@gmail.com   
Principal Investigator: Jose Luis Calleja Panero, Dr         
Hospital Universitario Fundación Alcorcon Recruiting
Alcorcon, Spain, 28291
Contact: Julia Molina    34 91 621 94 00 ext 6529    jmolina@fhalcorcon.es   
Principal Investigator: Conrado Fernandez Rodriguez, Dr         
Hospital General y Universitario de Alicante Recruiting
Alicante, Spain
Contact: Encarnacion Andreu    +34 965 933 464    andreu_enc@gva.es   
Principal Investigator: Pablo Bellot, Dr         
Hospital del Mar Recruiting
Barcelona, Spain, 08003
Contact: Maria D Gimenez    34932483220    17276@parcdesalutmar.cat   
Principal Investigator: Jose Carrion, Dr         
Hospital Universitario Vall d'Hebron Recruiting
Barcelona, Spain, 08035
Contact: Macarena Simon-Talero    +34 9327 46240    msimon@vhebron.net   
Principal Investigator: Victor Vargas, Dr         
Hospital Clinic de Barcelona Recruiting
Barcelona, Spain, 08036
Contact: Juan Caballeria Rovira, Dr    + 34 932271713    caballer@clinic.ub.es   
Principal Investigator: Juan Caballeria Rovira, Dr         
Hospital Universitario de León Recruiting
Leon, Spain
Contact: Pedro Linares       plinares68@gmail.com   
Principal Investigator: Francisco Jorquera Plaza, Dr         
Hospital Universitario Ramon y Cajal Recruiting
Madrid, Spain, 28034
Contact: Augustin Albillos, Dr    +34 639 442 551    agustin.albillos@uah.es   
Principal Investigator: Agustin Albillos, Dr         
Hospital Universitario La Paz Recruiting
Madrid, Spain, 28046
Contact: Maria Posada    34 656652954      
Principal Investigator: Antonio Olveira, Dr         
Hospital Universitario Virgen de la Victoria Recruiting
Malaga, Spain, 29010
Contact: Inmaculada Moreno    +34 951032058    inmaculada.moreno@hotmail.com   
Principal Investigator: Raul Andrade, Dr         
Clinica Universidad de Navarra Recruiting
Pamplona, Spain
Contact: Carmen Fuertes    +34 948 296 637    cfuertes@unav.es   
Principal Investigator: José Herrero, Dr         
Hospital Universitario Donostia Recruiting
San Sebastian, Spain, 20014
Contact: Edurne Almandoz    +34 943 007173    edurne.almandozcortajarena@osakidetza.eus   
Principal Investigator: Juan Ignacio Arenas Ruiz Tapiador, Dr         
Hospital Universitario Marqués de Valdecilla Recruiting
Santander, Spain, 39008
Contact: Angel Estebanes Gallo    +34 942202544    aesga@hotmail.com   
Principal Investigator: Javier Crespo Garcia, Dr         
Hospital Clínico de Santiago de Compostela Recruiting
Santiago de Compostela, Spain, 15706
Principal Investigator: Esther Molina, Dr         
Hospital (Universitario) Virgen del Rocio Recruiting
Sevilla, Spain, 41013
Contact: Manuel Romero-Gómez, Dr    +34 600162875    mromerogomez@us.es   
Principal Investigator: Manuel Romero-Gómez, Dr         
Consorcio Hospital General Universitario de Valencia Recruiting
Valencia, Spain, 41016
Contact: Alexa Boix    +34 677 718 141    boix_alenav@gva.es   
Principal Investigator: Moisés Diago Madrid, Dr         
Hospital Clinico Universitario de Valencia Recruiting
Valencia, Spain, 46010
Contact: Laura Puchades    34 961973820    laurapuchades@hotmail.com   
Principal Investigator: Miguel Angel Serra Desfilis, Dr         
La Fe Hospital Recruiting
Valencia, Spain, 46026
Contact: Vanessa Hontangas    +34 96 124 62 93    vahonpla@gmail.com   
Principal Investigator: Marina Berenguer, Dr         
Hospital Clinico Universitario Zaragoza Recruiting
Zaragoza, Spain, 50009
Principal Investigator: Miguel Simon, Dr         
Hospital Universitario Miguel Servet Recruiting
Zaragoza, Spain, 50009
Principal Investigator: Javier Fuentes Olmo, Dr         
Sweden
Sahlgrenska University Hospital Recruiting
Gothenburg, Sweden, 41345
Contact: Angeli Liden    +46 31 3428107    angeli.liden@vgregion.se   
Principal Investigator: Hanns-Ulrich Marschall, Prof         
Magtarmmedicinska mottagningen Universitetssjukhuset Recruiting
Linkoping, Sweden, 58185
Contact: Carola Fagerstrom    +46 70 399 29 31    carola.fagerstrom@regionostergotland.se   
Principal Investigator: Stergios Kechagias, Prof         
Karolinska Universitetssjukhuset Recruiting
Stockholm, Sweden, 14186
Contact: Pia Loqvist    +46 70 870 06 61    pia.loqvist@karolinska.se   
Principal Investigator: Per Stål, Dr         
Switzerland
University of Bern Recruiting
Bern, Switzerland, 3010
Contact: Francois Dufour, Dr    +41 31 632 21 11    Jean-Francois.Dufour@insel.ch   
Principal Investigator: Francois Dufour, Dr         
Centre Hospitalier Universitaire Vaudois Not yet recruiting
Lausanne, Switzerland, 1011
Contact: Pierre Deltenre, Dr    +41 21 314 47 16      
Principal Investigator: Pierre Deltenre, Dr         
Epatocentro Ticino SA Recruiting
Lugano, Switzerland, 6900
Principal Investigator: Benedetta Terziroli Beretta-Piccoli, Dr         
Kantonsspital St.Gallen Recruiting
St.Gallen, Switzerland, 9007
Contact: David Semela, Dr    +41 71 494 27 67    David.Semela@kssg.ch   
Principal Investigator: David Semela, Dr         
USZ Universitätsspital Zürich Recruiting
Zürich, Switzerland, 8091
Contact: Beat Müllhaupt, Prof Dr    +41 44 255 8726    beat.muellhaupt@usz.ch   
Principal Investigator: Beat Müllhaupt, Prof Dr         
United Kingdom
Royal Cornwall Hospital Recruiting
Truro, Cornwall, United Kingdom, TR1 3LJ
Contact: Jessica Summer    +44 1872 252479    jessicasummers@nhs.net   
Principal Investigator: Hyder Hussaini, Dr         
Royal Devon & Exeter Hospital Recruiting
Exeter, Devon, United Kingdom, EX2 5DW
Contact: Katherine Curley    +44 1392 402840    Katherine.curley@nhs.net   
Principal Investigator: Ulrich Thalheimer, Dr         
The Royal Bournemouth Hospital Recruiting
Bournemouth, Dorset, United Kingdom, BH7 7DW
Contact: Emma Gunter    +44 202 704563      
Principal Investigator: Safa Al-Shamma, Dr         
Portsmouth Hospitals NHS Trust, Queen Alexandra Hospital Recruiting
Portsmouth, Hampshire, United Kingdom, PO6 3LY
Contact: Beverley Longhurst       beverley.longhurst@porthosp.nhs.uk   
Principal Investigator: Andrew J Fowell, Dr         
Norfolk & Norwich University Hospitals NHS Foundation Trust Recruiting
Norwich, Norfolk, United Kingdom, NR4 7UY
Contact: Catherine Wright    +44 1603 646108    CATHERINE.WRIGHT@nnuh.nhs.uk   
Principal Investigator: Simon M Rushbrook, Dr         
Oxford University Hospital NHS Trust Recruiting
Headington, Oxford, United Kingdom, OX3 9DU
Contact: Mark Ainsworth       mark.ainsworth@ouh.nhs.uk   
Principal Investigator: Jeremy Cobbold, Dr         
Royal Surrey County Hospital NHS Trust Recruiting
Guildford, Surrey, United Kingdom, GU27XX
Contact: Sally Bradfield       sally.bradfield@nhs.net   
Principal Investigator: Aftab Ala, Prof         
University of Birmingham Recruiting
Birmingham, United Kingdom, B15 2TT
Contact: Kathy Guo    +44 12141 58700    kathy.guo@uhb.nhs.uk   
Principal Investigator: Philip Newsome, Prof         
Bradford Teaching Hospitals Foundation Trust Recruiting
Bradford, United Kingdom, BD9 6RJ
Contact: Janet Johnson    01274 383936    Janet.Johnson@bthft.nhs.uk   
Principal Investigator: Sulleman Moreea, Dr         
Royal Alexander Children's Hospital (CIRU) Recruiting
Brighton, United Kingdom
Contact: Mary FlowerDew    +44 1273 696955 ext 7728    Mary.Flowerdew@bsuh.nhs.uk   
Principal Investigator: Mark Austin, Dr         
University Hospital Bristol NHS Foundation Trust Recruiting
Bristol, United Kingdom, BS2 8HW
Contact: Louise Wright    +44 117 342 9206 ext 29206/29207    Louise.Wright@UHBristol.nhs.uk   
Principal Investigator: Peter Collins, Dr         
Cambridge University Hospital NHS Foundation Trust, Addenbrooke's Hospital Recruiting
Cambridge, United Kingdom, CB2 0QQ
Contact: Julie Ellis    +44 1223 586641      
Principal Investigator: Michael Allison, Dr         
Glasgow Royal Infirmary Recruiting
Glasgow, United Kingdom, G31 2ER
Contact: Susan Thornton    +44 141 211 6800    susan.thornton@ggc.scot.nhs.uk   
Principal Investigator: Ewan H Forrest, Dr         
Hull and East Yorkshire Hospitals NHS Trust Recruiting
Hull, United Kingdom, HU3 2JZ
Contact: Julie Willcox       julie.willcox@hey.nhs.uk   
Principal Investigator: Lynsey Corless, Dr         
Royal London Hospital, Barts Health NHS Trust Recruiting
London, United Kingdom, E1 1BB
Contact: James Hand    +44 20788 27195    j.hand@qmul.ac.uk   
Principal Investigator: William Alazawi, Dr         
The Royal Free Hospital Recruiting
London, United Kingdom, NW3 2QG
Contact: Audrey Esson    +44 207 794 0500 ext 22520    Audreyesson@nhs.net   
Principal Investigator: Emanuel Tsochatzis, Dr         
Guys and St. Thomas NHS Foundation Trust Recruiting
London, United Kingdom, SE1 7EH
Contact: Katila George    +44 207 188 4700    katila.george@gstt.nhs.uk   
Principal Investigator: Jude Oben, Dr         
Imperial College London and Imperial College Healthcare NHS Trust Recruiting
London, United Kingdom, W2 1NY
Contact: Claire Personage    +44 203 312 6404    c.parsonage@imperial.ac.uk   
Principal Investigator: Pinelopi Manousou, Dr         
Central Manchester University Hospital NHS Foundation Trust Manchester Royal Infirmary Recruiting
Manchester, United Kingdom, M13 9WL
Contact: Stephanie Yau    +44 161 701 0168    stephanie.yau@cmft.nhs.uk   
Principal Investigator: Shaun Greer, Dr         
The Newcastle Upon Tyne Hospitals NHS Foundation Trust Recruiting
Newcastle Upon Tyne, United Kingdom, NE7 7DN
Contact: Lorna Brownlee    +44 0191 244 81 82    Lorna.Brownlee@nuth.nhs.uk   
Principal Investigator: Quentin M Anstee, Dr         
Queens Medical Centre, Nottingham University Hospitals Recruiting
Nottingham, United Kingdom, NG7 2UH
Contact: Angela Andrew    0115 9249924 ext 70615    Angela.Andrew@nuh.nhs.uk   
Principal Investigator: Guruprasad P Aithal, Prof         
Derriford Hospital Recruiting
Plymouth, United Kingdom, PL6 8DH
Contact: Linda March    +44 1752 432644    lindamarch@nhs.net   
Principal Investigator: David A Sheridan, Dr         
Sponsors and Collaborators
Intercept Pharmaceuticals
Investigators
Study Director: David Shapiro, MD Intercept Pharmaceuticals

Responsible Party: Intercept Pharmaceuticals
ClinicalTrials.gov Identifier: NCT02548351     History of Changes
Other Study ID Numbers: 747-303
First Posted: September 14, 2015    Key Record Dates
Last Update Posted: January 24, 2018
Last Verified: January 2018

Keywords provided by Intercept Pharmaceuticals:
Non Alcoholic Steatohepatitis, fatty liver disease, NASH

Additional relevant MeSH terms:
Fatty Liver
Non-alcoholic Fatty Liver Disease
Liver Diseases
Digestive System Diseases
Chenodeoxycholic Acid
Cathartics
Gastrointestinal Agents