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221AD301 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease (ENGAGE)

This study is currently recruiting participants.
See Contacts and Locations
Verified June 2017 by Biogen
Sponsor:
Information provided by (Responsible Party):
Biogen
ClinicalTrials.gov Identifier:
NCT02477800
First received: June 18, 2015
Last updated: June 2, 2017
Last verified: June 2017
  Purpose
The primary objective of the study is to evaluate the efficacy of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) score as compared with placebo in participants with early AD. Secondary objectives are to assess the effect of monthly doses of aducanumab as compared with placebo on clinical progression as measured by Mini-Mental State Examination (MMSE), AD Assessment Scale-Cognitive Subscale (13 items) [ADAS-Cog 13], and AD Cooperative Study-Activities of Daily Living Inventory (Mild Cognitive Impairment version) [ADCS-ADL-MCI].

Condition Intervention Phase
Alzheimer's Disease Drug: Aducanumab (BIIB037) Drug: Placebo Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Participant, Care Provider, Investigator, Outcomes Assessor
Primary Purpose: Treatment
Official Title: A Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Aducanumab (BIIB037) in Subjects With Early Alzheimer's Disease

Resource links provided by NLM:


Further study details as provided by Biogen:

Primary Outcome Measures:
  • Change from baseline in CDR-SB score [ Time Frame: Week 78 ]

Secondary Outcome Measures:
  • Change from baseline in MMSE score [ Time Frame: Week 78 ]
  • Change from baseline in Alzheimer's Disease Assessment Scale-Cognitive Subscale (13 items) (ADAS-Cog 13) [ Time Frame: Week 78 ]
  • Change from baseline in Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory (Mild Cognitive Impairment version) (ADCS-ADL-MCI) score [ Time Frame: Week 78 ]

Estimated Enrollment: 1350
Actual Study Start Date: August 31, 2015
Estimated Study Completion Date: March 5, 2022
Estimated Primary Completion Date: November 18, 2019 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Low Dose
Monthly intravenous (IV) infusion
Drug: Aducanumab (BIIB037)
Low dose
Drug: Placebo
Placebo
Experimental: High Dose
Monthly intravenous (IV) infusion
Drug: Aducanumab (BIIB037)
High dose
Drug: Placebo
Placebo

  Eligibility

Ages Eligible for Study:   50 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Key Inclusion Criteria:

  • Must meet all of the following clinical criteria for MCI due to AD or mild AD and must have:
  • A Clinical Dementia Rating (CDR)-Global Score of 0.5.
  • Objective evidence of cognitive impairment at screening
  • An MMSE score between 24 and 30 (inclusive)
  • Must have a positive amyloid Positron Emission Tomography (PET) scan
  • Must consent to apolipoprotein E (ApoE) genotyping
  • If using drugs to treat symptoms related to AD, doses must be stable for at least 8 weeks prior to screening visit 1
  • Must have a reliable informant or caregiver

Key Exclusion Criteria:

  • Any medical or neurological condition (other than Alzheimer's Disease) that might be a contributing cause of the subject's cognitive impairment
  • Have had a stroke or Transient Ischemic Attack (TIA) or unexplained loss of consciousness in the past 1 year
  • Clinically significant unstable psychiatric illness in past 6 months
  • History of unstable angina, myocardial infarction, advanced chronic heart failure, or clinically significant conduction abnormalities within 1 year prior to Screening
  • Indication of impaired renal or liver function
  • Have human immunodeficiency virus (HIV) infection
  • Have a significant systematic illness or infection in past 30 days
  • Relevant brain hemorrhage, bleeding disorder and cerebrovascular abnormalities
  • Any contraindications to brain magnetic resonance imaging (MRI) or PET scans
  • Alcohol or substance abuse in past 1 year
  • Taking blood thinners (except for aspirin at a prophylactic dose or less)

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT02477800

Contacts
Contact: Aducanumab Global Clinical Trial Center clinicaltrials@biogen.com
Contact: Aducanumab US Call Center 877-231-7271 clinicaltrials@biogen.com

  Hide Study Locations
Locations
United States, Arizona
St. Joseph's Hospital and Medical Center Recruiting
Phoenix, Arizona, United States, 85013
Contact    602-406-6262      
Principal Investigator: Jiong Shi         
Center for Neurosciences Recruiting
Tucson, Arizona, United States, 85718
Contact    520-320-2147      
Principal Investigator: Michael Badruddoja         
United States, California
Neurology Center of North Orange County Recruiting
Fullerton, California, United States, 92835
Contact    714-879-7200      
Principal Investigator: Anthony Ciabarra         
Senior Clinical Trials, Inc. Recruiting
Laguna Hills, California, United States, 92653
Contact    949-588-0909      
Principal Investigator: Robert Feldman         
Torrance Clinical Research Institute, Inc. Active, not recruiting
Lomita, California, United States, 90717
University of California - Los Angeles Recruiting
Los Angeles, California, United States, 90095
Contact    310-794-6191      
Principal Investigator: Sarah Kremen         
UCSF - Memory and Aging Center Recruiting
San Francisco, California, United States, 94158
Contact    415-476-8333      
Principal Investigator: Adam Boxer         
California Neuroscience Research Medical Group Inc. Recruiting
Sherman Oaks, California, United States, 91403
Contact    818-990-2671      
Principal Investigator: Thomas Shiovitz         
Southern California Research LLC Recruiting
Simi Valley, California, United States, 93065
Contact    818-631-7489      
Principal Investigator: Brock Summers         
United States, Connecticut
Institute for Neurodegenerative Disorders Recruiting
New Haven, Connecticut, United States, 06510
Contact    203-401-4300      
Principal Investigator: David Russell         
United States, District of Columbia
Georgetown University Hospital Recruiting
Washington, D.C., District of Columbia, United States, 20057
Contact    202-687-7337      
Principal Investigator: Raymond Turner         
United States, Florida
Brain Matters Research, Inc. Recruiting
Delray Beach, Florida, United States, 33445
Contact    561-374-8461      
Principal Investigator: Mark Brody         
Neuropsychiatric Research Center of Southwest Florida Recruiting
Fort Myers, Florida, United States, 33912
Contact    239-939-7777      
Principal Investigator: Frederick Schaerf         
Jacksonville Center for Clinical Research Recruiting
Jacksonville, Florida, United States, 32216
Contact    904-730-0101      
Principal Investigator: Erin Doty         
University of Miami Recruiting
Miami, Florida, United States, 33136
Contact    305-243-0184      
Principal Investigator: Barry Baumel         
Miami Jewish Health Systems Recruiting
Miami, Florida, United States, 33137
Contact    305-751-8626      
Principal Investigator: Marc Agronin         
New Horizon Research Center, Inc Active, not recruiting
Miami, Florida, United States, 33175
Compass Research Main Recruiting
Orlando, Florida, United States, 32806
Contact    407-426-9299      
Principal Investigator: Craig Curtis         
Palm Beach Neurological Center Recruiting
Palm Beach Gardens, Florida, United States, 33410
Contact    561-282-5541      
Principal Investigator: Michael Tuchman         
Stedman Clinical Trials, LLC Recruiting
Tampa, Florida, United States, 33613
Contact    813-971-8311      
Principal Investigator: Mary Stedman         
USF Health Byrd Institute Recruiting
Tampa, Florida, United States, 33616
Contact    813-974-4355      
Principal Investigator: Amanda Smith         
Meridien Research Recruiting
Tampa, Florida, United States, 33634
Contact    813-877-8839      
Principal Investigator: Cynthia Huffman         
Compass Research Main Recruiting
The Villages, Florida, United States, 32162
Contact    352-261-0901      
Principal Investigator: David Subich         
Premiere Research Institute Recruiting
West Palm Beach, Florida, United States, 33407
Contact    561-845-0500      
Principal Investigator: Walter Martinez         
Cleveland Clinic Florida - Weston Recruiting
Weston, Florida, United States, 33331
Contact    954-659-5670      
Principal Investigator: Po-Heng Tsai         
United States, Georgia
MS Center of Atlanta Active, not recruiting
Atlanta, Georgia, United States, 30327
United States, Illinois
Alexian Brothers Neurosciences Institute Recruiting
Elk Grove Village, Illinois, United States, 60007
Contact    847-593-8553      
Principal Investigator: Concetta Forchetti         
Advocate Lutheran General Hospital Recruiting
Park Ridge, Illinois, United States, 60068
Contact    847-720-6464      
Principal Investigator: Darren Gitelman         
United States, Indiana
Fort Wayne Neurological Center Recruiting
Fort Wayne, Indiana, United States, 46804
Contact    260-436-3991      
Principal Investigator: James Stevens         
Indiana University School of Medicine Recruiting
Indianapolis, Indiana, United States, 46202
Contact    317-963-7411      
Principal Investigator: Martin Farlow         
United States, Kansas
University of Kansas Medical Center Research Institute, Inc. Recruiting
Kansas City, Kansas, United States, 66160
Contact    913-588-0555      
Principal Investigator: Jeffrey Burns         
Via Christi Research, a division of Via Christi Hospitals Wichita, Inc. Recruiting
Wichita, Kansas, United States, 67214
Contact    316-291-4774      
Principal Investigator: Paul Murphy         
United States, Kentucky
Baptist Health Lexington Recruiting
Lexington, Kentucky, United States, 40503
Contact    859-260-4330      
Principal Investigator: Gregory Cooper         
United States, Massachusetts
Brigham & Women's Hosp End/Dbt Recruiting
Boston, Massachusetts, United States, 02115
Contact    617-732-8085      
Principal Investigator: Scott McGinnis         
Beth Israel Deaconess Medical Center Recruiting
Boston, Massachusetts, United States, 02215
Contact    617-667-5553      
Principal Investigator: Henry Querfurth         
ActivMed Practices & Research Recruiting
Methuen, Massachusetts, United States, 01844
Contact    978-655-7155      
Principal Investigator: Michael McCartney         
Donald S. Marks, M.D., P.C. Recruiting
Plymouth, Massachusetts, United States, 02360
Contact    508-746-5060      
Principal Investigator: Donald Marks         
United States, Minnesota
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact    763-588-0661      
Principal Investigator: David Knopman         
United States, Missouri
Washington University Not yet recruiting
Saint Louis, Missouri, United States, 63131
Contact    314-747-2107      
Principal Investigator: Barbara Snider         
United States, Nevada
Las Vegas Medical research Recruiting
Las Vegas, Nevada, United States, 89113
Contact    310-993-9118      
Principal Investigator: Bharat Mocherla         
United States, New Jersey
Advanced Memory Research Institute of NJ, PC Recruiting
Toms River, New Jersey, United States, 08755
Contact    732-341-9500      
Principal Investigator: Sanjiv Sharma         
United States, New York
Albany Medical College Recruiting
Albany, New York, United States, 12208
Contact    518-262-0800      
Principal Investigator: Earl Zimmerman         
New York University Medical Center PRIME Recruiting
New York, New York, United States, 10016
Contact    212-263-7744      
Principal Investigator: Martin Sadowski         
University of Rochester Recruiting
Rochester, New York, United States, 14620
Contact    585-760-6560      
Principal Investigator: Anton Porsteinsson         
United States, North Carolina
ANI Neurology, PLLC d/b/a Alzheimer's Memory Center Recruiting
Charlotte, North Carolina, United States, 28270
Contact    704-364-4000      
Principal Investigator: Mohammad Bolouri         
Raleigh Neurology Associates, P.A. Recruiting
Raleigh, North Carolina, United States, 27607-6010
Contact    919-782-3456      
Principal Investigator: Michael Bowman         
United States, Ohio
Cleveland Clinic Recruiting
Cleveland, Ohio, United States, 44195
Contact    216-521-2228      
Principal Investigator: Babak Tousi         
United States, Oklahoma
Lynn Health Science Institute Recruiting
Oklahoma City, Oklahoma, United States, 73112
Contact    405-602-3939      
Principal Investigator: Carl Griffin         
United States, Pennsylvania
The Clinical Trial Center, LLC Recruiting
Jenkintown, Pennsylvania, United States, 19046
Contact    215-884-1700      
Principal Investigator: Marvin Kalafer         
University of Pittsburgh Recruiting
Pittsburgh, Pennsylvania, United States, 15213
Contact    412-692-2700      
Principal Investigator: Oscar Lopez         
Northeastern Pennsylvania Memory and Alzheimer's Center Recruiting
Plains, Pennsylvania, United States, 18705
Contact    570-207-3945      
Principal Investigator: Mario Cornacchione         
United States, Rhode Island
Rhode Island Mood & Memory Research Institute Recruiting
East Providence, Rhode Island, United States, 02915
Contact    401-435-8950      
Principal Investigator: John Stoukides         
Butler Hospital Recruiting
Providence, Rhode Island, United States, 02906
Contact    401-455-6203      
Principal Investigator: Stephen Salloway         
United States, South Carolina
Medical University of South Carolina (MUSC) Recruiting
Charleston, South Carolina, United States, 29425
Contact    843-792-3221      
Principal Investigator: David Clark         
United States, Tennessee
Neurology Clinic, PC Recruiting
Cordova, Tennessee, United States, 38108
Contact    901-866-9252      
Principal Investigator: Lee Stein         
Quillen College Of Medicine, East Tn State University Active, not recruiting
Johnson City, Tennessee, United States, 37614
University of Tennessee Medical Center. Knoxville Recruiting
Knoxville, Tennessee, United States, 37920
Contact    865-305-6740      
Principal Investigator: John Dougherty         
Clinical Neuroscience Solutions, Inc. Recruiting
Memphis, Tennessee, United States, 38119
Contact    901-843-1045      
Principal Investigator: Lora McGill         
United States, Texas
UT Southwestern Medical Center at Dallas Recruiting
Dallas, Texas, United States, 75390
Contact    214-648-9367      
Principal Investigator: Benjamin Williams         
Baylor College of Medicine Recruiting
Houston, Texas, United States, 77030
Contact    713-798-4734      
Principal Investigator: Joseph Kass         
United States, Virginia
National Clinical Research Inc.-Richmond Recruiting
Richmond, Virginia, United States, 23294
Contact    804-672-2995      
Principal Investigator: John Scott         
United States, Wisconsin
Medical College of Wisconsin, Inc. Recruiting
Milwaukee, Wisconsin, United States, 53266
Contact    414-805-5224      
Principal Investigator: Piero Antuono         
Australia, New South Wales
St Vincent's Hospital Sydney Recruiting
Darlinghurst, New South Wales, Australia, 2010
Central Coast Neurosciences Research, Gosford Recruiting
East Gosford, New South Wales, Australia, 2250
KARA Institute for Neurological Diseases Recruiting
North Ryde, New South Wales, Australia, 2113
Calvary Mater Newcastle Recruiting
Waratah, New South Wales, Australia, 2298
Australia, Queensland
Queensland University of Technology Recruiting
Brisbane, Queensland, Australia, 4222
The Prince Charles Hospital Recruiting
Chermside, Queensland, Australia, 4032
Royal Brisbane and Women's Hospital Recruiting
Herston, Queensland, Australia, 4006
Toowoomba Base Hospital Recruiting
Toowoomba, Queensland, Australia, 4350
Australia, Victoria
Box Hill Hospital Recruiting
Box Hill, Victoria, Australia, 3128
Austin Hospital Recruiting
Heidelberg, Victoria, Australia, 3084
Royal Melbourne Hospital Active, not recruiting
Parkville, Victoria, Australia, 3050
Epworth Healthcare Active, not recruiting
Richmond, Victoria, Australia, 3121
Australia, Western Australia
McCusker Alzheimer's Research Foundation Recruiting
Nedlands, Western Australia, Australia, 6009
Neurodegenerative Disorders Research Recruiting
West Perth, Western Australia, Australia, 6005
Austria
LKH - Universitaetsklinikum Graz Recruiting
Graz, Austria, 8036
Christian-Doppler-Klinik - Universitätsklinikum Salzburg Recruiting
Salzburg, Austria, 5020
AKH - Medizinische Universität Wien Active, not recruiting
Vienna, Austria, 1090
AKH - Medizinische Universität Wien Recruiting
Vienna, Austria, 1090
Canada, Alberta
Heritage Medical Research Clinic Recruiting
Calgary, Alberta, Canada, T2N 1N4
Canada, British Columbia
The Medical Arts Health Research Group Recruiting
Penticton, British Columbia, Canada, V2A 5C8
UBC Hospital Recruiting
Vancouver, British Columbia, Canada, V6T 2B5
Canada, Ontario
Toronto Memory Program (Neurology Research Inc.) Recruiting
Toronto, Ontario, Canada, M3B 2S7
Toronto Sunnybrook Hospital Recruiting
Toronto, Ontario, Canada, M4N 3M5
Canada, Quebec
The Montreal Neurological Institute Recruiting
Montreal, Quebec, Canada, H3A 2B4
McGill Centre for Studies in Aging Recruiting
Verdun, Quebec, Canada, H4H 1R3
Canada
CHU de Quebec - Hôpital de l' Enfant Jésus Recruiting
Quebec, Canada, G1J 1Z4
Denmark
CCBR - Ballerup - DK Recruiting
Ballerup, Denmark, 2750
Contact    +45 4470 4470      
Principal Investigator: Line Markdanner Lindgren         
Rigshospitalet Recruiting
København Ø, Denmark, 2100
Contact    +4535456702      
Principal Investigator: Dr. Peter Johannsen         
CCBR - Vejle - DK Recruiting
Vejle, Denmark, 7100
Contact    +45 7572 6066      
Principal Investigator: Annette Justesen         
CCBR - Ålborg - DK Recruiting
Ålborg, Denmark, 9100
Contact    +45 96334720      
Principal Investigator: Anna Areovimata         
France
CHU Strasbourg - Hôpital Hautepierre Recruiting
Strasbourg Cedex, Bas Rhin, France, 67098
Hopital Louis Pasteur Colmar Recruiting
Strasbourg, Bas Rhin, France, 67091
Contact    00 33 3 89 12 70 97      
Principal Investigator: Pierre Anthony         
CHU Dijon - Hopital General# Active, not recruiting
Dijon, Côte-d'Or, France, 21079
Groupe Hospitalier Pellegrin - Hôpital Pellegrin Recruiting
Bordeaux, Gironde, France, 33076
Contact    05 57 82 01 16      
Principal Investigator: Sophie Auriacombe         
CHU Reims - Hôpital Maison Blanche Recruiting
Reims, Marne, France, 51092
Hopital Neurologique Pierre Wertheimer Recruiting
Bron Cedex, Rhone, France, 69677
Contact    +33 4-72-35-71-32      
Principal Investigator: Helene Mollion         
Groupe hospitalier Broca - La Rochefoucauld - La Collégiale Recruiting
Paris, France, 75013
Groupe Hospitalier Pitie-Salpetriere Recruiting
Paris, France, 75013
Contact    33 1 42 16 7501      
Principal Investigator: Bruno Dubois         
Germany
Praxis Dr. Scholz Recruiting
Boeblingen, Baden Wuerttemberg, Germany, 71034
Aerztliche Gemeinschaftspraxis Recruiting
Ostfildern, Baden Wuerttemberg, Germany, 73760
Neuro MVZ Stuttgart Recruiting
Stuttgart, Baden Wuerttemberg, Germany, 70182
Klinikum der Johann Wolfgang Goethe-Universitaet Recruiting
Frankfurt, Bayern, Germany, 97080
Praxis Dr. med. Bergmann Recruiting
Neuburg, Bayern, Germany, 86633
Neurologische Gemeinschaftspraxis Kassel Recruiting
Kassel, Hessen, Germany, 34121
Klinische Forschung Hannover-Mitte GmbH Recruiting
Hannover, Niedersachsen, Germany, 30159
Universitaetsklinikum Aachen AOeR Recruiting
Aachen, Nordrhein Westfalen, Germany, 52074
Universitaetsklinikum Bonn AoeR Recruiting
Bonn, Nordrhein Westfalen, Germany, 53127
Universitaetsklinikum Koeln Recruiting
Cologne, Nordrhein Westfalen, Germany, 53105
Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin Recruiting
Berlin, Germany, 14050
Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti Recruiting
Torrette di Ancona, Ancona, Italy, 60126
Fondazione Istituto G.Giglio di Cefalù Not yet recruiting
Cefalù, Palermo, Italy, 90015
Azienda Ospedaliera Ospedali Riuniti di Bergamo Not yet recruiting
Bergamo, Italy, 24100
Azienda Ospedaliera Spedali Civili di Brescia Recruiting
Brescia, Italy, 25100
Azienda Ospedaliero Universitaria San Martino Recruiting
Genova, Italy, 16132
Ospedale San Raffaele Recruiting
Milano, Italy, 20132
Casa di Cura del Policlinico Recruiting
Milano, Italy, 20144
Azienda Ospedaliera Universitaria "Federico II" Recruiting
Napoli, Italy, 80131
Seconda Università degli Studi di Napoli Recruiting
Napoli, Italy, 80138
Azienda Ospedaliero Universitaria Pisana Recruiting
Pisa, Italy, 56126
Policlinico Universitario Agostino Gemelli Recruiting
Roma, Italy, 00168
Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona Recruiting
Salerno, Italy, 84131
A.O.U. Senese Policlinico Santa Maria alle Scotte Recruiting
Siena, Italy, 53100
Japan
Research Site Recruiting
Chiba-Shi, Chiba-Ken, Japan, 263-0043
Research Site Recruiting
Inzai-shi, Chiba-Ken, Japan
Research Site Recruiting
Aizuwakamatsu-shi, Fukushima-Ken, Japan, 965-8585
Research Site Recruiting
Asahikawa-shi, Hokkaido, Japan, 070-8644
Research Site Not yet recruiting
Sapporo-shi, Hokkaido, Japan, 006-8555
Research Site Recruiting
Sapporo-shi, Hokkaido, Japan, 064-8570
Research Site Recruiting
Atsugi-shi, Kanagawa-Ken, Japan, 243-8551
Research Site Recruiting
Kamakura-shi, Kanagawa-Ken, Japan, 247-8533
Research Site Not yet recruiting
Kawasaki-Shi, Kanagawa-Ken, Japan, 211-8533
Research Site Not yet recruiting
Yokohama-shi, Kanagawa-Ken, Japan, 225-0025
Research Site Not yet recruiting
Yokohama-shi, Kanagawa-Ken, Japan, 236-0004
Research Site Recruiting
Nagaoka-shi, Niigata-Ken, Japan, 940-2081
Research Site Recruiting
Kasukabe-shi, Saitama-Ken, Japan, 344-0036
Research Site Recruiting
Bunkyo-ku, Tokyo-To, Japan, 113-0034
Research Site Not yet recruiting
Bunkyo-ku, Tokyo-To, Japan, 113-8603
Research Site Recruiting
Shinjuku-ku (I), Tokyo-To, Japan, 162-8655
Research Site Recruiting
Shinjuku-ku, Tokyo-To, Japan, 162-8655
Research Site Recruiting
Ota-ku, Tokyo, Japan, 143-8541
Research Site Recruiting
Yamagata-shi, Yamagata-Ken, Japan, 990-0834
Research Site Recruiting
Itabashi-ku, Japan, 173-0015
Research Site Recruiting
Itabashi-ku, Japan, 173-8610
Research Site Recruiting
Kiyose-shi, Japan
Research Site Recruiting
Kodaira-shi, Japan, 187-8551
Research Site Not yet recruiting
Tsukuba-shi, Japan
Korea, Republic of
Inha University Hospital Recruiting
Incheon, Gyeonggi-do, Korea, Republic of, 22332
Seoul National University Bundang Hospital Recruiting
Seongnam-si, Gyeonggi-do, Korea, Republic of, 13620
Gachon University Gil Medical Center Recruiting
Incheon, Korea, Republic of, 21565
Asan Medical Center Recruiting
Seoul, Korea, Republic of, 05505
Samsung Medical Center Recruiting
Seoul, Korea, Republic of, 06351
Konkuk University Medical Center Recruiting
Seoul, Korea, Republic of, 143-729
Portugal
Hospital Professor Doutor Fernando Fonseca, E.P.E. Recruiting
Amadora, Portugal, 2720-276
Hospital de Braga Recruiting
Braga, Portugal, 4710-243
Centro Hospitalar e Universitário de Coimbra E.P.E Recruiting
Coimbra, Portugal, 3040-278
Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria Recruiting
Lisboa, Portugal, 1649-035
Hospital Beatriz Ângelo Recruiting
Loures, Portugal, 2674-514
Campus Neurologico Senior Recruiting
Torres Vedras, Portugal, 2560-280
Spain
Policlinica Guipuzcoa Recruiting
San Sebastian, Guipuzcoa, Spain, 20014
Contact    +34 637 45 01 82      
Principal Investigator: Nadege Van Blercon         
Hospital de Cruces Recruiting
Barakaldo, Vizcaya, Spain, 48903
Fundacio ACE Recruiting
Barcelona, Spain, 08028
Hospital Clinic i Provincial de Barcelona Recruiting
Barcelona, Spain, 08036
Hospital de la Santa Creu i Sant Pau Recruiting
Barcelona, Spain, 08041
Clinica Ruber Recruiting
Madrid, Spain, 28006
Hospital Universitario Dr. Peset Recruiting
Valencia, Spain, 46017
Hospital Universitari i Politecnic La Fe Recruiting
Valencia, Spain, 46026
Taiwan
Changhua Christian Hospital Recruiting
Changhua, Taiwan, 500
Kaohsiung Medical University Chung-Ho Memorial Hospital Recruiting
Kaohsiung, Taiwan, 807
Kaohsiung Chang Gung Memorial Hospital Recruiting
Kaohsiung, Taiwan, 83301
National Cheng Kung University Hospital Recruiting
Tainan, Taiwan, 704
National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Chang Gung Memorial Hospital, Linkou Recruiting
Taoyuan County, Taiwan, 333
United Kingdom
Southmead Hospital Recruiting
Bristol, Avon, United Kingdom, BS16 1LE
Re:Cognition Health Ltd Recruiting
London, Greater London, United Kingdom, W1G 9JF
Charing Cross Hospital Recruiting
London, Greater London, United Kingdom, W6 8RF
The National Hospital for Neurology and Neurosurgery Centre Recruiting
London, Greater London, United Kingdom, WC1N 3BG
Salford Royal Recruiting
Salford, Greater Manchester, United Kingdom, M6 8HD
The University of Edinburgh Recruiting
Edinburgh, Lothian Region, United Kingdom, EH8 9YL
Contact    07736069590      
Principal Investigator: Ritchie Craig         
West Middlesex Hospital Recruiting
Isleworth, Middlesex, United Kingdom, TW7 6AF
The RICE Centre Recruiting
Bath, Somerset, United Kingdom, BA1 3NG
Glasgow Memory Clinic Ltd Recruiting
Glasgow, Strathclyde, United Kingdom, G20 0XA
Stobhill ACH Hospital Recruiting
Glasgow, Strathclyde, United Kingdom, G21 3UW
Ninewells Hospital Recruiting
Dundee, Tayside Region, United Kingdom, DD2 1GZ
Newcastle University Recruiting
Newcastle upon Tyne, Tyne & Wear, United Kingdom, NE4 5PL
Contact    441912481270      
Principal Investigator: Andrew Byrne         
Kingshill Research Centre Active, not recruiting
Chippenham, Wiltshire, United Kingdom, SN15 1GG
Sponsors and Collaborators
Biogen
Investigators
Study Director: Medical Director Biogen
  More Information

Additional Information:
Responsible Party: Biogen
ClinicalTrials.gov Identifier: NCT02477800     History of Changes
Other Study ID Numbers: 221AD301
2015-000966-72 ( EudraCT Number )
Study First Received: June 18, 2015
Last Updated: June 2, 2017

Keywords provided by Biogen:
BIIB037
Aducanumab

Additional relevant MeSH terms:
Alzheimer Disease
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders

ClinicalTrials.gov processed this record on June 23, 2017